Naive, effector, and memory T lymphocytes efficiently scan dendritic cells in vivo: Contact frequency in T cell zones of secondary lymphoid organs does not depend on LFA-1 expression and facilitates survival of effector T cells

Journal of Immunology

Volumn 174, Issue 5, 2005, Pages 2517-2524

  Westermann, Jürgen ^a   Bode, Ulrike ^b   Sahle, Andrea ^b   Speck, Uwe ^a   Karin, Nathan ^c   Bell, Eric B ^d   Kalies, Kathrin ^a   Gebert, Andreas ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD18 ANTIGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL INTERACTION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DENDRITIC CELL; EFFECTOR CELL; HUMAN; IMMUNE RESPONSE; IN VIVO STUDY; LYMPH NODE; LYMPHOID ORGAN; MEMORY CELL; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SPLEEN; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 14044274300     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.5.2517     Document Type: Article

References (42)

1. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245.
2. Itano, A. A., and M. K. Jenkins. 2003. Antigen presentation to naive CD4 T cells in the lymph node. Nat. Immunol. 4:733.
3. Laickis, F. G., A. Arakelov, B. T. Konieczny, and Y. Inoue. 2000. Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat. Med. 6:686.
4. + effector T cell distribution in vivo: TGF-β1/TGF-β receptor II interaction during activation mediates accumulation in the target tissue by preferential proliferation. Eur. J. Immunol. 34:1050.
5. + T cells in vivo: implications for adaptive immunotherapy. Eur. J. Immunol. 31:1772.
6. Tanchot, C., F. A. Lemonnier, B. Peramau, A. A. Freitas, and B. Rocha. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276:2057.
7. Roman, E., E. Miller, A. Harmsen, J. Wiley, U. H. Von Andrian, G. Huston, and S. L. Swain. 2002. CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. J. Exp. Med. 196:957.
8. + T cells of both the naive and the memory phenotype enter rat lymph nodes and Peyer's patches via high endothelial venules: within the tissue their migratory behavior differs. Eur. J. Immunol 27:3174.
9. Luettig, B., M. Kaiser, U. Bode, E. B. Bell, S. M. Sparshott, M. Bette, and J. Westermann. 2001. Naive and memory T cells migrate in comparable numbers through the normal rat lung: only effector T cells accumulate and proliferate in the lamina propria of the bronchi. Am. J. Respir. Cell Mol. Biol. 25:69.
10. Bunce, C., and E. B. Bell. 1997. CD45RC isoforms define two types of CD4 memory T cells, one of which depends on persisting antigen. J. Exp. Med. 185:767.
11. + cells. J. Immunol. 169:6085.
12. Bode, U., G. Sparmann, and J. Westermann. 2001. Gut-derived effector T cells circulating in the blood of the rat: preferential re-distribution by TGFβ-1 and IL-4 maintained proliferation. Eur. J. Immunol. 31:2116.
13. Berlin-Rufenach, C., F. Otto, M. Mathies, J. Westermann, M. J. Owen, A. Hamann, and N. Hogg. 1999. Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. J. Exp. Med. 189:1467.
14. Kampinga, J., F. G. Kroese, G. H. Pol, D. Opstelten, H. G. Seijen, J. H. Boot, B. Roser, P. Nieuwenhuis, and R. Aspinall. 1990. RT7-defined alloantigens in rats are part of the leukocyte common antigen family. Scand. J. Immunol. 31:699.
15. Jecker, P., A. Beuleke, I. Dressendorfer, R. Pabst, and J. Westermann. 1997. Long-term oral application of 5-bromo-2-deoxyuridine does not reliably label proliferating immune cells in the LEW rat. J. Histochem. Cytochem. 45:393.
16. Fedrowitz, M., J. Westermann, and W. Loscher. 2002. Magnetic field exposure increases cell proliferation but does not affect melatonin levels in the mammary gland of female Sprague Dawley rats. Cancer Res. 62:1356.
17. Sims, T. N., and M. L. Dustin. 2002. The immunological synapse: integrins take the stage. Immunol. Rev. 186:100.
