Developmental program of mouse Vα14i NKT cells

Current Opinion in Immunology

Volumn 17, Issue 2, 2005, Pages 122-130

  Matsuda, Jennifer L ^a   Gapin, Laurent ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD1D ANTIGEN; CYTOKINE; CYTOKINE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR;

ANTIGEN EXPRESSION; CELL COUNT; CELL LINEAGE; CELL MATURATION; CELL SELECTION; DEVELOPMENTAL STAGE; GENE CONTROL; GENE FUNCTION; HUMAN; NATURAL KILLER CELL; NONHUMAN; ORGANOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; THYMUS; TRANSGENE;

EID: 14844303459     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2005.01.002     Document Type: Review

References (67)

1. M. Brigl, and M.B. Brenner CD1: antigen presentation and T cell function Annu Rev Immunol 22 2004 817 890
2. J.L. Matsuda, O.V. Naidenko, L. Gapin, T. Nakayama, M. Taniguchi, C.R. Wang, Y. Koezuka, and M. Kronenberg Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers J Exp Med 192 2000 741 754
3. D.I. Godfrey, H.R. MacDonald, M. Kronenberg, M.J. Smyth, and L. Van Kaer NKT cells: what's in a name? Nat Rev Immunol 4 2004 231 237
4. M. Kronenberg, and L. Gapin The unconventional lifestyle of NKT cells Nat Rev Immunol 2 2002 557 568
5. + CD1d-dependent precursor stage J Exp Med 195 2002 835 844
6. •].
7. • ] show that Vα14i NKT cells are susceptible to negative selection. Addition of α-GalCer at the early stages of FTOC cultures in vitro as well as overexpression of CD1d in vivo by means of transgenesis disrupt the development of Vα14i NKT cells.
8. L. Gapin, J.L. Matsuda, C.D. Surh, and M. Kronenberg NKT cells derive from double-positive thymocytes that are positively selected by CD1d Nat Immunol 2 2001 971 978
9. G. Eberl, and D.R. Littman Thymic origin of intestinal αβ T Cells Revealed by Fate Mapping of RORγt+ Cells Science 305 2004 248 251
10. K. Benlagha, T. Kyin, A. Beavis, L. Teyton, and A. Bendelac A thymic precursor to the NKT cell lineage Science 296 2002 553 555
11. P. Gadue, and P.L. Stein NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation J Immunol 169 2002 2397 2406
12. J.L. Matsuda, L. Gapin, S. Sidobre, W.C. Kieper, J.T. Tan, R. Ceredig, C.D. Surh, and M. Kronenberg Homeostasis of Vα14i NKT cells Nat Immunol 3 2002 966 974
13. -/- mice, suggesting that IL-15 might not be necessary for the development of these cells per se. However, the transfer of carboxyfluorescein diacetate succinimydil diester (CFSE)-labeled Vα14i NKT cells into immunocompromised recipient mice clearly demonstrated that IL-15 was essential to the survival and homeostatic proliferation of Vα14i NKT cells. Furthermore, these studies also suggested that IL-15 availability in vivo might control the size of the Vα14i NKT-cell population. A comparison of Vα14i NKT cell transfers into NK-proficient versus NK-deficient hosts suggests that Vα14i NKT cells and NK cells (and perhaps other IL-15-dependent cell populations) compete for peripheral IL-15.
14. J.P. Lodolce, D.L. Boone, S. Chai, R.E. Swain, T. Dassopoulos, S. Trettin, and A. Ma IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation Immunity 9 1998 669 676
15. M.K. Kennedy, M. Glaccum, S.N. Brown, E.A. Butz, J.L. Viney, M. Embers, N. Matsuki, K. Charrier, L. Sedger, and C.R. Willis Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice J Exp Med 191 2000 771 780
16. + cell development J Immunol 159 1997 5931 5935
17. M. Minagawa, H. Watanabe, C. Miyaji, K. Tomiyama, H. Shimura, A. Ito, M. Ito, J. Domen, I.L. Weissman, and K. Kawai Enforced expression of Bcl-2 restores the number of NK cells, but does not rescue the impaired development of NKT cells or intraepithelial lymphocytes, in IL-2/IL-15 receptor β-chain-deficient mice J Immunol 169 2002 4153 4160
18. D.C. Huang, M. Hahne, M. Schroeter, K. Frei, A. Fontana, A. Villunger, K. Newton, J. Tschopp, and A. Strasser Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L) Proc Natl Acad Sci USA 96 1999 14871 14876
19. + T cells by CD1-expressing cortical thymocytes J Exp Med 182 1995 2091 2096
20. + cells J Immunol 164 2000 2412 2418
21. •].
