T-Cell Receptor Excision Circles (TREC) in SHIV 89.6p and SIVmac251 Models of HIV-1 Infection

DNA and Cell Biology

Volumn 23, Issue 1, 2004, Pages 1-13

  Richardson, Max W ^a   Sverstiuk, Andrij E ^a   Silvera, Peter ^b   Greenhouse, Jack ^b   Lisziewicz, Julianna ^c,d   Lori, Franco ^c,d   Khalili, Kamel ^a   Lewis, Mark G ^e   Rappaport, Jay ^a  

^a TEMPLE UNIVERSITY   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

^c FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^d RIGHT at IRCCS Policlinico   (United States)

^e BIOQUAL INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD28 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; DIDANOSINE; HYDROXYUREA; T LYMPHOCYTE RECEPTOR; TENOFOVIR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPATHOGENIC EFFECT; DISEASE MARKER; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPH NODE; LYMPHOCYTE COUNT; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RHESUS MONKEY; THYMUS; VIRUS LOAD; VIRUS REPLICATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANALYSIS OF VARIANCE; ANIMALS; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; MACACA MULATTA; RECEPTORS, ANTIGEN, T-CELL; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTES; TIME FACTORS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA; MACACA MULATTA; SIMIAN IMMUNODEFICIENCY VIRUS; SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS;

EID: 1542312651     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454904322745880     Document Type: Article

References (58)

