Mathematical modeling of epidermal growth factor receptor signaling through the phospholipase C pathway: Mechanistic insights and predictions for molecular interventions

Biotechnology and Bioengineering

Volumn 70, Issue 2, 2000, Pages 225-238

  Haugh, Jason M ^a   Wells, Alan ^c   Lauffenburger, Douglas A ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Complexity; Intracellular processes; Mathematical model; Signaling networks

Indexed keywords

ENZYMES; LIPIDS; MATHEMATICAL MODELS; MOLECULAR STRUCTURE;

EPIDERMAL GROWTH FACTOR RECEPTORS; FIBROBLASTS; MOLECULAR INTERVENTION; PHOSPHOLIPASE;

CYTOLOGY;

EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHOLIPASE C;

ARTICLE; AUTOPHOSPHORYLATION; BIOENGINEERING; BIOPROCESS; CELL LINE; CELL MEMBRANE; CELL MIGRATION; CELL TYPE; ENZYME ACTIVATION; FIBROBLAST CULTURE; MAMMAL CELL; MATHEMATICAL MODEL; PROTEIN ANALYSIS; QUANTITATIVE ASSAY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 0034693459     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0290(20001020)70:2<225::AID-BIT12>3.0.CO;2-S     Document Type: Article

References (39)

1. Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells
2. Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts
3. Emergent properties of networks of biological signaling pathways
4. Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation
5. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils
6. Intracellular signaling as a parallel distributed process
7. A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility
8. Epidermal growth factor receptor-mediated cell motility: Phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement
9. Interaction between the epidermal growth factor receptor and phosphoinositide kinases
10. Phosphatidylinositol transfer proteins: A requirement in signal transduction and vesicle traffic
11. Mathematical model for the effects of adhesion and mechanics on cell migration speed
12. Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs
13. Regulation of phospholipase C-γ1 by profilin and tyrosine phosphorylation
14. Early changes in inositol lipids and their metabolites induced by platelet-derived growth factor in quiescent Swiss mouse 3T3 cells
15. Physical modulation of intracellular signaling processes by locational regulation
16. Analysis of receptor internalization as a mechanism for modulating signal transduction
17. Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-γ1 signaling pathway
18. Growth factor-dependent phosphoinositide signalling
19. Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells
20. Regulation of human type II phosphatidylinositol kinase activity by epidermal growth factor-dependent phosphorylation and receptor association
21. Requirement for phosphatidylinositol transfer protein in epidermal growth factor receptor signaling
22. Phosphatidylinositol transfer proteins: The long and winding road to physiological function
23. Quantification of information transfer via cellular signal transduction pathways
24. Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase (γ) in the formylmethionylleucyl-phenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils
25. Cell migration: A physically integrated molecular process
26. Regulation of the epidermal growth factor receptor by phosphorylation
27. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
28. Protein modules and signaling networks
29. Presence of SH2 domains of phospholipase C-γ1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor
30. Interactions between mitogenic stimuli, or, a thousand and one connections
31. U73122: A potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions
32. An essential role for phosphatidylinositol transfer protein in phospholipase C-mediated inositol lipid signaling
33. The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate
34. Receptor protein-tyrosine kinases and their signal transduction pathways
35. The PTB domain: A new protein module implicated in signal transduction
36. U73122 affects the equilibria between the phosphoinositides as well as phospholipase C activity in unstimulated and thrombin-stimulated human and rabbit platelets
37. EGF receptor
38. Epidermal growth factor receptor-mediated motility in fibroblasts
39. EGF receptor regulation of cell-substratum interactions: EGF induces disassembly of focal adhesions independently of the motility- associated PLCγ signaling pathway