Probing the cruzain S 2 recognition subsite: A kinetic and binding energy calculation study

Biochemistry

Volumn 44, Issue 8, 2005, Pages 2781-2789

  Polticelli, Fabio ^c   Zaini, Germano ^c   Bolli, Alessandro ^c   Antonini, Giovanni ^c   Gradoni, Luigi ^a   Ascenzi, Paolo ^b,c  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^c ROMA TRE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARASITE CHEMOTHERAPY; BINDING FREE-ENERGY; DEACYLATION; ENZYME CATALYSIS;

BINDING ENERGY; BIOCHEMISTRY; CATALYSIS; CHEMOTHERAPY; HYDROLYSIS; REACTION KINETICS;

ENZYMES;

CRUZIPAIN; CYSTEINE PROTEINASE; N ALPHA BENZYLOXYCARBONYL ARGINYL ALANINE (7 AMINO 4 METHYLCOUMARIN); N ALPHA BENZYLOXYCARBONYL PHENYLALANYL ALANINE (7 AMINO 4 METHYLCOUMARIN); N ALPHA BENZYLOXYCARBONYL TYROSYL ALANINE (7 AMINO 4 METHYLCOUMARIN); UNCLASSIFIED DRUG; ANTITRYPANOSOMAL AGENT; CRUZAIN, TRYPANOSOMA CRUZI; PROTOZOAL PROTEIN;

ARTICLE; BINDING AFFINITY; CALCULATION; CATALYSIS; CHEMICAL STRUCTURE; COMPLEX FORMATION; DEACYLATION; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME MECHANISM; EPIMASTIGOTE; HYDROLYSIS; KINETICS; MATHEMATICAL ANALYSIS; MOLECULAR RECOGNITION; NONHUMAN; PARAMETER; PRIORITY JOURNAL; PROTEIN FUNCTION; SOLVATION; TRYPANOSOMA CRUZI; ANIMAL; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; THERMODYNAMICS;

ANIMALS; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTOZOAN PROTEINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 14344258527     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048417v     Document Type: Article

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