IgH V-region sequence does not predict the survival fate of human germinal center B cells

Journal of Immunology

Volumn 174, Issue 5, 2005, Pages 2805-2813

  Jackson, Stephen M ^a   Capra, J Donald ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; IMMUNOGLOBULIN HEAVY CHAIN; LIPOCORTIN 5;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL FATE; CELL FRACTIONATION; CELL INTERACTION; CELL SELECTION; CELL SURVIVAL; CONTROLLED STUDY; DNA SEQUENCE; FLOW CYTOMETRY; GENE MUTATION; GERMINAL CENTER; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; MACROPHAGE; MOLECULAR CLONING; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TONSIL CELL;

EID: 14044273649     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.5.2805     Document Type: Article

References (63)

1. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302:575.
2. Alt, F. W., E. M. Oltz, F. Young, J. Gorman, G. Taccioli, and J. Chen. 1992. VDJ recombination. Immunol. Today 13:306.
3. Kolar, G. R., and J. D. Capra. 2003. Immunoglobulin structure and function. In Fundamental Immunology. W. E. Paul, ed. Lippincott Williams and Wilkins, Philadelphia, p. 47.
4. Pascual, V., Y. J. Liu, A. Magalski, O. de Bouteiller, J. Banchereau, and J. D. Capra. 1994. Analysis of somatic mutation in five B cell subsets of human tonsil. J. Exp. Med. 180:329.
5. Neuberger, M. S., and C. Milstein. 1995. Somatic hypermutation. Curr. Opin. Immunol. 7:248.
6. MacLennan, I. C. 1994. Germinal centers. Annu. Rev. Immunol. 12:117.
7. Jacob, J., G. Kelsoe, K. Rajewsky, and U. Weiss. 1991. Intraclonal generation of antibody mutants in germinal centres. Nature 354:389.
8. Shih, T. A., E. Meffre, M. Roederer, and M. C. Nussenzweig. 2002. Role of BCR affinity in T cell dependent antibody responses in vivo. Nat. Immunol. 3:570.
9. Kline, G. H., L. Hartwell, G. B. Beck-Engeser, U. Keyna, S. Zaharevitz, N. R. Klinman, and H. M. Jack. 1998. Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional μ heavy chains. J. Immunol. 161:1608.
10. Defrance, T., M. Casamayor-Palleja, and P. H. Krammer. 2002. The life and death of a B cell. Adv. Cancer Res. 86:195.
11. Liu, Y. J., O. de Bouteiller, and I. Fugier-Vivier. 1997. Mechanisms of selection and differentiation in germinal centers. Curr. Opin. Immunol. 9:256.
12. Galibert, L., N. Burdin, C. Barthelemy, G. Meffre, I. Durand, E. Garcia, P. Garrone, F. Roussel, J. Banchereau, and Y. J. Liu. 1996. Negative selection of human germinal center B cells by prolonged BCR cross-linking. J. Exp. Med. 183:2075.
13. Liu, Y. J., G. D. Johnson, J. Gordon, and I. C. MacLennan. 1992. Germinal centres in T-cell-dependent antibody responses. Immunol. Today 13:17.
14. Grouard, G., O. de Bouteiller, C. Barthelemy, S. Lebecque, J. Banchereau, and Y. J. Liu. 1995. Regulation of human B cell activation by follicular dendritic cell and T cell signals. Curr. Top. Microbiol. Immunol. 201:105.
15. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature 381:751.
16. Dubois, B., C. Barthelemy, I. Durand, Y. J. Liu, C. Caux, and F. Briere. 1999. Toward a role of dendritic cells in the germinal center reaction: triggering of B cell proliferation and isotype switching. J. Immunol. 162:3428.
17. Donahue, A. C., and D. A. Fruman. 2003. Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation. J. Immunol. 170:5851.
18. Brandtzaeg, P. 1996. The B-cell development in tonsillar lymphoid follicles. Acta Otolaryngol. Suppl. 523:55.
19. Tsunoda, R., E. Heinen, and N. Sugai. 2000. Follicular dendritic cells in vitro modulate the expression of Fas and Bcl-2 on germinal center B cells. Cell Tissue Res. 299:395.
20. Siepmann, K., J. Skok, D. van Essen, M. Harnett, and D. Gray. 2001. Rewiring of CD40 is necessary for delivery of rescue signals to B cells in germinal centres and subsequent entry into the memory pool. Immunology 102:263.
