Ligand-binding regulation of LXR/RXR and LXR/PPAR heterodimerizations: SPR technology-based kinetic analysis correlated with molecular dynamics simulation

Protein Science

Volumn 14, Issue 3, 2005, Pages 812-822

  Yue, Liduo ^a   Ye, Fei ^a   Gui, Chunshan ^a   Luo, Haibin ^a   Cai, Jianhua ^a   Shen, Jianhua ^a   Chen, Kaixian ^a   Shen, Xu ^a   Jiang, Hualiang ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Kinetic analysis; Liver X receptor (LXR); Molecular dynamics (MD) simulation; Peroxisome proliferator activated receptor (PPAR); Retinoid X receptor (RXR); Surface plasmon resonance (SPR)

Indexed keywords

CHOLESTEROL; FATTY ACID; LIVER X RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR;

ARTICLE; BINDING AFFINITY; BIOLOGICAL MODEL; DIMERIZATION; DNA BINDING; FAT INTAKE; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; HYDROGEN BOND; KINETICS; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; NUTRIENT DYNAMICS; PRIORITY JOURNAL; RECEPTOR BINDING; SIMULATION; SURFACE PLASMON RESONANCE;

DIMERIZATION; DNA-BINDING PROTEINS; KINETICS; LIGANDS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PROTEIN INTERACTION MAPPING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SURFACE PLASMON RESONANCE;

EID: 14144255498     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.04951405     Document Type: Article

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