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Volumn 21, Issue 1, 1999, Pages 116-122

LC/ESI-MS allows simultaneous and specific quantification of SDZ RAD and cyclosporine, including groups of their metabolites in human blood

Author keywords

Analytics; Cyclosporine; ESI MS; Immunosuppressants; Macrolides; Metabolites; SDZ RAD

Indexed keywords

CYCLOSPORIN; EVEROLIMUS; IMMUNOSUPPRESSIVE AGENT; MACROLIDE; RAPAMYCIN; TACROLIMUS; UNCLASSIFIED DRUG;

EID: 0033060549     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199902000-00018     Document Type: Article
Times cited : (36)

References (34)
  • 1
    • 0022903308 scopus 로고
    • Cyclosporine nephrotoxicity
    • Myers BD. Cyclosporine nephrotoxicity. Kidney Int 1986;30:964-74.
    • (1986) Kidney Int , vol.30 , pp. 964-974
    • Myers, B.D.1
  • 2
    • 0025132130 scopus 로고
    • The pathophysiology of Sandimmune (cyclosporine) in man and animals
    • Mason J. The pathophysiology of Sandimmune (cyclosporine) in man and animals. Pediatr Nephrol 1990;4:554-74.
    • (1990) Pediatr Nephrol , vol.4 , pp. 554-574
    • Mason, J.1
  • 3
    • 0025879435 scopus 로고
    • The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver
    • Abu-Elmagd K, Fung JJ, Alessiani M, et al. The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver. Transplantation 1991;52:71-7.
    • (1991) Transplantation , vol.52 , pp. 71-77
    • Abu-Elmagd, K.1    Fung, J.J.2    Alessiani, M.3
  • 4
    • 0025347180 scopus 로고
    • The effects of FK506 on renal function after liver transplantation
    • McCauly J, van Thiel D, Jain AB, et al. The effects of FK506 on renal function after liver transplantation. Transplant Proc 1990; 22:17-20.
    • (1990) Transplant Proc , vol.22 , pp. 17-20
    • McCauly, J.1    Van Thiel, D.2    Jain, A.B.3
  • 5
    • 0021743009 scopus 로고
    • Association between cyclosporine neurotoxicity and hypomagnesemia
    • Thompson CB, June CH, Sullivan EM, et al. Association between cyclosporine neurotoxicity and hypomagnesemia. Lancet 1984;2: 1116-20.
    • (1984) Lancet , vol.2 , pp. 1116-1120
    • Thompson, C.B.1    June, C.H.2    Sullivan, E.M.3
  • 6
    • 0028676652 scopus 로고
    • Neurological complicalions in the European multicentre study of FK506 and cyclosporin in primary liver transplantation
    • Neuhaus P, McMaster P, Calne R, et al. Neurological complicalions in the European multicentre study of FK506 and cyclosporin in primary liver transplantation. Transpl Int 1994;7:27-31.
    • (1994) Transpl Int , vol.7 , pp. 27-31
    • Neuhaus, P.1    McMaster, P.2    Calne, R.3
  • 7
    • 0039897482 scopus 로고
    • Cyclosporine A and hypertension
    • Schachter M. Cyclosporine A and hypertension. J Hypertens 1988; 6:511-6.
    • (1988) J Hypertens , vol.6 , pp. 511-516
    • Schachter, M.1
  • 8
    • 0028676511 scopus 로고
    • Renal complications and development of hypertension in the European study of FK506 and cyclosporin in primary liver transplantation recipients
    • Devlin J, Williams R, Neuhaus P, et al. Renal complications and development of hypertension in the European study of FK506 and cyclosporin in primary liver transplantation recipients. Transpl Int 1994;7:22-4.
    • (1994) Transpl Int , vol.7 , pp. 22-24
    • Devlin, J.1    Williams, R.2    Neuhaus, P.3
  • 9
    • 0027529357 scopus 로고
    • Adverse effects of FK506 overdosage after liver transplantation
