메뉴 건너뛰기




Volumn 7, Issue 20, 2002, Pages

Small- and large-scale biosimulation applied to drug discovery and development

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BIOLOGICAL MARKER; INSULIN; INTERLEUKIN 5; LEUKOTRIENE RECEPTOR BLOCKING AGENT; PROTEINASE INHIBITOR;

EID: 0037107986     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(02)02442-X     Document Type: Review
Times cited : (26)

References (33)
  • 2
    • 0010562538 scopus 로고    scopus 로고
    • Lehman Brothers and McKinsey & Company Report
    • The Fruits of Genomics (2001) Lehman Brothers and McKinsey & Company Report 30, 34
    • (2001) The Fruits of Genomics , vol.30 , pp. 34
  • 3
    • 0010631801 scopus 로고    scopus 로고
    • In silico biology prediction: Fortune telling gets sophisticated
    • Fikes, B.J. (2000) In silico biology prediction: fortune telling gets sophisticated. Biopeople Winter, 17-23
    • (2000) Biopeople , vol.WINTER , pp. 17-23
    • Fikes, B.J.1
  • 4
    • 0010629999 scopus 로고    scopus 로고
    • Biosystems modelling for in silico target validation: Challenges to implementation
    • Ho R.L. Biosystems modelling for in silico target validation: challenges to implementation. Emerg. Ther. Targets. 4:2000;699-714.
    • (2000) Emerg. Ther. Targets , vol.4 , pp. 699-714
    • Ho, R.L.1
  • 5
    • 0010596118 scopus 로고    scopus 로고
    • Biosimulation: Dynamic modeling of biological systems
    • in press
    • Hall, K. et al. (2002) Biosimulation: dynamic modeling of biological systems. Annu. Rep. Med. Chem. (in press)
    • (2002) Annu. Rep. Med. Chem.
    • Hall, K.1
  • 6
    • 0032783433 scopus 로고    scopus 로고
    • Biological simulations in drug discovery
    • Noble D., et al. Biological simulations in drug discovery. Drug Discov. Today. 4:1999;10-16.
    • (1999) Drug Discov. Today , vol.4 , pp. 10-16
    • Noble, D.1
  • 7
    • 0002814313 scopus 로고    scopus 로고
    • A return to rational drug discovery: Computer-based models of cells, organs and systems in drug target identification
    • Noble D., Colatsky T.J. A return to rational drug discovery: computer-based models of cells, organs and systems in drug target identification. Emerging Therapeutic Targets. 4:2000;39-49.
    • (2000) Emerging Therapeutic Targets , vol.4 , pp. 39-49
    • Noble, D.1    Colatsky, T.J.2
  • 8
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • DeFronzo R.A., et al. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237:1979;E214-E223.
    • (1979) Am. J. Physiol. , vol.237
    • DeFronzo, R.A.1
  • 9
    • 0029610745 scopus 로고
    • How to explore insulin sensitivity in man?
    • Scheen A.J., et al. How to explore insulin sensitivity in man? Ann. Endocrinol. (Paris). 56:1995;523-530.
    • (1995) Ann. Endocrinol. (Paris) , vol.56 , pp. 523-530
    • Scheen, A.J.1
  • 10
    • 0018487598 scopus 로고
    • Quantitative estimation of insulin sensitivity
    • Bergman R.N., et al. Quantitative estimation of insulin sensitivity. Am. J. Physiol. 236:1979;E667-E677.
    • (1979) Am. J. Physiol. , vol.236
    • Bergman, R.N.1
  • 11
    • 0024834748 scopus 로고
    • Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach
    • Bergman R.N. Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach. Diabetes. 38:1989;1512-1527.
    • (1989) Diabetes , vol.38 , pp. 1512-1527
    • Bergman, R.N.1
  • 12
    • 0028606395 scopus 로고
    • Minimal model for determination of insulin sensitivity: Repeatability in control and obese subjects
    • Krempf M., et al. Minimal model for determination of insulin sensitivity: repeatability in control and obese subjects. Diabetes Res. Clin. Pract. 26:1994;145-148.
    • (1994) Diabetes Res. Clin. Pract. , vol.26 , pp. 145-148
    • Krempf, M.1
  • 13
    • 0023120630 scopus 로고
    • Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp
    • Bergman R.N., et al. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J. Clin. Invest. 79:1987;790-800.
    • (1987) J. Clin. Invest. , vol.79 , pp. 790-800
    • Bergman, R.N.1
  • 14
    • 0022626715 scopus 로고
    • The insulin sensitivity index in nondiabetic man. Correlation between clamp-derived and IVGTT-derived values
    • Beard J.C., et al. The insulin sensitivity index in nondiabetic man. Correlation between clamp-derived and IVGTT-derived values. Diabetes. 35:1986;362-369.
    • (1986) Diabetes , vol.35 , pp. 362-369
    • Beard, J.C.1
  • 15
    • 0028221966 scopus 로고
    • Assessment of insulin sensitivity in man: A comparison of minimal model- and euglycaemic clamp-derived measures in health and heart failure
    • Swan J.W., et al. Assessment of insulin sensitivity in man: a comparison of minimal model- and euglycaemic clamp-derived measures in health and heart failure. Clin. Sci. (Lond. 86:1994;317-322.
    • (1994) Clin. Sci. (Lond. , vol.86 , pp. 317-322
    • Swan, J.W.1
  • 16
    • 0033038329 scopus 로고    scopus 로고
    • Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: The Insulin Resistance Atherosclerosis Study
    • Haffner S.M., et al. Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 22:1999;562-568.
    • (1999) Diabetes Care , vol.22 , pp. 562-568
    • Haffner, S.M.1
