Statins stimulate arachidonic acid release and prostaglandin I2 production in rat liver cells

Lipids in Health and Disease

Volumn 2, Issue , 2003, Pages 1-9

  Levine, Lawrence ^a  

^a BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; ATORVASTATIN; COMPACTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LACTACYSTIN; MEVALONIC ACID; MEVINOLIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTACYCLIN; SIMVASTATIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID TRANSPORT; LIVER CELL; NONHUMAN; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS; RAT;

ANIMALIA;

EID: 0242584758     PISSN: 1476511X     EISSN: None     Source Type: Journal    
DOI: 10.1186/1476-511X-2-1     Document Type: Article

References (31)

1. Goldstein JL and Brown MS Regulation of the mevalonate pathway. Nature 1990, 343:425-430
2. Bellosta S, Bernini F, Ferri N, Quarato P, Canavesi M, Arnaboldi L, Fumagalli R, Paoletti R and Corsini A Direct vascular effects of HMG-CoA reductase inhibitors. Atherosclerosis 1998, 137(Suppl):S101-109
3. Koh KK Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability. Cardiovasc Res 2000, 47:648-657
4. Vaughan CJ and Delanty N Neuroprotective properties of statins in cerebral ischemia and stroke. Stroke 1999, 30:1969-1973
5. Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M and Gutierrez G Stimulation of bone formation in vitro and in rodents by statins. Science 1999, 286:1946-1949
6. Jick H, Zornberg GL, Jick SS, Seshadri S and Drachman DA Statins and the risk of dementia. Lancet 2000, 356:1627-1631
7. Knapp AC, Huang J, Starling G and Kiener PA Inhibitors of HMG-CoA reductase sensitize human smooth muscle cells to Fas-ligand and cytokine-induced cell death. Atherosclerosis 2000, 152:217-227
8. Ihara-Watanabe M, Umekawa H, Takahashi T and Furuichi Y Effects of dietary alpha- or gamma-linolenic acid on levels and fatty acid compositions of serum and hepatic lipids, and activity and mRNA abundance of 3-hydroxy-3-methylglutaryl CoA reductase in rats. Comp Biochem Physiol A Mol Integr Physiol 1999, 122:213-220
9. Proksch E, Feingold KR and Elias PM Epidermal HMG CoA reductase activity in essential fatty acid deficiency: barrier requirements rather than eicosanoid generation regulate cholesterol synthesis. J Invest Dermatol 1992, 99:216-220
10. Das UN Essential fatty acids as possible mediators of the actions of statins. Prostaglandins Leukot Essent Fatty Acids 2001, 65:37-40
11. Degraeve F, Bolla M, Blaie S, Creminon C, Quere I, Boquet P, Levy-Toledano S, Bertoglio J and Habib A Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins. J Biol Chem 2001, 276:46849-46855
12. Inoue I, Goto S, Mizotani K, Awata T, Mastunaga T, Kawai S, Nakajima T, Hokari S, Komoda T and Katayama S Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: reduction of mRNA levels for interleukin-1beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor alpha (PPARalpha) in primary endothelial cells. Life Sci 2000, 67:863-876
13. Falke P, Mattiasson I, Stavenow L and Hood B Effects of a competitive inhibitor (mevinolin) of 3-hydroxy-3-methylglutaryl coenzyme A reductase on human and bovine endothelial cells, fibroblasts and smooth muscle cells in vitro. Pharmacol Toxicol 1989, 64:173-176
14. Pong SS, Hong SL and Levine L Prostaglandin production by methylcholanthrene-transformed mouse BALB/3T3. Requirement for protein synthesis. J Biol Chem 1977, 252:1408-1413
15. Levine L Nuclear receptor agonists stimulate release of arachidonic acid from rat liver cells. Prostaglandins Leukot Essent Fatty Acids 2002, 67:453-459
16. Smith WL The eicosanoids and their biochemical mechanisms of action. Biochem J 1989, 259:315-324
17. Dana R, Leto TL, Malech HL and Levy R Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase. J Biol Chem 1998, 273:441-445
18. Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM and Lehmann JM Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci U S A 1997, 94:4318-4323
19. Henderson LM, Thomas S, Banting G and Chappell JB The arachidonate-activatable, NADPH oxidase-associated H+ channel is contained within the multi-membrane-spanning N-terminal region of gp91-phox. Biochem J 1997, 325:701-705
20. Lesage F, Maingret F and Lazdunski M Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel. FEBS Lett 2000, 471:137-140
21. Mignen O and Shuttleworth TJ I(ARC), a novel arachidonate-regulated, noncapacitative Ca(2+) entry channel. J Biol Chem 2000, 275:9114-9119
22. Jurivich DA, Sistonen L, Sarge KD and Morimoto RI Arachidonate is a potent modulator of human heat shock gene transcription. Proc Natl Acad Sci U S A 1994, 91:2280-2284
23. Surette ME, Fonteh AN, Bernatchez C and Chilton FH Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells. Carcinogenesis 1999, 20:757-763
24. Siegel G, Sternfeld L, Gonzalez A, Schulz I and Schmid A Arachidonic acid modulates the spatiotemporal characteristics of agonist-evoked -Ca2+ waves in mouse pancreatic acinar cells. J Biol Chem 2001, 276:16986-16991
25. Hannah VC, Ou J, Luong A, Goldstein JL and Brown MS Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells. J Biol Chem 2001, 276:4365-4372
26. Chan TA, Morin PJ, Vogelstein B and Kinzler KW Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. Proc Natl Acad Sci U S A 1998, 95:681-686
27. Levine I Does the release of arachidonic acid from cells play a role in cancer chemoprevention? FASEB Journal 2003,
28. Rigas A and Levine L Arachidonic acid metabolism by rat liver cells (the C-9 cell line). J Pharmacol Exp Ther 1984, 231:230-235
29. Ulrich V, Brugger R, Lottspeich F and Siegle I Properties of prostacyclin synthase in Honn er all. Eicosanoids and other bioactive lipids in cancer, inflammation and radiation injury 1997, 113-119
30. Levine L Stimulated release of arachidonic acid from rat liver cells by celecoxib and indomethacin. Prostaglandins Leukot Essent Fatty Acids 2001, 65:31-35
31. Levine L Measurement of arachidonic acid metabolites by radioimmunoassay. Manual of Clinical Laboratory Immunology (Edited by: Rose NR, Friedman H, fahey JL) Washington DC: American Society for Microbiology 1986, 685-691