The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript

Journal of Virology

Volumn 70, Issue 2, 1996, Pages 976-984

  Perng, Guey Chuen ^a   Ghiasi, Homayon ^a,b   Slanina, Susan M ^a   Nesburn, Anthony B ^a,b   Wechsler, Steven L ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; EYE INFECTION; FEMALE; GENE MAPPING; HERPES SIMPLEX VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RABBIT; RNA TRANSCRIPTION; VIRUS GENE; VIRUS LATENCY; VIRUS MUTANT; VIRUS REACTIVATION;

ANIMALS; BASE SEQUENCE; BLOTTING, SOUTHERN; CELLS, CULTURED; CULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; DNA, VIRAL; FEMALE; GENES, OVERLAPPING; GENES, VIRAL; HERPESVIRUS 1, HUMAN; HUMANS; KERATITIS, DENDRITIC; MOLECULAR SEQUENCE DATA; RABBITS; RNA, VIRAL; TRANSCRIPTION, GENETIC; TRIGEMINAL GANGLION; VIRULENCE; VIRUS ACTIVATION; VIRUS REPLICATION;

EID: 0030030341     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.2.976-984.1996     Document Type: Article

References (47)

1. Block, T. M., J. G. Spivack, I. Steiner, S. Deshmane, M. T. McIntosh, R. P. Lirette, and N. W. Fraser. 1990. A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection. J. Virol 64:3417-3426.
2. Bloom, D. C., G. B. Devi-Rao, J. M. Hill, J. G. Stevens, and E. K. Wagner. 1994. Molecular analysis of herpes simplex virus type 1 during epinephrine-induced reactivation of latently infected rabbits in vivo. J. Virol 68:1283-1292.
3. Bohenzky, R. A., M. Lagunoff, B. Roizman, E. K. Wagner, and S. Silverstein. 1995. Two overlapping transcription units which extend across the L-S junction of herpes simplex virus type 1. J. Virol. 69:2889-2897.
4. Bolovan, C. A., N. M. Sawtell, and R. L. Thompson. 1994 ICP34 5 mutants in herpes simplex virus type 1 strain 17 syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cells J Virol. 68:48-55.
5. Chou, J., E. R. Kern, R. J. Whitley, and B. Roizman. 1990. Mapping of herpes simplex virus-neurovirulence to gamma 134.5, a gene nonessential for growth in culture. Science 250:1262-1265.
6. Croen, K. D., J. M. Ostrove, L. J. Dragovic, J. E. Smialek, and S. E. Straus. 1987. Latent herpes simplex virus in human trigeminal ganglia, detection of an immediate early gene "antisense" transcript by in situ hybridization. N. Engl. J. Med. 317:1427-1432.
7. Crowl, R., C. Seamens, P. Lomedico, and S. McAndrew. 1985. Versatile expression vectors for high-level synthesis of cloned gene products in E. coli. Gene 38:31-38.
8. Fanagan, W. M., A. G. Papavassiliou, M. Rice, L. B. Hect, S. Silverstein, and E. K. Wagner, 1991. Analysis of the herpes simplex virus type 1 promoter controlling the expression of UL38, a true late gene involved in capsid assembly. J. Virol. 65:769-786.
9. Gordon, Y.J., B. Johnson, E. Romanowski, and T. Araullo-Cruz. 1988 RNA complementary to herpes simplex virus type 1 1CP0 gene demonstrated in neurons of human trigeminal ganglia. J Virol. 62:1832-1835.
10. Gordon, Y. J., J. L. C. McKnight, J. M. Ostrove, E. Romanowski, and T. Araullo-Cruz. 1990. Host species and strain differences affect the ability of an HSV-1 ICP0 deletion mutant to establish latency and spontaneously reactivate in vivo. Virology 178:469-477.
11. Hill, J. M., F. Sederati, R. T. Javier, E. K. Wagner, and J. G. Stevens. 1990. Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology 174:117-125.
12. Ho, D. Y., and E. S. Mocarski. 1989. Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse. Proc. Natl. Acad. Sci. USA 86:7596-7600.
13. Javier, R. T., J. G. Stevens, V. B. Dissette, and E. K. Wagner. 1988. A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state Virology 166:254-257.