    • Alessiani M, Cillo U, Fung J, et al. Adverse effects of FK506 overdosage after liver transplantation. Transplant Proc 1993;25: 628-34.
    • (1993) Transplant Proc , vol.25 , pp. 628-634
    • Alessiani, M.1    Cillo, U.2    Fung, J.3
  • 10
    • 0024976004 scopus 로고
    • Cyclosporine
    • Kahan BD. Cyclosporine. N Engl J Med 1989;321:1725-38.
    • (1989) N Engl J Med , vol.321 , pp. 1725-1738
    • Kahan, B.D.1
  • 11
    • 0026326401 scopus 로고
    • Cyclosporine: Lessons learned, future strategies
    • Lorber MI. Cyclosporine: Lessons learned, future strategies. Clin Transplant 1991;5:505-16.
    • (1991) Clin Transplant , vol.5 , pp. 505-516
    • Lorber, M.I.1
  • 12
    • 0026662551 scopus 로고
    • Cytochrome P450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat
    • Sattler M, Guengerich FP, Yun CH, et al. Cytochrome P450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metab Dispos 1992;20:753-61
    • (1992) Drug Metab Dispos , vol.20 , pp. 753-761
    • Sattler, M.1    Guengerich, F.P.2    Yun, C.H.3
  • 13
    • 0026545650 scopus 로고
    • Monoclonal fluorescence polarization immunoassay evaluated for monitoring cyclosporine in whole blood after kidney, heart, and liver transplantation
    • Winkler M, Schumann G, Petersen D, et al. Monoclonal fluorescence polarization immunoassay evaluated for monitoring cyclosporine in whole blood after kidney, heart, and liver transplantation. Clin Chem 1992;38:123-6.
    • (1992) Clin Chem , vol.38 , pp. 123-126
    • Winkler, M.1    Schumann, G.2    Petersen, D.3
  • 14
    • 0025124513 scopus 로고
    • Three commercial polyclonal immunoassays for cyclosporine in whole blood compared. II. Cross-reactivity of the antisera with cyclosporine metabolites
    • Lensmeyer GL, Wiebe DA, Carlson DH, et al. Three commercial polyclonal immunoassays for cyclosporine in whole blood compared. II. Cross-reactivity of the antisera with cyclosporine metabolites. Clin Chem 1990;36:119-23.
    • (1990) Clin Chem , vol.36 , pp. 119-123
    • Lensmeyer, G.L.1    Wiebe, D.A.2    Carlson, D.H.3
  • 15
    • 0025221317 scopus 로고
    • Abbott TDx monoclonal antibody assay evaluated for measuring cyclosporine in whole blood
    • Yatscoff RW, Copeland KR, Faraci CJ. Abbott TDx monoclonal antibody assay evaluated for measuring cyclosporine in whole blood. Clin Chem 1990;36:1969-73.
    • (1990) Clin Chem , vol.36 , pp. 1969-1973
    • Yatscoff, R.W.1    Copeland, K.R.2    Faraci, C.J.3
  • 16
    • 0023662663 scopus 로고
    • Measurement of cyclosporin A and four metabolites in whole blood by high-performance liquid chromatography
    • Christians U, Zimmer KO, Wonigeit K, et al. Measurement of cyclosporin A and four metabolites in whole blood by high-performance liquid chromatography. J Chromatogr 1987;413: 121-9.
    • (1987) J Chromatogr , vol.413 , pp. 121-129
    • Christians, U.1    Zimmer, K.O.2    Wonigeit, K.3
  • 17
    • 0023853205 scopus 로고
    • Liquid-chromatographic measurement of cyclosporin A and its metabolites in blood, bile and urine
    • Christians U, Zimmer KO, Wonigeit K, et al. Liquid-chromatographic measurement of cyclosporin A and its metabolites in blood, bile and urine. Clin Chem 1988;34:34-9.
    • (1988) Clin Chem , vol.34 , pp. 34-39
    • Christians, U.1    Zimmer, K.O.2    Wonigeit, K.3
  • 18
    • 0028824489 scopus 로고
    • Lake louise consensus conference on cyclosporin monitoring in organ transplantation: Report of the consensus panel
