메뉴 건너뛰기




Volumn 23, Issue 9, 1999, Pages 1425-1434

Involvement of the cyclic AMP-responsive element binding protein gene transcription factor in genetic preference for alcohol drinking behavior

Author keywords

Alcohol Preference; Brain; cAMP; CREB; Protein Kinase A

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR;

EID: 0032851509     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1999.tb04663.x     Document Type: Article
Times cited : (35)

References (50)
  • 2
    • 0000171238 scopus 로고
    • Mechanism of trans‐synaptic regulation of the gene expression
    • Comb M, Hyman SE (1987) Mechanism of trans‐synaptic regulation of the gene expression. Trends Neurosci 10: 473–478.
    • (1987) Trends Neurosci , vol.10 , pp. 473-478
    • Comb, M1    Hyman, SE2
  • 3
    • 0023257348 scopus 로고
    • Neurogenetic adaptive mechanisms in alcoholism. Science (Wash
    • Cloninger CR (1987) Neurogenetic adaptive mechanisms in alcoholism. Science (Wash. DC) 236: 410–416.
    • (1987) DC) , vol.236 , pp. 410-416
    • Cloninger, CR1
  • 4
    • 0028270269 scopus 로고
    • Neurotransmission in rat amygdala related to fear and anxiety
    • Davis M, Rainnie D, Cassell M (1994) Neurotransmission in rat amygdala related to fear and anxiety. Trends Neurosci 17: 208–214.
    • (1994) Trends Neurosci , vol.17 , pp. 208-214
    • Davis, M1    Rainnie, D2    Cassell, M3
  • 5
    • 0344948777 scopus 로고
    • Basal and adenosine receptor‐stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients
    • Diamond I, Wrubel B, Estrin W, Gordon A (1987) Basal and adenosine receptor‐stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients. Proc Natl Acad Sci USA 84: 1413–1416.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 1413-1416
    • Diamond, I1    Wrubel, B2    Estrin, W3    Gordon, A4
  • 6
    • 0027442942 scopus 로고
    • Transcriptional regulation of human corticotropin releasing factor gene expression by cyclic adenosine 3′,5′‐monophosphate: Differential effects at proximal and distal promoter elements
    • Dorin RI, Zlock DW, Kilpatrick K (1993) Transcriptional regulation of human corticotropin releasing factor gene expression by cyclic adenosine 3′,5′‐monophosphate: Differential effects at proximal and distal promoter elements. Mol Cell Endocrinol 96: 99–111.
    • (1993) Mol Cell Endocrinol , vol.96 , pp. 99-111
    • Dorin, RI1    Zlock, DW2    Kilpatrick, K3
  • 7
    • 0031760196 scopus 로고    scopus 로고
    • Neuropeptide Y levels in ethanol‐naive alcohol‐preferring and non‐preferring rats and in Wistar rats after ethanol exposure
    • Ehlers CL, Li T‐K, Lumeng L, Hwang BH, Somes C, Jimenez P, Marthe AA (1998) Neuropeptide Y levels in ethanol‐naive alcohol‐preferring and non‐preferring rats and in Wistar rats after ethanol exposure. Alcohol Clin Exp Res 22: 1778–1782.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 1778-1782
    • Ehlers, CL1    Li, T‐K2    Lumeng, L3    Hwang, BH4    Somes, C5    Jimenez, P6    Marthe, AA7
  • 8
    • 0026501345 scopus 로고
    • Corticotropin releasing factor (CRF): Studies in alcohol‐preferring (P) and ‐nonpreferring (NP) rats
    • Ehlers CL, Chaplin RI, Wall TL, Lumeng L, Li T‐K, Owens MJ, Nemeroff CB (1992) Corticotropin releasing factor (CRF): Studies in alcohol‐preferring (P) and ‐nonpreferring (NP) rats. Psychopharmacology 106: 359–364.
    • (1992) Psychopharmacology , vol.106 , pp. 359-364
    • Ehlers, CL1    Chaplin, RI2    Wall, TL3    Lumeng, L4    Li, T‐K5    Owens, MJ6    Nemeroff, CB7
  • 9
    • 0029081968 scopus 로고
    • Identifying alcoholism vulnerability alleles
    • Goldman D (1995) Identifying alcoholism vulnerability alleles. Alcohol Clin Exp Res 19: 824–831.