1. ALLEN, T.M., O'CONNOR, D.H., JING, P., DZURIS, J.L., MOTHE, B.R., VOGEL, T.U., DUNPHY, E., LIEBL, M.E., EMERSON, C., WILSON, N., et al. (2000). Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia. Nature 407, 386-390.
2. ALLEN, T.M., MORTARA, L., MOTHE, B.R., LIEBL, M., JING, P., CALORE, B., PIEKARCZYK, M., RUDDERSDORF, R., O'CONNOR, D.H., WANG, X., et al. (2002). Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication. J. Virol. 76, 4108-4112.
3. AROSA, F.A. (2002). CD8+CD28- T cells: Certainties and uncertainties of a prevalent human T-cell subset. Immunol. Cell Biol. 80, 1-13.
4. BAROUCH, D.H., KUNSTMAN, J., KURODA, M.J., SCHMITZ, J.E., SANTRA, S., PEYERL, F.W., KRIVULKA, G.R., BEAUDRY, K., LIFTON, M.A., GORGONE, D.A., et al. (2002). Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. Nature 415, 335-339.
5. BAROUCH, D.H., SANTRA, S., SCHMITZ, J.E., KURODA, M.J., FU, T.M., WAGNER, W., BILSKA, M., CRAIU, A., ZHANG, X.X., KRIVULKA, G.R., et al. (2000). Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 290, 486-492.
6. CHAKRABARTI, L.A., LEWIN, S.R., ZHANG, L., GETTIE, A., LUCKAY, A., MARTIN, L.N., SKULSKY, E., HO, D.D., CHENG-MAYER, C., and MARX, P.A. (2000a). Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection. J. Virol. 74, 1209-1223.
7. CHAKRABARTI, L.A., LEWIN, S.R., ZHANG, L., GETTIE, A., LUCKAY, A., MARTIN, L.N., SKULSKY, E., HO, D.D., CHENG-MAYER, C., and MARX, P.A. (2000b). Age-dependent changes in T cell homeostasis and SIV load in sooty mangabeys. J. Med. Primatol. 29, 158-165.
8. DE ROSSI, A., WALKER, A.S., KLEIN, N., DE FORNI, D.D., KING, D., and GIBB, D.M. (2002). Increased thymic output after initiation of antiretroviral therapy in human immunodeficiency virus type 1-infected children in the paediatric European network for treatment of AIDS (PENTA) 5 trial. J. Infect. Dis. 186, 312-320.
9. DIAZ, M., DOUEK, D.C., VALDEZ, H., HILL, B.J., PETERSON, D., SANNE, I., PILIERO, P.J., KOUP, R.A., GREEN, S.B., SCHNITTMAN, S., et al. (2003). T cells containing T cell receptor excision circles are inversely related to HIV replication and are selectively and rapidly released into circulation with antiretroviral treatment. AIDS 17, 1145-1149.
10. DITTMER, U., PETRY, H., STAHL-HENNIG, C., NIBLEIN, T., SPRING, M., LUKE, W., BODEMER, W., KAUP, F.J., and HUNSMANN, G. (1996). T cell apoptosis in human immunodeficiency virus type 2-and simian immunodeficiency virus-infected macaques. J. Gen. Virol. 77, 2433-2436.
11. DOUEK, D.C., BETTS, M.R., BRENNA, J.H., LITTLE, S.J., LEMPICKI, R., METCALF, J.A., CASAZZA, J., YODER, C., ADELSBERGER, J.W., STEVENS, R.A., et al. (2001). Evidence for increased T cell turnover and decreased thymic output in HIV infection. J. Immunol. 167, 6663-6668.
12. DOUEK, D.C., MCFARLAND, R., KEISER, P.H., GAGE, E.A., MASSEY, J.M., HAYNES, B.F., POLIS, M.A., HAASE, A.T., FEINBERG, M.B., SULLIVAN, J.L., et al. (1998). Changes in thymic function with age and during the treatment of HIV infection. Nature 396, 690-695.
13. EFFROS, R.B., ALLSOPP, R., CHIUI, C.P., HAUSNER, M.A., HIRJI, K., WANG, L., HARLEY, C.B., VILLEPONTEAU, B., WEST, M.D., and GIORGI, J.V. (1996). Shortened telomeres in the expanded CD28- CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 10, F17-F22.
14. ESTAQUIER, J., MONCEAUX, V., CUMONT, M.-C., AUBERTIN, A.-M., HURTREL, B., and AMEISEN, J.C. (2000). Early changes in peripheral blood T cells during primary infection of rhesus macaques with a pathogenic SIV. J. Med. Primatol. 29, 127-135.
