-
1
-
-
0347356355
-
Signal transduction inhibitors - A work in progress
-
J. Becker Signal transduction inhibitors - a work in progress Nat. Biotech. 22 2004 15 18
-
(2004)
Nat. Biotech.
, vol.22
, pp. 15-18
-
-
Becker, J.1
-
2
-
-
0037392444
-
Issues and progress with protein kinase inhibitors for cancer treatment
-
J. Dancey, and E.A. Sausville Issues and progress with protein kinase inhibitors for cancer treatment Nat. Rev. Drug Discov. 2 2003 296 313
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 296-313
-
-
Dancey, J.1
Sausville, E.A.2
-
3
-
-
0038004636
-
Clinical biomarkers in drug discovery and development
-
R. Frank, and R. Hargreaves Clinical biomarkers in drug discovery and development Nat. Rev. Drug Discov. 2 2003 566 580
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 566-580
-
-
Frank, R.1
Hargreaves, R.2
-
4
-
-
18244370796
-
How molecular profiling could revolutionize drug discovery
-
in press
-
Stoughton, R.B., Friend, S.H. (2005). How molecular profiling could revolutionize drug discovery. Nat Rev Drug Discov. in press
-
(2005)
Nat Rev Drug Discov
-
-
Stoughton, R.B.1
Friend, S.H.2
-
5
-
-
0042326159
-
Pharmacogenomic applications in clinical drug development
-
N.C. Dracopoli Pharmacogenomic applications in clinical drug development Cancer Chemother. Pharmacol. 52 Suppl. 1 2003 S57 S60
-
(2003)
Cancer Chemother. Pharmacol.
, vol.52
, Issue.SUPPL. 1
-
-
Dracopoli, N.C.1
-
6
-
-
0035375137
-
Computational analysis of microarray data
-
J. Quackenbush Computational analysis of microarray data Nat. Rev. Genet. 2 2001 418 427
-
(2001)
Nat. Rev. Genet.
, vol.2
, pp. 418-427
-
-
Quackenbush, J.1
-
7
-
-
0242490780
-
Cytoscape: A software environment for integrated models of biomolecular interaction networks
-
P. Shannon Cytoscape: a software environment for integrated models of biomolecular interaction networks Genome Res. 13 2003 2498 2504
-
(2003)
Genome Res.
, vol.13
, pp. 2498-2504
-
-
Shannon, P.1
-
8
-
-
84988044292
-
Bioinformatics - From genes to pathways
-
L. Bonetta Bioinformatics - from genes to pathways Nat. Meth. 1 2004 169 176
-
(2004)
Nat. Meth.
, vol.1
, pp. 169-176
-
-
Bonetta, L.1
-
9
-
-
0038048325
-
Inferring genetic networks and identifying compound mode of action via expression profiling
-
T.S. Gardner, D. di Bernardo, D. Lorenz, and J.J. Collins Inferring genetic networks and identifying compound mode of action via expression profiling Science 301 2003 102 105
-
(2003)
Science
, vol.301
, pp. 102-105
-
-
Gardner, T.S.1
Di Bernardo, D.2
Lorenz, D.3
Collins, J.J.4
-
10
-
-
0033737840
-
Inferring qualitative relations in genetic networks and metabolic pathways
-
T. Akutsu, S. Miyano, and S. Kuhara Inferring qualitative relations in genetic networks and metabolic pathways Bioinformatics 16 2000 727 734
-
(2000)
Bioinformatics
, vol.16
, pp. 727-734
-
-
Akutsu, T.1
Miyano, S.2
Kuhara, S.3
-
11
-
-
0030848624
-
A test case of correlation metric construction of a reaction pathway from measurements
-
A. Arkin, P. Shen, and J. Ross A test case of correlation metric construction of a reaction pathway from measurements Science 277 1997 1275 1279
-
(1997)
Science
, vol.277
, pp. 1275-1279
-
-
Arkin, A.1
Shen, P.2
Ross, J.3
-
12
-
-
0033736476
-
Genetic network inference: From coexpression clustering to reverse engineering
-
P. D'Haeseleer, S. Liang, and R. Somogyi Genetic network inference: from coexpression clustering to reverse engineering Bioinformatics 16 2000 707 726
-
(2000)
Bioinformatics
, vol.16
, pp. 707-726
-
-
D'Haeseleer, P.1
Liang, S.2
Somogyi, R.3
-
14
-
-
0036366689
-
Combining location and expression data for principled discovery of genetic regulatory network models
-
A.J. Hartemink, D.K. Gifford, T.S. Jaakkola, and R.A. Young Combining location and expression data for principled discovery of genetic regulatory network models Pac. Symp. Biocomput. 2002 437 449
-
(2002)
Pac. Symp. Biocomput.
