Stress-activated signalling pathways in yeast

Genes to Cells

Volumn 3, Issue 8, 1998, Pages 485-498

  Toone, W Mark ^a   Jones, Nic ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION REGULATION; YEAST;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; GENE EXPRESSION REGULATION, FUNGAL; HEAT-SHOCK RESPONSE; OSMOTIC PRESSURE; OXIDATIVE STRESS; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; ULTRAVIOLET RAYS;

EID: 0031717526     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1998.00211.x     Document Type: Review

References (91)

1. +, which encodes a 115-kDa protein preferentially localized to the nucleus and its periphery. J. Cell. Biol. 108, 1195-1207.
2. Billard, P., Dumond, H. & Bolotinfukuhara, M. (1997) Characterization of an AP-1-like transcription factor that mediates an oxidative stress-response in Kluyveromyces lactis. Mol. Gen. Genet. 257, 62-70.
3. Bossier, P., Fernandes, L., Rocha, D. & Rodrigues-Pousada, C. (1993) Overexpression of YAP2, coding for a new yAP protein, and YAP1 in Saccharomyces cerevisiae alleviates growth inhibition caused by 1,10-phenanthroline. J. Biol. Chem. 268, 23640-23645.
4. Brewster, J.L., de Valoir, T., Dwyer, N.D., Winter, E. & Gustin, M.C. (1993) An osmosensing signal transduction pathway in yeast. Science 259, 1760-1763.
5. Brown, J.L., Bussey, H. & Stewart, R.C. (1994) Yeast Skn7p functions in a eukaryotic two-component regulatory pathway. EMBO J. 13, 5186-5194.
6. Burbulys, D., Trach, K.A. & Hoch, J.A. (1991) Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay. Cell 64, 545-552.
7. Cavigelli, M., Dolfi, F., Claret, F.X. & Karin, M. (1995) Induction of cFos expression through JNK-mediated TCF/ Elk-1 phosphorylation. EMBOJ. 14, 5957-5964.
8. Cohen, P. (1997) The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol. 7, 353-361.
9. Degols, G. & Russell, P. (1997) Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe. Mol. Cell. Biol. 17, 3356-3363.
10. Degols, G., Shiozaki, K. & Russell, P. (1996) Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe. Mol. Cell. Biol. 16, 2870-2877.
11. Derijard, B., Hibi, M., Wu, I.H., et al. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 16, 1025-1037.
12. Egger, L.A., Park, H. & Inouye, M. (1997) Signal transduction via histidyl-aspartyl phosphorelay. Genes Cells 2, 167-184.
13. Elion, E.A. (1995) Ste5: a meeting place for MAP kinases and their associates. Trends Cell Biol. 5, 322-327.
14. Estruch, F. & Carlson, M. (1993) Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. Mol. Cell. Biol. 13, 3872-3881.
15. Fernandes, L., Rodrigues-Pousada, C. & Strahl, K. (1997) Yap, a family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol. Cell. Biol. 17, 6982-6993.
16. Fornerod, M., Ohno, M., Yoshida, M. & Mattaj, I.W. (1997) CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90, 1051-1060.
17. Fukuda, M., Asano, S., Nakamura, T., et al. (1997) CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 390, 308-311.
18. Gaits, F., Degols, G., Shiozaki, K. & Russell, P. (1998). Phosphorylation and association with the transcription factor Atf1 regulate localization of the Sty1/Spc1 stress-activated kinase in fission yeast. Genes Dev. 12, 1464-1473.
19. Galcheva-Gargova, Z., Derijard, B., Wu, I.-H. & Davis, R. (1994) An osmosensing signal transduction pathway in mammalian cells. Science 265, 806-808.
20. Gorner, W, Durchschlag, E., Martinez-Pastor, M.T., et al. (1998) Nuclear localization of the C2H2 zinc finger protein Msn2 is regulated by stress and protein kinase A activity. Genes Dev. 12, 586-597.
21. Gottesman, M.M. & Pastan, I. (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62, 385-427.
22. Gounalaki, N. & Thieros, G. (1994) Yap1p, a yeast transcriptional activator that mediates multidrug resistance, regulates the metabolic stress response. EMBOJ. 13, 4036-4041.