    • Oellerich M, Armstrong VW, Kahan B, et al. Lake Louise consensus conference on cyclosporin monitoring in organ transplantation: Report of the consensus panel. Ther Drug Monit 1995;17: 642-54.
    • (1995) Ther Drug Monit , vol.17 , pp. 642-654
    • Oellerich, M.1    Armstrong, V.W.2    Kahan, B.3
  • 19
    • 0032232418 scopus 로고    scopus 로고
    • Structural elucidation by electrospray-mass spectrometry: An approach to the in vitro metabolism of the macrolide immunosuppressant SDZ RAD
    • Vidai C, Kirchner GI, Sewing K-F. Structural elucidation by electrospray-mass spectrometry: An approach to the in vitro metabolism of the macrolide immunosuppressant SDZ RAD. J Am Soc Mass Spectr 1998;9:1267-74.
    • (1998) J Am Soc Mass Spectr , vol.9 , pp. 1267-1274
    • Vidai, C.1    Kirchner, G.I.2    Sewing, K.-F.3
  • 20
    • 0025148248 scopus 로고
    • Consensus document: Hawk's Cay meeting of therapeutic drug monitoring of cyclosporine
    • Kahan BD, Shaw LM, Holt D, et al. Consensus document: Hawk's Cay meeting of therapeutic drug monitoring of cyclosporine. Clin Chem 1990;36:1510-6.
    • (1990) Clin Chem , vol.36 , pp. 1510-1516
    • Kahan, B.D.1    Shaw, L.M.2    Holt, D.3
  • 21
    • 0031430977 scopus 로고    scopus 로고
    • A specific method for the measurement of tacrolimus in human whole blood by liquid chromatography/tandem mass spectrometry
    • Zhang Q, Simpson J, Aboleneen HI. A specific method for the measurement of tacrolimus in human whole blood by liquid chromatography/tandem mass spectrometry. Ther Drug Monit 1997; 19:470-6.
    • (1997) Ther Drug Monit , vol.19 , pp. 470-476
    • Zhang, Q.1    Simpson, J.2    Aboleneen, H.I.3
  • 22
    • 0029738491 scopus 로고    scopus 로고
    • Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry
    • Streit F, Christians U, Schiebel HM, et al. Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry. Clin Chem 1996;42:1417-25.
    • (1996) Clin Chem , vol.42 , pp. 1417-1425
    • Streit, F.1    Christians, U.2    Schiebel, H.M.3
  • 23
    • 0026668330 scopus 로고
    • Therapeutic drug monitoring of cyclosporine, FK506, and rapamycin
    • Yatscoff R, Shaw L. Therapeutic drug monitoring of cyclosporine, FK506, and rapamycin. Ther Drug Monit 1992;14:267-8.
    • (1992) Ther Drug Monit , vol.14 , pp. 267-268
    • Yatscoff, R.1    Shaw, L.2
  • 24
    • 0023232859 scopus 로고
    • Critical issues in cyclosporine monitoring: Report of the task force on cyclosporine monitoring
    • Shaw LM, Bowers LD, Demers L, et al. Critical issues in cyclosporine monitoring: Report of the task force on cyclosporine monitoring. Clin Chem 1987;33:1269-88.
    • (1987) Clin Chem , vol.33 , pp. 1269-1288
    • Shaw, L.M.1    Bowers, L.D.2    Demers, L.3
  • 25
    • 0028567238 scopus 로고
    • Plasma vs whole blood for therapeutic drug monitoring of patients receiving FK506 for immunosuppression
    • Winkler M, Ringe B, Baumann J, et al. Plasma vs whole blood for therapeutic drug monitoring of patients receiving FK506 for immunosuppression. Clin Chem 1994;40:2247-53.
    • (1994) Clin Chem , vol.40 , pp. 2247-2253
    • Winkler, M.1    Ringe, B.2    Baumann, J.3
  • 27
    • 0026710725 scopus 로고
    • Measurement of rapamycin in whole blood using reverse-phase high-performance liquid chromatography
    • Yatscoff RW, Farad C, Bolingbroke P. Measurement of rapamycin in whole blood using reverse-phase high-performance liquid chromatography. Ther Drug Monit 1992;14:138-41.
