Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: Preparation and characterization

Bioconjugate Chemistry

Volumn 14, Issue 2, 2003, Pages 420-429

  Choi, Joon Sig ^a   MacKay, J Andrew ^a   Szoka Jr , Francis C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENCAPSULATION; GENE THERAPY; GENE TRANSFER; PH SENSORS;

ACID-LABILE; CATIONIC LIPIDS; ENDOSOMES; IN-VITRO; LIPID NANOPARTICLES; NANOPARTICLE CHARACTERISATION; NANOPARTICLE PREPARATIONS; PH SENSITIVE; PHOSPHATIDYLETHANOLAMINE; POLY(ETHYLENE GLYCOL);

NANOPARTICLES;

DISTEAROYLGLYCEROL; GLYCEROL DERIVATIVE; LIPID; MACROGOL; NANOPARTICLE; PHOSPHATIDYLETHANOLAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; ENCAPSULATION; ENDOSOME; GENE THERAPY; GENE TRANSFER; IN VITRO STUDY; INCUBATION TIME; NONHUMAN; PH; PHYSICAL CHEMISTRY; PLASMID;

ANIMALIA;

EID: 0037345649     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc025625w     Document Type: Article

References (36)

1. Asokan, A., and Cho, M. J. (2002) Exploitation of Intracellular pH Gradients in the Cellular Delivery of Macromolecules. J. Pharm. Sci. 91, 903-913.
2. Banerjee, R., Das, P. K., and Chaudhuri, A. (1988) Interfacial indazolization: novel chemical evidence for remarkably high exo-surface pH of cationic liposomes used in gene transfection. Biochim. Biophys. Acta 1373, 299-308.
3. Boomer, J. A., and Thompson, D. H. (1999) Synthesis of Acid-labile Diplasmenyl Lipids for Drug and Gene Delivery Applications. Chem. Phys. Lipids 99, 145-153.
4. Budker, V., Gurevich, V., Hagstrom, J. E., Bortzov, F., and Wolff, J. A. (1996) pH-sensitive, cationic liposomes: A new synthetic virus-like vector. Nat. Biotech. 14, 760-764.
5. Choi, J. S., Lee, E. J., Choi, Y. H., Jeong, Y. J., and Park, J. S. (1999) Poly(ethylene glycol)-block-poly(L-lysine) Dendrimer: Novel Linear Polymer/Dendrimer Block Copolymer Forming a Spherical Water-Soluble Polyionic Complex with DNA. Bioconjate Chem. 10, 62-65.
6. Choi, J. S., Joo, D. K., Kim, C. H., Kim, K., and Park, J. S. (2000) Synthesis of a barbell-like triblock copolymer, poly(L- lysine) dendrimer-block-poly(ethylene glycol)-block-poly(L- lysine) dendrimer, and its self-assembly with plasmid DNA. J. Am. Chem. Soc. 122, 474-480.
7. Deshiikan, S. R., and Papadopoulos, K. D. (1998) Modified Booth equation for the calculation of zeta potential. Colloid Polym. Sci. 276, 117-124.
8. Dillman, R. O., Johnson, D. E., Shawler, D. L., and Koziol, J. A. (1988) Superiority of an Acid-labile Daunorubicin-Monoclonal Antibody Immunoconjugate Compared to Free Drug. Cancer Res. 48, 6097-6102.
9. Drummond D. C., Zignani, M., and Leroux, J. (2000) Current Status of pH-Sensitive Liposomes in Drug Delivery. Prog. Lipid Res. 39, 409-460.
10. Felgner, J. H., Kumar, R., Sridhar, C. N., Wheeler, C. J., Tsai, Y. J., Border, R., Ramsey, P., Martin, M., and Felgner, P. L. (1994) Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J. Biol. Chem. 269, 2550-2561.
11. Fenske, D. B., Palmer, L. R., Chen, T., Wong, K. F., and Cullis, P. R. (2001) Cationic Poly(ethyleneglycol) Lipids Incorporated into Preformed Vesicles Enhance Binding and Uptake to BHK Cells. Biochim. Biophys. Acta 1512, 259-272.
12. Fernandez, M. S., and Fromherz, P. (1977) Lipoid pH Indicators as Probes of Electrical Potential and Polarity in Micelles. J. Phys. Chem. 81, 1755-1761.
13. Guo, X., and Szoka, F. C., Jr. (2001) Steric Stabilization of Fusogenic Liposomes by a Low-pH Sensitive PEG-Diortho Ester-Lipid Conjugate. Bioconj. Chem. 12, 291-300.
14. Guo, X., MacKay, J. A., and Szoka, F. C., Jr. (2003) Mechanism of pH-Triggered Collapse of Phosphatidylethanolamine Liposomes Stabilized by an Orthoester Poly(ethylene glycol) Lipid. Biophys. J. 84, in press.
15. Hellberg, P., Bergström, K., and Juberg, M. (2000) Nonionic Cleavable Ortho Ester Surfactants. J. Surfactants Deterg. 3, 369-379.
