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Volumn 9, Issue 2, 1997, Pages 256-262

Mechanisms of selection and differentiation in germinal centers

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CELL DIFFERENTIATION; CELL SELECTION; GERMINAL CENTER; MEMORY CELL; PLASMA CELL; REVIEW; T LYMPHOCYTE;

EID: 0030887835     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(97)80145-8     Document Type: Article
Times cited : (54)

References (56)
  • 1
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • of special interest. A comprehensive review of early and late B cell development.
    • Rajewsky K. Clonal selection and learning in the antibody system. of special interest Nature. 381:1996;751-758 A comprehensive review of early and late B cell development.
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 2
    • 0029665307 scopus 로고    scopus 로고
    • In vitro analysis of the generation and propagation of memory B cells
    • Klinman NR. In vitro analysis of the generation and propagation of memory B cells. Immunol Rev. 150:1996;91-111.
    • (1996) Immunol Rev , vol.150 , pp. 91-111
    • Klinman, N.R.1
  • 3
    • 0002716483 scopus 로고    scopus 로고
    • The paths and molecular controls of peripheral B-cell development
    • of special interest. An updated review of peripheral B cell development in humans.
    • Liu YJ, Banchereau J. The paths and molecular controls of peripheral B-cell development. of special interest Immunologist. 4:1996;55-66 An updated review of peripheral B cell development in humans.
    • (1996) Immunologist , vol.4 , pp. 55-66
    • Liu, Y.J.1    Banchereau, J.2
  • 5
    • 0027994675 scopus 로고
    • Biology of germinal centers in lymphoid tissue
    • Thorbecke GJ, Amin AR, Tsiagbe VK. Biology of germinal centers in lymphoid tissue. FASEB J. 8:1994;832-840.
    • (1994) FASEB J , vol.8 , pp. 832-840
    • Thorbecke, G.J.1    Amin, A.R.2    Tsiagbe, V.K.3
  • 7
    • 0030001674 scopus 로고    scopus 로고
    • Immunological memory and protective immunity: Understanding their relation
    • Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science. 272:1996;54-60.
    • (1996) Science , vol.272 , pp. 54-60
    • Ahmed, R.1    Gray, D.2
  • 8
    • 0028049190 scopus 로고
    • Developmental switches in the immune system
    • Weissman IL. Developmental switches in the immune system. Cell. 76:1994;207-218.
    • (1994) Cell , vol.76 , pp. 207-218
    • Weissman, I.L.1
  • 9
    • 0028182886 scopus 로고
    • Differentiation of the secondary B-lymphocyte repertoire: The germinal center reaction
    • Nossal GJ. Differentiation of the secondary B-lymphocyte repertoire: the germinal center reaction. Immunol Rev. 137:1994;173-183.
    • (1994) Immunol Rev , vol.137 , pp. 173-183
    • Nossal, G.J.1
  • 10
    • 0027273684 scopus 로고
    • Somatic mutation and memory
    • Berek C. Somatic mutation and memory. Curr Opinion Immunol. 5:1993;218-222.
    • (1993) Curr Opinion Immunol , vol.5 , pp. 218-222
    • Berek, C.1
  • 12
    • 0029917123 scopus 로고    scopus 로고
    • Human germinal center B cells express the apoptosis inducing genes Fas, c-myc, P53 and Bax but not the survival gene bcl-2
    • of special interest. See annotation [14].
    • Martinez-Valdez H, Guret C, De Bouteiller O, Fugier I, Banchereau J, Liu YJ. Human germinal center B cells express the apoptosis inducing genes Fas, c-myc, P53 and Bax but not the survival gene bcl-2. of special interest J Exp Med. 183:1996;971-977 See annotation [14].
    • (1996) J Exp Med , vol.183 , pp. 971-977
    • Martinez-Valdez, H.1    Guret, C.2    De Bouteiller, O.3    Fugier, I.4    Banchereau, J.5    Liu, Y.J.6
  • 14
    • 0028897446 scopus 로고
    • Transfection of the c-myc oncogene into normal Epstein-Barr virus-harboring B cells results in new phenotypic and functional features resembling those of Burkitt lymphoma cells and normal centroblasts
    • of special interest. This paper, together with [12,13], shows that c-myc expression confers two unique features to GC centroblasts, high proliferation rate and apoptotic propensity.