    • (1995) Alcohol Clin Exp Res , vol.19 , pp. 824-831
    • Goldman, D1
  • 10
    • 0024698559 scopus 로고
    • Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high‐and low‐alcohol drinking lines of rats
    • Gongwer MA, Murphy JM, McBride WJ, Lumeng L, Li T‐K (1989) Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high‐and low‐alcohol drinking lines of rats. Alcohol 6: 317–320.
    • (1989) Alcohol , vol.6 , pp. 317-320
    • Gongwer, MA1    Murphy, JM2    McBride, WJ3    Lumeng, L4    Li, T‐K5
  • 12
    • 0027207452 scopus 로고
    • Alcohol‐preferring (P) and ‐nonpreferring (NP) rats display different levels of neurofilament proteins in the ventral tegmental area
    • Guitart XL, Lumeng L, Li T‐K, Nestler EJ (1993) Alcohol‐preferring (P) and ‐nonpreferring (NP) rats display different levels of neurofilament proteins in the ventral tegmental area. Alcohol Clin Exp Res 17: 580–585.
    • (1993) Alcohol Clin Exp Res , vol.17 , pp. 580-585
    • Guitart, XL1    Lumeng, L2    Li, T‐K3    Nestler, EJ4
  • 13
    • 0025331134 scopus 로고
    • Ethanol and guanine nucleotide binding proteins: A selective interaction
    • Hoffman PL, Tabakoff B (1990) Ethanol and guanine nucleotide binding proteins: A selective interaction. Fed Am Soc Exp Biol J 4: 2612–2622.
    • (1990) Fed Am Soc Exp Biol J , vol.4 , pp. 2612-2622
    • Hoffman, PL1    Tabakoff, B2
  • 14
    • 0026636883 scopus 로고
    • The regulation of transcription by phosphorylation
    • Hunter T, Karin M (1992) The regulation of transcription by phosphorylation. Cell 70: 375–387.
    • (1992) Cell , vol.70 , pp. 375-387
    • Hunter, T1    Karin, M2
  • 15
    • 0029922595 scopus 로고    scopus 로고
    • Major role of 3′,5′‐cyclic adenosine monophosphate‐dependent protein kinase A pathway in corticotropin releasing factor gene expression in the rat hypothalamus in vivo
    • Itoi K, Horiba N, Tozawa F, Sakai Y, Sakai K, Abe K, Demura H, Suda T (1996) Major role of 3′,5′‐cyclic adenosine monophosphate‐dependent protein kinase A pathway in corticotropin releasing factor gene expression in the rat hypothalamus in vivo. Endocrinology 137: 2389–2396.
    • (1996) Endocrinology , vol.137 , pp. 2389-2396
    • Itoi, K1    Horiba, N2    Tozawa, F3    Sakai, Y4    Sakai, K5    Abe, K6    Demura, H7    Suda, T8
  • 16
    • 0025365050 scopus 로고
    • The relation between alcohol problems and the anxiety disorders
    • Kushner MG, Sher KJ, Beitman BD (1990) The relation between alcohol problems and the anxiety disorders. Am J Psychiatry 147: 685–695.
    • (1990) Am J Psychiatry , vol.147 , pp. 685-695
    • Kushner, MG1    Sher, KJ2    Beitman, BD3
  • 17
    • 71849104860 scopus 로고
    • Protein measurement with the Folin phenol reagent
    • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265–275.
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, OH1    Rosebrough, NJ2    Farr, AL3    Randall, RJ4
  • 18
    • 0000461835 scopus 로고
    • New strains of rats with alcohol‐preference (P) and ‐nonpreference (NP), in: Alcohol and Aldehyde Metabolizing Systems
    • Lumeng L, Hawkins TD, Li T‐K (1977) New strains of rats with alcohol‐preference (P) and ‐nonpreference (NP), in Alcohol and Aldehyde Metabolizing Systems ( Thurman RG, Williamson JR, Drott H, Chance B eds) pp 537–544. Academic Press, New York.