22. -/- mice to assess the importance of CD1d ligands on the selection of Vα14i NKT cells. With the help of transgenesis, CD1d was re-expressed under the control of MHC class II or MHC class I promoters. Neither expression pattern was able to fully restore the Vα14i NKT-cell population. These studies highlight the crucial role played by the cell type, probably the DP cortical thymocytes expressing CD1d, for the positive selection of Vα14i NKT cells.
23. K. Honey, K. Benlagha, C. Beers, K. Forbush, L. Teyton, M.J. Kleijmeer, A.Y. Rudensky, and A. Bendelac Thymocyte expression of cathepsin L is essential for NKT cell development Nat Immunol 3 2002 1069 1074
24. A.K. Stanic, A.D. De Silva, J.J. Park, V. Sriram, S. Ichikawa, Y. Hirabyashi, K. Hayakawa, L. Van Kaer, R.R. Brutkiewicz, and S. Joyce Defective presentation of the CD1d1-restricted natural Vα14Jα18 NKT lymphocyte antigen caused by β-D-glucosylceramide synthase deficiency Proc Natl Acad Sci USA 100 2003 1849 1854
25. D. Zhou, C. Cantu III, Y. Sagiv, N. Schrantz, A.B. Kulkarni, X. Qi, D.J. Mahuran, C.R. Morales, G.A. Grabowski, and K. Benlagha Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins Science 303 2004 523 527
26. S.J. Kang, and P. Cresswell Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells Nat Immunol 5 2004 175 181
27. S. Brozovic, T. Nagaishi, M. Yoshida, S. Betz, A. Salas, D. Chen, A. Kaser, J. Glickman, T. Kuo, and A. Little CD1d function is regulated by microsomal triglyceride transfer protein Nat Med 10 2004 535 539
28. M. Cernadas, M. Sugita, N. van der Wel, X. Cao, J.E. Gumperz, S. Maltsev, G.S. Besra, S.M. Behar, P.J. Peters, and M.B. Brenner Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development J Immunol 171 2003 4149 4155
29. D. Elewaut, A.P. Lawton, N.A. Nagarajan, E. Maverakis, A. Khurana, S. Honing, C.A. Benedict, E. Sercarz, O. Bakke, and M. Kronenberg The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells J Exp Med 198 2003 1133 1146
30. A.P. Lawton, and M. Kronenberg The Third Way: Progress on pathways of antigen processing and presentation by CD1 Immunol Cell Biol 82 2004 295 306
31. ••].
32. •• ] show that an appropriate balance between positive immunoreceptor-tyrosine activation motifs (ITAM) signaling and negative immunoreceptor-tyrosine inhibition motifs (ITIM) signaling plays an important role in the developmental program of Vα14i NKT cells.
33. J. Schumann, R.B. Voyle, B.Y. Wei, and H.R. MacDonald Cutting Edge: Influence of the TCR Vβ Domain on the Avidity of CD1d:α- Galactosylceramide Binding by Invariant Vα14 NKT Cells J Immunol 170 2003 5815 5819
34. •].
35. -/- mice. These intriguing results suggest that Fyn might play a role before the α-chain rearrangement rather than for the positive selection or the survival of Vα14i NKT cells. Although current evidence suggests otherwise, these results raise the possibility that Vα14i NKT cells might derive from a distinct parallel precursor cell that exists in the thymus with a specific requirement for Fyn.
36. -/- Vα14i NKT cells induces the upregulation of CD122.
37. + T cells Nat Immunol 3 2002 549 557
38. A. Takeda, S. Hamano, A. Yamanaka, T. Hanada, T. Ishibashi, T.W. Mak, A. Yoshimura, and H. Yoshida Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment J Immunol 170 2003 4886 4890
39. E.E. Nieuwenhuis, M.F. Neurath, N. Corazza, H. Iijima, J. Trgovcich, S. Wirtz, J. Glickman, D. Bailey, M. Yoshida, and P.R. Galle Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice Proc Natl Acad Sci USA 99 2002 16951 16956
40. A. Yamanaka, S. Hamano, Y. Miyazaki, K. Ishii, A. Takeda, T.W. Mak, K. Himeno, A. Yoshimura, and H. Yoshida Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis J Immunol 172 2004 3590 3596
41. •].
42. T. Kawamura, R. Koka, A. Ma, and V. Kumar Differential roles for IL-15R α-chain in NK cell development and Ly-49 induction J Immunol 171 2003 5085 5090
43. L. Van Parijs, Y. Refaeli, J.D. Lord, B.H. Nelson, A.K. Abbas, and D. Baltimore Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death Immunity 11 1999 281 288
44. A. Cipres, S. Gala, A.C. Martinez, I. Merida, and P. Williamson An IL-2 receptor β subdomain that controls Bcl-X(L) expression and cell survival Eur J Immunol 29 1999 1158 1167
45. T.L. Walunas, B. Wang, C.R. Wang, and J.M. Leiden Cutting edge: the Ets1 transcription factor is required for the development of NK T cells in mice J Immunol 164 2000 2857 2860