    • Cutrona G, Ulivi M, Fais F, Roncella S, Ferrarini M. Transfection of the c-myc oncogene into normal Epstein-Barr virus-harboring B cells results in new phenotypic and functional features resembling those of Burkitt lymphoma cells and normal centroblasts. of special interest J Exp Med. 181:1995;699-711 This paper, together with [12,13], shows that c-myc expression confers two unique features to GC centroblasts, high proliferation rate and apoptotic propensity.
    • (1995) J Exp Med , vol.181 , pp. 699-711
    • Cutrona, G.1    Ulivi, M.2    Fais, F.3    Roncella, S.4    Ferrarini, M.5
  • 15
    • 0022556211 scopus 로고
    • Antigen-driven selection of virgin and memory B cells
    • MacLennan ICM, Gray D. Antigen-driven selection of virgin and memory B cells. Immunol Rev. 9:1986;61-85.
    • (1986) Immunol Rev , vol.9 , pp. 61-85
    • MacLennan, I.C.M.1    Gray, D.2
  • 16
    • 0023865664 scopus 로고
    • In vivo obtained antigen presented by germinal center B cells to T cells in vitro
    • Kosco MH, Szakal AK, Tew JG. In vivo obtained antigen presented by germinal center B cells to T cells in vitro. J Immunol. 140:1988;354-360.
    • (1988) J Immunol , vol.140 , pp. 354-360
    • Kosco, M.H.1    Szakal, A.K.2    Tew, J.G.3
  • 18
    • 0027491651 scopus 로고
    • Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections
    • Küppers R, Zhao M, Hansmann M-L, Rajewsky K. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J. 12:1993;4955-4967.
    • (1993) EMBO J , vol.12 , pp. 4955-4967
    • Küppers, R.1    Zhao, M.2    Hansmann, M.-L.3    Rajewsky, K.4
  • 19
    • 0031041644 scopus 로고    scopus 로고
    • Germinal center founder cells display propensity for apoptosis before onset of somatic mutation
    • Lebecque S, De Bouteiller O, Arpin C, Banchereau J, Liu YJ. Germinal center founder cells display propensity for apoptosis before onset of somatic mutation. J Exp Med. 185:1997;563-571.
    • (1997) J Exp Med , vol.185 , pp. 563-571
    • Lebecque, S.1    De Bouteiller, O.2    Arpin, C.3    Banchereau, J.4    Liu, Y.J.5
  • 20
    • 0026515436 scopus 로고
    • Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen
    • Weiss U, Zoebelein R, Rajewsky K. Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen. Eur J Immunol. 22:1992;511-517.
    • (1992) Eur J Immunol , vol.22 , pp. 511-517
    • Weiss, U.1    Zoebelein, R.2    Rajewsky, K.3
  • 21
    • 0025273816 scopus 로고
    • The generation of B-cell memory: A working hypothesis
    • Klinman NR, Linton PJ. The generation of B-cell memory: a working hypothesis. Curr Top Microbiol Immunol. 159:1990;19-35.
    • (1990) Curr Top Microbiol Immunol , vol.159 , pp. 19-35
    • Klinman, N.R.1    Linton, P.J.2
  • 22
    • 0027533532 scopus 로고
    • Soluble antigen profoundly reduces memory B-cell numbers even when given after challenge immunization
    • Nossal GJ, Karvelas M, Pulendran B. Soluble antigen profoundly reduces memory B-cell numbers even when given after challenge immunization. Proc Natl Acad Sci USA. 90:1993;3088-3092.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3088-3092
    • Nossal, G.J.1    Karvelas, M.2    Pulendran, B.3
  • 23
    • 0029014435 scopus 로고
    • Antigen-induced B-cell death and elimination during germinal-centre immune responses
    • of special interest. See annotation [26].
    • Shokat KM, Goodnow CC. Antigen-induced B-cell death and elimination during germinal-centre immune responses. of special interest Nature. 375:1995;334-338 See annotation [26].