    • (1977) , pp. 537-544
    • Lumeng, L1    Hawkins, TD2    Li, T‐K3
  • 20
    • 0032407460 scopus 로고    scopus 로고
    • Effects of abstinence and family history for alcoholism on platelets adenylyl cyclase activity
    • Menninger JA, Baron AE, Tabakoff B (1998) Effects of abstinence and family history for alcoholism on platelets adenylyl cyclase activity. Alcohol Clin Exp Res 22: 1955–1961.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 1955-1961
    • Menninger, JA1    Baron, AE2    Tabakoff, B3
  • 21
    • 0027195403 scopus 로고
    • Cyclic adenosine 3′,5′ monophosphate response element binding protein (CREB) and related transcription‐activating deoxyribonucleic acid binding proteins
    • Meyer TE, Habener JF (1993) Cyclic adenosine 3′,5′ monophosphate response element binding protein (CREB) and related transcription‐activating deoxyribonucleic acid binding proteins. Endocr Rev 14: 269–290.
    • (1993) Endocr Rev , vol.14 , pp. 269-290
    • Meyer, TE1    Habener, JF2
  • 23
    • 0032511188 scopus 로고    scopus 로고
    • Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway
    • Moore MS, Dezazzo J, Luk AY, Tully T, Singh CM, Heberlein U (1998) Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93: 997–1007.
    • (1998) Cell , vol.93 , pp. 997-1007
    • Moore, MS1    Dezazzo, J2    Luk, AY3    Tully, T4    Singh, CM5    Heberlein, U6
  • 24
    • 0024300175 scopus 로고
    • Chronic ethanol causes heterologous desensitization of receptors by reducing αs messenger RNA
    • Mochly‐Rosen D, Chang FH, Cheever L, Kim M, Diamond I, Gordon AS (1988) Chronic ethanol causes heterologous desensitization of receptors by reducing α s messenger RNA. Nature (Lond.) 333: 848–850.
    • (1988) Nature (Lond.) , vol.333 , pp. 848-850
    • Mochly‐Rosen, D1    Chang, FH2    Cheever, L3    Kim, M4    Diamond, I5    Gordon, AS6
  • 25
    • 0024362408 scopus 로고
    • Operant responding for oral ethanol in the alcohol‐preferring and alcohol‐nonpreferring lines of rats
    • Murphy JM, Gatto GJ, McBride WJ, Lumeng L, Li T‐K (1989) Operant responding for oral ethanol in the alcohol‐preferring and alcohol‐nonpreferring lines of rats. Alcohol 6: 127–131.
    • (1989) Alcohol , vol.6 , pp. 127-131
    • Murphy, JM1    Gatto, GJ2    McBride, WJ3    Lumeng, L4    Li, T‐K5
  • 26
    • 0020038065 scopus 로고
    • Regional brain levels of monoamines in alcohol‐preferring and ‐nonpreferring lines of rats
    • Murphy JM, McBride WJ, Lumeng L, Li T‐K (1982) Regional brain levels of monoamines in alcohol‐preferring and ‐nonpreferring lines of rats. Pharmacol Biochem Behav 16: 145–149.
    • (1982) Pharmacol Biochem Behav , vol.16 , pp. 145-149
    • Murphy, JM1    McBride, WJ2    Lumeng, L3    Li, T‐K4
  • 27
    • 0023158733 scopus 로고
    • Contents of monoamines in forebrain regions of alcohol‐preferring (P) and ‐nonpreferring (NP) lines of rats
    • Murphy JM, McBride WJ, Lumeng L, Li T‐K (1987) Contents of monoamines in forebrain regions of alcohol‐preferring (P) and ‐nonpreferring (NP) lines of rats. Pharmacol Biochem Behav 26: 389–392.
    • (1987) Pharmacol Biochem Behav , vol.26 , pp. 389-392
    • Murphy, JM1    McBride, WJ2    Lumeng, L3    Li, T‐K4
  • 28
    • 0029992189 scopus 로고    scopus 로고
    • Chronic antidepressant administration increases the expression of the cAMP‐responsive element binding protein (CREB) in the rat hippocampus
    • Nibuya M, Nestler EJ, Duman RS (1996) Chronic antidepressant administration increases the expression of the cAMP‐responsive element binding protein (CREB) in the rat hippocampus. J Neurosci 16: 2365–2372.
