The decreased phosphorylation of cyclic adenosine monophosphate (cAMP) response element binding (CREB) protein in the central amygdala acts as a molecular substrate for anxiety related to ethanol withdrawal in rats

Alcoholism: Clinical and Experimental Research

Volumn 27, Issue 3, 2003, Pages 396-409

  Pandey, Subhash C ^a,b,c   Roy, Adip ^a,c   Zhang, Huaibo ^a,c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Department of Anatomy ^*  (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Alcohol Preference; Alcohol Withdrawal; Anxiety; Calmodulin Dependent Protein Kinase IV; Cyclic Adenosine Monophosphate Responsive Element Binding (CREB) Protein; Neuropeptide Y; Protein Kinase A

Indexed keywords

ALCOHOL; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GOLD; ISOENZYME; MESSENGER RNA; NEUROPEPTIDE Y; PROTEIN SUBUNIT;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANTIBODY LABELING; ANXIETY; ARTICLE; CATALYSIS; CEREBROSPINAL FLUID; CONTROLLED STUDY; MALE; MAZE TEST; MOLECULAR DYNAMICS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ALCOHOL DRINKING; AMYGDALA; ANIMALS; ANXIETY; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ETHANOL; MALE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0037346976     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000056616.81971.49     Document Type: Article

References (48)