15. FRY, T.J., MONIUSZKO, M., CREEKMORE, S., DONOHOE, S.J., DOUEK, D.C., GIARDINA, S., HECHT, T.T., HILL, B.J., KOMSCHLIES, K., TOMASZEWSKI, J., et al. (2003). IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates. Blood 101, 2294-2299.
16. GOEDERT, J.J., O'BRIEN, T.R., HATZAKIS, A., and KOSTRIKIS, L.G. (2001). T cell receptor excision circles and HIV-1 2-LTR episomal DNA to predict AIDS in patients not receiving effective therapy. AIDS 15, 2245-2250.
17. HATZAKIS, A., TOULOUMI, G., KARANICOLAS, R., KARAFOULIDOU, A., MANDALAKI, T., ANASTASSO-POULOU, C., ZHANG, L., GOEDERT, J.J, HO, D.D., and KOSTRIKIS, L.G. (2000). Effect of recent thymic emigrants on progression of HIV-1 disease. Lancet 355, 599-604.
18. HAYNES, B.F., MARKERT, M.L., SEMPOWSKI, G.D., DHAVALKUMAR, D.P., and HALE, L.P. (2000). The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu. Rev. Immunol. 18, 529-560.
19. HAZENBERG, M.D, COHEN-STUART, J.W.T., OTTO, S.A., BORLEFFS, J.C.C., BOUCHER, C.A.B., DE BOER, R.J, MIEDEMA, F., and HAMANN, D. (2000a). T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: A longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 95, 249-255.
20. HAZENBERG, M.D., OTTO, S.A., COHEN STUART, J.W.T., VERSCHUREN, M.C.M., BORLEFFS, J.C.C., BOUCHER, C.A.B., COUTINHO, R.A., LANGE, J.M.A., RINKE DE WIT, T.F., TSEGAYE, A., et al. (2000b). Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naïve T cell population in HTV-1 infection. Nat. Med. 6, 1036-1042.
21. HAZENBERG, M.D., VERSCHUREN, M.C.M., HAMANN, D., MIEDEMA, F., and VAN DONGEN, J.J.M. (2001). T cell receptor excision circles as markers for recent thymic emigrants: Basic aspects, technical approach, and guidelines for interpretation. J. Mol. Med. 79, 631-640.
22. IIDA, T., ICHIMURA, H., SHIMADA, T., IBUKI, K., UI, M., TAMARU, K., KUWATA, T., YONEHARA, S., IMANISHI, J., and HAYAMI, M. (2000). Role of apoptosis induction in both peripheral lymph nodes and thymus in progressive loss of CD4+ cells in SHIV-infected macaques. AIDS Res. Hum. Retrovir. 16, 9-18.
23. IIDA, T., ICHIMURA, H., UI, M., SHIMADA, T., AKAHATA, W., IGARASHI, T., KUWATA, T., IDO, E., YONEHARA, S., IMANISHI, J., et al. (1999). Sequential analysis of apoptosis induction in peripheral blood mononuclear cells and lymph nodes in the early phase of pathogenic and nonpathogenic SIVmac infection. AIDS Res. Hum. Retrovir. 15, 721-729.
24. KARLSSON, G.B., HALLORAN, M., LI, J., PARK, I.-W., GOMILA, R., REIMANN, K.A., AXTHELM, M.K., ILIFF, S.A., LETVIN, N.L., and SODROSKI, J. (1997). Characterization of molecularly cloned simian human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys. J. Virol. 71, 4218-4228.
25. LENSCHOW, D.J., WALUNAS, T.L., and BLUESTONE, J.A. (1996). CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14, 233-258.
26. LETVIN, N.L. (1992). Animal models for the study of human immunodeficiency virus infections. Curr. Opin. Immunol. 4, 481-485.
27. LEWIN, S.R., RIBEIRO, R.M., KAUFMANN, G.R., SMITH, D., ZAUNDERS, J., LAW, M., SOLOMON, A., CAMERON, P.U., COOPER, D., and PERELSON, A.S. (2002). Dynamics of T cells and TCR excision circles differ after treatment of acute and chronic HIV infection. J. Imunol. 169, 4657-4666.
28. LORI, F., LEWIS, M.G., XU, J., VARGA, G., ZINN, D.E., JR., CRABBS, C., WAGNER, W., GREENHOUSE, J., SILVERA, P., YALLEY-OGUNRO, J., et al. (2000). Control of SIV rebound through structured treatment interruptions during early infection. Science 290, 1591-1593.
29. LU, S., MANSON, K., WYAND, M., and ROBINSON, H.L. (1997). SIV DNA vaccine trial in macaques: Post-challenge necropsy in vaccine and control groups. Vaccine 15, 920-923.