    • (1995) Nature , vol.375 , pp. 334-338
    • Shokat, K.M.1    Goodnow, C.C.2
  • 24
    • 0029059370 scopus 로고
    • Soluble antigen can cause enhanced apoptosis of germinal-centre B cells
    • of special interest. See annotation [26].
    • Pulendran B, Kannourakis G, Nouri S, Smith KGC, Nossal GJV. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. of special interest Nature. 375:1995;331-334 See annotation [26].
    • (1995) Nature , vol.375 , pp. 331-334
    • Pulendran, B.1    Kannourakis, G.2    Nouri, S.3    Smith, K.G.C.4    Nossal, G.J.V.5
  • 25
    • 0029052398 scopus 로고
    • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers
    • of special interest. See annotation [26].
    • Han S, Hathcock K, Kheng B, Kepler TB, Hodes R, Kelsoe G. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. of special interest J Immunol. 155:1995;556-567 See annotation [26].
    • (1995) J Immunol , vol.155 , pp. 556-567
    • Han, S.1    Hathcock, K.2    Kheng, B.3    Kepler, T.B.4    Hodes, R.5    Kelsoe, G.6
  • 26
    • 0030061131 scopus 로고    scopus 로고
    • CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype
    • of special interest. This paper together with [23-25] directly shows antigen-induced apoptosis in GCs, which might reflect a negative selection mechanism on autoreactive B cells generated by somatic hypermuation.
    • Galibert L, Burdin N, De Saint-Vis B, Garrone P, Van Kooten C, Banchereau J, Rousset F. CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype. of special interest J Exp Med. 183:1996;77-85 This paper together with [23-25] directly shows antigen-induced apoptosis in GCs, which might reflect a negative selection mechanism on autoreactive B cells generated by somatic hypermuation.
    • (1996) J Exp Med , vol.183 , pp. 77-85
    • Galibert, L.1    Burdin, N.2    De Saint-Vis, B.3    Garrone, P.4    Van Kooten, C.5    Banchereau, J.6    Rousset, F.7
  • 27
    • 0029965138 scopus 로고    scopus 로고
    • Balancing immunity and tolerance: Deleting and tuning lymphocyte repertoires
    • Goodnow CC. Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci USA. 93:1996;2264-2271.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2264-2271
    • Goodnow, C.C.1
  • 28
    • 0028032155 scopus 로고
    • Positive selection of lymphocytes
    • Von Boehmer H. Positive selection of lymphocytes. Cell. 76:1994;219-227.
    • (1994) Cell , vol.76 , pp. 219-227
    • Von Boehmer, H.1
  • 30
    • 0025951891 scopus 로고
    • Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens
    • Liu Y-J, Zhang J, Lane PJL, Chan EY-T, MacLennan ICM. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur J Immunol. 21:1991;2951-2962.
    • (1991) Eur J Immunol , vol.21 , pp. 2951-2962
    • Liu, Y.-J.1    Zhang, J.2    Lane, P.J.L.3    Chan, E.-T.4    MacLennan, I.C.M.5
  • 31
    • 0027529976 scopus 로고
    • The dynamic relationship between B-cell populations in adults
    • MacLennan I, Chan E. The dynamic relationship between B-cell populations in adults. Immunol Today. 14:1993;29-34.
    • (1993) Immunol Today , vol.14 , pp. 29-34
    • MacLennan, I.1    Chan, E.2
  • 33
    • 0027236043 scopus 로고
    • B cell apoptosis induced by antigen receptor cross-linking is blocked by T cell signal through CD40
    • Tsubata T, Wu J, Honjo T. B cell apoptosis induced by antigen receptor cross-linking is blocked by T cell signal through CD40. Nature. 364:1993;645-648.
    • (1993) Nature , vol.364 , pp. 645-648
    • Tsubata, T.1    Wu, J.2    Honjo, T.3
  • 34
    • 0027998754 scopus 로고
    • Antibodies to murine CD40 protect normal and malignant B cells from induced growth arrest
    • Santos-Argumedo L, Gordon J, Heath AW, Howard M. Antibodies to murine CD40 protect normal and malignant B cells from induced growth arrest. Cell Immunol. 156:1994;272-285.
