First line of defense in early human life

Seminars in Perinatology

Volumn 28, Issue 4, 2004, Pages 304-311

  Yoshio, Hiroyuki ^a   Lagercrantz, Hugo ^b   Gudmundsson, Gudmundur H ^c   Agerberth, Birgitta ^d  

^a NATIONAL HOSPITAL ORGANIZATION OKAYAMA MEDICAL CENTER   (Japan)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF ICELAND   (Iceland)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; BETA DEFENSIN; CATHELICIDIN; DEFENSIN; HEPCIDIN; HISTATIN; ANTIMICROBIAL CATIONIC PEPTIDE; BIOLOGICAL MARKER; CALCIUM BINDING PROTEIN; CHEMOTACTIC FACTOR;

BACTERIAL OUTER MEMBRANE; BACTERIOLYSIS; BETA SHEET; BREAST MILK; CELL FUNCTION; CHEMOTAXIS; CONFERENCE PAPER; DEVELOPMENTAL STAGE; FETUS (ANATOMY); GASTROINTESTINAL TRACT; GENOMICS; HOST RESISTANCE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; LUNG INFECTION; NECROTIZING ENTEROCOLITIS; NEUTROPHIL; NORTHERN BLOTTING; PANETH CELL; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RESPIRATORY EPITHELIUM; SKIN; FEMALE; IMMUNOLOGY; MALE; METABOLISM; NEWBORN; PHYSIOLOGY; REVIEW; RISK FACTOR; SENSITIVITY AND SPECIFICITY;

ALPHA-DEFENSINS; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL MARKERS; CALCIUM-BINDING PROTEINS; CHEMOTACTIC FACTORS; FEMALE; HUMANS; INFANT, NEWBORN; MALE; RISK FACTORS; SENSITIVITY AND SPECIFICITY;

EID: 14244257155     PISSN: 01460005     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semperi.2004.08.008     Document Type: Conference Paper

References (72)