30. MASCOLA, J.R., LEWIS, M.G., STIEGLER, G., HARRIS, D., VANCOTT, T.C., HAYES, D., LOUDER, M.K., BROWN, C.R., SAPAN, C.V., FRANKEL, S.S., et al. (1999). Protection of macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies. J. Virol. 73, 4009-4018.
31. MCCUNE, J.M. (1997). Thymic function in HIV-1 disease. Semin. Immunol. 9, 397-404.
32. MONTEIRO, J., BATLIWALLA, F., OSTRER, H., and GREGERSEN, P.K. (1996). Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J. Immunol. 156, 3587-3590.
33. MUGNAINI, E.N., HAAHEIM, L.L., SANNES, M., and BRINCH-MANN, J.E. (1999). In vivo expansion coincident with excessive in vitro cell death within the memory subset of CD8+ T cells in HIV type I infection. AIDS Res. Hum. Retrovir. 15, 265-272.
34. MUSSINI, C., PINTI, M., BORGHI, V., NASI, M., AMORICO, G., MONTERASTELLI, E., MORETTI, L., TROIANO, L., ESPOSITO, R., and COSSARIZZA, A. (2002). Features of "CD4-exploders," HIV-positive patients with an optimal immune reconstitution after potent antiretroviral therapy. AIDS 16, 1609-1616.
35. NOKTA, M.A., LI, X-D., AL-HARTHI, L., NICHOLS, J., POU, A., ASMUTH, D., LANDAY, A., and POLLARD, R.B. (2002). Entrapment of recent thymic emigrants in lymphoid tissues from HIV-infected patients: Association with HIV cellular viral load. AIDS 16, 2119-2127.
36. OMETTO, L., DE FORNI, D., PATIRI, F., TROUPLIN, V., MAMMANO, F., GIACOMET, V., GIAQUINTO, C., DOUEK, D., KOUP, R., and DE ROSSI, A. (2002). Immune reconstitution in HIV-1-infected children on antiretroviral therapy: Role of thymic output and viral fitness. AIDS 16, 839-849.
37. REIMANN, K.A., LI, J.T., VEAZEY, R., HALLORAN, M., PARK, I.-W., KARLSSON, G.B., SODROSKI, J., and LETVIN, N.L. (1996a). A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus macaques. J. Virol. 70, 6922-6928.
38. REIMANN, K.A., LI, J.T., VOSS, G., LEKUTIS, C., TENNER-RACZ, K., RACZ, P., LIN, W., MONTEFIORI, D.C., LEE-PARRITZ, D.E., LU, Y., et al. (1996b). An env gene derived from a primary human immunodeficiency virus type 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys. J. Virol. 70, 3198-3206.
39. REIMANN, K.A., WATSON, A., DAILEY, P.J., LIN, W., LORD, C.I., STEENBEKE, T.C., PARKER, R.A., AXTHELM, M.K., and KARLSSON, G.B. (1999). Viral burden and disease progression in rhesus monkeys infected with chimeric simian-human immunodeficiency viruses. Virology 256, 15-21.
40. RICHARDSON, M.W., MIRCHANDANI, J., SILVERA, P., REGULIER, E.G., CAPINI, C., BOJCZUK, P.M., HU, J., GRACELY, E.J., BOYER, J.D., KHALILI, K., et al. (2002). Immunogenicity of HIV-1 IIIB and SHIV 89.6P Tat and Tat toxoids in rhesus macaques: Induction of humoral and cellular immune responses. DNA Cell Biol. 21, 637-651.
41. RICHARDSON, M.W., SVERSTIUK, A.E., GRACELY, E.J., HENDEL, H., KHALILI, K., ZAGURY, J.F., and RAPPAPORT, J. (2003). T-cell receptor excision circles (TREC) and maintenance of long-term nonprogression status in HIV-1 infection. AIDS 17, 915-917.
42. SCHMITZ, J.E., KURODA, M.J., SANTRA, S., SASSEVILLE, V.G., SIMON, M.A., LIFTON, M.A., RACZ, P., TENNER-RACZ, K., DALESANDRO, M., SCALLON, B.J., et al. (1999). Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283, 857-860.
43. SILVERA, P., RICHARDSON, M.W., GREENHOUSE, I., YALLEY-OGUNRO, I., SHAW, N., MIRCHANDANI, I., KHALILI, K., ZAGURY, I.-F., LEWIS, M.G., and RAPPAPORT, I. (2002). Outcome of simian-human immunodeficiency virus strain 89.6p challenge following vaccination of rhesus macaques with human immunodeficiency virus Tat protein. J. Virol. 76, 3800-3809.
