Cysteine protease as a target for nitric oxide in parasitic organisms [4]

Trends in Parasitology

Volumn 17, Issue 12, 2001, Pages 575-

  Colasanti, Marco ^a   Salvati, Luca ^a   Venturini, Giorgio ^a   Ascenzi, Paolo ^a   Gradoni, Luigi ^b  

^a ROMA TRE UNIVERSITY   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARASITIC AGENT; CYSTEINE PROTEINASE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR;

BLOOD CULTURE; CATALYSIS; CHEMOTHERAPY; CYTOTOXICITY; DRUG TARGETING; ENTAMOEBA; ENZYME ACTIVITY; ENZYME INHIBITION; LEISHMANIA INFANTUM; LETTER; MACROPHAGE; MEDIATOR RELEASE; NONHUMAN; OXIDATIVE STRESS; OXYGEN TENSION; PARASITE SURVIVAL; PLASMODIUM FALCIPARUM; PROMASTIGOTE; PROTEIN MODIFICATION; PROTON TRANSPORT; SCHISTOSOMA; TOXOPLASMA; TRYPANOSOMA BRUCEI;

ENTAMOEBA; LEISHMANIA INFANTUM; PLASMODIUM FALCIPARUM; SCHISTOSOMA; TOXOPLASMA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0035698004     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4922(01)02191-2     Document Type: Letter

References (10)

1. Nitric oxide and parasitic disease
2. Nitric oxide inhibits falcipain, the Plasmodium falciparum trophozoite cysteine protease
3. Nitric oxide inhibits cruzipain, the major papain-like cysteine protease from Trypanosoma cruzi
4. Inhibition of cysteine protease activity by NO-donors
5. NO donors inhibit Leishmania infantum cysteine proteinase activity
6. Sensitivity of malaria parasites to nitric oxide at low oxygen tensions
7. Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress
8. Glutathione protects macrophages and Leishmania major against nitric oxide-mediated cytotoxicity
9. Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: Insights on safety, target validation, and mechanism of action
10. A topical nitric oxide-generating therapy for cutaneous leishmaniasis