18. Steinman, R. M., and M. Pope. 2002. Exploiting dendritic cells to improve vaccine efficacy. J. Clin. Invest. 109:1519.
19. Takahashi, K., A. Kenji, T. Norihiro, K. Eisaku, O. Takashi, H. Kazuhiko, Y. Tadashi, and A. Tadaatsu. 2001. Morphological interactions of interdigitating dendritic cells with B and T cells in human mesenteric lymph nodes. Am. J. Pathol. 159:131.
20. Kamath, A. T., J. Pooley, M. A. O'Keeffe, D. Vremec, Y. Zhan, A. M. Lew, A. D'Amico, L. Wu, D. F. Tough, and K. Shortman. 2000. The development, maturation, and turnover rate of mouse spleen dendritic cell populations. J. Immunol. 165:6762.
21. Zell, T., A. Khoruts, E. Ingulli, J. L. Bonnevier, D. L. Mueller, and M. K. Jenkins. 2001. Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivo. Proc. Natl. Acad. Sci. USA 98:10805.
22. Miller, M. J., A. S. Hejazi, S. H. Wei, M. D. Cahalan, and I. Parker. 2004. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc. Natl. Acad. Sci. USA 101:998.
23. Miller, M. J., S. H. Wei, I. Parker, and M. D. Cahalan. 2002. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296:1869.
24. Stoll, S., J. Delon, T. M. Brotz, and R. N. Germain. 2002. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296:1873.
25. + T cell priming by dendritic cells in intact lymph nodes. Nat. Immunol. 4:579.
26. Wilson, N. S., D. El-Sukkari, G. T. Belz, C. M. Smith, R. J. Steptoe, W. R. Heath, K. Shortman, and J. A. Villadangos. 2003. Most lymphoid organ dendritic cell types are phenotypically and functionally immature. Blood 102:2187.
27. Anjuere, F., P. Martin, I. Ferrero, M. L. Fraga, G. M. del Hoyo, N. Wright, and C. Ardavin. 1999. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse. Blood 93:590.
28. Yrlid, U., and G. Macpherson. 2003. Phenotype and function of rat dendritic cell subsets. APMIS 111:756.
29. Mempel, T. R., S. E. Henrickson, and U. H. Von Andrian. 2004. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427:154.
30. + T cells. J. Exp. Med. 185:2133.
31. Forster, R., A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp. 1999. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99:23.
32. Kraal, G., and R. E. Mebius. 1997. High endothelial venules: lymphocyte traffic control and controlled traffic. Adv. Immunol. 65:347.
33. Miller, M. J., S. H. Wei, M. D. Cahalan, and I. Parker. 2003. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc. Natl. Acad. Sci. USA 100:2604.
34. Reif, K., E. H. Ekland, L. Ohl, H. Nakano, M. Lipp, R. Forster, and J. G. Cyster. 2002. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature 416:94.
35. Ford, W. L. 1975. Lymphocyte migration and immune responses. Prog. Allergy 19:1.
36. Hawiger, D., K. Inaba, Y. Dorsett, M. Guo, K. Mahnke, M. Rivera, J. V. Ravetch, R. M. Steinman, and M. C. Nussenzweig. 2001. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194:769.
37. Wilson, N. S., D. El-Sukkari, and J. A. Villadangos. 2004. Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis. Blood 103:2187.
38. Stefanova, I., J. R. Dorfman, and R. N. Germain. 2002. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 420:429.
39. MacLennan, I. C., A. Gulbranson-Judge, K. M. Toellner, M. Casamayor-Palleja, E. Chan, D. M. Sze, S. A. Luther, and H. A. Orbea. 1997. The changing preference of T and B cells for partners as T-dependent antibody responses develop. Immunol. Rev. 156:53.
40. Westermann, J., and R. Pabst. 1992. Distribution of lymphocyte subsets and natural killer cells in the human body. Clin. Invest. 70:539.
41. Westermann, J., B. Engelhardt, and J. C. Hoffmann. 2001. Migration of T cells in vivo: molecular mechanisms and clinical implications. Ann. Intern. Med. 135:279.
42. Bajenoff, M., S. Granjeaud, and S. Guerder. 2003. The strategy of T cell antigen-presenting cell encounter in antigen-draining lymph nodes revealed by imaging of initial T cell activation. J. Exp. Med. 198:715.