44. SODORA, D.L., DOUEK, D.C., SILVESTRI, G., MONTGOMERY, L., ROSENZWEIG, M., IGARASHI, T., BERNACKY, B., JOHNSON, R.P., FEINBERG, M.B., MARTIN, M.A., et al. (2000). Quantification of thymic function by measuring T cell receptor excision circles within peripheral blood and lymphoid tissues in monkeys. Eur. J. Immunol. 30, 1145-1153.
45. SODORA, D.L., MILUSH, J.M., WARE, F., WOZNIAKOWSKI, A., MONTGOMERY, L., McCLURE, H.M., LACKNER, A.A., MARTHAS, M., HIRSCH, V., JOHNSON, R.P., et al. (2002). Decreased levels of recent thymic emigrants in peripheral blood of simian immunodeficiency virus-infected macaques correlate with alternations within the thymus. J. Virol. 76, 9981-9990.
46. SOPPER, S., SAUER, U., MULLER, J.G., STAHL-HENNIG, C., and TER MEULEN, V. (2000). Early activation and proliferation of T cells in simian immunodeficiency virus-infected rhesus monkeys. AIDS Res. Hum. Retrovir. 16, 689-697.
47. SOUSA, A.E., CARNEIRO, J., MEIER-SCHELLERSHEIM, M., GROSSMAN, Z., and VICTORINO, R.M.M. (2002). CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load. J. Immunol. 169, 3400-3406.
48. STEFFENS, C.M., AL-HARTHI, L., SCHOTT, S., YOGEV, R., and LANDAY, A. (2000). Evaluation of thymopoiesis using T-cell receptor excision circles (TRECs): Differential correlation between adult and pediatric TRECs and naïve phenotypes. Clin. Immunol. 97, 95-101.
49. STEFFENS, C.M., SMITH, K.Y., LANDAY, A., SHOTT, S., TRUCKENBROD, A., RUSSERT, M., and AL-HARTHI, L. (2001). T cell receptor excision circle (TREC) content following maximum suppression is equivalent in HIV-infected and HIV-uninfected individuals. AIDS 15, 1757-1764.
50. STEINMANN, G. (1986). Changes in the human thymus during aging. Curr. Top. Pathol. 75, 43-80.
51. STULNIG, T., MACZEK, C., BOCK, G., MAJDIK, O., and WICK, G. (1995). Reference intervals for human peripheral blood lymphocyte subpopulations from "healthy" young and aged subjects. Int. Arch. Allergy Immunol. 108, 205-210.
52. TEIXEIRA, L., VALDEZ, H., McCUNE, J.M., KOUP, R.A., BADLEY, A.D., HELLERSTEIN, M.K., NAPOLITANO, L.A., DOUEK, D.C., MBISA, G., DEEKS, S., et al. (2001). Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS 15, 1749-1756.
53. UTSUYAMA, M., HIROKAWA, K., KURASHIMA, C., FUKAYAMA, M., INAMATSU, T., SUZUKI, K., HASHTMOTO, W., and SATO, K. (1992). Differential age-change in the numbers of CD4+CD45RA+ and CD4+CD29+ T cell subsets in human peripheral blood. Mech. Ageing Dev. 63, 57-68.
54. VAN DONGEN, J.J.M., COMANS-BITTER, W.M., WOLVER-STETTERO, I.L.M., and BORST, J. (1990). Development of human T lymphocytes and their thymus-dependency. Thymus 16, 207-234.
55. VERSCHUREN, M.C., WOLVERS-TETTERO, I.L., BREIT, T.M., NOORDZIJ, J., VAN WERING, E.R., and VAN DONGEN, J.J. (1997). Preferential rearrangements of the T cell receptor-delta-deleting elements in human T cells. J. Immunol. 158, 1208-1216.
56. VINGERHOETS, J.H., VANHAM, G.L., KESTENS, L.L., PENNE, G.G., COLEBUNDERS, R.L., VANDENBRUAENE, M.J., GOEMAN, J., GIGASE, P.L., DE BOER, M., and CEUPPENS, J.L. (1995). Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD84-T cells from HIV-infected subjects. Clin. Exp. Immunol. 100, 425-433.
57. YE, P., and KIRSCHNER, D.E. (2002). Reevaluation of T cell receptor excision circles as a measure of human recent thymic emigrants. J. Immunol. 169, 4968-4979.
58. ZHANG, L., LEWIN, S.R., MARKOWITZ, M., LIN, H.H., SKULSKY, E., KARANICOLAS, R., HE, Y., JIN, X., TUTTLETON, S., VESANEN, M., et al. (1999). Measuring recent thymic emigrants in blood of normal and HIV-I-infected individuals before and after effective therapy. J. Exp. Med. 190, 725-732.