Autospecific γδ thymocytes that escape negative selection find sanctuary in the intestine

Journal of Clinical Investigation

Volumn 104, Issue 9, 1999, Pages 1297-1305

  Lin, Tesu ^a,c   Yoshida, Hiroki ^b   Matsuzaki, Goro ^b   Guehler, Sarah R ^c   Nomoto, Kikuo ^b   Barrett, Terrence A ^c   Green, Douglas R ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; CELL MATURATION; CELL SELECTION; INTESTINE EPITHELIUM; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMOCYTE; TRANSGENIC MOUSE; AGING; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL DIVISION; CELL MOTION; CYTOLOGY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GROWTH, DEVELOPMENT AND AGING; HUMAN; IMMUNOLOGY; INTESTINE MUCOSA; LEUKEMIA CELL LINE; LYMPHOCYTE; PHENOTYPE; THYMUS;

AGING; ANIMALS; ANIMALS, NEWBORN; CELL DIVISION; CELL MOVEMENT; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INTESTINAL MUCOSA; JURKAT CELLS; LYMPHOCYTES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; THYMUS GLAND;

EID: 0032590211     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7437     Document Type: Article

References (42)

1. Kappler J.W., Staerz, U., White, J., and Marrack, P.C. 1988. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatability complex. Nature. 332:35-40.
2. Acha-Orbea, H., and Palmer, E. 1991. Mls: a retrovirus exploits the immune system. Immunol. Today. 12:356-361.
3. Dent, A.L., et al. 1990. Self-reactive gamma delta T cells are eliminated in the thymus. Nature. 343:714-719.
4. Teh, H.S., Kishi, H., Scott, B., and von Boehmer, H. 1989. Deletion of autospecific T cells in T cell receptor transgenic mice spare cells with normal TCR levels and low levels of CD8 molecules. J. Exp. Med. 169:795-806.
5. + thymocytes. Nature. 333:742-746.
6. Sha, W.C., et al. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature. 336:73-76.
7. Sha, W.C., et al. 1988. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature. 335:271-274.
8. + T lymphocytes depending upon MHC compatibility of neonatally injected cells. Int. Immunol. 3:127-134.
9. a mice. Thymus. 13:35-43.
10. a mice. J. Exp. Med. 169:2149-2154.
11. Teh, H.S., et al. 1990. Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice. Dev. Immunol. 1:1-10.
12. Dent, A.L., Matis, L.A., Bluestone, J.A., and Hedrick, S.M. 1993. Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes. Eur. J. Immunol. 23:2482-2487.
13. Bandeira, A., et al. 1991. Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-antigen receptor γδ. Proc. Natl. Acad. Sci. USA. 88:43-47.
14. Sperling, A., et al. 1997. Selective expansion of Vgamma2-Vdelta7 TCR gamma delta cells in C57BL/6 mice is postnatal and extrathymic. J. Immunol. 159:86-91.
15. Yoshikai, Y., Reis, M.D., and Mak, T.W. 1986. Athymic mice express a high level of functional gamma-chain but greatly reduced levels of alpha-and beta-chain T-cell receptor messages. Nature. 324:482-485.
16. Barrett, T.A., et al. 1992. Mechanism of self-tolerance of γ/δ T cells in epithelial tissue. J. Exp. Med. 175:65-70.
17. + lymphocytes reveals a major extrathymic pathway of T cell differentiation. J. Exp. Med. 173:483-486.
18. Rocha, B., von Boehmer, H., and Guy-Grand, D. 1992. Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self antigen in the murine gut. Proc. Natl. Acad. Sci. USA. 89:5336-5340.
19. Poussier, P., Teh, H.S., and Julius, M. 1993. Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I restricted transgenic T cell receptor αβ in the intestinal epithelium. J. Exp. Med. 178:1947-1957.