, pp. 437-449
-
-
Hartemink, A.J.1
Gifford, D.K.2
Jaakkola, T.S.3
Young, R.A.4
-
15
-
-
0031616241
-
Reveal, a general reverse engineering algorithm for inference of genetic network architectures
-
S. Liang, S. Fuhrman, and R. Somogyi Reveal, a general reverse engineering algorithm for inference of genetic network architectures Pac. Symp. Biocomput. 1998 18 29
-
(1998)
Pac. Symp. Biocomput.
, pp. 18-29
-
-
Liang, S.1
Fuhrman, S.2
Somogyi, R.3
-
17
-
-
0037009894
-
A smooth response surface algorithm for constructing a gene regulatory network
-
H. Xu, P. Wu, C.F. Wu, C. Tidwell, and Y. Wang A smooth response surface algorithm for constructing a gene regulatory network Physiol. Genom. 11 2002 11 20
-
(2002)
Physiol. Genom.
, vol.11
, pp. 11-20
-
-
Xu, H.1
Wu, P.2
Wu, C.F.3
Tidwell, C.4
Wang, Y.5
-
18
-
-
0348136789
-
Reverse engineering of genetic networks with Bayesian networks
-
D. Husmeier Reverse engineering of genetic networks with Bayesian networks Biochem. Soc. Trans. 31 2003 1516 1518
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 1516-1518
-
-
Husmeier, D.1
-
19
-
-
0000042837
-
Evaluating functional network inference using simulations of complex biological systems
-
V.A. Smith, E.D. Jarvis, and A.J. Hartemink Evaluating functional network inference using simulations of complex biological systems Bioinformatics 18 Suppl. 1 2002 S216 S224
-
(2002)
Bioinformatics
, vol.18
, Issue.SUPPL. 1
-
-
Smith, V.A.1
Jarvis, E.D.2
Hartemink, A.J.3
-
20
-
-
0041627865
-
Influence of network topology and data collection on network inference
-
V.A. Smith, E.D. Jarvis, and A.J. Hartemink Influence of network topology and data collection on network inference Pac. Symp. Biocomput. 2003 164 175
-
(2003)
Pac. Symp. Biocomput.