    • (1994) Cell Immunol , vol.156 , pp. 272-285
    • Santos-Argumedo, L.1    Gordon, J.2    Heath, A.W.3    Howard, M.4
  • 35
    • 0026427043 scopus 로고
    • Growing human B lymphocytes in the CD40 system
    • Banchereau J, Rousset F. Growing human B lymphocytes in the CD40 system. Nature. 353:1991;678-679.
    • (1991) Nature , vol.353 , pp. 678-679
    • Banchereau, J.1    Rousset, F.2
  • 36
    • 23444461024 scopus 로고
    • How B and T cells talk to each other
    • Clark EA, Ledbetter JA. How B and T cells talk to each other. Nature. 367:1994;425-428.
    • (1994) Nature , vol.367 , pp. 425-428
    • Clark, E.A.1    Ledbetter, J.A.2
  • 38
    • 0029046321 scopus 로고
    • CD40 ligand-independent B cell activation revealed by CD40 ligand-deficient T cell clones: Evidence for distinct activation requirements for antibody formation and B cell proliferation
    • of special interest. See annotation [39].
    • Lane P, Burdet C, McConnell F, Lanzavecchia A, Padovan E. CD40 ligand-independent B cell activation revealed by CD40 ligand-deficient T cell clones: evidence for distinct activation requirements for antibody formation and B cell proliferation. of special interest Eur J Immunol. 25:1995;1788-1793 See annotation [39].
    • (1995) Eur J Immunol , vol.25 , pp. 1788-1793
    • Lane, P.1    Burdet, C.2    McConnell, F.3    Lanzavecchia, A.4    Padovan, E.5
  • 39
    • 0028860544 scopus 로고
    • CD40-cross-linking inhibits specific antibody production by human B cells
    • of special interest. This paper together with [37,38] demonstrates that the CD40 ligand directs B cell differentiation towards memory B cells, by inhibiting plasma cell differentiation.
    • Callard RE, Herbert J, Smith SH, Armitage RJ, Costelloe KE. CD40-cross-linking inhibits specific antibody production by human B cells. of special interest Int Immunol. 7:1995;1809-1815 This paper together with [37,38] demonstrates that the CD40 ligand directs B cell differentiation towards memory B cells, by inhibiting plasma cell differentiation.
    • (1995) Int Immunol , vol.7 , pp. 1809-1815
    • Callard, R.E.1    Herbert, J.2    Smith, S.H.3    Armitage, R.J.4    Costelloe, K.E.5
  • 40
    • 0030152162 scopus 로고    scopus 로고
    • CD40 and its ligand in host defense
    • Noelle RJ. CD40 and its ligand in host defense. Immunity. 4:1996;415-419.
    • (1996) Immunity , vol.4 , pp. 415-419
    • Noelle, R.J.1
  • 41
    • 0027056241 scopus 로고
    • Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles. Roles of T cell-B cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help
    • Lederman S, Yellin MJ, Inghirami G, Lee JJ, Knowles DM, Chess L. Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles. Roles of T cell-B cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help. J Immunol. 149:1992;3817-3826.
    • (1992) J Immunol , vol.149 , pp. 3817-3826
    • Lederman, S.1    Yellin, M.J.2    Inghirami, G.3    Lee, J.J.4    Knowles, D.M.5    Chess, L.6
  • 42
    • 0028939698 scopus 로고
    • + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex
    • of special interest. This paper together with [41] concludes that a subset of GC T cells express CD40 ligand.
    • + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex. of special interest J Exp Med. 181:1995;1293-1301 This paper together with [41] concludes that a subset of GC T cells express CD40 ligand.
    • (1995) J Exp Med , vol.181 , pp. 1293-1301
    • Casamayor-Palleja, M.1    Khan, M.2    MacLennan, I.C.M.3
  • 43
    • 0028964162 scopus 로고
    • Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid upregulation of B7.1 and B7.2
    • Liu YJ, Barthélémy C, De Bouteiller O, Arpin C, Durand I, Banchereau J. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid upregulation of B7.1 and B7.2. Immunity. 2:1995;238-248.
