Lovastatin induces apoptosis in a metastatic ovarian tumour cell line

Cell Death and Differentiation

Volumn 3, Issue 2, 1996, Pages 223-228

  Han, Zhiyong ^a   Wyche, James H ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Apoptosis; Cell cycle; Farnesol; Lovastatin

Indexed keywords

CAMPTOTHECIN; ETOPOSIDE; FARNESOL; FLUOROURACIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVALONIC ACID; MEVINOLIN; PYROPHOSPHORIC ACID DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; METASTASIS; NONHUMAN; OVARY TUMOR; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0029938301     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Beck L, Hosick TJ and Shinensky M (1988) Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei. J. Cell Biol. 107: 1307-1316
2. Brown MS and Goldstein JL (1974) Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol. J. Biol. Chem. 249: 7306-7314
3. Casey, PJ, Solski, PA, Der, CJ and Buss JE (1989) p21 ras is modified by a farnesyl isoprenoid. Proc. Natl. Acad. Sci. USA 86: 8323-8327
4. Chen HW, Kandutsch AA and Waymouth C (1974) Inhibition of cell growth by oxygenated derivatives of cholesterol. Nature 251: 419-421
5. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD, Brenner DA and Der CJ (1994) The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J. Biol. Chem. 269: 19203-19206
6. DeClue JE, Vass WC, Papageorge AG, Lowy DR and Willumsen BM (1991) Inhibition of cell growth by lovastatin is independent of ras function. Cancer Res. 51: 712-717
7. Endo A (1985) HMG CoA reductase inhibitors. Adv. Exp. Med. Biol. Chem. 258: 10219-10222
8. Ericsson J, Thelin A, Chojnacki T and Dallner G (1992) Substrate specificity of cis-prenyltransferase in rat liver microsomes. J. Biol. Chem. 267: 19730-19735
9. Fairbanks KP, Witte LD and Goodman DS (1984) Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor. J. Biol. Chem. 259: 1546-1551
10. Gibbs JB, Pompliano DL, Mosser SD, Rands E, Lingham RB, Singh SB, Scolnick EM, Kohl NE and Oliff A (1993) Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. J. Biol. Chem. 268: 7617-7620
11. Goldstein JL and Brown MS (1990) Regulation of the mevalonate pathway. Nature 343: 425-430
12. Habenicht AJR, Glomset JA and Ross R (1980) Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and Swiss 3T3 cells stimulated to divide by platelet-derived growth factor. J. Biol. Chem. 255: 5134-5140
13. Han ZY and Wyche JH (1994) Guanosine induces necrosis of cultured aortic endothelial cells. Am. J. Pathol. 145: 423-427
14. Hancock JF, Magee AI, Childs JE and Marshall CJ (1989) All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 57: 1167-1177
15. Hoeg JM, Maher MB, Zech LA, Bailey KR, Gregg RE, Lackner KJ, Fojo SS, Anchors MA, Bojanovski M, Sprecher DL and Brewer HB (1986) Effectiveness of mevinolin on plasma lipoprotein concentrations in type II hypercholesteinemia. Am. J. Cardiol. 57: 933-936
16. Jackson JH, Cochrane CG, Bourne JR, Solski PA, Buss JE and Der CJ (1990) Farnesol modification of Kirstein-ras exon 4B protein is essential for transformation. Proc. Natl. Acad. Sci. USA 87: 3042-3046
17. James GL, Goldstein JL, Brown MS, Rawson TE, Somers TC, McDowell RS, Crowley CW, Lucas BK, Levinson AD and Marsters Jr. JC (1993) Benzodiazepine peptidomimetics: potent inhibitors of ras farnesylation in animal cells. Science 260: 1937-1942
18. Jones KD, Couldwell WT, Hinton DR, Su Y, He S, Anker L and Law RE (1995) Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells. Biochem. Biophys. Res. Commun. 205: 1681-1687
19. Kerr JFR, Wyllie AH and Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26: 239-257
20. 1 to multiple cell cycles by lovastatin. Cancer Res. 51: 3602-3609
21. Kohl NE, Mosser SD, deSolms SJ, Giuliani EA, Pompaliano DL, Graham SG, Smith RL, Scolnick EM, Oliff A and Gibbs JB (1993) Selective inhibition of ras-dependent transformation by farnesyltransferase inhibitor. Science 260: 1934-1937
22. Maltese WA (1984) Induction of differentiation in murine neuroblastoma cells by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Biochem. Biophys. Res. Commun. 120: 454-460
23. Maltese WA and Sheridan KM (1987) Isoprenylated proteins in cultured cells: subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation. J. Cell Physiol. 133: 471-481
24. Maltese WA (1990) Posttranslational modification of proteins by isoprenoids in mammalian cells. FASB J, 4: 3319-3328
25. O'Donnell MP, Kasiske BL, Kim Y, Atluru D and Keane WF (1993) Lovastatin inhibits proliferation of rat mesangial cells. J. Clin. Invest. 91: 83-87
26. Peres-Sala D and Mollinedo F (1994) Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells. Biochem. Biophys. Res. Commun. 199: 1209-1215
27. Pompliano DL, Schaber MD, Mosser SD, Omer CA, Shafer JA and Gibbs JB (1993) Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway. Biochemistry 32: 8341-8347
28. Quesney-Huneeus V, Wiley HM and Siperstein MD (1979) Essential role for mevalonate synthesis in DNA replication. Proc. Natl. Acad. Sci. USA 76: 5056-5060
29. Quesney-Huneeus V, Galick HA, Siperstein MD, Erickson SK, Spencer TA and Nelson JA (1983) The dual role of mevalonate in the cell cycle. J. Biol. Chem. 258: 378-385
30. ras farnesyl:protein transferase by Cyx-AAX tetrapeptides. Cell 62:81-88
31. Repko EM and Maltese WA (1989) Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability. J. Biol. Chem. 264: 9945-9952
32. Schafer WR, Kim R, Sterne R, Thorner J, Kim S-H and Rine J (1989) Genetic and pharmacological suppression of oncogenic mutations in ras genes in yeast and humans. Science 245: 379-385
33. Schmidt RA, Schneider CJ and Glomset JA (1984) Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins. J. Biol. Chem. 259: 10175-10180
34. Sinensky M, Beck LA, Leonard S and Evans R (1990) Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis. J. Biol. Chem. 265: 19937-19941
35. Thompson GR, Ford J, Jenkinson M and Trayner I (1986) Efficacy of mevinolin as adjuvant therapy for refractory familial hypercholesteinemia. Q. J. Med. 60: 803-811
36. Tobert JA (1987) New developments in lipid-lowering therapy: The role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase. Circulation 76: 534-538
37. Turner J and Wyche JH (1980) Regulation of metastatic ovarian cells in serum-free medium by epidermal growth factor and transferrin. J. Cell Physiol. 104: 233-240
38. Vega GL and Grundy SM (1987) Treatment of primary moderate hypercholesteinemia with lovastatin (mevinolin) and cholestipol. Am. Med. Assoc. 257: 33-38
39. Wolda SL and Glomset JA (1988) Evidence for modification of lamin B by a product of mevalonic acid. J. Biol. Chem. 263: 5997-6000
40. Wyllie AH, Kerr JFR and Currie AR (1980) Cell death: the significance of apoptosis. Int. Rev. Cytol. 68: 251-307
41. Wyllie AH, Morris RG, Smith AL and Dunlop D (1984) Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol. 142: 67-77