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4
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0003549270
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Novartis announces favorable decision in patent infringement action brought against its Certican drug by AHP
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362823; April 05
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(2000)
Novartis AG Press Release
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8
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0031713649
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The in vivo effect of rapamycin derivative SDZ RAD on lymphocyte proliferation
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375156
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10
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0031786057
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In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: Comparison with rapamycin
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375164; note
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Pharm Res
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Crowe, A.1
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11
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SDZ RAD, a new rapamycin derivative: Pharmacological properties in vitro and in vivo
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375172; note
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Schuler, W.1
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Schreier, M.H.9
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12
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SDZ RAD, a new rapamycin derivative. Synergism with cyclosporine
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375180; note
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Schuurman, H.J.1
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Sedrani, R.6
Tanner, M.7
Zenke, G.8
Schuler, W.9
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14
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-
0034636055
-
The immunosuppressive macrolide RAD inhibits growth of human Epstein- Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders
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375578; note
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(2000)
Proc Natl Acad Sci USA
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Majewski, M.1
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19
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17344391595
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Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: Induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low doses of both microemulsion cyclosporine and 40-O-(2-hydroxyethyl)-rapamycin
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375583
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(2000)
Transplantation
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Hausen, B.1
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Schuler, W.9
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Morris, R.E.11
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20
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0033966044
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The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates
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375584
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(2000)
Br J Pharmacol
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Serkova, N.1
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Benet, L.Z.7
Christians, U.8
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21
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0343775809
-
Isolation from pig liver microsomes, identification by tandem mass spectrometry and in vitro immunosuppressive activity of an SDZ-RAD 17,18,19,20,21,22-tris-epoxide
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375585
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(2000)
J Mass Spectrom
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Lhoest, G.J.1
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Latinne, D.8
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23
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0034104205
-
Immunosuppressive therapies after heart transplantation: Best, better, and beyond
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375600
-
(2000)
Curr Opin Cardiol
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Taylor, D.O.1
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24
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375603; note
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(2000)
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Hausen, B.1
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Benet, L.Z.9
Schuler, W.10
Morris, R.E.11
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29
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0033561428
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Coadministration of Neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: Potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment
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375621
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(1999)
Transplantation
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Hausen, B.1
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Benet, L.Z.5
Christians, U.6
Morris, R.E.7
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30
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0032736334
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Entry-into-human study with the novel immunosuppressant SDZ RAD in stable renal transplant recipients
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375624
-
(1999)
Br J Clin Pharmacol
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Neumayer, H.H.1
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32
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LC/ESI-MS allows simultaneous and specific quantification of SDZ RAD and cyclosporine, including groups of their metabolites in human blood
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375630
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(1999)
Ther Drug Monit
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Kirchner, G.I.1
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Sewing, K.F.7
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38
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Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin
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375698
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(1998)
J Chromatogr B Biomed Sci Appl
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Segarra, I.1
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Benet, L.Z.7
Christians, U.8
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41
-
-
0003548221
-
UK Court of Appeal decides in favour of Novartis in patent action against AHP: Investigational transplant drug Certican does not infringe AHP patent: Decision important for patients and for research-based pharmaceutical industry in general
-
376559; July 27
-
(2000)
Novartis AG Press Release
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-
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44
-
-
0003541322
-
Novartis announces positive trial results for two novel transplantation drugs
-
380501; August 29
-
(2000)
Novartis AG Press Release
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45
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-
0003710799
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Novartis R & D investor seminar, Basel
-
392881; 2000 December 06
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47
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-
0003624710
-
Annual Report 2000: Review of operations - Pharmaceuticals - pipeline
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401979; 2000 December 31
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50
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Long-term pharmacokinetics of the metabolites of SDZ RAD and cyclosporine in transplant recipients
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411023; Abstr 2853
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(2001)
Gastroenterology
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Kirchner, G.I.1
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56
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RAD (everolimus) pharmacokinetics in de novo renal transplant patients: Dose-proportional, stable exposure over 6 months
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413251; Abs 650
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(2001)
Am J Transplant
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Kaplan, B.1
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57
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RAD (everolimus) pharmacokinetics are unaltered with full-dose versus reduced-dose cyclosporine
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413252; Abstr 651
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(2001)
Am J Transplant
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Curtis, J.1
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58
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0003541325
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A one-year, multicenter, randomized, placebo-controlled, double-blind, parallel group, dose-finding study to evaluate the safety, tolerability and pharmacokinetics of RAD in de novo liver transplant recipients
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413254; Abs 696
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(2001)
Am J Transplant
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Longitudinal assessment of everolimus in de novo renal transplant recipients over the first post-transplant year: Pharmacokinetics, exposure-response relationships, and influence on cyclosporine
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416368; note
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(2001)
Clin Pharmacol Ther
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Kovank, J.M.1
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Gerbeau, C.7
Cambon, N.8
Boger, R.9
Rordorf, C.10
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67
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Sirolimus (rapamycin) halts and reverses progression of allograft vascular disease in non-human primates
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417313
-
(2000)
Transplantation
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Ikonen, T.S.1
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Hausen, B.5
Christians, U.6
Berry, G.J.7
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69
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0000373661
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International, double-blind, parallel group study of the safety and efficacy of Certican™ (RAD) versus mycophenolate mofetil (MMF) in combination with Neoral® and steroids
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417317; Abs 1337; note
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(2001)
Am J Transplant
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Vitko, S.1
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72
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The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T- and B-cells in cynomolgus monkeys when given alone, with Cyclosporine Neoral or with RAD
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417322
-
(2000)
Transpl Immunol
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Quesniaux, V.F.1
Menninger, K.2
Kunkler, A.3
Vedrine, C.4
Bernhard, M.5
Hedinger, R.6
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Schuurman, H.J.8
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417342
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Br J Clin Pharmacol
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Kirchner, G.I.1
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Wagner, S.7
Blick, S.8
Manns, M.P.9
Sewing, K.F.10
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86
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0003725585
-
Opus Diagnostics Inc. entered into an agreement with Novartis Pharma AG for Opus to develop and market an assay to monitor Certican™ (everolimus) blood levels
-
417363; December 06
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(2000)
Opus Diagnostics Inc Press Release
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91
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Sirolimus-induced thrombocytopenia and leukopenia in renal transplant recipients: Risk factors, incidence, progression, and management
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417386
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Transplantation
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Hong, J.C.1
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Clin Transplant
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Kahan, B.D.1
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Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: A randomised multicentre study
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Lancet
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Kahan, B.D.1
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96
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Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain
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417395
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(2001)
Br J Pharmacol
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Serkova, N.1
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99
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Pharma cokinetics and tolerability of RAD in pediatric renal transplant patients
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418777; Abs P0877W
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XVIII International Congress of the Transplantation Society, Rome 2000
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-
Vandamme-Lombaerts, R.1
Mahan, J.2
Webb, N.3
Lemire, J.4
Ettenger, R.5
Hoyer, P.F.6
Kovarik, J.7
McMahon, L.8
Wehr, S.9
Cambon, N.10
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