46. D. Elewaut, L. Brossay, S.M. Santee, O.V. Naidenko, N. Burdin, H. De Winter, J. Matsuda, C.F. Ware, H. Cheroutre, and M. Kronenberg Membrane lymphotoxin is required for the development of different subpopulations of NK T cells J Immunol 165 2000 671 679
47. +T) cells, natural killer cells, and intestinal intraepithelial T cells J Exp Med 187 1998 967 972
48. •].
49. •].
50. -/- mice). Also, they identify some deficiencies as cell intrinsic (NF-κB p50), whereas others are required in the thymic stroma but not in Vα14i NKT cells (RelB, NF-κB p52).
51. H.D. Lacorazza, Y. Miyazaki, A. Di Cristofano, A. Deblasio, C. Hedvat, J. Zhang, C. Cordon-Cardo, S. Mao, P.P. Pandolfi, and S.D. Nimer The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells Immunity 17 2002 437 449
52. O. Lantz, L.I. Sharara, F. Tilloy, A. Andersson, and J.P. DiSanto Lineage relationships and differentiation of natural killer (NK) T cells: intrathymic selection and interleukin (IL)-4 production in the absence of NKR-P1 and Ly49 molecules J Exp Med 185 1997 1395 1401
53. K. Iizuka, D.D. Chaplin, Y. Wang, Q. Wu, L.E. Pegg, W.M. Yokoyama, and Y.X. Fu Requirement for membrane lymphotoxin in natural killer cell development Proc Natl Acad Sci USA 96 1999 6336 6340
54. H. Sato, T. Nakayama, Y. Tanaka, M. Yamashita, Y. Shibata, E. Kondo, Y. Saito, and M. Taniguchi Induction of differentiation of pre-NKT cells to mature Vα14 NKT cells by granulocyte/macrophage colony-stimulating factor Proc Natl Acad Sci USA 96 1999 7439 7444
55. J.L. Matsuda, L. Gapin, J.L. Baron, S. Sidobre, D.B. Stetson, M. Mohrs, R.M. Locksley, and M. Kronenberg Mouse Vα14i natural killer T cells are resistant to cytokine polarization in vivo Proc Natl Acad Sci USA 100 2003 8395 8400
56. E.M. Behrens, P. Gadue, S.Y. Gong, S. Garrett, P.L. Stein, and P.L. Cohen The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity Eur J Immunol 33 2003 2160 2167
57. + T cells in CD45-deficient mice J Immunol 166 2001 6066 6073
58. D.S. Vinay, B.K. Choi, J.S. Bae, W.Y. Kim, B.M. Gebhardt, and B.S. Kwon CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharide-induced shock syndromes, and have lower IL-4 responses J Immunol 173 2004 4218 4229
59. M. Lohoff, G.S. Duncan, D. Ferrick, H.W. Mittrucker, S. Bischof, S. Prechtl, M. Rollinghoff, E. Schmitt, A. Pahl, and T.W. Mak Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells J Exp Med 192 2000 325 336
60. P. Gadue, N. Morton, and P.L. Stein The Src family tyrosine kinase Fyn regulates natural killer T cell development J Exp Med 190 1999 1189 1196
61. G. Eberl, B. Lowin-Kropf, and H.R. MacDonald Cutting edge: NKT cell development is selectively impaired in Fyn- deficient mice J Immunol 163 1999 4091 4094
62. K.L. Williams, A.J. Zullo, M.H. Kaplan, R.R. Brutkiewicz, C.D. Deppmann, C. Vinson, and E.J. Taparowsky BATF transgenic mice reveal a role for activator protein-1 in NKT cell development J Immunol 170 2003 2417 2426
63. D.B. Stetson, M. Mohrs, R.L. Reinhardt, K. Mohrs, J.L. Baron, Z.-E. Wang, L. Gapin, M. Kronenberg, and R.M. Locksley Constitutive cytokine mRNAs mark natural killer (NK) and NKT cells poised for rapid effector function J Exp Med 198 2003 1069 1076
64. + cells in T cell factor-1-deficient mice Eur J Immunol 26 1996 351 355
65. + T cells Blood 99 2002 513 519
66. T. Dao, D. Guo, A. Ploss, A. Stolzer, C. Saylor, T.E. Boursalian, J.S. Im, and D.B. Sant'Angelo Development of CD1d-restricted NKT cells in the mouse thymus Eur J Immunol 34 2004 3542 3552
67. D. Zhou, J. Mattner, C. Cantu III, N. Schrantz, N. Yin, Y. Gao, Y. Sagiv, K. Hudspeth, Y.-P. Wu, T. Yamashita, S. Teneberg, D. Wang, R.L. Proia, S.B. Levery, P.B. Savage, L. Teyton, and A. Bendelac Lysosomal glycosphingolipid recognition by NKT cells Science 306 2004 1786 1789 This study identifies the lysosomal glycosphingolipid isoglobothihexosylceramide (iGb3) as a natural endogenous ligand for mouse and human NKT cells. Furthermore, the impaired generation of lysosomal iGb3 in mice lacking β-hexosaminidase b results in severe Vα14i NKT cell deficiency, suggesting that this lipid might also mediate Vα14i NKT-cell development in mice.