    • (1996) J Neurosci , vol.16 , pp. 2365-2372
    • Nibuya, M1    Nestler, EJ2    Duman, RS3
  • 29
    • 0026714673 scopus 로고
    • Phosphorylation of CREB affects its binding to high and low affinity sites: Implications for cAMP induced gene transcription
    • Nichols M, Weik F, Schmid W, DeVack C, Kowenz‐Leutz E, Luckow B, Boshart M, Schutz G (1992) Phosphorylation of CREB affects its binding to high and low affinity sites: Implications for cAMP induced gene transcription. EMBO J 11: 3337–3346.
    • (1992) EMBO J , vol.11 , pp. 3337-3346
    • Nichols, M1    Weik, F2    Schmid, W3    DeVack, C4    Kowenz‐Leutz, E5    Luckow, B6    Boshart, M7    Schutz, G8
  • 30
    • 0032437380 scopus 로고    scopus 로고
    • Neuronal signaling systems and ethanol dependence
    • Pandey SC (1998) Neuronal signaling systems and ethanol dependence. Mol Neurobiol 17: 1–15.
    • (1998) Mol Neurobiol , vol.17 , pp. 1-15
    • Pandey, SC1
  • 31
    • 0029043306 scopus 로고
    • Phosphoinositide system‐linked serotonin receptor subtypes and their pharmacological properties and clinical correlates
    • Pandey SC, Davis JM, Pandey GN (1995) Phosphoinositide system‐linked serotonin receptor subtypes and their pharmacological properties and clinical correlates. J Psychiatry Neurosci 20: 215–225.
    • (1995) J Psychiatry Neurosci , vol.20 , pp. 215-225
    • Pandey, SC1    Davis, JM2    Pandey, GN3
  • 32
    • 0029658467 scopus 로고    scopus 로고
    • Serotonin2C receptors and serotonin2C receptor‐mediated phosphoinositide hydrolysis in the brain of alcohol‐preferring (P) and alcohol‐nonpreferring (NP) rats
    • Pandey SC, Lumeng L, Li T‐K (1996) Serotonin 2C receptors and serotonin 2C receptor‐mediated phosphoinositide hydrolysis in the brain of alcohol‐preferring (P) and alcohol‐nonpreferring (NP) rats. Alcohol Clin Exp Res 20: 1038–1042.
    • (1996) Alcohol Clin Exp Res , vol.20 , pp. 1038-1042
    • Pandey, SC1    Lumeng, L2    Li, T‐K3
  • 33
    • 0032988476 scopus 로고    scopus 로고
    • Potential role of the gene transcription factor cyclic AMP‐responsive element binding protein in ethanol withdrawal‐related anxiety
    • Pandey SC, Zhang D, Mittal N, Nayyar D (1999) Potential role of the gene transcription factor cyclic AMP‐responsive element binding protein in ethanol withdrawal‐related anxiety. J Pharmacol Exp Ther 288: 866–878.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 866-878
    • Pandey, SC1    Zhang, D2    Mittal, N3    Nayyar, D4
  • 34
    • 0027415929 scopus 로고
    • Microinjection of a corticotropin‐releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic‐like effects of ethanol withdrawal
    • Rassnick S, Heinrichs SC, Briton KT, Koob GF (1993) Microinjection of a corticotropin‐releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic‐like effects of ethanol withdrawal. Brain Res 605: 25–32.
    • (1993) Brain Res , vol.605 , pp. 25-32
    • Rassnick, S1    Heinrichs, SC2    Briton, KT3    Koob, GF4
  • 35
    • 0029993105 scopus 로고    scopus 로고
    • Analysis of the structural properties of the cAMP‐responsive element binding protein (CREB) and phosphorylated CREB
    • Richards JP, Bachinger HP, Goodman RH, Brennan RG (1996) Analysis of the structural properties of the cAMP‐responsive element binding protein (CREB) and phosphorylated CREB. J Biol Chem 271: 13716–13723.