23. Grant, C.M., Collinson, L.P, Roe, J.-H. & Dawes, I.W. (1996) Yeast glutathione-reductase is required for protection against oxidative stress and is a target for yAP-1 transcriptional regulation. Mol. Microbiol. 21, 171-179.
24. Gupta, S., Campbell, D., Derijard, B. & Davies, R.J. (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science. 267, 389-393.
25. Han, J., Lee, J.-D, Bibbs, L. & Ullevitch, R.J. (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265, 808-811.
26. Herskowitz, I. (1995) MAP kinase pathways in yeast: for mating and more. Cell 80, 187-197.
27. Herde, K., Haase, E. & Brendel, M. (1991) The SNQ3 gene of Saccharomyces cerevisiae confers hyper-resistance to several functionally unrelated chemicals. Curr. Genet. 19, 1-14.
28. Hibi, M., A.Lin, T., Smeal, A., Minden & Karin, M., (1993) Identification of an oncoprotein and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7, 2135-2148.
29. Hussain, M. & Lenard, J. (1991) Characterization of PDR4, a Saccharomyces cerevisiae Gene that confers pleiotropic drug resistance in high-copy number: identity with YAP1, encoding a transcriptional activator. Gene 101, 149-152. [published erratum appears in Gene (1991), 107, 175.]
30. Jones, R.H. & Jones, N.C. (1989) Mammalian cAMP-responsive element can activate transcription in yeast and binds a yeast factor(s) that resembles the mammalian factor ATF. Proc. Natl. Acad. Sci. USA 86, 2176-2180.
31. Kallunki, T., Su, B., Sluss, H.K., et al. (1994) JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phophorylation. Genes Dev. 8, 2996-3007.
32. + encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation. Genes Cell 1, 391-408.
33. Karin, M., Liu, Z. & Zandi, E. (1997) AP-1 function and regulation. Curr. Opinion Cell Biol. 9, 240-246.
34. Kato, T., Okazaki, K., Murakami, H., Stettler, S., Fantes, P. & Okayama, H. (1996) Stress signal, mediated by a HOG1-like MAP kinase, controls sexual development in fission yeast. FEBS Lett. 378, 207-212.
35. Kobayashi, N. & McEntee, K. (1991) Evidence for a heat shock transcription factor-independent mechanism for heat shock induction of transcription in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 87, 6550-6554.
36. Kobayashi, N. & McEntee, K. (1993) Identification of cis and trans components of a novel heat shock stress regulatory pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 13, 248-256.
37. Krems, B., Charizanis, C. & Entian, K. (1996) The response regulator-like protein Pos9/Skn7 of Saccharomyces cerevisiae is involved in oxidative stress resistance. Curr. Genet. 29, 327-334.
38. Kuge, S. & Jones, N. (1994) YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides. EMBOJ. 13, 655-664.
39. Kuge, S., Jones, N. & Nomoto, A. (1997) Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J. 16, 1710-1720.
40. Kuge, S., Toda, T, lizuka, N. & Nomoto, A. (1998) Crm1 (XpoI) dependent nuclear export of the budding yeast transcription factor yAP-1 is sensitive to oxidative stress. Genes Cells 3, 521-532.
41. +. Mol. Gen. Genet. 250, 59-68.
42. Kyriakis, J.M. & Avruch, J. (1996) Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays 18, 567-577.
43. Kyriakis, J.M., Banerjee, P., Nikolakaki, E., et al. (1994) The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 156-160.
44. Lee, J.C., Laydon, J.T., McDonnel, P.C., et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739-746.
45. Livingstone, C., Patel, G. & Jones, N. (1995) ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBOJ. 14, 1785-1797.
46. Maeda, T, Takekawa, M. & Saito, H. (1995) Activation of yeast Pbs2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 269, 554-558.
47. Maeda, T., Wurgler-Murphy, S.M. & Saito, H. (1994) A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369, 242-245.