    • (1995) Immunity , vol.2 , pp. 238-248
    • Liu, Y.J.1    Barthélémy, C.2    De Bouteiller, O.3    Arpin, C.4    Durand, I.5    Banchereau, J.6
  • 44
    • 0028799935 scopus 로고
    • Fas ligation induces apoptosis of CD40-activated human B lymphocytes
    • of special interest. See annotation [47].
    • Garrone P, Neidhardt EM, Garcia E, Galibert L, Van Kooten C, Banchereau J. Fas ligation induces apoptosis of CD40-activated human B lymphocytes. of special interest J Exp Med. 182:1995;1265-1273 See annotation [47].
    • (1995) J Exp Med , vol.182 , pp. 1265-1273
    • Garrone, P.1    Neidhardt, E.M.2    Garcia, E.3    Galibert, L.4    Van Kooten, C.5    Banchereau, J.6
  • 45
    • 0028920079 scopus 로고
    • Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells
    • of special interest. See annotation [47].
    • Rothstein TL, Wang JKM, Panka DJ, Foote LC, Wang Z, Stanger B, Cui H, Ju S-T, Marshak-Rothstein A. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. of special interest Nature. 374:1995;163-165 See annotation [47].
    • (1995) Nature , vol.374 , pp. 163-165
    • Rothstein, T.L.1    Wang, J.K.M.2    Panka, D.J.3    Foote, L.C.4    Wang, Z.5    Stanger, B.6    Cui, H.7    Ju, S.-T.8    Marshak-Rothstein, A.9
  • 46
    • 0029913687 scopus 로고    scopus 로고
    • Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis
    • of special interest. See annotation [47].
    • Lagresle C, Mondière P, Bella C, Krammer PH, Defrance T. Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis. of special interest J Exp Med. 183:1996;1377-1388 See annotation [47].
    • (1996) J Exp Med , vol.183 , pp. 1377-1388
    • Lagresle, C.1    Mondière, P.2    Bella, C.3    Krammer, P.H.4    Defrance, T.5
  • 47
    • 0030070299 scopus 로고    scopus 로고
    • Expression and function of Fas antigen on activated murine B cells
    • of special interest. This paper together with [44-46,48] shows that although antigen-receptor triggering protected B cells from Fas-mediated apoptosis in vitro, CD40 triggering did not protect B cells from Fas-mediated apoptosis and that even primed resting B cells become sensitive to Fas-mediated apoptosis.
    • Wang J, Taniuchi I, Maekawa Y, Howard M, Cooper MD, Watanabe T. Expression and function of Fas antigen on activated murine B cells. of special interest Eur J Immunol. 26:1996;92-96 This paper together with [44-46,48] shows that although antigen-receptor triggering protected B cells from Fas-mediated apoptosis in vitro, CD40 triggering did not protect B cells from Fas-mediated apoptosis and that even primed resting B cells become sensitive to Fas-mediated apoptosis.
    • (1996) Eur J Immunol , vol.26 , pp. 92-96
    • Wang, J.1    Taniuchi, I.2    Maekawa, Y.3    Howard, M.4    Cooper, M.D.5    Watanabe, T.6
  • 48
    • 0030592564 scopus 로고    scopus 로고
    • Expansion or elimination of B cells in vivo: Dual roles for CD40- And Fas (CD95)-Ligand modulated by the B cell antigen receptor
    • of special interest. This paper provides direct in vivo evidence that only antigen receptor triggering enables CD40 ligand or Fas ligand to exert positive signals to B cells. It suggests that the bystander T-B cell interaction may lead to B cell death.
    • Rathmell JC, Townsend SE, Xu JC, Flavell RA, Goodnow CC. Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-Ligand modulated by the B cell antigen receptor. of special interest Cell. 87:1996;319-329 This paper provides direct in vivo evidence that only antigen receptor triggering enables CD40 ligand or Fas ligand to exert positive signals to B cells. It suggests that the bystander T-B cell interaction may lead to B cell death.
    • (1996) Cell , vol.87 , pp. 319-329
    • Rathmell, J.C.1    Townsend, S.E.2    Xu, J.C.3    Flavell, R.A.4    Goodnow, C.C.5
  • 49
    • 0027411552 scopus 로고
    • Direct evidence that human follicular dendritic cells (FDC) rescue germinal center cells from death by apoptosis
    • Lindhout E, Mevissen ML, Kwekkeboom J, Tager JM, De-Groot C. Direct evidence that human follicular dendritic cells (FDC) rescue germinal center cells from death by apoptosis. Clin Exp Immunol. 91:1993;330-336.