    • (1996) J Biol Chem , vol.271 , pp. 13716-13723
    • Richards, JP1    Bachinger, HP2    Goodman, RH3    Brennan, RG4
  • 36
    • 0021206772 scopus 로고
    • Subjective responses to alcohol in sons of alcoholics and control subjects
    • Schuckit MA (1984) Subjective responses to alcohol in sons of alcoholics and control subjects. Arch Gen Psychiatry 41: 879–884.
    • (1984) Arch Gen Psychiatry , vol.41 , pp. 879-884
    • Schuckit, MA1
  • 37
    • 0025807509 scopus 로고
    • CREB: A Ca2+‐regulated transcription factor phosphorylated by calmodulin‐dependent kinases
    • Sheng M, Thompson MA, Greenberg ME (1991) CREB: A Ca 2+ ‐regulated transcription factor phosphorylated by calmodulin‐dependent kinases. Science 252: 1428–1430.
    • (1991) Science , vol.252 , pp. 1428-1430
    • Sheng, M1    Thompson, MA2    Greenberg, ME3
  • 38
    • 0032566803 scopus 로고    scopus 로고
    • NPY upregulates genes containing cyclic AMP response element in human neuroblastoma cell lines bearing Y1 and Y2 receptors: Involvement of CREB
    • Sheriff S, Dayal R, Kasckow J, Regmi A, Chance W, Fischer J, Balasu‐bramaniam A (1998) NPY upregulates genes containing cyclic AMP response element in human neuroblastoma cell lines bearing Y 1 and Y 2 receptors: Involvement of CREB. Regul Pept 75‐76: 309–318.
    • (1998) Regul Pept , vol.75‐76 , pp. 309-318
    • Sheriff, S1    Dayal, R2    Kasckow, J3    Regmi, A4    Chance, W5    Fischer, J6    Balasu‐bramaniam, A7
  • 39
    • 0031002007 scopus 로고    scopus 로고
    • Neuropeptide Y treatment and food deprivation increase cyclic AMP response element binding in rat hypothalamus
    • Sheriff S, Chance WT, Fischer JE, Balasubramaniam A (1997) Neuropeptide Y treatment and food deprivation increase cyclic AMP response element binding in rat hypothalamus. Mol Pharmacol 51: 597–604.
    • (1997) Mol Pharmacol , vol.51 , pp. 597-604
    • Sheriff, S1    Chance, WT2    Fischer, JE3    Balasubramaniam, A4
  • 41
    • 0025953870 scopus 로고
    • Cyclic AMP‐dependent protein kinase activity in the brains of alcohol‐preferring (P) and ‐nonpreferring (NP) rats
    • Smith CP, King BR, Pennington SN (1991) Cyclic AMP‐dependent protein kinase activity in the brains of alcohol‐preferring (P) and ‐nonpreferring (NP) rats. Alcohol 8: 329–332.
    • (1991) Alcohol , vol.8 , pp. 329-332
    • Smith, CP1    King, BR2    Pennington, SN3
  • 42
    • 0027516283 scopus 로고
    • Comparison of alcohol ‐preferring (P) and ‐nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol
    • Stewart RB, Gatto GJ, Lumeng L, Li T‐K, Murphy JM (1993) Comparison of alcohol ‐preferring (P) and ‐nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol. Alcohol 10: 1–10.
    • (1993) Alcohol , vol.10 , pp. 1-10
    • Stewart, RB1    Gatto, GJ2    Lumeng, L3    Li, T‐K4    Murphy, JM5
  • 43
    • 0032569940 scopus 로고    scopus 로고
    • Ethanol consumption and resistance are inversely related to neuropeptide Y levels
    • Thiele TE, Marsh DJ, Marie LS, Bernstein IL, Palmiter RD (1998) Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature 396: 366–369.
    • (1998) Nature , vol.396 , pp. 366-369
    • Thiele, TE1    Marsh, DJ2    Marie, LS3    Bernstein, IL4    Palmiter, RD5
  • 44
    • 0030762749 scopus 로고    scopus 로고
    • Regional densities of benzodiazepine sites in the CNS of alcohol‐naïve (P) and (NP) rats
    • Thielen RJ, McBride WJ, Chernet E, Lumeng L, Li T‐K (1997) Regional densities of benzodiazepine sites in the CNS of alcohol‐naïve (P) and (NP) rats. Pharmacol Biochem Behav 57: 875–882.