  • 17
    • 0036110469 scopus 로고    scopus 로고
    • The oral glucose minimal model: Estimation of insulin sensitivity from a meal test
    • Dalla Man C., et al. The oral glucose minimal model: estimation of insulin sensitivity from a meal test. IEEE Trans. Biomed. Eng. 49:2002;419-429.
    • (2002) IEEE Trans. Biomed. Eng. , vol.49 , pp. 419-429
    • Dalla Man, C.1
  • 18
    • 0034527683 scopus 로고    scopus 로고
    • Insulin sensitivity from meal tolerance tests in normal subjects: A minimal model index
    • Caumo A., et al. Insulin sensitivity from meal tolerance tests in normal subjects: a minimal model index. J. Clin. Endocrinol. Metab. 85:2000;4396-4402.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 4396-4402
    • Caumo, A.1
  • 19
    • 0030659571 scopus 로고    scopus 로고
    • The hot IVGTT two-compartment minimal model: Indexes of glucose effectiveness and insulin sensitivity
    • Vicini P., et al. The hot IVGTT two-compartment minimal model: indexes of glucose effectiveness and insulin sensitivity. Am. J. Physiol. 273:1997;E1024-E1032.
    • (1997) Am. J. Physiol. , vol.273
    • Vicini, P.1
  • 21
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson A.S., et al. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science. 271:1996;1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1
  • 22
    • 0036371443 scopus 로고    scopus 로고
    • Modelling viral and immune system dynamics
    • Perelson A.S. Modelling viral and immune system dynamics. Nat. Rev. Immunol. 2:2002;28-36.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 28-36
    • Perelson, A.S.1
  • 23
    • 0036499997 scopus 로고    scopus 로고
    • Modeling the heart - From genes to cells to the whole organ
    • Noble D. Modeling the heart - from genes to cells to the whole organ. Science. 295:2002;1678-1682.
    • (2002) Science , vol.295 , pp. 1678-1682
    • Noble, D.1
  • 24
    • 8344223841 scopus 로고    scopus 로고
    • Computational models of the failing myocyte: Relating altered gene expression to cellular function
    • Winslow R.L., et al. Computational models of the failing myocyte: relating altered gene expression to cellular function. Philos. Trans. R. Soc. Lond. A. 359:2001;1187-1200.
    • (2001) Philos. Trans. R. Soc. Lond. A , vol.359 , pp. 1187-1200
    • Winslow, R.L.1
  • 25
    • 0346041902 scopus 로고    scopus 로고
    • Computational modeling of biological systems: Tools and visions
    • Kohl P., et al. Computational modeling of biological systems: tools and visions. Philos. Trans. R. Soc. Lond. A. 358:2000;579-610.
    • (2000) Philos. Trans. R. Soc. Lond. A , vol.358 , pp. 579-610
    • Kohl, P.1
  • 26
    • 25944438641 scopus 로고    scopus 로고
    • Computer-based mathematical model of asthma
    • Stokes C.L., et al. Computer-based mathematical model of asthma. J. Allergy Clin. Immunol. 103:1999;A980.
    • (1999) J. Allergy Clin. Immunol. , vol.103
    • Stokes, C.L.1
  • 27
    • 4243541856 scopus 로고    scopus 로고
    • A computer model of chronic asthma with application to clinical studies: Example of treatment of exercise-induced asthma
    • Stokes C.L., et al. A computer model of chronic asthma with application to clinical studies: example of treatment of exercise-induced asthma. J. Allergy Clin. Immunol. 107:2001;A933.
    • (2001) J. Allergy Clin. Immunol. , vol.107
    • Stokes, C.L.1
  • 28
    • 0035044634 scopus 로고    scopus 로고
    • The roles of cells and mediators in a computer model of chronic asthma
    • Lewis A.K., et al. The roles of cells and mediators in a computer model of chronic asthma. Int. Arch. Allergy Immunol. 124:2001;282-286.
    • (2001) Int. Arch. Allergy Immunol. , vol.124 , pp. 282-286
    • Lewis, A.K.1
  • 29
    • 0029371991 scopus 로고
    • Involvement of IL-5 in a murine model of allergic pulmonary inflammation: Prophylactic and therapeutic effect of an anti-IL-5 antibody
    • Kung T.T., et al. Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody. Am. J. Respir. Cell. Mol. Biol. 13:1995;360-365.
    • (1995) Am. J. Respir. Cell. Mol. Biol. , vol.13 , pp. 360-365
    • Kung, T.T.1
  • 30
    • 0029146701 scopus 로고
    • Effects of an antibody to interleukin-5 in a monkey model of asthma
    • Mauser P.J., et al. Effects of an antibody to interleukin-5 in a monkey model of asthma. Am. J. Respir. Crit. Care Med. 152:1995;467-472.
    • (1995) Am. J. Respir. Crit. Care Med. , vol.152 , pp. 467-472
    • Mauser, P.J.1
  • 31
    • 0027729739 scopus 로고
    • Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma
    • Mauser P.J., et al. Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma. Am. Rev. Respir. Dis. 148:1993;1623-1627.
    • (1993) Am. Rev. Respir. Dis. , vol.148 , pp. 1623-1627
    • Mauser, P.J.1
  • 32
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie M.J., et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 356:2000;2144-2148.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1
  • 33
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson A.S., et al. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature. 387:1997;188-191.
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.