    • (1993) Clin Exp Immunol , vol.91 , pp. 330-336
    • Lindhout, E.1    Mevissen, M.L.2    Kwekkeboom, J.3    Tager, J.M.4    De-Groot, C.5
  • 50
    • 0027466402 scopus 로고
    • A subset of anti-CD21 antibodies promote the rescue of germinal center B cells from apoptosis
    • Bonnefoy JY, Henchoz S, Hardie D, Holder MJ, Gordon J. A subset of anti-CD21 antibodies promote the rescue of germinal center B cells from apoptosis. Eur J Immunol. 23:1993;969-972.
    • (1993) Eur J Immunol , vol.23 , pp. 969-972
    • Bonnefoy, J.Y.1    Henchoz, S.2    Hardie, D.3    Holder, M.J.4    Gordon, J.5
  • 51
    • 15844412034 scopus 로고    scopus 로고
    • Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen
    • of special interest. See annotation [52].
    • Ahearn JM, Fischer MB, Croix D, Goerg S, Ma M, Xia J, Zhou X, Howard RG, Rothstein TL, Carroll MC. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. of special interest Immunity. 4:1996;251-262 See annotation [52].
    • (1996) Immunity , vol.4 , pp. 251-262
    • Ahearn, J.M.1    Fischer, M.B.2    Croix, D.3    Goerg, S.4    Ma, M.5    Xia, J.6    Zhou, X.7    Howard, R.G.8    Rothstein, T.L.9    Carroll, M.C.10
  • 52
    • 0030593030 scopus 로고    scopus 로고
    • C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
    • of special interest. This paper together with [51] demonstrates again that complement fragment C3d and its receptor CR2 play key roles in GC reactions and in humoral immune responses.
    • Dempsey PW, Allison ME, Akkaraju S, Goodnow CC, Fearon DT. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. of special interest Science. 271:1996;348-350 This paper together with [51] demonstrates again that complement fragment C3d and its receptor CR2 play key roles in GC reactions and in humoral immune responses.
    • (1996) Science , vol.271 , pp. 348-350
    • Dempsey, P.W.1    Allison, M.E.2    Akkaraju, S.3    Goodnow, C.C.4    Fearon, D.T.5
  • 53
    • 0023652377 scopus 로고
    • Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary response
    • Siekevitz M, Kocks C, Rajewsky K, Dildrop R. Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary response. Cell. 48:1987;757-770.
    • (1987) Cell , vol.48 , pp. 757-770
    • Siekevitz, M.1    Kocks, C.2    Rajewsky, K.3    Dildrop, R.4
  • 54
    • 0025201892 scopus 로고
    • Development of B cell lineages during a primary anti-hapten immune response
    • Tao W, Bothwell AL. Development of B cell lineages during a primary anti-hapten immune response. J Immunol. 145:1990;3216-3222.
    • (1990) J Immunol , vol.145 , pp. 3216-3222
    • Tao, W.1    Bothwell, A.L.2
  • 55
    • 0024470168 scopus 로고
    • Molecular analysis of original antigenic sin I. Clonal selection, somatic mutation and isotype switching during a memory B cell response
    • Fish S, Zenowich E, Fleming M, Manser T. Molecular analysis of original antigenic sin I. Clonal selection, somatic mutation and isotype switching during a memory B cell response. J Exp Med. 170:1989;1191-1209.
    • (1989) J Exp Med , vol.170 , pp. 1191-1209
    • Fish, S.1    Zenowich, E.2    Fleming, M.3    Manser, T.4
  • 56
    • 0024357983 scopus 로고
    • Molecular analysis of clonal stability and longevity in B cell memory
    • Dell CL, Lu Y, Claflin JL. Molecular analysis of clonal stability and longevity in B cell memory. J Immunol. 143:1989;3364-3370.
    • (1989) J Immunol , vol.143 , pp. 3364-3370
    • Dell, C.L.1    Lu, Y.2    Claflin, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.