14. Johnson, P. A., and R. D. Everett. 1986. The control of herpes simplex virus type 1 late gene transcription, a TATA box/cap site region is sufficient for fully efficient regulated activity. Nucleic Acids Res. 14:8247-8264.
15. Katz, J. P., E. T. Bodin, and D. M. Coen. 1990. Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants J. Virol. 64:4288-4295
16. 134.5 gene and transcribed by an RNA 3′ terminal with the unspliced latency-associated transcript. J. Virol. 68: 6021-6028.
17. Lagunoff, M., and B. Roizman. 1995 The regulation of synthesis and properties of the protein product of open reading frame P of the herpes simplex virus 1 genome. J Virol. 69:3615-3623.
18. Leib, D. A., C. L. Bogard, M. Kosz-Vnenchak, K. A. Hicks, D. M. Coen. D. M. Knipe, and P. A. Schaffer. 1989. A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. J. Virol 63:2893-2900.
19. Leib, D. A., K. C. Nadeau, K. C. Rundle, S. A. Rundle, and P. A. Schaffer, 1991. Promoter of the latency-associated transcripts of herpes simplex virus type-1 contains a functional cAMP-response element: role of the latency associated transcripts and cAMP in reactivation of viral latency. Proc Natl. Acad. Sci. USA 88:48-52.
20. Mitchell, W. J., R. P. Lirette, and N. W. Fraser. 1990. Mapping of low-abundance latency-associated RNA in trigeminal ganglia of mice latently infected with herpes simplex virus type 1 Virology 71:125-132.
21. Nesburn, A, B. 1983 In A B Nesburn (ed.). Report of the corneal disease panel, vision research: a national plan 1983-1987, vol II, part III. The C V Mosby Co., St. Louis.
22. Nesburn, A. B., H. Ghiasi, and S. L. Wechsler. 1990 Ocular safety and efficacy of an HSV-1 gD vaccine during primary and latent infection Invest Ophthal Vis. Sci. 31:77-82.
23. Perng, G.-C., K. Chokephaibulkit, R. L. Thompson, N. M. Sawtell, S. M. Slanina, H. Ghiasi, A. B. Nesburn, and S. L. Wechsler. 1996 The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation J Virol 70:282-291.
24. Perng, G. C., E. C. Dunkel, P. A. Geary, S. M. Slanina, H. Ghiasi, R. Kaiwar, A. B. Nesburn, and S. L. Wechsler. 1994 The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency. J. Virol. 68:8045-8055.
25. Perng, G. C., H. Ghiasi, R. Kaiwar, A.B. Nesburn, and S. L. Wechsler. 1994. An improved method for cloning portions of the repeat regions of herpes simplex virus type 1. J. Virol. Methods 46:111-116.
26. Perng, G. C., R. L. Thompson, N. M. Sawtell, W. E. Taylor, S. M. Slanina, H. Ghiasi, R. Kaiwar, A. B. Nesburn, and S. L. Wechsler. 1995. An avirulent ICP34.5 deletion mutant of herpes simplex virus type 1 is capable of in vivo spontaneous reactivation. J. Virol. 69:3033-3041.
27. Ramakrishnan, R., D. J. Fink, G. Jiang, P. Desai, J. C. Glorioso, and M. Levine. 1994. Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain. J. Virol. 68:1864-1873.
28. Rock, D. L., A. B. Nesburn, H. Ghiasi, J. Ong, T. L. Lewis, J. R. Lokensgard, and S. L. Wechsler. 1987. Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1. J. Virol. 61:3820-3826.
29. Sawtell, N. M., and R. L. Thompson. 1992. Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency. J. Virol. 66:2157-2169.
30. Shapira, M., F. L. Homa, J. C. Glorioso, and M. Levine. 1987. Regulation of the herpes simplex virus type 1 late (gamma 2) glycoprotein C gene: sequences between base pairs -34 to +29 control transient expression and responsiveness to transactivation by the products of the immediate early alpha 4 and 0 genes. Nucleic Acids Res. 15:3097-3111.
