Ligand-dependent inhibition of CD1d-restricted NKT cell development in mice transgenic for the activating receptor Ly49D

Journal of Experimental Medicine

Volumn 197, Issue 7, 2003, Pages 919-925

  Voyle, Roger B ^a   Beermann, Friedrich ^b   Lees, Rosemary K ^a   Schümann, Jens ^a   Zimmer, Jacques ^a   Held, Werner ^a   MacDonald, H Robson ^a,c  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

Author keywords

ITAM containing receptors; ITIM containing receptors; NK receptor repertoire; NKT cell development; TCR repertoire

Indexed keywords

CD1D ANTIGEN; LECTIN RECEPTOR; LIGAND; LY49D RECEPTOR; T LYMPHOCYTE RECEPTOR; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL MATURATION; GENE EXPRESSION; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE; TRANSGENE; TRANSGENIC MOUSE;

AMINO ACID MOTIFS; ANIMALS; ANTIGENS, CD1; ANTIGENS, LY; H-2 ANTIGENS; KILLER CELLS, NATURAL; LECTINS, C-TYPE; LIGANDS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, IMMUNOLOGIC;

EID: 0344406189     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021615     Document Type: Article

References (30)

1. Bendelac, A., M. Bonneville, and J.F. Kearney. 2001. Autoreactivity by design: innate B and T lymphocytes. Nat. Rey. Immunol. 1:177-186.
2. Kronenberg, M., and L. Gapin. 2002. The unconventional lifestyle of NKT Cells. Nat. Rev. Immunol. 2:557-568.
3. Park, S.H., A. Weiss, K. Benlagha, T. Kyin, L. Teyton, and A. Bendelac. 2001. The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families. J. Exp. Med. 193:893-904.
4. Ugolini, S., and E. Vivier. 2000. Regulation of T cell function by NK cell receptors for classical MHC class I molecules. Curr. Opin. Immunol. 12:295-300.
5. Raulet, D.H., R.E. Vance, and C.W. McMahon. 2001. Regulation of the natural killer cell receptor repertoire. Annu. Rev. Immunol. 19:291-330.
6. Ikarashi, Y., R. Mikami, A. Bendelac, M. Terme, N. Chaput, M. Terada, T. Tursz, E. Angevin, F.A. Lemonnier, H. Wakasugi, and L. Zitvogel. 2001. Dendritic cell maturation overrules H-2D-mediated natural killer T (NKT) cell inhibition: critical role for B7 in CD1d-dependent NKT cell interferon gamma production. J. Exp. Med. 194:1179-1186.
7. Maeda, M., S. Lohwasser, T. Yamamura, and F. Takei. 2001. Regulation of NKT cells by Ly49: analysis of primary NKT cells and generation of NKT cell line. J. Immunol. 167:4180-4186.
8. Lanier, L.L., and A.B. Bakker. 2000. The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function. Immunol. Today. 21:611-614.
9. Ortaldo, J.R., R. Winkler-Pickett, A.T. Mason, and L.H. Mason. 1998. The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells. J. Immunol. 160:1158-1165.
10. Smith, H.R., H.H. Chuang, L.L. Wang, M. Salcedo, J.W. Heusel, and W.M. Yokoyama. 2000. Nonstochastic coexpression of activation receptors on murine natural killer cells. J. Exp. Med. 191:1341-1354.
11. Lees, R.K., I. Ferrero, and H.R. MacDonald. 2001. Tissue-specific segregation of TCR gamma delta+ NKT cells according to phenotype TCR repertoire and activation status: parallels with TCR alphabeta+NKT cells. Eur. J. Immunol. 31:2901-2909.
12. Pauza, M., K.M. Smith, H. Neal, C. Reilly, L.L. Lanier, and D. Lo. 2000. Transgenic expression of Ly-49A in thymocytes alters repertoire selection. J. Immunol. 164:884-892.
