메뉴 건너뛰기




Volumn 63, Issue 1, 2005, Pages 69-75

Involvement of PI3K/Akt pathway in prostate cancer. Potential strategies for developing targeted therapies;Implication de la voie PI3K/Akt dans le cancer de la prostate. Nouvelles stratégies pour concevoir des thérapies ciblées

Author keywords

Farnesyltransferase; Kinases; PI3K Akt signalling; Prostate cancer

Indexed keywords

GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN FARNESYLTRANSFERASE; PROTEIN KINASE B;

EID: 14244255644     PISSN: 00034509     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0003-4509(05)82253-9     Document Type: Article
Times cited : (7)

References (38)
  • 1
    • 5044235623 scopus 로고    scopus 로고
    • Is there a role for chemotherapy in prostate cancer?
    • Canil CM, Tannock IF. Is there a role for chemotherapy in prostate cancer? Br J Cancer 2004; 1-7.
    • (2004) Br J Cancer , pp. 1-7
    • Canil, C.M.1    Tannock, I.F.2
  • 3
    • 10744222860 scopus 로고    scopus 로고
    • Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
    • Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 2003; 4: 209-21.
    • (2003) Cancer Cell , vol.4 , pp. 209-221
    • Wang, S.1    Gao, J.2    Lei, Q.3    Rozengurt, N.4    Pritchard, C.5    Jiao, J.6
  • 4
    • 0035914394 scopus 로고    scopus 로고
    • Pro-survival function of Akt/Protein kinase B in prostate cancer cells. Relationship with TRAIL resistance
    • Thakkar H, Chen X, Tyan F, Gim S, Robinson H, Lee C et al. Pro-survival function of Akt/Protein kinase B in prostate cancer cells. Relationship with TRAIL resistance. J Biol Chem 2001; 276: 38361-9.
    • (2001) J Biol Chem , vol.276 , pp. 38361-38369
    • Thakkar, H.1    Chen, X.2    Tyan, F.3    Gim, S.4    Robinson, H.5    Lee, C.6
  • 5
    • 0141927222 scopus 로고    scopus 로고
    • Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
    • Gao N, Zhang Z, Jiang BH, Shi X. Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem Biophys Res Commun 2003; 310: 1124-32.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 1124-1132
    • Gao, N.1    Zhang, Z.2    Jiang, B.H.3    Shi, X.4
  • 7
    • 0034749615 scopus 로고    scopus 로고
    • Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state
    • Murillo H, Huang H, Schmidt LJ, Smith DI, Tindall DJ. Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinology 2001; 142: 4795-805.
    • (2001) Endocrinology , vol.142 , pp. 4795-4805
    • Murillo, H.1    Huang, H.2    Schmidt, L.J.3    Smith, D.I.4    Tindall, D.J.5
  • 8
    • 0347407794 scopus 로고    scopus 로고
    • Akt in prostate cancer: Possible role in androgen-independence
    • Ghosh PM, Malik S, Bedolla R, Kreisberg JI. Akt in prostate cancer: possible role in androgen-independence. Curr Drug Metab 2003; 4: 487-96.
    • (2003) Curr Drug Metab , vol.4 , pp. 487-496
    • Ghosh, P.M.1    Malik, S.2    Bedolla, R.3    Kreisberg, J.I.4
  • 9
    • 0036830256 scopus 로고    scopus 로고
    • Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells
    • Grunwald V, DeGraffenried L, Russel D, Friedrichs WE, Ray RB, Hidalgo M. Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells. Cancer Res 2002; 62: 6141-5.
    • (2002) Cancer Res , vol.62 , pp. 6141-6145
    • Grunwald, V.1    DeGraffenried, L.2    Russel, D.3    Friedrichs, W.E.4    Ray, R.B.5    Hidalgo, M.6
  • 10
    • 1242329830 scopus 로고    scopus 로고
    • Epidermal growth factor receptor: A promising target in solid tumours
    • Laskin JJ, Sandler AB. Epidermal growth factor receptor: a promising target in solid tumours. Cancer Treat Rev 2004; 30: 1-17.