48. Marchler, G., Schuller, C., Adam, G. & Ruis, H. (1993) A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J. 12, 1997-2003.
49. Marshall, C.J. (1994) MAP kinase kinase kinase, MAP kinase kinase, and MAP kinase. Curr. Opin. Genet. Dev. 4, 82-89.
50. Martinez-Pastor, M.T., Marchler, G., Schuller, C., Marchler-Bauer, A., Ruis, H. & Estruch, F. (1996) The Saccharomyces cerevisiae zinc finger proteins Msn2 and Msn4 are required for transcriptional induction through the stress-response element (STRE). EMBOJ. 15, 2227-2235.
51. Millar, J.B.A., Buck, V. & Wilkinson, M.G. (1995) Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast. Genes Dev. 9, 2117-2130.
52. Miyahara, K., Hirata, D. & Miyakawa, T. (1996) yAP-1 and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae. Curr. Genet. 29, 103-105.
53. Molz, L., Booher, R., Young, P. & Beach, D. (1989) cdc2 and the regulation of mitosis: six interacting mes genes. Genetics 122, 773-782.
54. Morgan, B.A., Banks, G.R., Toone, W.M., Raitt, D., Kuge, S. & Johnston, L.H. (1997) The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae. EMBO J. 16, 1035-1044.
55. Morrison, D.K. & Cutler, R.E. (1997) The complexity of Raf-1 regulation. Curr. Opin. Cell Biol. 9, 174-179.
56. Moye-Rowley, W.S., Harshman & Parker, C.S. (1989) Yeast Yap1 encodes a novel form of the jun family of transcriptional activator proteins. Genes Dev. 3, 283-292.
57. +, a novel gene of Schizosaccharomyces pombe which confers brefeldin-a resistance is structurally related to the ATP-binding cassette superfamily. J. Bacteriol. 177, 1536-1543.
58. Neville, M., Stutz, F., Lee, L., Davis, L.I. & Rosbash, M. (1997) The importin-beta family member Crm1p bridges the interaction between Rev. and the nuclear pore complex during nuclear export. Curr. Biol. 7, 767-775.
59. Nishi, K., Yoshida, M., Nishimura, M., et al. (1992) A leptomycin resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P-glycoproteins. Mol. Microbiol. 6, 761-769.
60. Ossareh-Nazari, B., Bachelerie, F. & Dargemont, C. (1997) Evidence for the role of Crm1 in signal-mediated nuclear protein export. Science 278, 141-144.
61. Posas, F. & Saito, H. (1997) Osmotic activation of the HOG1 MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science 276, 1702-17005.
62. Posas, F. & Saito, H. (1998) Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator. EMBO J. 17, 1385-1394.
63. Posas, E, Wurgler-Murphy, S.M., Maeda, T., Witten, E.A., Thai, T.C. & Saito, H. (1996) Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the Sln1-Ypd1-Ssk1 'two-component' osmosensor. Cell 86, 865-875.
64. Raingeaud, J., Gupta, S., Rogers, J., et al. (1995) Proinlammatory cytokines and environmental stress cause p38 mitogen-activated protein kinasde activity by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270, 7420-7426.
65. Samejima, I., Mackie, S. & Fantes, P.A. (1997) Multiple modes of activation of the stress responsive MAP-kinase pathway in fission yeast. EMBO J. 16, 6162-6170.
66. Schnell, N. & Entian, K.D. (1991) Identification and characterization of a Saccharomyces cerevisiae gene (PAR1) conferring resistance to iron chelators. Eur. J. Biochem. 200, 487-493.
67. Schnell, N., Krems, B. & Entian, K.D. (1992) The Pari (YAP1/ SNQ3) gene of Saccharomyces cerevisiae, a c-jun homolog, is involved in oxygen metabolism. Curr. Genet. 21, 269-273.
68. Schuller, S., Brewster, J.L., Alexander, M.R., Gustin, M.C. & Ruis, H. (1994) The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene. EMBO J. 13, 4382-4389.
69. Shieh, J.-C., Wilkinson, M.G., Buck, V., Morgan, B.A., Makino, K. & Millar, J.B.A. (1997) The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle. Genes Dev. 10, 2276-2288.
