Synthesis and antiproliferative properties of 4-aminoquinazoline derivatives as inhibitors of EGF receptor-associated tyrosine kinase activity

Anti-Cancer Drug Design

Volumn 13, Issue 8, 1998, Pages 893-922

  Bouey Bencteux, Edith ^a   Loison, Cécile ^a   Pommery, Nicole ^b   Houssin, Raymond ^a   Hénichart, Jean Pierre ^a  

^a Faculte de Sciences Pharmaceutiques et Biologiques   (France)

^b UNIV LILLE   (France)

Author keywords

A431; EGF receptor; Proliferation; Quinazoline; Tyrosine kinase inhibitors

Indexed keywords

2,4 DIAMINOQUINAZOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; AROMATIC AMINE; EPIDERMAL GROWTH FACTOR RECEPTOR; MORPHOLINE; PIPERAZINE; PROTEIN TYROSINE KINASE INHIBITOR; QUINAZOLINE; QUINAZOLINE DERIVATIVE;

ARTICLE; AUTOPHOSPHORYLATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PHOSPHORYLATION; QUINAZOLINES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR CELLS, CULTURED;

EID: 0032425739     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (2)

1. AKIYAMA, T., ISHIDA, J., NAKAGAWA, S., OGAWARA, H., WATANABE, S.I., ITOH, N., SHIBUYA, M. & FUKAMI, Y. (1987). Genistein, a specific inhibitor of tyrosine-specific protein kinases. Journal of Biological Chemistry, 262, 5592.
2. BENCTEUX, E., HOUSSIN, R. & HENICHART, J.P. (1997). A short and unequivocal synthesis of 5-aminotetrazolo[1,5-a]quinazoline as a tricyclic analogue of 4-(3-bromoanilino)-6,7-dimethoxy-quinazoline (PD 153035). Journal of Heterocyclic Chemistry, 34, 1375.