    • (2004) Cancer Treat Rev , vol.30 , pp. 1-17
    • Laskin, J.J.1    Sandler, A.B.2
  • 11
    • 0033178247 scopus 로고    scopus 로고
    • Novel anticancer drug discovery
    • Buolamwini JK. Novel anticancer drug discovery. Curr Opin Chem Biol 1999; 3: 500-9.
    • (1999) Curr Opin Chem Biol , vol.3 , pp. 500-509
    • Buolamwini, J.K.1
  • 12
    • 0346365445 scopus 로고    scopus 로고
    • Smart drugs in prostate cancer
    • Van der Poel HG. Smart drugs in prostate cancer. Eur Urol 2004; 45: 1-17.
    • (2004) Eur Urol , vol.45 , pp. 1-17
    • Van Der Poel, H.G.1
  • 13
    • 0942268143 scopus 로고    scopus 로고
    • Novel radiosensitizers for locally advanced epithelial tumors: Inhibition of the PI3K/Akt survival pathway in tumor cells and in tumor-associated endothelial cells as a novel treatment strategy?
    • Riesterer O, Tenzer A, Zingg D, Hofstetter B, Vuongt V, Pruschy M, Bodis S. Novel radiosensitizers for locally advanced epithelial tumors: inhibition of the PI3K/Akt survival pathway in tumor cells and in tumor-associated endothelial cells as a novel treatment strategy? Int J Radiat Oncol Biol Phys 2004; 58: 361-8.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 361-368
    • Riesterer, O.1    Tenzer, A.2    Zingg, D.3    Hofstetter, B.4    Vuongt, V.5    Pruschy, M.6    Bodis, S.7
  • 16
    • 0013364640 scopus 로고    scopus 로고
    • A short and unequivocal synthesis of 5-aminotetrazolo[1,5α]- quinazoline as a tricyclic analogue of 4-(3-bromoanilino)-6,7- dimethoxyquinazoline (PD 153035)
    • Bencteux E, Houssin R, Hénichart J-P. A short and unequivocal synthesis of 5-aminotetrazolo[1,5α]-quinazoline as a tricyclic analogue of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035). J Heterocyclic Chem 1997; 34: 1375-8.
    • (1997) J Heterocyclic Chem , vol.34 , pp. 1375-1378
    • Bencteux, E.1    Houssin, R.2    Hénichart, J.-P.3
  • 17
    • 4444314778 scopus 로고    scopus 로고
    • The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells
    • Wu T, Leng J, Han C, Demetris AJ. The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells. Mol Cancer Ther 2004; 3: 299-307.
    • (2004) Mol Cancer Ther , vol.3 , pp. 299-307
    • Wu, T.1    Leng, J.2    Han, C.3    Demetris, A.J.4
  • 18
    • 0032425739 scopus 로고    scopus 로고
    • Synthesis and antiproliferative properties of 4-aminoquinazoline derivatives as inhibitors of EGF-receptor-associated tyrosine kinase activity
    • Bouey-Bencteux E, Loison C, Pommery N, Houssin R, Hénichart J-P. Synthesis and antiproliferative properties of 4-aminoquinazoline derivatives as inhibitors of EGF-receptor-associated tyrosine kinase activity. Anti-Cancer Drug Design 1998; 13: 893-922.
    • (1998) Anti-Cancer Drug Design , vol.13 , pp. 893-922
    • Bouey-Bencteux, E.1    Loison, C.2    Pommery, N.3    Houssin, R.4    Hénichart, J.-P.5
  • 19
    • 0037008686 scopus 로고    scopus 로고
    • Celecoxib induces apoptosis by inhibiting 3-phosphoinositide -dependent protein kinase-1 activity in the human colon cancer HT-29 cell line
    • Arico S, Pattingre S, Bauvy C, Gane P, Barbat A, Codogno P, et al. Celecoxib induces apoptosis by inhibiting 3-phosphoinositide -dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. J Biol Chem 2002; 277: 27613-21.
    • (2002) J Biol Chem , vol.277 , pp. 27613-27621
    • Arico, S.1    Pattingre, S.2    Bauvy, C.3    Gane, P.4    Barbat, A.5    Codogno, P.6
  • 20
    • 0041822007 scopus 로고    scopus 로고
    • Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: Evidence for Akt inhibition in celecoxib-induced apoptosis
