Restoration of NK T Cell Development in fyn-Mutant Mice by a TCR Reveals a Requirement for Fyn during Early NK T Cell Ontogeny

Journal of Immunology

Volumn 172, Issue 10, 2004, Pages 6093-6100

  Gadue, Paul ^a,c   Yin, Liqun ^a   Jain, Sumesh ^b   Stein, Paul L ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; BROXURIDINE; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 7; PROTEIN KINASE FYN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CELL LABELING; CELL MATURATION; CHIMERA; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; GENE REARRANGEMENT; LIVER; MOUSE; MUTANT; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE ACTIVATION; THYMUS; TRANSGENE; TURNOVER TIME; WILD TYPE;

EID: 2442597072     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.10.6093     Document Type: Article

References (45)

1. - T cells in mice and humans. J. Exp. Med. 180:1097.
2. + T cell populations. Int. Immunol. 7:1157.
3. Bendelac, A., M. G. Rivera, S. Park, and J. Roark. 1997. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15:535.
4. Kawano, T., J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, et al. 1997. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 278:1626.
5. + T cell subsets: a subset (Thy0) that secretes diverse cytokines and overexpresses the Vβ8 T cell receptor gene family. J. Exp. Med. 176:269.
6. - thymocytes with specific lymphokine secretion. Eur. J. Immunol. 23:307.
7. Benlagha, K., and A. Bendelac. 2000. CD1d-restricted mouse Vα14 and human Vα24 T cells: lymphocytes of innate immunity. Semin. Immunol. 12:537.
8. Godfrey, D. I., K. J. Hammond, L. D. Poulton, M. J. Smyth, and A. G. Baxter. 2000. NKT cells: facts, functions and fallacies. Immunol. Today 21:573.
9. Smyth, M. J., and D. I. Godfrey. 2000. NKT cells and tumor immunity - a double-edged sword. Nat. Immunol. 1:459.
10. Kennedy, M. K., M. Glaccum, S. N. Brown, E. A. Butz, J. L. Viney, M. Embers, N. Matsuki, K. Charrier, L. Sedger, C. R. Willis, et al. 2000. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191:771.
11. Elewaut, D., L. Brossay, S. M. Santee, O. V. Naidenko, N. Burdin, H. De Winter, J. Matsuda, C. F. Ware, H. Cheroutre, and M. Kronenberg. 2000. Membrane lymphotoxin is required for the development of different subpopulations of NK T cells. J. Immunol. 165:671.
12. Walunas, T. L., B. Wang, C. R. Wang, and J. M. Leiden. 2000. Cutting edge: the Ets1 transcription factor is required for the development of NK T cells in mice. J. Immunol. 164:2857.
13. Di Santo, J. P., and H. Rodewald. 1998. In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development. Curr. Opin. Immunol. 10:196.
14. Gadue, P., N. Morton, and P. L. Stein. 1999. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J. Exp. Med. 190:1189.
15. Eberl, G., B. Lowin-Kropf, and H. R. MacDonald. 1999. NKT cell development is selectively impaired in Fyn-deficient mice. J. Immunol. 163:4091.
16. + T cells by CD1-expressing cortical thymocytes. J. Exp. Med. 182:2091.
17. + cells. J. Immunol. 164:2412.
18. + T cell development and early IL-4 production in CD1-deficient mice. Immunity 6:459.
19. Mendiratta, S. K., W. D. Martin, S. Hong, A. Boesteanu, S. Joyce, and L. Van Kaer. 1997. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6:469.
20. Smiley, S. T., M. H. Kaplan, and M. J. Grusby. 1997. Immunoglobulin E production in the absence of interleukin-4 secreting CD1-dependent cells. Science 275:977.
21. fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70:741.
22. lck. Nature 357:161.
23. Bendelac, A., R. D. Hunziker, and O. Lantz. 1996. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J. Exp. Med. 184:1285.
24. Matsuda, J. L., O. V. Naidenko, L. Gapin, T. Nakayama, M. Taniguchi, C. R. Wang, Y. Koezuka, and M. Kronenberg. 2000. Trucking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192:741.
25. Watanabe, H., K. Ohtsuka, M. Kimura, Y. Ikarashi, K. Ohmori, A. Kusumi, T. Ohteki, S. Seki, and T. Abo. 1992. Details of an isolation method for hepatic lymphocytes in mice. J. Immunol. Methods 146:145.
26. Lantz, O., L. I. Sharara, F. Tilloy, A. Andersson, and J. P. Di Santo. 1997. Lineage relationships and differentiation of NK T cells: intrathymic selection and IL-4 production in the absence of NKR-P1 and Ly49 molecules. J. Exp. Med. 185:1395.
27. - cells: implications for the regulation of Th1- and Th2-type responses. Int. Immunol. 9:1123.
28. + thymocytes selected by MHC class I molecules. Science 263:1774.
29. Gapin, L., J. L. Matsuda, C. D. Surh, and M. Kronenberg. 2001. NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nat. Immunol. 2:971.
30. Benlagha, K., T. Kyin, A. Beavis, L. Teyton. and A. Bendelac. 2002. A thymic precursor to the NK T cell lineage. Science 296:553.
31. + CD1d-dependent precursor stage. J. Exp. Med. 195:835.
32. Gadue, P., and P. L. Stein. 2002. NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation. J. Immunol. 169:2379.
33. Benlagha, K., A. Weiss, A. Beavis, L. Teyton, and A. Bendelac. 2000. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J. Exp. Med. 191:1895.
34. Carnaud, C., D. Lee, O. Donnars, S. H. Park, A. Beavis, Y. Koezuka, and A. Bendelac. 1999. Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163:4647.
35. Eberl, G., and H. R. MacDonald. 2000. Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells. Eur. J. Immunol. 30:985.
36. Kitamura, H., A. Ohta, M. Sekimoto, M. Sato, K. Iwakabe, M. Nakui, T. Yahata, H. Meng, T. Keda, S. Nishimura, et al. 2000. α-Galactosylceramide induces early B-cell activation through IL-4 production by NKT cells. Cell. Immunol. 199:37.
37. + T cells from γδ T cell precursors. Eur. J. Immunol. 28:828.
38. Petersson, K., F. Ivars. 2001. Early TCR αβ expression promotes maturation of T cells expressing FcΕRIγ containing TCR/CD3 complexes. J. Immunol. 166:6616.
39. Trop, S., M. Rhodes, D. L. Wiest, P. Hugo, and J. C. Zuniga-Pflucker. 2000. Competitive displacement of pTα by TCR-α during TCR assembly prevents surface coexpression of pre-TCR and αβ TCR. J. Immunol. 165:5566.
40. lck. EMBO J. 11:4877.
41. MacDonald, H. R. 2002. Development and selection of NKT cells. Curr. Opin. Immunol. 14:250.
42. Alberola-Ila, J., K. A. Hogquist, K. A. Swan, M. J. Bevan, and R. M. Perlmutter. 1996. Positive and negative selection invoke distinct signaling pathways. J. Exp. Med. 184:9.
43. Williams, K. L., A. J. Zullo, M. H. Kaplan, R. R. Brutkiewicz, C. D. Deppmann, C. Vinson, and E. J. Taparowsky. 2003. BATF transgenic mice reveal a role for activator protein-1 in NKT cell development. J. Immunol. 170:2417.
44. fyn. Cell 70:751.
45. fyn in T cell development and optimal stimulation of T cells by antigen. J. Immunol. 160:5410.