Homing of intestinal immune cells

Novartis Foundation Symposium

Volumn 263, Issue , 2004, Pages 179-188

  Uhlig, Holm H ^a,b   Mottet, Christian ^a,c   Powrie, Fiona ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; SELECTIN;

BIOLOGICAL MODEL; CD4+ T LYMPHOCYTE; CYTOLOGY; ENTERITIS; HUMAN; IMMUNE SYSTEM; IMMUNOLOGY; INFLAMMATION; INTESTINE; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PEYER PATCH; REVIEW;

CD4-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNE SYSTEM; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; INTEGRINS; INTESTINAL MUCOSA; INTESTINES; MODELS, BIOLOGICAL; PEYER'S PATCHES; SELECTINS;

EID: 13844320539     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (47)

1. Ajuebor MN, Hogaboam CM, Kunkel SL, Proudfoot AE, Wallace JL 2001 The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat. J Immunol 166:552-558
2. Andres PG, Beck PL, Mizoguchi Eet al 2000 Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine. J Immunol 164:6303-6312
3. Baekkevold ES, Yamanaka T, Palframan RT et al 2001 The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J Exp Med 193:1105-1112
4. Banks C, Bateman A, Payne R, Johnson P, Sheron N 2003 Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease. J Pathol Bacteriol 199:28-35
5. Becker C, Wirtz S, Blessing M et al 2003 Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 112:693-706
6. Butcher EC, Picker LJ 1996 Lymphocyte homing and homeostasis. Science 272:60-66
7. Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG 2001 B cells and professional APCs recruit regulatory T cells via CCL4. Nat Immunol 2:1126-1132
8. Campbell DJ, Butcher EC 2002 Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues. J Exp Med 195:135-141
9. Campbell DJ, Kim CH, Butcher EC 2003 Chemokines in the systemic organization of immunity. Immunol Rev 195:58-71
10. Cebra JJ 1999 Influences of microbiota on intestinal immune system development. Am J Clin Nutr 69:1046S-1051S
11. Cook DN, Prosser DM, Forster R et al 2000 CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 12:495-503
12. Gao Z, Metz WA 2003 Unraveling the chemistry of chemokine receptor ligands. Chem Rev 103:3733-3752
13. Ghosh S, Goldin E, Gordon FH et al 2003 Natalizumab for active Crohn's disease. N Engl J Med 348:24-32
14. Gordon FH, Hamilton MI, Donoghue S et al 2002 A pilot study of treatment of active ulcerative colitis with natalizumab, a humanized monoclonal antibody to alpha-4 integrin. Aliment Pharmacol Ther 16:699-705
15. Gordon FH, Lai CW, Hamilton MI et al 2001 A randomized placebo-controlled trial of a humanized monoclonal antibody to alpha4 integrin in active Crohn's disease. Gastroenterology 121:268-274
16. Goulvestre C, Batteux F, Charreire J 2002 Chemokines modulate experimental autoimmune thyroiditis through attraction of autoreactive or regulatory T cells. Eur J Immunol 32:3435-3442
17. Gowans JL, Knight EJ 1964 The route of re-circulation of lymphocytes in the Rat. Proc R Soc Lond B Biol Sci 159:257-282
18. Hesterberg PE, Winsor-Hines D, Briskin MJ et al 1996 Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7. Gastroenterology 111:1373-1380
19. Iellem A, Mariani M, Lang R et al 2001 Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med 194:847-853
20. Iwasaki A, Kelsall BL 2000 Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine. J Exp Med 191:1381-1394
21. Iwasaki A, Kelsall BL 2001 Unique functions of CD11b+, CD8 alpha+, and double-negative Peyer's patch dendritic cells. J Immunol 166:4884-4890
22. Johansson-Lindbom B, Svensson M, Wurbel MA et al 2003 Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J Exp Med 198:963-969
23. Kanamori Y, Ishimaru K, Nanno M et al 1996 Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop. J Exp Med 184:1449-1459
24. Kraehenbuhl JP, Neutra MR 2000 Epithelial M cells: differentiation and function. Annu Rev Cell Dev Biol 16:301-332
25. Krajina T, Leithauser F, Moller P, Trobonjaca Z, Reimann J 2003 Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis. Eur J Immunol 33:1073-1083
26. Kunkel EJ, Campbell DJ, Butcher EC 2003 Chemokines in lymphocyte trafficking and intestinal immunity. Microcirculation 10:313-323
27. Malmstrom V, Shipton D, Singh B et al 2001 CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J Immunol 166:6972-6981
28. Maloy KJ, Powrie F 2001 Regulatory T cells in the control of immune pathology. Nat Immunol 2:816-822
29. Manlongat NTV, Mak S, Manning S, Picarella D 2003 Exploring the role of gastrointestinal homing receptors in murine models of inflammatory bowel disease. New York Academy of Sciences Conference. Oral tolerance: mechanisms and applications (abstr 19)
30. Mebius RE 2003 Organogenesis of lymphoid tissues. Nat Rev Immunol 3:292-303
31. Mora JR, Bono MR, Manjunath N et al 2003 Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 424:88-93
32. Mottet C, Uhlig HH, Powrie F 2003 Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 170:3939-3943
33. Mowat AM 2003 Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 3:331-341
34. Neutra MR, Pringault E, Kraehenbuhl JP 1996 Antigen sampling across epithelial barriers and induction of mucosal immune responses. Annu Rev Immunol 14:275-300
35. O'Neil D, Steidler L 2003 Cytokines, chemokines and growth factors in the pathogenesis and treatment of inflammatory bowel disease. Adv Exp Med Biol 252-285
36. Picarella D, Hurlbut P, Rottman J et al 1997 Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells. J Immunol 158:2099-2106
37. Sakaguchi S, Sakaguchi N, Shimizu J et al 2001 Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 182:18-32
38. Scheerens H, Hessel E, de Waal-Malefyt R, Leach MW, Rennick D 2001 Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/- mice and Rag-2-/- mice reconstituted with CD4+CD45RBhigh T cells. Eur J Immunol 31:1465-1474
39. Shevach EM 2002 CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2:389-400
40. Shreedhar VK, Kelsall BL, Neutra MR 2003 Cholera toxin induces migration of dendritic cells from the subepithelial dome region to T- and B-cell areas of Peyer's patches. Infect Immun 71:504-509
41. Sydora BC, Wagner N, Lohler J et al 2002 beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis. Clin Exp Immunol 129:35-42
42. Szanya V, Ermann J, Taylor C, Holness C, Fathman CG 2002 The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol 169:2461-2465
43. Takayama T, Morelli AE, Onai N et al 2001 Mammalian and viral IL-10 enhance C-C chemokine receptor 5 but down-regulate C-C chemokine receptor 7 expression by myeloid dendritic cells: impact on chemotactic responses and in vivo homing ability. J Immunol 166:7136-7143
44. Yamanaka T, Helgeland L, Farstad IN et al 2003 Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches. J Immunol 170:816-822
45. Yang S, Choi M, Kim O et al 2002 The increased expression of an array of C-X-C and C-C chemokines in the colonic mucosa of patients with ulcerative colitis: regulation by corticosteroids. Am J Gastroenterol 97:126-132
46. Yoshida M, Watanabe T, Usui T et al 2001 CD4 T cells monospecific to ovalbumin produced by Escherichia coli can induce colitis upon transfer to BALB/c and SCID mice. Int Immunol 13:1561-1570
47. Zhao X, Sato A, Dela Cruz CS et al 2003 CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol 171:2797-2803