1. Lagercrantz H., Slotkin T.A. The "stress" of being born. Sci Am. 254:1986;100-107
2. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 415:2002;389-395
3. Boman H.G. Antibacterial peptides Basic facts and emerging concepts. J Intern Med. 254:2003;197-215
4. Ganz T. Defensins Antimicrobial peptides of innate immunity. Nat Rev Immunol. 3:2003;710-720
5. Huttner K.M., Bevins C.L. Antimicrobial peptides as mediators of epithelial host defense. Pediatr Res. 45:1999;785-794
6. Zasloff M. Vernix, the newborn, and innate defense. Pediatr Res. 53:2003;203-204
7. Zanetti M. Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol. 75:2004;39-48
8. Lehrer R.I., Ganz T. Defensins of vertebrate animals. Curr Opin Immunol. 14:2002;96-102
9. Ganz T., Lehrer R.I. Antimicrobial peptides of leukocytes. Curr Opin Hematol. 4:1997;53-58
10. Wilde C.G., Griffith J.E., Marra M.N., et al. Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J Biol Chem. 264:1989;11200-11203
11. Jones D.E., Bevins C.L. Defensin-6 mRNA in human Paneth cells Implications for antimicrobial peptides in host defense of the human bowel. FEBS Lett. 315:1993;187-192
12. Jones D.E., Bevins C.L. Paneth cells of the human small intestine express an antimicrobial peptide gene. J Biol Chem. 267:1992;23216-23225
13. Zhao C., Wang I., Lehrer R.I. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett. 396:1996;319-322
14. Harder J., Bartels J., Christophers E., et al. A peptide antibiotic from human skin. Nature. 387:1997;861
15. Harder J., Bartels J., Christophers E., et al. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem. 276:2001;5707-5713
16. Garcia J.R., Krause A., Schulz S., et al. Human beta-defensin 4 A novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J. 15:2001;1819-1821
17. Jia H.P., Schutte B.C., Schudy A., et al. Discovery of new human beta-defensins using a genomics-based approach. Gene. 263:2001;211-218
18. Schutte B.C., Mitros J.P., Bartlett J.A., et al. Discovery of five conserved beta-defensin gene clusters using a computational search strategy. Proc Natl Acad Sci USA. 99:2002;2129-2133
19. Uzzell T., Stolzenberg E.D., Shinnar A.E., et al. Hagfish intestinal antimicrobial peptides are ancient cathelicidins. Peptides. 24:2003;1655-1667
20. Gudmundsson G.H., Agerberth B., Odeberg J., et al. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur J Biochem. 238:1996;325-332
21. Johansson J., Gudmundsson G.H., Rottenberg M.E., et al. Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J Biol Chem. 273:1998;3718-3724
22. Hancock R.E., Diamond G. The role of cationic antimicrobial peptides in innate host defenses. Trends Microbiol. 8:2000;402-410
23. Shai Y. Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Biochim Biophys Acta. 1462:1999;55-70
24. Singh P.K., Jia H.P., Wiles K., et al. Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci USA. 95:1998;14961-14966
25. Valore E.V., Park C.H., Quayle A.J., et al. Human beta-defensin-1 An antimicrobial peptide of urogenital tissues. J Clin Invest. 101:1998;1633-1642
26. Gudmundsson G.H., Magnusson K.P., Chowdhary B.P., et al. Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member Comparative mapping of the locus for the human peptide antibiotic FALL-39. Proc Natl Acad Sci USA. 92:1995;7085-7089
27. Frohm Nilsson M., Sandstedt B., Sorensen O., et al. The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6. Infect Immun. 67:1999;2561-2566
28. Agerberth B., Charo J., Werr J., et al. The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood. 96:2000;3086-3093
29. Bals R., Wang X., Zasloff M., et al. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci USA. 95:1998;9541-9546
30. Singh P.K., Tack B.F., McCray P.B. Jr, et al. Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am J Physiol Lung Cell Mol Physiol. 279:2000;L799-L805
31. Ganz T., Selsted M.E., Lehrer R.I. Defensins. Eur J Haematol. 44:1990;1-8
32. Raghunathan R., Miller M.E., Everett S., et al. Phagocyte chemotaxis in the perinatal period. J Clin Immunol. 2:1982;242-245
33. Carr R. Neutrophil production and function in newborn infants. Br J Haematol. 110:2000;18-28
34. Weiss J., Elsbach P., Olsson I., et al. Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes. J Biol Chem. 253:1978;2664-2672
35. Elsbach P. The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense. J Leukoc Biol. 64:1998;14-18
36. Levy O., Martin S., Eichenwald E., et al. Impaired innate immunity in the newborn Newborn neutrophils are deficient in bactericidal/permeability- increasing protein. Pediatrics. 104:1999;1327-1333
37. Nupponen I., Turunen R., Nevalainen T., et al. Extracellular release of bactericidal/permeability-increasing protein in newborn infants. Pediatr Res. 51:2002;670-674
38. Qing G., Howlett S., Bortolussi R. Lipopolysaccharide binding proteins on polymorphonuclear leukocytes Comparison of adult and neonatal cells. Infect Immun. 64:1996;4638-4642
39. Levy O., Sisson R.B., Kenyon J., et al. Enhancement of neonatal innate defense Effects of adding an N-terminal recombinant fragment of bactericidal/permeability-increasing protein on growth and tumor necrosis factor-inducing activity of gram-negative bacteria tested in neonatal cord blood ex vivo. Infect Immun. 68:2000;5120-5125