, pp. 164-175
-
-
Smith, V.A.1
Jarvis, E.D.2
Hartemink, A.J.3
-
21
-
-
12344259602
-
Advances to Bayesian network inference for generating causal networks from observational biological data
-
J. Yu, V.A. Smith, P.P. Wang, A.J. Hartemink, and E.D. Jarvis Advances to Bayesian network inference for generating causal networks from observational biological data Bioinformatics 20 2004 3594 3603
-
(2004)
Bioinformatics
, vol.20
, pp. 3594-3603
-
-
Yu, J.1
Smith, V.A.2
Wang, P.P.3
Hartemink, A.J.4
Jarvis, E.D.5
-
22
-
-
0842288337
-
Inferring cellular networks using probabilistic graphical models
-
N. Friedman Inferring cellular networks using probabilistic graphical models Science 303 2004 799 805
-
(2004)
Science
, vol.303
, pp. 799-805
-
-
Friedman, N.1
-
23
-
-
0037059461
-
A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules
-
A.H. Tong A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules Science 295 2002 321 324
-
(2002)
Science
, vol.295
, pp. 321-324
-
-
Tong, A.H.1
-
24
-
-
1942469444
-
Network motifs in integrated cellular networks of transcription- regulation and protein-protein interaction
-
E. Yeger-Lotem, S. Sattath, N. Kashtan, S. Itzkovitz, R. Milo, R.Y. Pinter, U. Alon, and H. Margalit Network motifs in integrated cellular networks of transcription-regulation and protein-protein interaction Proc. Natl. Acad. Sci. USA 101 2004 5934 5939
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 5934-5939
-
-
Yeger-Lotem, E.1
Sattath, S.2
Kashtan, N.3
Itzkovitz, S.4
Milo, R.5
Pinter, R.Y.6
Alon, U.7
Margalit, H.8
-
25
-
-
11144319853
-
Use of logic relationships to decipher protein network organization
-
P.M. Bowers, S.J. Cokus, D. Eisenberg, and T.O. Yeates Use of logic relationships to decipher protein network organization Science 306 2004 2246 2249
-
(2004)
Science
, vol.306
, pp. 2246-2249
-
-
Bowers, P.M.1
Cokus, S.J.2
Eisenberg, D.3
Yeates, T.O.4
-
26
-
-
0041843750
-
An integrated model of epidermal growth factor receptor trafficking and signal transduction
-
H. Resat, J.A. Ewald, D.A. Dixon, and H.S. Wiley An integrated model of epidermal growth factor receptor trafficking and signal transduction Biophys. J. 85 2003 730 743
-
(2003)
Biophys. J.
, vol.85
, pp. 730-743
-
-
Resat, H.1
Ewald, J.A.2
Dixon, D.A.3
Wiley, H.S.4
-
27
-
-
0037302108
-
Regulation of the mammalian cell cycle: A model of the G1-to-S transition
-
Z. Qu, J.N. Weiss, and W.R. MacLellan Regulation of the mammalian cell cycle: a model of the G1-to-S transition Am. J. Physiol. Cell Physiol. 284 2003 C349 C364
-
(2003)
Am. J. Physiol. Cell Physiol.
, vol.284
-
-
Qu, Z.1
Weiss, J.N.2
MacLellan, W.R.3
-
28
-
-
4444349425
-
A model for restriction point control of the mammalian cell cycle
-
B. Novak, and J.J. Tyson A model for restriction point control of the mammalian cell cycle J. Theor. Biol. 230 2004 563 579
-
(2004)
J. Theor. Biol.
, vol.230
, pp. 563-579
-
-
Novak, B.1
Tyson, J.J.2
-
29
-
-
2442526725
-
Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA
-
M. Maeda, S. Lu, G. Shaulsky, Y. Miyazaki, H. Kuwayama, Y. Tanaka, A. Kuspa, and W.F. Loomis Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA Science 304 2004 875 878
-
(2004)
Science
, vol.304
, pp. 875-878
-
-
Maeda, M.1
Lu, S.2
Shaulsky, G.3
Miyazaki, Y.4
Kuwayama, H.5
Tanaka, Y.6
Kuspa, A.7
Loomis, W.F.8
-
30
-
-
0037931402
-
Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: Distribution of homo- and heterodimers depends on relative HER2 levels
-
B.S. Hendriks, L.K. Opresko, H.S. Wiley, and D. Lauffenburger Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: distribution of homo- and heterodimers depends on relative HER2 levels J. Biol. Chem. 278 2003 23343 23351
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 23343-23351
-
-
Hendriks, B.S.1
Opresko, L.K.2
Wiley, H.S.3
Lauffenburger, D.4
-
31
-
-
0034693459
-
Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions
-
J.M. Haugh, A. Wells, and D.A. Lauffenburger Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: mechanistic insights and predictions for molecular interventions Biotechnol. Bioeng. 70 2000 225 238
-
(2000)
Biotechnol. Bioeng.
