Cutting Edge: The Ontogeny and Function of Va14Ja18 Natural T Lymphocytes Require Signal Processing by Protein Kinase Cθ and NF-κB

Journal of Immunology

Volumn 172, Issue 8, 2004, Pages 4667-4671

  Stanic, Aleksandar K ^a   Bezbradica, Jelena S ^a   Park, Jang June ^a   Van Kaer, Luc ^a   Boothby, Mark R ^a   Joyce, Sebastian ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE C THETA; PROTEIN VA14JA18; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; CYTOLOGY; IMMUNOREGULATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; SIGNAL PROCESSING; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 1842424840     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.8.4667     Document Type: Article

References (24)

1. Joyce, S. 2001. CD1d and natural T cells: how their properties jump start the immune system. Cell. Mol. Life Sci. 58:442.
2. Stanic, A. K., J. S. Bezbradica, J.-J. Park, N. Matsuki, A. L. Mora, L. Van Kaer, M. R. Boothby, and S. Joyce. 2004. NF-κB controls cell fate specification, survival and molecular differentiation of immunoregulatory natural T lymphocytes. J. Immunol. 172:2265.
3. Elewaut, D., R. B. Shaikh, K. J. Hammond, H. De Winter, A.J. Leishman, S. Sidobre, O. Turovskaya, T. I. Prigozy, L. Ma, T. A. Banks, et al. 2003. NIK-dependent RelB activation defines a unique signaling pathway for the development of Vα14i NKT cells. J. Exp. Med. 197:1623.
4. Sivakumar, V., K. J. Hammond, N. Howells, K. Pfeffer, and F. Weih. 2003. Differential requirement for Rel/nuclear factor κB family members in natural killer T cell development. J. Exp. Med. 197:1613.
5. Mendiratta, S. K., W. D. Martin, S. Hong, A. Boesteanu, S. Joyce, and L. Van Kaer. 1997. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6:469.
6. Boothby, M. R., A. L. Mora, D. C. Scherer, J. A. Brockman, and D. W. Ballard. 1997. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB. J. Exp. Med. 185:1897.
7. Sun, Z., C. W. Arendt, W. Ellmeier, E. M. Schaeffer, M. J. Sunshine, L. Gandhi, J. Annes, D. Petrzilka, A. Kupfer, P. L. Schwartzberg, and D. R. Littman. 2000. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes. Nature 404:402.
8. L and Bcl-2 repress a common pathway of cell death. J. Exp. Med. 182:821.
9. Matsuki, N., A. K. Stanic, M. E. Embers, L. Van Kaer, L. Morel, and S. Joyce. 2003. Genetic dissection of Vα14Jα18 natural T cell number and function in autoimmune-prone mice. J. Immunol. 170:5429.
10. Gui, M., J. Li, L. J. Wen, R. R. Hardy, and K. Hayakawa. 2001. TCRβ chain influences but does not solely control autoreactivity of Vα14Jα281 T cells. J. Immunol. 167:6239.
11. Stanic, A. K., R. Shashidharamurthy, J. S. Bezbradica, N. Matsuki, Y. Yoshimura, S. Miyake, E. Y. Choi, T. D. Schell, L. Van Kaer, S. S. Tevethia, et al. 2003. Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T (iNKT) cell receptor. J. Immunol. 171:4539.
12. Arendt, C. W., B. Albrecht, T. J. Soos, and D. R. Littman. 2002. Protein kinase Cθ: signaling from the center of the T-cell synapse. Curr. Opin. Immunol. 14:323.
13. Coudronniere, N., M. Villalba, N. Englund, and A. Altman. 2000. NF-κB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase Cθ. Proc. Natl. Acad. Sci. USA 97:3394.
14. Gadue, P., and P. L. Stein. 2002. NKT cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation. J. Immunol. 169:2397.
15. Voll, R. E., E. Jimi, R. J. Phillips, D. F. Barber, M. Rincon, A. C. Hayday, R. A. Flavell, and S. Ghosh. 2000. NF-κB activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity 13:677.
16. Sha, W. C., H. C. Liou, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321.
17. Aronica, M. A., A. L. Mora, D. B. Mitchell, P. W. Finn, J. E. Johnson, J. R. Sheller, and M. R. Boothby. 1999. Preferential role for NF-κB/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J. Immunol. 163:5116.
18. Corn, R. A., M. A. Aronica, F. Zhang, Y. Tong, S. A. Stanley, S. R. Kim, L. Stephenson, B. Enerson, S. McCarthy, A. Mora, and M. Boothby. 2003. T cell-intrinsic requirement for NF-κB induction in postdifferentiation IFN-γ production and clonal expansion in a Th1 response. J. Immunol. 171:1816.
19. + thymocytes correlates with negative selection. Cell Death Differ. 7:1253.
20. Akbari, O., P. Stock, E. Meyer, M. Kronenberg, S. Sidobre, T. Nakayama, M. Taniguchi, M. J. Grusby, R. H. DeKruyff, and D. T. Umetsu. 2003. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat. Med. 9:582.
21. Kaneko, Y., M. Harada, T. Kawano, M. Yamashita, Y. Shibata, F. Gejyo, T. Nakayama, and M. Taniguchi. 2000. Augmentation of Vα14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J. Exp. Med. 191:105.
22. Takeda, K., Y. Hayakawa, L. Van Kaer, H. Matsuda, H. Yagita, and K. Okumura. 2000. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc. Natl. Acad. Sci. USA 97:5498.
23. Hansen, D. S., M. A. Siomos, L. Buckingham, A. A. Scalzo, and L. Schofield. 2003. Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex. Immunity 18:391.
24. Heller, F., I. J. Fuss, E. E. Nieuwenhuis, R, S. Blumberg, and W. Strober. 2002. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 17:629.