40. Marchini G., Lindow S., Brismar H., et al. The newborn infant is protected by an innate antimicrobial barrier Peptide antibiotics are present in the skin and vernix caseosa. Br J Dermatol. 147:2002;1127-1134
41. Bardan A., Nizet V., Gallo R.L. Antimicrobial peptides and the skin. Exp Opin Biol Ther. 4:2004;543-549
42. Frohm M., Agerberth B., Ahangari G., et al. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem. 272:1997;15258-15263
43. Schroder J.M. Epithelial antimicrobial peptides Innate local host response elements. Cell Mol Life Sci. 56:1999;32-46
44. Dorschner R.A., Lin K.H., Murakami M., et al. Neonatal skin in mice and humans expresses increased levels of antimicrobial peptides Innate immunity during development of the adaptive response. Pediatr Res. 53:2003;566-572
45. Youssef W., Wickett R.R., Hoath S.B. Surface free energy characterization of vernix caseosa. Potential role in waterproofing the newborn infant. Skin Res Technol. 7:2001;10-17
46. Yoshio H., Tollin M., Gudmundsson G.H., et al. Antimicrobial polypeptides of human vernix caseosa and amniotic fluid Implications for newborn innate defense. Pediatr Res. 53:2003;211-216
47. Hein M., Valore E.V., Helmig R.B., et al. Antimicrobial factors in the cervical mucus plug. Am J Obstet Gynecol. 187:2002;137-144
48. Diamond G., Zasloff M., Eck H., et al. Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa Peptide isolation and cloning of a cDNA. Proc Natl Acad Sci USA. 88:1991;3952-3956
49. Agerberth B., Grunewald J., Castanos-Velez E., et al. Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients. Am J Respir Crit Care Med. 160:1999;283-290
50. McCray P.B. Jr, Bentley L. Human airway epithelia express a beta-defensin. Am J Respir Cell Mol Biol. 16:1997;343-349
51. Schaller-Bals S., Schulze A., Bals R. Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection. Am J Respir Crit Care Med. 165:2002;992-995
52. th Annual Meeting of the European Society for Paediatric Research, Bilbao, Spain
53. Mallow E.B., Harris A., Salzman N., et al. Human enteric defensins. Gene structure and developmental expression. J Biol Chem. 271:1996;4038-4045
54. Kliegman R.M., Walker W.A., Yolken R.H. Necrotizing enterocolitis Research agenda for a disease of unknown etiology and pathogenesis. Pediatr Res. 34:1993;701-708
55. Salzman N.H., Polin R.A., Harris M.C., et al. Enteric defensin expression in necrotizing enterocolitis. Pediatr Res. 44:1998;20-26
56. Islam D., Bandholtz L., Nilsson J., et al. Downregulation of bactericidal peptides in enteric infections A novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med. 7:2001;180-185
57. Schauber J., Svanholm C., Termen S., et al. Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes Relevance of signalling pathways. Gut. 52:2003;735-741
58. May J.T. Antimicrobial factors and microbial contaminants in human milk Recent studies. J Paediatr Child Health. 30:1994;470-475
59. Jia H.P., Starner T., Ackermann M., et al. Abundant human beta-defensin-1 expression in milk and mammary gland epithelium. J Pediatr. 138:2001;109-112
60. Tunzi C.R., Harper P.A., Bar-Oz B., et al. Beta-defensin expression in human mammary gland epithelia. Pediatr Res. 48:2000;30-35
61. Oppenheim J.J., Biragyn A., Kwak L.W., et al. Roles of antimicrobial peptides such as defensins in innate and adaptive immunity. Ann Rheum Dis. 62:(suppl 2):2003;17-21
62. Gudmundsson G.H., Agerberth B. Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune system. J Immunol Methods. 232:1999;45-54
63. Chertov O., Michiel D.F., Xu L., et al. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J Biol Chem. 271:1996;2935-2940
64. Van Wetering S., Mannesse-Lazeroms S.P., Van Sterkenburg M.A, et al. Effect of defensins on interleukin-8 synthesis in airway epithelial cells. Am J Physiol. 272:1997;L888-L896
65. O'Neil D.A., Porter E.M., Elewaut D., et al. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol. 163:1999;6718-6724
66. Yang D., Chertov O., Bykovskaia S.N., et al. Beta-defensins Linking innate and adaptive immunity through dendritic and T cell CCR6. Science. 286:1999;525-528
67. Yang D., Chen Q., Schmidt A.P., et al. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med. 192:2000;1069-1074
68. Nizet V., Ohtake T., Lauth X., et al. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature. 414:2001;454-457
69. Boxer L.A., Hutchinson R., Emerson S. Recombinant human granulocyte-colony-stimulating factor in the treatment of patients with neutropenia. Clin Immunol Immunopathol. 62:1992;S39-S46
70. Kostmann R. Infantile genetic agranulocytosis; agranulocytosis infantilis hereditaria. Acta Paediatr. 45:1956;1-78
71. Putsep K., Carlsson G., Boman H.G., et al. Deficiency of antibacterial peptides in patients with morbus Kostmann An observation study. Lancet. 360:2002;1144-1149
72. Ong P.Y., Ohtake T., Brandt C., et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med. 347:2002;1151-1160