, vol.70
, pp. 225-238
-
-
Haugh, J.M.1
Wells, A.2
Lauffenburger, D.A.3
-
32
-
-
0036034789
-
Modeling the early signaling events mediated by FcepsilonRI
-
B. Goldstein, J.R. Faeder, W.S. Hlavacek, M.L. Blinov, A. Redondo, and C. Wofsy Modeling the early signaling events mediated by FcepsilonRI Mol. Immunol. 38 2002 1213 1219
-
(2002)
Mol. Immunol.
, vol.38
, pp. 1213-1219
-
-
Goldstein, B.1
Faeder, J.R.2
Hlavacek, W.S.3
Blinov, M.L.4
Redondo, A.5
Wofsy, C.6
-
33
-
-
0037044575
-
The IkappaB-NFkappaB signaling module: Temporal control and selective gene activation
-
A. Hoffmann, A. Levchenko, M.L. Scott, and D. Baltimore The IkappaB-NFkappaB signaling module: temporal control and selective gene activation Science 298 2002 1241 1245
-
(2002)
Science
, vol.298
, pp. 1241-1245
-
-
Hoffmann, A.1
Levchenko, A.2
Scott, M.L.3
Baltimore, D.4
-
34
-
-
3042668006
-
In silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics
-
M.H. Sung, and R. Simon in silico simulation of inhibitor drug effects on nuclear factor-kappaB pathway dynamics Mol. Pharmacol. 66 2004 70 75
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 70-75
-
-
Sung, M.H.1
Simon, R.2
-
35
-
-
2942576105
-
Data-driven computer simulation of human cancer cell
-
R. Christopher Data-driven computer simulation of human cancer cell Ann. N. Y. Acad. Sci. 1020 2004 132 153
-
(2004)
Ann. N. Y. Acad. Sci.
, vol.1020
, pp. 132-153
-
-
Christopher, R.1
-
36
-
-
0037107986
-
Small- and large-scale biosimulation applied to drug discovery and development
-
C.J. Musante, A.K. Lewis, and K. Hall Small- and large-scale biosimulation applied to drug discovery and development Drug Discov. Today 7 2002 S192 S196
-
(2002)
Drug Discov. Today
, vol.7
-
-
Musante, C.J.1
Lewis, A.K.2
Hall, K.3
-
37
-
-
0242574982
-
Parameter estimation in biochemical pathways: A comparison of global optimization methods
-
C.G. Moles, P. Mendes, and J.R. Banga Parameter estimation in biochemical pathways: a comparison of global optimization methods Genome Res. 13 2003 2467 2474
-
(2003)
Genome Res.
, vol.13
, pp. 2467-2474
-
-
Moles, C.G.1
Mendes, P.2
Banga, J.R.3
-
38
-
-
42749109054
-
Statistical mechanical approaches to models with many poorly known parameters
-
K.S. Brown, and J.P. Sethna Statistical mechanical approaches to models with many poorly known parameters Phys. Rev. E 68 2003 021904
-
(2003)
Phys. Rev. e
, vol.68
, pp. 021904
-
-
Brown, K.S.1
Sethna, J.P.2
-
39
-
-
10744226821
-
Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays
-
S. Nishizuka Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays Proc. Natl. Acad. Sci. USA 100 2003 14229 14234
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 14229-14234
-
-
Nishizuka, S.1
-
40
-
-
0037370373
-
Proteomics: The first decade and beyond
-
S.D. Patterson, and R.H. Aebersold Proteomics: the first decade and beyond Nat. Genet. 33 Suppl. 2003 311 323
-
(2003)
Nat. Genet.
, vol.33
, Issue.SUPPL.
, pp. 311-323
-
-
Patterson, S.D.1
Aebersold, R.H.2
-
41
-
-
4444371652
-
-
Blagoev, B., Ong, S.-E., Kratchmarova, I. and Mann, M. (2004) Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics. 22, 1139-1145
-
(2004)
Temporal Analysis of Phosphotyrosine-dependent Signaling Networks by Quantitative Proteomics
, vol.22
, pp. 1139-1145
-
-
Blagoev, B.1
Ong, S.-E.2
Kratchmarova, I.3
Mann, M.4
|