    • Leng J, Han CA, Demetris AJ, Michalopoulos GK, Wu T. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: Evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology 2003; 38: 756-68.
    • (2003) Hepatology , vol.38 , pp. 756-768
    • Leng, J.1    Han, C.A.2    Demetris, A.J.3    Michalopoulos, G.K.4    Wu, T.5
  • 22
    • 3042562279 scopus 로고    scopus 로고
    • From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors
    • Zhu J, Huang JW, Tseng PH, Yang YT, Fowble J, Shiau CW et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide- dependent protein kinase-1 inhibitors. Cancer Res 2004; 64: 4309-18.
    • (2004) Cancer Res , vol.64 , pp. 4309-4318
    • Zhu, J.1    Huang, J.W.2    Tseng, P.H.3    Yang, Y.T.4    Fowble, J.5    Shiau, C.W.6
  • 23
    • 0034629345 scopus 로고    scopus 로고
    • The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide- dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase
    • Lali FV, Hunt AE, Turner SJ, Foxwell BM. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J Biol Chem 2000; 275: 7395-402.
    • (2000) J Biol Chem , vol.275 , pp. 7395-7402
    • Lali, F.V.1    Hunt, A.E.2    Turner, S.J.3    Foxwell, B.M.4
  • 24
    • 0037060906 scopus 로고    scopus 로고
    • Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor
    • Barbey S, Goossens L, Taverne T, Cornet J, Choesme V, Rouaud C et al. Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor. Bioorg. Med Chem Lett 2002; 12: 779-82.
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 779-782
    • Barbey, S.1    Goossens, L.2    Taverne, T.3    Cornet, J.4    Choesme, V.5    Rouaud, C.6
  • 25
    • 9744265658 scopus 로고    scopus 로고
    • New COX-2/5-LOX inhibitors, apoptosis-inducing agents potentially useful in prostate cancer chemotherapy
    • 2004
    • Pommery N, Taverne T, Telliez A, Goossens L, Charlier C, Pommery J et al. New COX-2/5-LOX inhibitors, apoptosis-inducing agents potentially useful in prostate cancer chemotherapy. 2004, J Med Chem 2004; 47: 6-20.
    • (2004) J Med Chem , vol.47 , pp. 6-20
    • Pommery, N.1    Taverne, T.2    Telliez, A.3    Goossens, L.4    Charlier, C.5    Pommery, J.6
  • 26
    • 0037122699 scopus 로고    scopus 로고
    • Design, synthesis and pharmacological evaluation of new farnesyl protein transferase inhibitors
    • Houssin R, Pommery J, Salaun M-C, Deweer S, Goossens J-F, Chavatte P, et al. Design, synthesis and pharmacological evaluation of new farnesyl protein transferase inhibitors. J Med Chem 2002; 45: 533-6.
    • (2002) J Med Chem , vol.45 , pp. 533-536
    • Houssin, R.1    Pommery, J.2    Salaun, M.-C.3    Deweer, S.4    Goossens, J.-F.5    Chavatte, P.6
  • 28
    • 0028318136 scopus 로고
    • Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
    • Prendergast GC, Davide JP, deSolms SJ, Giuliani E, Graham S, Gibbs JB et al. Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Mol Cell Biol 1994; 14: 4193-202.
    • (1994) Mol Cell Biol , vol.14 , pp. 4193-4202
    • Prendergast, G.C.1    Davide, J.P.2    DeSolms, S.J.3    Giuliani, E.4    Graham, S.5    Gibbs, J.B.6
  • 29
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesyl protein transferase blocks the anchorage-dependent and independent growth of human tumor cell lines
    • Sepp-Lorenzino L, Ma Z, Rands E, Kohl NE, Gibbs JB, Oliff A, et al. A peptidomimetic inhibitor of farnesyl protein transferase blocks the anchorage-dependent and independent growth of human tumor cell lines. Cancer Res 1995; 55: 5302-9.
