Entrapment of recent thymic emigrants in lymphoid tissues from HIV-infected patients: Association with HIV cellular viral load

AIDS

Volumn 16, Issue 16, 2002, Pages 2119-2127

  Nokta, Mostafa A ^a   Li, Xiao Dong ^a   Al Harthi, Lena ^b   Nichols, Joan ^a   Pou, Anna ^a   Asmuth, David ^a   Landay, Alan ^b   Pollard, Richard B ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

AIDS; HIV; Naive T cells; Recent thymic emigrants; TRECs

Indexed keywords

CELL ADHESION MOLECULE; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; CELL COMPARTMENTALIZATION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOID TISSUE; MALE; MEMORY CELL; MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS LOAD;

ADULT; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; HIV INFECTIONS; HUMANS; L-SELECTIN; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; LYMPHOID TISSUE; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL; RNA, VIRAL; THYMUS GLAND; VIRAL LOAD;

EID: 0037045035     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200211080-00003     Document Type: Article

References (40)

1. Rabin RL, Roedereer M, Maldonado T, Petry A, Herzenberg LA, Herzenberg LA. Altered representations of naive and memory CD8T -cells subsets in HIV-1 infected children. J Clin Invest 1995, 95:2054-2060.
2. Roedereer M, Dubs JG, Anderson MT, Raju PA, Herzenberg LA, Herzenberg LA. CD8 naive T-cell counts decrease progressively in HIV-infected adults. J Clin Invest 1995, 95:2061-2066.
3. Schnittman SM, Lane HC, Greenhouse J, Justement JS, Baseler M, Fauci AS. Preferential infection of CD4 memory T cells by human immunodeficiency virus type 1: Evidence for a role in the selective T-cell functional defects observed in infected individuals. Proc Natl Acad Sci USA 1990, 87:6058-6062.
4. Roederer M, Raju P, Mitra D, Herzenberg LA, Herzenberg LA. HIV does not replicate in naïve CD4 T cells stimulated with CD3/CD28. J Clin Invest 1997, 99:1555-1564.
5. Woods T, Roberts B, Butera S, Folks T. Loss of inducible virus in CD45RA naive cells after human immunodeficiency virus-1 entry accounts for preferential viral replication in CD45RO memory cells. Blood 1997, 89:1635-1641.
6. McCune JM. HIV-1: The infective process in vivo. Cell 1991, 64:351-363.
7. Su K, Kaneshima H, Bnonyhadi M, Salimi S, Kraft D, Rabin L, et al. HIV-1 induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo. Immunity 1995, 2:25-36.
8. Hellerstein MK McCune JM. T-cell turnover in HIV-1 disease. Immunity 1997, 7:583-589.
9. Gougeon M-L, Garcia S, Heeney J, et al. PCD in AIDS-related HIV and SIV infections. AIDS Res Hum Retrovirus 1993, 9:553-563.
10. Nokta M, Rossero R, Nichols J, Rosenbaum M, Pollard RB. Effect of didanosine stavudine and hydroxyurea therapy on apoptosis in CD45RA and CD45RO T-lymphocyte subpopulations. AIDS Res Hum Retrovirus 1999, 15(3):255-264.
11. Lederman M, Connick, E, Landay A, et al. Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: Results of AIDS Clinical Trials Group Protocol 315. J Infect Dis 1998, 178:70-79.
12. + T-cell homeostasis and function in advanced HIV disease. Science 1997, 277:112-116.
13. Al-Harthi L, Siegel J, Spritzler J, Pottage J, Agnoli M, Landay A. Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease. AIDS 2000, 14:761-770.
14. Nikolic-Zugic J. Phenotypic and functional stages in the intrathymic development of αβ T cells. Immunol Today 1991, 65:65-70.
15. McCune JM, Loftus R, Schmidt DK, et al. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest 1998, 101 (11):2301-2308.
16. Smith KY, Valdez H, Landay A, et al. Thymic size and lymphocyte restoration in-patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy. J Infect Dis 2000, 181:141-147.
17. Douek DC, McFarland RD, Keiser PH, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998, 396:690-695.
18. Zhang L, Lewin SR, Markowitz M, et al. Measuring recent thymic emigrants in blood of normal and HIV-1 infected individuals before and after effective therapy. J Exp Med 1999, 190:725-732.
19. Steffens CM, Al-Harthi L, Shott S, Yogev R, Landay A. Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): Differential correlation between adult and pediatric TRECs and naive phenotypes. Clin Immunol 2000, 97:95-101.
20. Poulin JF, Viswanathan MN, Harris JM, et al. Direct evidence for thymic function in adult humans. J Exp Med 1999, 190:479-486.
21. Butcher EC. The regulation of lymphocyte traffic. Curr Topics Microbiol Immunol 1986, 128:85-122.
22. Mackay CR. Migration pathways and immunologic memory among T lymphocytes. Semin Immunol 1992, 4:51-58.
23. Picker LJ, Butcher EC. Physiological and molecular mechanisms of lymphocyte homing. Annu Rev Immunol 1992, 10:561-591.
24. Hamann A, Westrick DJ, Duijevstijn A, et al. Evidence for an accessory role of LFA-1 in lymphocyte-high endothelium interaction during homing. J Immunol 1988, 140:693-699.
25. Camp RL, Scheynius A, Johansson C, Pure E. CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation. J Exp Med 1993, 178:497-507.
26. Pantaleo G, Graziosi C, Demarest JF, et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 1993, 362:355-358.
27. Pantaleo G, Graziosi C, Fauci AS. The immunopathogenesis of human immuno-deficiency virus infection. N Engl J Med 1993, 328:327-335.
28. Nokta MA, Li X-D, Nichols J, et al. Chemokine/CD4 receptor density ratios correlate with HIV replication in lymph node and peripheral blood of HIV infected individuals. AIDS 2001, 15:161-169.
29. Al-Harthi L, Marchetti G, Steffens CM, Poulin J, Sekaly R, Landay A. Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA). J Immunol Methods 2000, 237:187-197.
30. Picker LJ. Physiological and molecular mechanisms of lymphocyte homing. Annu Rev Immunol 1992, 10:561-591.
31. Haxenberg MD, Otto SA, Cohen-Stuart JW, JC, et al. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naïve T cell population in HIV-1 infection. Nature Med 2000, 6:1036-1042.
32. Spina CA, Prince HE, Richman DD. Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro. J Clin Invest 1997, 99:1774-1785.
33. Woods TC, Roberts BD, Butera ST, Folks TM. Loss of inducible virus in CD45RA naive cells after human immunodeficiency virus-1 entry accounts for preferential viral replication in CD45RO memory cells. Blood 1997, 89:1635-1641.
34. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 1994, 76:301-314.
35. Springer TA. Adhesion receptors of the immune system. Nature 1990, 346:426-433.
36. Dustin ML, Springer TA. Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. Ann Rev Immunol 1991, 9:27-66.
37. Shimizu Y, Shaw S. Lymphocyte interactions with extracellular matrix. FASEB J 1991, 5:2292-2299.
38. Arnaout MA. Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood 1990, 75:1037-1050.
39. + lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J Clin Invest 1999, 103(10):1391-1398.
40. + T cell repopulation of lymphoid tissues after treatment of HIV-1 infection. Proc Natl Acad Sci USA 1998, 95:1154-1159.