Neural underpinnings of fear and its modulation: Implications for anxiety disorders

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 17, Issue 1, 2005, Pages 1-6

  Miller, Lisa A ^a   Taber, Katherine H ^a   Gabbard, Glen O ^a   Hurley, Robin A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMYGDALOID NUCLEUS; ANXIETY DISORDER; ARTICLE; BRAIN BLOOD FLOW; BRAIN FUNCTION; BRAIN MAPPING; BRAIN REGION; CINGULATE GYRUS; EMOTION; FEAR; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; IMAGE ANALYSIS; IMAGE RECONSTRUCTION; IMAGING SYSTEM; NERVE PROJECTION; NEUROIMAGING; NEUROPSYCHIATRY; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; POSTTRAUMATIC STRESS DISORDER; PREFRONTAL CORTEX; PRIORITY JOURNAL; SOCIAL PHOBIA; TASK PERFORMANCE; THREE DIMENSIONAL IMAGING;

EID: 14144254798     PISSN: 08950172     EISSN: None     Source Type: Journal    
DOI: 10.1176/jnp.17.1.1     Document Type: Article

References (62)

1. Hendler T, Rotshtein P, Yeshurun Y, et al: Sensing the invisible: differential sensitivity of visual cortex and amygdala to traumatic content. Neuroimage 2003; 19:587-600
2. Whalen PJ, Rauch SL, Etcoff NL, et al: Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci 1998; 18:411-418
3. Nomura M, Ohira H, Haneda K, et al: Functional association of the amygdala and ventral prefrontal cortex during cognitive evaluation of facial expressions primed by masked angry faces: an event-related fMRI study. Neuroimage 2004; 21:352-363
4. Hariri AR, Bookheimer SY, Mazziotta JC: Modulating emotional responses: effects of a neocortical network on the limbic system. Neuroreport 2000; 11:43-48
5. Hariri AR, Mattay VS, Tessitore A, et al: Neocortical modulation of the amygdala response to fearful stimuli. Biol Psychiatry 2003; 53:494-501
6. Furmark T, Tillfors M, Marteinsdottir I, et al: Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Arch Gen Psychiatry 2002; 59:425-433
7. Merriam Webster I: Merriam Webster's Collegiate Dictionary. Springfield, MA, Merriam-Webster, 1997.
8. LeDoux JE: The Emotional Brain: The Mysterious Underpinnings of Emotional Life. New York, NY, Simon & Schuster, Inc, 1996.
9. LeDoux JE: Emotion circuits in the brain. Annu Rev Neurosci 2000; 23:155-184
10. LeDoux JE: Synaptic Self: How Our Brains Become Who We Are. New York, NY, Penguin, Putman, Inc, 2002.
11. Adolphs R: The neurobiology of social cognition. Curr Opin Neurobiol 2001; 11:231-239
12. McIntyre CK, Power AE, Roozendaal B, et al: Role of the basolateral amygdala in memory consolidation. Ann N Y Acad Sci 2003; 985:273-293
13. Davidson RJ: Anxiety and affective style: Role of prefrontal cortex and amygdala. Biol Psychiatry 2002; 51:68-80
14. Fanselow MS, Gale GD: The amygdala, fear, and memory. Ann N Y Acad Sci 2003; 985:125-134
15. Maren S, Quirk GJ: Neuronal signalling of fear memory. Nat Rev Neurosci 2004; 5:844-852
16. Maren S: Neurobiology of Pavlovian fear conditioning. Annu Rev Neurosci 2001; 24:897-931
17. Quirk GJ, Gehlert DR: Inhibition of the amygdala: Key to pathological states? Ann N Y Acad Sci 2003; 985:263-272
18. Pape HC, Stork O: Genes and mechanisms in the amygdala involved in the formation of fear memory. Ann N Y Acad Sci 2003; 985:92-105
19. Charney DS: Neuroanatomic circuits modulating fear and anxiety behaviors. Acta Psychiatr Scand 2003; 108:38-50
20. Frankland PW, Bontempi B, Talton LE, et al: The involvement of the anterior cingulate cortex in remote contextual fear memory. Science 2004; 304:881-883
21. Izquierdo I, Cammarota M: Neuroscience. Zif and the survival of memory. Science 2004; 304:829-830
22. Sotres-Bayon F, Bush DEA, LeDoux JE: Emotional perseveration: An update on prefrontal-amygdala interactions in fear extinction. Learn Mem 2004; 11:525-535
23. Nader K: Memory traces unbound. Trends Neurosci 2003; 26:65-72
24. Lee JL, Everitt BJ, Thomas KL: Independent cellular processes for hippocampal memory consolidation and reconsolidation. Science 2004; 304:839-843
25. Duvarci S, Nader K: Characterization of fear memory reconsolidation. J Neurosci 2004; 24:9269-9275
26. Bouton ME: Context and behavioral processes in extinction. Learn Mem 2004; 11:485-494
27. LaBar KS, Gatenby JC, Gore JC, et al: Human amygdala activation during conditioned fear acquisition and extinction: A mixed-trial fMRI study. Neuron 1998; 20:937-945
28. Morris JS, Dolan RJ: Dissociable amygdala and orbitofrontal responses during reversal fear conditioning. Neuroimage 2004; 22:372-380
29. Phelps EA, Delgado MR, Nearing KI, et al: Extinction learning in humans: Role of the amygdala and vmPFC. Neuron 2004; 43:897-905