    • (1995) Cancer Res , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3    Kohl, N.E.4    Gibbs, J.B.5    Oliff, A.6
  • 30
    • 0030923192 scopus 로고    scopus 로고
    • K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
    • Whyte DB, Kirschmeier P, Hockenberry TN, Nunez-Oliva I, James L, Catino JJ et al. K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J Biol Chem 1997; 272: 14459-64.
    • (1997) J Biol Chem , vol.272 , pp. 14459-14464
    • Whyte, D.B.1    Kirschmeier, P.2    Hockenberry, T.N.3    Nunez-Oliva, I.4    James, L.5    Catino, J.J.6
  • 31
    • 0030952552 scopus 로고    scopus 로고
    • Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines
    • Lerner EA, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti SM. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines. Oncogene 1997; 15: 1283-8.
    • (1997) Oncogene , vol.15 , pp. 1283-1288
    • Lerner, E.A.1    Zhang, T.T.2    Knowles, D.B.3    Qian, Y.4    Hamilton, A.D.5    Sebti, S.M.6
  • 32
    • 0034777538 scopus 로고    scopus 로고
    • Protein farnesylation in mammalian cells: Effects of farnesyltransferase inhibitors on cancer cells
    • Tamanoi F, Gau CL, Jiang C, Edamatsu H, Kato-Stankiewicz J. Protein farnesylation in mammalian cells: effects of farnesyltransferase inhibitors on cancer cells. Cell Mol Life Sci 2001; 58: 1636-49.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 1636-1649
    • Tamanoi, F.1    Gau, C.L.2    Jiang, C.3    Edamatsu, H.4    Kato-Stankiewicz, J.5
  • 33
    • 0034071688 scopus 로고    scopus 로고
    • A phase I trial of the farnesyl transferase inhibitor SCH66336: Evidence for biological and clinical activity
    • Adjei AA, Erlichman C, Davis JN, Cutler DL, Sloan JA, Marks RS et al. A phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity. Cancer Res 2000; 60: 1871-7.
    • (2000) Cancer Res , vol.60 , pp. 1871-1877
    • Adjei, A.A.1    Erlichman, C.2    Davis, J.N.3    Cutler, D.L.4    Sloan, J.A.5    Marks, R.S.6
  • 34
    • 1342331479 scopus 로고    scopus 로고
    • Opinion: Searching for the elusive targets of farnesyltransferase inhibitors
    • Sebti SM, Der CJ. Opinion: Searching for the elusive targets of farnesyltransferase inhibitors. Nat Rev Cancer 2003; 3: 945-51.
    • (2003) Nat Rev Cancer , vol.3 , pp. 945-951
    • Sebti, S.M.1    Der, C.J.2
  • 35
    • 0030888163 scopus 로고    scopus 로고
    • The Ras-related protein Rheb is farnesylated and antagonizes ras signaling and transformation
    • Clark GJ, Kinch MS, Rogers-Graham K, Sebti SM, Hamilton A, Der CJ. The Ras-related protein Rheb is farnesylated and antagonizes ras signaling and transformation. J Biol Chem 1997; 272: 10608-15.
    • (1997) J Biol Chem , vol.272 , pp. 10608-10615
    • Clark, G.J.1    Kinch, M.S.2    Rogers-Graham, K.3    Sebti, S.M.4    Hamilton, A.5    Der, C.J.6
  • 36
    • 3142546236 scopus 로고    scopus 로고
    • The Rheb family of GTP-binding proteins
    • Aspuria PJ, Tamanoi F. The Rheb family of GTP-binding proteins. Cell Signal 2004; 16: 1105-12.
    • (2004) Cell Signal , vol.16 , pp. 1105-1112
    • Aspuria, P.J.1    Tamanoi, F.2
  • 37
    • 0041356888 scopus 로고    scopus 로고
    • Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation -dependent manner
    • Castro AF, Rebhun JF, Clark GJ, Quilliam LA. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation -dependent manner. J Biol Chem 2003; 278: 32493-6.
    • (2003) J Biol Chem , vol.278 , pp. 32493-32496
    • Castro, A.F.1    Rebhun, J.F.2    Clark, G.J.3    Quilliam, L.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.