16. Heller, J. (1993) Polymers for Controlled Parenteral Delivery of Peptides and Proteins. Adv. Drug Deliv. Rev. 10, 163-204.
17. Henry, C. M. (2001) Gene Delivery - without Viruses. Chem. Eng. News 79, 35-41.
18. Hofland, H. E., Shephard, L., and Sullivan, S. M. (1996) Formation of Stable Cationic Lipid/DNA Complexes for Gene Transfer. Proc. Natl. Acad. Sci. U.S.A. 93, 7305-7309.
19. Hood, J. D., Bednarski, M., Frausto, R., Guccione, S., Reisfeld, R. A., Xiang, R., and Cheresh, D. A. (2002) Tumor Regression by Targeted Gene Delivery to the Neovasculature. Science 296, 2404-2407.
20. Kakizawa, Y., and Kataoka, K. (2002) Block copolymer micelles for delivery of gene and related compounds. Adv. Drug Deliv. Rev. 54, 203-222.
21. Kraayenhof, R., Sterk, G. J., and Wong Fong Sang, H. W. (1993) Probing Biomembrane Interfacial Potential and pH Profiles with a New Type of Float-like Fluorophores Positioned at Varying Distance from the Membrane Surface. Biochemistry 32, 10057-10066.
22. Legendre, J., and Szoka, F. C., Jr. (1992) Delivery of Plamid DNA into Mammalian Cell Lines Using pH-Sensitive Liposomes: Comparison with Cationic Liposomes. Pharm. Res. 9, 1235-1242.
23. Marshall, E. (2001) Viral Vectors Still Pack Surprises. Science 294, 1640.
24. McLaughlin, S. (1989) The electrostatic properties of membranes. Annu. Rev. Biophys. Biophys. Chem. 18, 113-36.
25. Miller, C. R., Bondurant, B., McLean, S. D., McGovern, K. A., and O'Brien, D. F. (1998) Liposome-cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes. Biochemistry 37, 12875-83.
26. Mok, K. W. C., Lam, A. M. I., and Cullis, P. R. (1999) Stabilized Plasmid-Lipid Particles: Factors Influencing Plasmid Entrapment and Transfection Properties. Biochim. Biophys. Acta 1419, 137-150.
27. Ogris, M., and Wagner, E. (2002) Targeting Tumors with Nonviral Gene Delivery Systems. Drug Discov. Today 7, 479-485.
28. Remy, J., Abdallah, B., Zanta, M. A., Boussif, O., Behr, J., and Demeneix, B. (1998) Gene transfer with lipospermines and polyethylenimines. Adv. Drug. Del. Rev. 30, 85-95.
29. Shimada, K., Miyagishima, A., Sadzuka, Y., Nozawa, Y., Mochizuki, Y., Ohshima, H., and Hirota, S. (1995) Determination of the Thickness of the Fixed Aqueous Layer Around Polyethyleneglycol-coated Liposomes. J. Drug Targeting 3, 283-289.
30. Tam, P., Monck, M., Lee. D., Ludkovski, O., Leng, E. C., Clow, K., Stark, H., Scherrer, P., Graham, R. W., and Cullis, P. R. (2000) Stabilized Plasmid-Lipid Particles for Systemic Gene Therapy. Gene Ther. 7, 1867-1874.
31. Tocanne, J. F., and Tessie, J. (1990) Ionization of phospholipids and phospholipids-supported interfacial lateral diffusion of protons in membrane model systems. Biochim. Biophys. Acta 1031, 111-142.
32. Wheeler, J. J., Palmer, L., Ossanlou, M., MacLachlan, I., Graham, R. W., Zhang, Y. P., Hope, M. J., Scherrer, P., and Cullis, P. R. (1999) Stabilized Plasmid-Lipid Particles: Construction and Characterization. Gene Ther. 6, 271-281.
33. Yue, C., Harris, J. M., Hellberg., P., and Bergstrom, K. (1996) Synthesis and Characterization of Cleavable Surfactants Derived from Poly(ethylene glycol) Monomethyl Ether. J. Am. Oil Chem. Soc. 73, 841-845.
34. Zhang, Y. P., Sekirov, L., Saravolac, E. G. Wheeler, J. J., Tardi, P. Clow, K., Leng, E., Sun, R., and Cullis, P. R. (1999) Stabilized Plasmid-Lipid Particles for Regional Gene Therapy: Formulation and Transfection Properties. Gene Ther. 6, 1438-1447.
35. Zhu, J., Munn, R. J., and Nantz, M. H. (2000) Self-Cleaving Ortho Ester Lipids: A New Class of pH-Vulnerable Amphiphiles. J. Am. Chem. Soc. 122, 2645-2646.
36. Zuidam, N. J., and Barenholz, Y. (1997) Electrostatic parameters of cationic liposomes commonly used for gene delivery as determined by 4-heptadecyl-7-hydroxycoumarin. Biochim. Biophys. Acta 1329, 211-222.