    • (1992) Ther Drug Monit , vol.14 , pp. 138-141
    • Yatscoff, R.W.1    Farad, C.2    Bolingbroke, P.3
  • 28
    • 0026519765 scopus 로고
    • Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin
    • Christians U, Sattler M, Schiebel HM, et al. Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin. Drug Metab Dispos 1992;20:186-91.
    • (1992) Drug Metab Dispos , vol.20 , pp. 186-191
    • Christians, U.1    Sattler, M.2    Schiebel, H.M.3
  • 29
    • 0028219564 scopus 로고
    • Sample clean-up and high-performance liquid chromatographic techniques for measurement of whole blood rapamycin concentrations
    • Napoli KL, Kahan BD. Sample clean-up and high-performance liquid chromatographic techniques for measurement of whole blood rapamycin concentrations. J Chromatogr B;1994;654:111-120.
    • (1994) J Chromatogr B , vol.654 , pp. 111-120
    • Napoli, K.L.1    Kahan, B.D.2
  • 30
    • 0029156771 scopus 로고
    • Simplified high-performance liquid chromatography-mass spectrometry assay for measurement of tacrolimus and its metabolites and cross-validation with microparticle enzyme immunoassay
    • Gonschior A-K, Christians U, Winkler M, et al. Simplified high-performance liquid chromatography-mass spectrometry assay for measurement of tacrolimus and its metabolites and cross-validation with microparticle enzyme immunoassay. Ther Drug Monit 1995;17:504-10.
    • (1995) Ther Drug Monit , vol.17 , pp. 504-510
    • Gonschior, A.-K.1    Christians, U.2    Winkler, M.3
  • 31
    • 0019431663 scopus 로고
    • Fully automated high-performance liquid chromatography. A new chromatograph for pharmacokinetic drug monitoring by direct injection of body fluids
    • Roth W, Beschke K, Jauch R, et al. Fully automated high-performance liquid chromatography. A new chromatograph for pharmacokinetic drug monitoring by direct injection of body fluids. J Chromatogr 1981;222:13-22.
    • (1981) J Chromatogr , vol.222 , pp. 13-22
    • Roth, W.1    Beschke, K.2    Jauch, R.3
  • 32
    • 0023921505 scopus 로고
    • Cyclosporine metabolism in human liver:Identification of a cytochrome P450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs
    • Kronbach T, Fischer V, Meyer UA. Cyclosporine metabolism in human liver:identification of a cytochrome P450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin Pharmacol Ther 1988;43: 630-5.
    • (1988) Clin Pharmacol Ther , vol.43 , pp. 630-635
    • Kronbach, T.1    Fischer, V.2    Meyer, U.A.3
  • 33
    • 0024603850 scopus 로고
    • Metabolism of cyclosporin a. IV. Purification and identification of the rifampicin inducible human liver cytochrome P-450 (cyclosporin a oxidase) as a product of P450IIIA gene subfamily
    • Combalbert J, Fabre I, Fabre G, et al. Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily. Drug Metab Dispos 1989;17:197-207.
    • (1989) Drug Metab Dispos , vol.17 , pp. 197-207
    • Combalbert, J.1    Fabre, I.2    Fabre, G.3
  • 34
    • 0026511860 scopus 로고
    • Cyclosporine metabolism by P450IIIA in rat enterocytes: Another determinant of oral bioavailability?
    • Kolars JC, Stetson PL, Rush BD, et al. Cyclosporine metabolism by P450IIIA in rat enterocytes: Another determinant of oral bioavailability? Transplantation 1992;53:596-602.
    • (1992) Transplantation , vol.53 , pp. 596-602
    • Kolars, J.C.1    Stetson, P.L.2    Rush, B.D.3


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