70. Shieh, J.C., Wilkinson, M.G. & Millar, J.B.A. (1998) The Win1 mitotic regulator is a component of the fission yeast stress-activated Sty1 MAPK pathway. Mol. Biol. Cell 9, 311-322.
71. Shin, D.-Y., Matsumoto, K., Iidda, H., Uno, I. & Ishikawa, T. (1987) Heat shock response of Saccharomyces cerevisiae mutants altered in cAMP-dependent protein phosphorylation. Mol. Cell. Biol. 7, 244-250.
72. Shiozaki, K. & Russell, P. (1995) Cell cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Nature 378, 739-743.
73. Shiozaki, K. & Russell, P. (1996) Conjugation, meiosis, and the osmotic stress response are regulated by the Spc1 kinase through the Atf1 transcription factor in fission yeast. Genes Dev. 10, 2276-2288.
74. Shiozaki, K., Shiozaki, M. & Russell, P (1997) Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade. Mol. Biol. Cell 8, 409-419.
75. Stade, K., Ford, C.S., Gutherie, C. & Weis, K. (1997) Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90, 1041-1050.
76. + encodes a transcription factor required for sexual development and entry into stationary phase. EMBO J. 14, 6193-6208.
77. Toda, T, Shimanuki, M., Saka, Y., et al. (1992). Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, Crm1. Mol. Cell. Biol. 12, 5474-5484.
78. Toda, T, Shimanuki, M. & Yanagida, M. (1991) Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP1 and budding yeast FUS3 and KSS1 kinases. Genes Dev. 5, 60-73.
79. Toone, W.M., Kuge, S., Samuels, M., Morgan, B.A., Toda, T. & Jones, N. (1998) Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase, Sty1. Genes Dev. 12, 1453-1463.
80. Treisman, R. (1996) Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell Biol. 8, 205-215.
81. Turi, T.G. & Rose, J.K. (1995) Characterization of a novel Schizosaccharomyces pombe multidrug resistance transporter conferring brefeldin-a resistance. Biochem. Biophys. Res. Com. 212, 410-418.
82. Van Dam, H., Wilhelm, D., Herr, I, Steffen, A., Herrlich, P. & Angel, P. (1995) Atf-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14, 1798-1811.
83. Warbrick, E. & Fantes, P.A. (1991) The wis1 protein kinase is a dose-dependent regulator of mitosis in Scizosaccharomyces pombe. EMBOJ. 10, 4291-4299.
84. Waskiewicz, A.J. & Cooper, J.A. (1995) Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr. Opin. Cell Biol. 7, 798-805.
85. Weiser, R., Adam, G., Wagner, A., et al. (1991) Heat shock factor-independent heat control of transcription of the CTT1 gene encoding the cytosolic catalase T of Saccharomyces cerevisiae. J. Biol. Chem. 266, 12406-12411.
86. Wemmie, J.A., Szczypka, M.S., Thiele, D.J. & Moye-Rowley, W.S. (1994) Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1. J. Biol. Chem. 269, 32592-32597.
87. Wilkinson, M.G., Samuels, M., Takeda, T., et al (1996) The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast. Genes Dev. 10, 2289-2301.
88. Wu, A. & Moye-Rowley, W.S. (1994) GSH1, which encodes G-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation. Mol. Cell. Biol. 14, 5832-5839.
89. Wu, A., Wemmie, J.A., Edington, N.P., et al. (1993) Yeast bZIP proteins mediate pleiotropic drug and metal resistance. J. Biol. Chem. 268, 18850-18858.
90. Wurgler-Murphy, S.M., Maeda, T, Witten, E.A. & Saito, H. (1997) Regulation of the Saccharomyces cerevisiae Hog1mitogen-activated protein-kinase by the Ptp2 and Ptp3 protein-tyrosine phosphatases. Mol. Cell. Biol. 17, 1289-1297.
91. Wurgler-Murphy, S.M. & Saito, H. (1997) Two-component signal transducers and MAPK cascades. Trends Bioch. Sci. 22, 172-176.