    • (1997) Pharmacol Biochem Behav , vol.57 , pp. 875-882
    • Thielen, RJ1    McBride, WJ2    Chernet, E3    Lumeng, L4    Li, T‐K5
  • 45
    • 0021278559 scopus 로고
    • Intragastric self‐infusion of ethanol by ethanol‐preferring (P) and ‐nonpreferring (NP) lines of rats. Science (Wash
    • Waller MB, McBride WJ, Gatto GJ, Lumeng L, Li T‐K (1984) Intragastric self‐infusion of ethanol by ethanol‐preferring (P) and ‐nonpreferring (NP) lines of rats. Science (Wash. DC) 225: 78–80.
    • (1984) DC) , vol.225 , pp. 78-80
    • Waller, MB1    McBride, WJ2    Gatto, GJ3    Lumeng, L4    Li, T‐K5
  • 46
    • 0027238536 scopus 로고
    • Enhanced expression of the inhibitory protein Gi2α and decreased activity of adenylyl cyclase in lymphocytes of abstinent alcoholics
    • Waltman C, Levine MA, McCaul ME, Svikis DS, Wand GS (1993) Enhanced expression of the inhibitory protein G i2 α and decreased activity of adenylyl cyclase in lymphocytes of abstinent alcoholics. Alcohol Clin Exp Res 17: 315–320.
    • (1993) Alcohol Clin Exp Res , vol.17 , pp. 315-320
    • Waltman, C1    Levine, MA2    McCaul, ME3    Svikis, DS4    Wand, GS5
  • 47
    • 0028059907 scopus 로고
    • Differential expression of guanosine triphosphate binding proteins in men at high and low risk for the future development of alcoholism
    • Wand GS, Waltman C, Martin CS, McCaul ME, Levine MA, Wolfgang D (1994) Differential expression of guanosine triphosphate binding proteins in men at high and low risk for the future development of alcoholism. J Clin Invest 94: 1004–1011.
    • (1994) J Clin Invest , vol.94 , pp. 1004-1011
    • Wand, GS1    Waltman, C2    Martin, CS3    McCaul, ME4    Levine, MA5    Wolfgang, D6
  • 48
    • 0027330278 scopus 로고
    • Greater abundance of serotonini1A receptor in some brain areas of alcohol‐preferring (P) rats compared to ‐nonpreferring (NP) rats
    • Wong DT, Reid LR, Li T‐K, Lumeng L (1993) Greater abundance of serotonini 1A receptor in some brain areas of alcohol‐preferring (P) rats compared to ‐nonpreferring (NP) rats. Pharmacol Biochem Behav 46: 173–177.
    • (1993) Pharmacol Biochem Behav , vol.46 , pp. 173-177
    • Wong, DT1    Reid, LR2    Li, T‐K3    Lumeng, L4
  • 49
    • 0031981194 scopus 로고    scopus 로고
    • Chronic ethanol exposure impairs phosphorylation of CREB and CRE‐binding activity in rat striatum
    • Yang X, Horn K, Wand GS (1998a) Chronic ethanol exposure impairs phosphorylation of CREB and CRE‐binding activity in rat striatum. Alcohol Clin Exp Res 22: 382–390.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 382-390
    • Yang, X1    Horn, K2    Wand, GS3
  • 50
    • 0031983182 scopus 로고    scopus 로고
    • Chronic ethanol administration decreases phosphorylation of cyclic AMP‐response‐element binding protein in granule cells of rat cerebellum
    • Yang X., Horn K, Barban JM, Wand GS (1998b) Chronic ethanol administration decreases phosphorylation of cyclic AMP‐response‐element binding protein in granule cells of rat cerebellum. J Neurochem 70: 224–232.
    • (1998) J Neurochem , vol.70 , pp. 224-232
    • Yang, X.1    Horn, K2    Barban, JM3    Wand, GS4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.