30. Berntson GG, Sarter M, Cacioppo JT: Ascending visceral regulation of cortical affective information processing. Eur J Neurosci 2003; 18:2103-2109
31. de Gelder B, Vroomen J, Pourtois G, et al: Non-conscious recognition of affect in the absence of striate cortex. Neuroreport 1999; 10:3759-3763
32. Morris JS, de Gelder B, Weiskrantz L, et al: Differential extrageniculate and amygdala responses to presentation of emotional faces in a cortically blind field. Brain 2001; 124:1241-1252
33. Morris JS, Ohman A, Dolan RJ: A subcortical pathway to the right amygdala mediating unseen fear. Proc Natl Acad Sci U S A 96:1680-1685
34. Williams MA, Mattingley JB: Unconscious perception of non-threatening facial emotion in parietal extinction. Exp Brain Res 2004; 154:403-406
35. Morris JS, Buchel C, Dolan RJ: Parallel neural responses in amygdala subregions and sensory cortex during implicit fear conditioning. Neuroimage 2001; 13:1044-1052
36. Vuilleumier P, Armony JL, Driver J, et al: Effects of attention and emotion on face processing in the human brain: An event-related fMRI study. Neuron 2001; 30:829-841
37. Anderson AK, Christoff K, Panitz D, et al: Neural correlates of the automatic processing of threat facial signals. J Neurosci 2003; 23:5627-5633
38. Goleman D: Emotional Intelligence: Why It Can Matter More Than IQ. New York, NY, Random House, 1995
39. Dolan RJ, Vuilleumier P: Amygdala automaticity in emotional processing. Ann N Y Acad Sci 2003; 985:348-355
40. Stein MB, Goldin PR, Sareen J, et al: Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry 2002; 59:1027-1034
41. Damasio AR: Descartes' Error: Emotion, Reason, and the Human Brain. New York, Avon, 1994
42. Winkielman P, Berridge K: Irrational wanting and subrational liking: How rudimentary motivational and affective processes shape preferences and choices. Political Psychol 2003; 24:657-680
43. Winkielman P, Berridge K: Unconscious emotion. Curr Dir Psychol Sci 2004; 13:120-123
44. Stuss DT, Knight RT: Principles of Frontal Lobe Function. New York, Oxford University Press, 2002
45. Lange K, Williams LM, Young AW, et al: Task instructions modulate neural responses to fearful facial expressions. Biol Psychiatry 2003; 53:226-232
46. Anand A, Shekhar A: Brain imaging studies in mood and anxiety disorders: special emphasis on the amygdala. Ann N Y Acad Sci 2003; 985:370-388
47. Rauch SL, Shin LM, Wright CI: Neuroimaging studies of amygdala function in anxiety disorders. Ann N Y Acad Sci 2003; 985:389-410
48. Davis M, Walker DL, Myers KM: Role of the amygdala in fear extinction measured with potentiated startle. Ann N Y Acad Sci 2003; 985:218-232
49. Paquette V, Levesque J, Mensour B, et al: Change the mind and you change the brain: effects of cognitive-behavioral therapy on the neural correlates of spider phobia. Neuroimage 2003; 18:401-409
50. Richardson R, Ledgerwood L, Cranney J: Facilitation of fear extinction by D-cycloserine: Theoretical and clinical implications. Learn Mem 2004; 11:510-516
51. Ressler K, Rothbaum B, Tannenbaum L, et al: Cognitive enhancers as adjuncts to psychotherapy. Arch Gen Psychiatry 2004; 61:1136-1144
52. Hariri AR, Mattay VS, Tessitore A, et al: Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297:400-403
53. Furmark T, Tillfors M, Garpenstrand H, et al: Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia. Neurosci Lett 2004; 362:189-192
54. Lesch KP, Bengel D, Heils A, et al: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274:1527-1531
55. Osher Y, Hamer D, Benjamin J: Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs. Mol Psychiatry 2000; 5:216-219
56. Garpenstrand H, Annas P, Ekblom J, et al: Human fear conditioning is related to dopaminergic and serotonergic biological markers. Behav Neurosci 2001; 115:358-364
57. Caspi A, Sugden K, Moffitt TE, et al: Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 2003; 301:386-389
58. Hettema JM, Annas P, Neale MC, et al: A twin study of the genetics of fear conditioning. Arch Gen Psychiatry 2003; 60:702-708
59. Tillfors M, Furmark T, Marteinsdottir I, et al: Cerebral blood flow in subjects with social phobia during stressful speaking tasks: A PET study. Am J Psychiatry 2001; 158:1220-1226
60. Veit R, Flor H, Erb M, et al: Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neurosci Lett 2002; 328:233-236
61. Rauch SL, Whalen PJ, Shin LM, et al: Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: A functional MRI study. Biol Psychiatry 2000; 47:769-776
62. Shin LM, Orr SP, Carson MA, et al: Regional cerebral blood flow in the amygdala and medical prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD. Arch Gen Psychiatry 2004; 61:168-176