31. Shelton, L. S., M. N. Pensiero, and F. J. Jenkins. 1990. Identification and characterization of the herpes simplex virus type 1 protein encoded by the UL37 open reading frame J. Virol. 64:6101-6109.
32. Spivack, J. G., and N. W. Fraser. 1988. Expression of herpes simplex virus type I latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection. J. Virol 62:1479-1485.
33. Steiner, I., J. G. Spivack, R. P. Lirette, S. M. Brown, A. R. MacLean, J. H. Subak-Sharpe, and N. W. Fraser. 1989. Herpes simplex virus type 1 latency associated transcripts are evidently not essential for latent infection. EMBO J. 8:505-511.
34. Steiner, I., J. G. Spivack, D. R. O'Bovle II, E. Lavi, and N. W. Fraser. 1988. Latent herpes simplex virus type 1 transcription in human trigeminal ganglia. J. Virol. 62:3493-3496.
35. Stevens, J. G., E. K. Wagner, G. B. Devi-Rao, M. L. Cook, and L. T. Feldman. 1987. RNA complementary to a herpesvirus alpha gene mRNA is prominant in latently infected neurons. Science 235:1056-1059.
36. Takasu, T., Y. Furuta, K. C. Sato, S. Fukuda, Y. Inuyama, and K. Nagashima. 1992. Detection of latent herpes simplex virus DNA and RNA in human geniculate ganalia by the polymerase chain reaction. Acta Otolaryngol 112:1004-1011.
37. Thompson, R. L., G. V. Devi-Rao, J. G. Stevens, and E. K. Wagner. 1985. Rescue of a herpes simplex virus type 1 neurovirulence function with a cloned DNA fragment. J Virol. 55:504-508.
38. Thompson, R. L., E. K. Wagner, and J. G. Stevens. 1983 Physical location of a herpes simplex virus type 1 gene function(s) specifically associated with a 10 million fold increase in HSV neurovirulence. Virology 131:180-192.
39. Trousdale, M. D., I. Steiner, J. G. Spivack, S. L. Deshmane, S. M. Brown, A. R. MacLean, J. H. Subak-Sharpe, and N. W. Fraser. 1091. In vivo and in vitro reactivation impairment of a herpes simplex virus type I latency-associated transcript variant in a rabbit eye model. J. Virol. 65:6989-6993
40. Wagner, E. K., G. Devi-Rao, L. T. Feldman, A. T. Dobson, Y. Zhang, W. M. Flanagan, and J. G. Stevens. 1988. Physical characterization of the herpes simplex virus latency-associated transcript in neurons. J. Virol 62:1194-1202
41. Wagner, E. K., W. M. Flanagan, G. Devi-Rao, Y. Zhang, J. M. Hill, K. P. Anderson, and J. G. Stevens. 1988. The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection. J Virol. 62: 4577-4585
42. Wechsler, S. L., A. B. Nesburn, R. J. Watson, S. Slanina, and H. Ghiasi. 1988. Fine mapping of the major latency related-RNA of herpes simplex virus type 1 in humans. J. Gen. Virol. 69:3101-3106.
43. Wechsler, S. L., A. B. Nesburn, R. J. Watson, S. M. Slanina, and H. Ghiasi. 1988. Fine mapping of the latency-related gene of herpes simplex virus type 1: alternative splicing produces distinct latency-related RNAs containing open reading frames. J. Virol 62:4051-4058.
44. Wechsler, S. L., A. B. Nesburn, J. C. Zwaagstra, and H. Ghiasi. 1989. Sequence of the latency related gene of herpes simplex virus type 1. Virology 168:168-172.
45. Whitley, R. J., E. R. Kern, S. Chatterjee, J. Chou, and B. Roizman. 1993 Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models. J. Clin Invest. 91:2837-2843.
46. Yeh, L., and P. A. Schaffer. 1993. A novel class of transcripts expressed with late kinetics in the absence of ICP4 spans the junction between the long and short segments of the herpes simplex virus type 1 genome. J. Virol 67: 7373-7382.
47. Zwaagstra, J. C., H. Ghiasi, S. M. Slanina, A. B. Nesburn, S. C. Wheatley, K. Lillycrop, J. Wood, D. S. Latchman, K. Patel, and S. L. Wechsler. 1990. Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J. Virol. 64:5019-5028.