13. Fahlen, L., L. Oberg, T. Brannstrom, N.K. Khoo, U. Lendahl, and C.L. Sentman. 2000. Ly49A expression on T cells alters T cell selection. Int. Immuol. 12:215-222.
14. MacDonald, H.R., R.K. Lees, and W. Held. 1998. Developmentally regulated extinction of Ly-49 receptor expression permits maturation and selection of NK1.1+ T cells. J. Exp. Med. 187:2109-2114.
15. Pircher, H., T.W. Mak, R. Lang, W. Ballhausen, E. Ruedi, H. Hengartner, R.M. Zinkernagel, and K. Burki. 1989. T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice. EMBO J. 8:719-727.
16. Held, W., D, Cado, and D.H. Raulet. 1996. Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection. J. Exp. Med. 184:2037-2041.
17. Ioannidis, V., J. Zimmer, F. Beermann, and W. Held. 2001. Cre recombinase-mediated inactivation of H-2Dd transgene expression: evidence for partial missing self-recognition by Ly49A NK cells. J. Immunol. 167:6256-6262.
18. Eberl, G., R. Lees, S.T. Smiley, M. Taniguchi, M.J. Grusby, and H.R. MacDonald. 1999. Tissue-specific segregation of CD1d-dependent and CD1d-independent NKT cells. J. Immunol. 162:6410-6419.
19. Wolfer, A., T. Bakker, A. Wilson, M. Nicolas, V. Ioannidis, D.R. Littman, P.P. Lee, C.B. Wilson, W. Held, H.R. MacDonald, and F. Radtke. 2001. Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nat. Immunol. 2:235-241.
20. Matsuda, J.L., O.V. Naidenko, L. Gapin, T. Nakayama, M. Taniguchi, C.R. Wang, Y. Koezuka, and M. Kronenberg. 2000. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. Med. 192:741-754.
21. Ortaldo, J.R., R. Winkler-Pickett, J. Willette-Brown, R.L. Wange, S.K. Anderson, G.J. Palumbo, L.H. Mason, and D.W. McVicar. 1999. Structure/function relationship of activating Ly-49D and inhibitory Ly-49G2 NK receptors. J. Immunol. 163:5269-5277.
22. Bakker, A.B., R.M. Hoek, A. Cerwenka, B. Blom, L. Lucian, T. McNeil, R. Murray, L.H. Phillips, J.D. Sedgwick, and L.L. Lanier. 2000. DAP12-deficient mice fail to develop autoimnmnity due to impaired antigen priming. Immunity. 13:345-353.
23. Eberl, G., H.J. Fehling, H. von Boehmer, and H.R. MacDonald. 1999. Absolute requirement for the pre-T cell receptor alpha chain during NK1.1+ TCRalphabeta cell development. Eur. J. Immunol. 29:1966-1971.
24. Benlagha, K., A. Weiss, A. Beavis, L. Teyton, and A. Bendelac. 2000. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J. Exp. Med. 191:1895-1903.
25. Benlagha, K., T. Kyin, A. Beavis, L. Teyton, and A. Bendelac. 2002. A thymic precursor to the NK T cell lineage. Science. 296:553-555.
26. Pellicci, D.G., K.J. Hammond, A.P. Uldrich, A.G. Baxter, M.J. Smyth, and D.I. Godfrey. 2002. A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage. J. Exp. Med. 195:835-844.
27. Gadue, P., and P.L. Stein. 2002. NK T cell precursors exhibit differential cytokine regulation and require itk for efficient maturation. J. Immunol. 169:2397-2406.
28. Gapin, L., J.L. Matsuda, C.D. Surh, and M. Kronenberg. 2001. NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nat. Immunol. 2:971-978.
29. Oberg, L., M. Eriksson, L. Fahlen, and C.L. Sentman. 2000. Expression of Ly49A on T cells alters the threshold for T cell responses. Eur. J. Immunol. 30:2849-2856.
30. Kim, S., K. Iizuka, H.S. Kang, A. Dokun, A.R. French, S. Greco, and W.M. Yokoyama. 2002. In vivo developmental stages in murine natural killer cell maturation. Nat. Immunol. 3:523-528.