20. Cruz, D., et al. 1998. An opposite pattern of selection of a single T cell antigen receptor in the thymus and among intraepithelial lymphocytes. J. Exp. Med. 188:255-265.
21. Rocha, B., Vassalli, P., and Guy-Grand, D. 1992. The extrathymic T cell development pathway. Immunol. Today. 13:449-454.
22. Lin, T., Matsuzaki, G., Kenai, H., and Nomoto, K. 1995. Extrathymic and thymic origin of IEL: are most IEL in eurhymic mice derived from rhe thymus? Immunol. Cell Biol. 73:469-473.
23. Lefrancois, L., and Puddington, L. 1995. Extrathymic intestinal T-cell development: virtual reality. Immunol. Today. 16:16-21.
24. Matsuzaki, G., Lin, T., and Nomoto, K. 1994. Differentiation and function of intestinal intraepithelial lymphocytes. Int. Rev. Immunol. 11:47-53.
25. Lin, T., Matsuzaki, G., Kishihara, K., Mak, T.W., and Nomoto, K. 1994. Characteristics of fetal thymus-derived T cell receptor γδ intestinal intraepithelial lymphocytes. Eur. J. Immunol. 24:1792-1798.
26. Lefrancois, L., and Olsen, S. 1994. A novel pathway of thymus-directed T lymphocyte maturation. J. Immunol. 157:987-995.
27. Barrett, T.A., Tatsumi, Y., and Bluestone, J.A. 1993. Tolerance of T cell receptor γδ cells in the intestine. J. Exp. Med. 177:1755-1762.
28. + intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL. Eur. J. Immunol. 24:1080-1087.
29. Sjodin, K., Dalmasso, A.P., Smith, J.M., and Martinez, C. 1966. Thymectomy in newborn and adult mice. Transplantation. 1:521-525.
30. Lin, T., Matsuzaki, G., Kenai, H., Nakamura, T., and Nomoto, K. 1993. Thymus influences the development of extrathymically derived intestinal intraepithelial lymphocytes early in ontogeny. Eur. J. Immunol. 23:1968-1974.
31. + αα intestinal intraepithelial lymphocytes early in ontogeny. Eur.J. Immunol. 31:1785-1791.
32. Lin, T., et al. 1998. Fas-ligand-mediated killing by intestinal intraepithelial lymphocytes. J. Clin. Invest. 101:570-577.
33. Schild, H., et al. 1994. The nature of MHC recognition by γ/δ T cells. Cell. 76:29-36.
34. Weintraub, B.C., Jackson, M.R., and Hedrick, S.M. 1994. γδ T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides. J. Immunol. 153:3051-3058.
35. Guy-Grand, D., et al. 1992. Different expression of the recombinant activating gene RAG-1 in various populations of thymocytes, peripheral T cells and gut thymus-independent intraepithelial lymphocytes suggest two pathways of T cell receptor rearrangement. Eur. J. Immunol. 22:505-510.
36. Budd, R.C., et al. 1987. Distinction of virgin and memory T lymphocytes. J. Immunol. 138:3120-3124.
37. Wells, F.B., et al. 1993. Phenotypic and functional analysis of positive selection in the γδ T cell lineage. J. Exp. Med. 177:1061-1070.
38. Schweighoffer, E., and Fowlkes, B.J. 1996. Positive selection is not required for thymic maturation of transgenic γδ T cells. J. Exp. Med. 183:2033-2041.
39. Pereira, P., and Tonegawa, S. 1993. Gamma/delta cells. Annu. Rev. Immunol. 35:637-685.
40. Rocha, B., Vassalli, P., and Guy-Grand, D. 1994. Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice. J. Exp. Med. 180:681-686.
41. Guehler, S.R., Bluestone, J.A., and Barrett, T.A. 1996. Immune deviation of 2C transgenic intraepithelial lymphocytes in antigen-bearing hosts. J. Exp. Med. 184:493-503.
42. Groh, V., Steinle, A., Bauer, S., and Spies, T. 1998. Recognition of stress-induced MHC molecules by intestinal epithelial gamma-delta T cells. Science. 13:1737-1740.