21. Koopman, G., R. M. Keehnen, E. Lindhout, D. F. Zhou, C. de Groot, and S. T. Pals. 1997. Germinal center B cells rescued from apoptosis by CD40 ligation or attachment to follicular dendritic cells, but not by engagement of surface immunoglobulin or adhesion receptors, become resistant to CD95-induced apoptosis. Eur. J. Immunol. 27:1.
22. Grouard, G., O. de Bouteiller, J. Banchereau, and Y. J. Liu. 1995. Human follicular dendritic cells enhance cytokine-dependent growth and differentiation of CD40-activated B cells. J. Immunol. 155:3345.
23. Van Nierop, K., and C. de Groot. 2002. Human follicular dendritic cells: function, origin and development. Semin. Immunol. 14:251.
24. Liu, Y. J., G. Grouard, O. de Bouteiller, and J. Banchereau. 1996. Follicular dendritic cells and germinal centers. Int. Rev. Cytol. 166:139.
25. Petrasch, S. G., M. H. Kosco, C. J. Perez-Alvarez, J. Schmitz, and G. Brittinger. 1991. Proliferation of germinal center B lymphocytes in vitro by direct membrane contact with follicular dendritic cells. Immunobiology 183:451.
26. Liu, Y. J., C. Arpin, O. de Bouteiller, C. Guret, J. Banchereau, H. Martinez-Valdez, and S. Lebecque. 1996. Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development. Semin. Immunol. 8:169.
27. Choi, Y. S. 1997. Differentiation and apoptosis of human germinal center B-lymphocytes. Immunol. Res. 16:161.
28. Reynolds, J. D. 1986. Evidence of extensive lymphocyte death in sheep Peyer's patches. I. A comparison of lymphocyte production and export. J. Immunol. 136:2005.
29. Liu, Y. J., and C. Arpin. 1997. Germinal center development. Immunol. Rev. 156:111.
30. Tuscano, J. M., K. M. Druey, A. Riva, J. Pena, C. B. Thompson, and J. H. Kehrl. 1996. Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center. Blood 88:1359.
31. Klein, U., Y. Tu, G. A. Stolovitzky, J. L. Keller, J. Haddad, Jr., V. Miljkovic, G. Cattoretti, A. Califano, and R. Dalla-Favera. 2003. Transcriptional analysis of the B cell germinal center reaction. Proc. Natl. Acad. Sci. USA 100:2639.
32. + germinal center B lymphocytes after rescue from apoptosis. Mol. Immunol. 32:333.
33. Martinez-Valdez, H., C. Guret, O. de Bouteiller, I. Fugier, J. Banchereau, and Y. J. Liu. 1996. Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. J. Exp. Med. 183:971.
34. Lindhout, E., A. Lakeman, and C. de Groot. 1995. Follicular dendritic cells inhibit apoptosis in human B lymphocytes by a rapid and irreversible blockade of preexisting endonuclease. J. Exp. Med. 181:1985.
35. Lindhout, E., M. L. Mevissen, J. Kwekkeboom, J. M. Tager, and C. de Groot. 1993. Direct evidence that human follicular dendritic cells (FDC) rescue germinal centre B cells from death by apoptosis. Clin. Exp. Immunol. 91:330.
36. De Boer, R. J., A. A. Freitas, and A. S. Perelson. 2001. Resource competition determines selection of B cell repertoires. J. Theor. Biol. 212:333.
37. Kesmir, C., and R. J. De Boer. 2003. A spatial model of germinal center reactions: cellular adhesion based sorting of B cells results in efficient affinity maturation. J. Theor. Biol. 222:9.
38. Danial, N. N., and S. J. Korsmeyer. 2004. Cell death: critical control points. Cell 116:205.
39. Koopman, G., C. P. Reutelingsperger, G. A. Kuijten, R. M. Keehnen, S. T. Pals, and M. H. van Oers. 1994. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84:1415.
40. Vermes, I., C. Haanen, H. Steffens-Nakken, and C. Reutelingsperger. 1995. A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods 184:39.
41. Verhoven, B., S. Krahling, R. A. Schlegel, and P. Williamson. 1999. Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes. Cell Death Differ. 6:262.
42. Krahling, S., M. K. Callahan, P. Williamson, and R. A. Schlegel. 1999. Exposure of phosphatidylserine is a general feature in the phagocytosis of apoptotic lymphocytes by macrophages. Cell Death Differ. 6:183.
43. Segundo, C., F. Medina, C. Rodriguez, R. Martinez-Palencia, F. Leyva-Cobian, and J. A. Brieva. 1999. Surface molecule loss and bleb formation by human germinal center B cells undergoing apoptosis: role of apoptotic blebs in monocyte chemotaxis. Blood 94:1012.
44. Van Eijk, M., and C. de Groot. 1999. Germinal center B cell apoptosis requires both caspase and cathepsin activity. J. Immunol. 163:2478.
45. Zheng, N. Y., K. Wilson, X. Wang, A. Boston, G. R. Kolar, S. M. Jackson, Y. J. Liu, V. Pascual, J. D. Capra, and P. C. Wilson. 2004. Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C-δ class-switched B cells. J. Clin. Invest. 113:1188.
46. H4 gene segment repertoire in the human tonsil. Chem. Immunol. 67:45.
47. Wilson, P. C., O. de Bouteiller, Y. J. Liu, K. Potter, J. Banchereau, J. D. Capra, and V. Pascual. 1998. Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J. Exp. Med. 187:59.
48. Liu, Y. J., O. de Bouteiller, C. Arpin, I. Durand, and J. Banchereau. 1994. Five human mature B cell subsets. Adv. Exp. Med. Biol. 355:289.
49. Liu, Y. J., C. Barthelemy, O. de Bouteiller, and J. Banchereau. 1994. The differences in survival and phenotype between centroblasts and centrocytes. Adv. Exp. Med. Biol. 355:213.
50. H gene replacement. Ann. NY Acad. Sci. 987:270.
51. Zemlin, M., K. Bauer, M. Hummel, S. Pfeiffer, S. Devers, C. Zemlin, H. Stein, and H. T. Versmold. 2001. The diversity of rearranged immunoglobulin heavy chain variable region genes in peripheral blood B cells of preterm infants is restricted by short third complementarity-determining regions but not by limited gene segment usage. Blood 97:1511.
52. Radic, M. Z., J. Mackle, J. Erikson, C. Mol, W. F. Anderson, and M. Weigert. 1993. Residues that mediate DNA binding of autoimmune antibodies. J. Immunol. 150:4966.
53. Aguilera, I., J. Melero, A. Nunez-Roldan, and B. Sanchez. 2001. Molecular structure of eight human autoreactive monoclonal antibodies. Immunology 102:273.
54. Callahan, M. K., M. S. Halleck, S. Krahling, A. J. Henderson, P. Williamson, and R. A. Schlegel. 2003. Phosphatidylserine expression and phagocytosis of apoptotic thymocytes during differentiation of monocytic cells. J. Leukocyte Biol. 74:846.
55. Dillon, S. R., A. Constantinescu, and M. S. Schlissel. 2001. Annexin V binds to positively selected B cells. J. Immunol. 166:58.
56. Dillon, S. R., M. Mancini, A. Rosen, and M. S. Schlissel. 2000. Annexin V binds to viable B cells and colocalizes with a marker of lipid rafts upon B cell receptor activation. J. Immunol. 164:1322.
57. Wardemann, H., S. Yurasov, A. Schaefer, J. W. Young, E. Meffre, and M. C. Nussenzweig. 2003. Predominant autoantibody production by early human B cell precursors. Science 301:1374.
58. Ninomiya, E., Y. Ito, M. A. Shibata, K. Kawashima, T. Sakamoto, E. Maruyama, H. Doi, K. Tokitsu, and Y. Otsuki. 2003. The activation of caspase-3 and DNA fragmentation in B cells phagocytosed by macrophages. Med. Electron Microsc. 36:87.
59. Nakamura, M., H. Yagi, S. Kayaba, T. Ishii, T. Gotoh, S. Ohtsu, and T. Itoh. 1996. Death of germinal center B cells wilhout DNA fragmentation. Eur. J. Immunol. 26:1211.
60. Allen, D., T. Simon, F. Sablitzky, K. Rajewsky, and A. Cumano. 1988. Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J. 7:1995.
61. Casola, S., K. L. Otipoby, M. Alimzhanov, S. Humme, N. Uyttersprot, J. L. Kutok, M. C. Carroll, and K. Rajewsky. 2004. B cell receptor signal strength determines B cell fate. Nat. Immunol. 5:317.
62. Niiro, H., and E. A. Clark. 2002. Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2:945.
63. Pittner, B. T., and E. C. Snow. 1998. Strength of signal through BCR determines the fate of cycling B cells by regulating the expression of the Bcl-2 family of survival proteins. Cell. Immunol. 186:55.