1. Akabayashi A, Zaia CT, Gabriel SM, Silva I, Cheung WK, Leibowitz SF (1994) Intracerebroventricular injection of dibutyryl cyclic adenosine 3′, 5′-monophosphate increases hypothalamic levels of neuropeptide Y. Brain Res 660:323-328.
2. Badia-Elder NE, Stewart RB, Powrozek TA, Roy KF, Murphy JM, Li T-K (2001) Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol-preferring (P), and -nonpreferring (NP) rats. Alcohol Clin Exp Res 25:386-390.
3. Bibb J, Chamblers DL (1986) Alcohol use and abuse among diagnosed agoraphobics. Behav Res Ther 24:49-58.
4. Cappell H, Herman CP (1972) Alcohol and tension reduction, a review. Q J Study Alcohol 33:33-64.
5. Chance WT, Sheriff S, Peng F, Balasubramaniam A (2000) Antagonism of NPY inducing feeding by pretreatment with cAMP response element binding protein antisense oligonucleotide. Neuropeptides 34:167-172.
6. Davis M (1997) Neurobiology of fear responses, the role of the amygdala. J Neuropsychiatry 9:382-402.
7. Davis M, Rainnie D, Cassell M (1994) Neurotransmission in rat amygdala related to fear and anxiety. Trends Neurosci 17:208-214.
8. Diamond I, Gordon A (1997) Cellular and molecular neuroscience of alcoholism. Physiol Rev 77:1-20.
9. Duman RS, Malberg J, Nakagawa S, D'Sa C (2000) Neuronal plasticity and survival in mood disorders. Biol Psychiatry 48:732-739.
10. Duman RS (2002) Synaptic plasticity and mood disorders. Mol Psychiatry 7:S29-S34.
11. Foulkes NS, Borrelli E, Sassone-Corsi P (1991) CREM gene, use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64:739-749.
12. Graves L, Dalvi A, Lucki I, Blendy JA, Abel T (2002) Behavioral analysis of CREB αΔ mutation on B6/129 F1 background. Hippocampus 12:18-26.
13. Heilig M, McLeod S, Brot M, Heinrichs SC, Menzaghi F, Koob GF, Britton KT (1993) Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptor in amygdala and dissociation from food intake effects. Neuropsychopharmacology 8:357-363.
14. Hoffman PL, Tabakoff B (1990) Ethanol and guanine nucleotide binding proteins: a selective interaction. Fed Am Soc Exp Biol J 17:580-585.
15. Hwang BH, Zhang J-K, Ehlers CL, Lumeng L, Li T-K (1999) Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdala between selectively bred rats with high and low alcohol preference. Alcohol Clin Exp Res 23:1023-1030.
16. Impey S, Obrietan K, Storm DR (1999) Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity. Neuron 23:11-14.
17. Izzo E, Auta J, Impagnatiello F, Pesold C, Guidotti A, Costa E (2001) Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepines. Proc Natl Acad Sci U.S.A. 98:3483-3488.
18. Josselyn SA, Shi C, Carlezon WA, Neve RL, Nestler EJ, Davis M (2001) Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala. J Neurosci 21:2404-2412.
19. Katner SN, Slawecki CJ, Ehlers CL (2002) Neuropeptide Y administration into the amygdala does not affect ethanol consumption. Alcohol 28:29-38.
20. Kelley SP, Nannini MA, Bratt AM, Hodge CW (2001) Neuropeptide-Y in the paraventricular nucleus increases ethanol self-administration. Peptides 22:515-522.
21. Koob GF, Bloom FE (1988) Cellular and molecular mechanisms of drug dependence. Science (Wash. DC) 224:715-723.
22. Koob GF, Markou A, Weiss F, Schulteis G (1993) Opponent process and drug dependence: neurobiological mechanisms. Sem Neurosci 5:351-358.
23. 2 receptors in the mianserin-induced prevention of anxiogenic behaviors occurring during ethanol withdrawal. Alcohol Clin Exp Res 17:411-417.
24. Li MD, Kane JK, Parker SL, McAllen K, Matta SG, Sharp BM (2000) Nicotine administration enhances NPY expression in rat hypothalamus. Brain Res 867:157-164.
25. Maldonado R, Smadja C, Mazucchelli C, Sassone-Corsi P (1999) Altered emotional and locomotor responses in mice deficient in the transcription factor CREM. Proc Natl Acad Sci USA 96:14094-14099.
26. Nestler EJ (2001) Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2:119-128.
27. Pandey SC, Zhang D, Mittal N, Nayyar D (1999a) Potential role of the gene transcription factor cyclic AMP-responsive element binding protein in ethanol withdrawal-related anxiety. J Pharmacol Exp Ther 288:866-878.
28. Pandey SC, Mittal N, Lumeng L, Li T-K (1999b) Involvement of the cyclic AMP-responsive element binding protein gene transcription factor in genetic preference for alcohol drinking behavior. Alcohol Clin Exp Res 23:1425-1434.
29. Pandey SC, Roy A, Xu T, Mittal N (2001a) Effects of protracted nicotine exposure and withdrawal on the expression and phosphorylation of the CREB gene transcription factor in the rat brain. J Neurochem 77:943-952.
30. Pandey SC, Roy A, Mittal N (2001b) Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the CREB gene transcription factor in rat cortex. J Pharmacol Exp Ther 296:857-868.
31. Pliakas AM, Carlson R, Neve RL, Konradi C, Nestler EJ, Carlezon Jr WA (2001) Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. J Neurosci 21:7397-7403.
32. Punch LJ, Self DW, Nestler EJ, Taylor JR (1997) Opposite modulation of opiate withdrawal behaviors on microinfusion of a protein kinase A inhibitor versus activator in the locus coeruleus or periaqueductal gray. J Neurosci 17:8520-8527.
33. Rassnick S, Heinrichs SC, Britton KT, Koob GF (1993) Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal. Brain Res 605:25-32.
34. Roy A, Pandey SC (2002) The decreased cellular expression of neuropeptide Y protein in the rat brain structures during ethanol withdrawal after chronic ethanol exposure. Alcohol Clin Exp Res 26:796-803.
35. Schuckit MA, Hasselbrock V (1994) Alcohol dependence and anxiety disorders, what is the relationship? Am J Psychiatry 151:1723-1734.
36. Silva AJ, Kogan JH, Frankland PW, Kida S (1998) CREB and memory. Annu Rev Neurosci 21:127-148.
37. Slawecki CJ, Betancourt M, Walpole T, Ehlers CL (2000) Increases in sucrose consumption, but not ethanol consumption, following ICV NPY administration. Pharmacol Biochem Behav 66:591-594.
38. 2+-calmodulin-dependent protein kinase cascade. Trends Biochem Sci 24:232-236.
39. Spanagel R, Montkowski A, Allingham K, Stöhr T, Shoaib M, Holsboer F, Landgraf R (1995) Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats. Psychopharmacology 122:369-373.
40. Stewart RB, Gatto GJ, Lumeng L, Li T-K, Murphy JM (1993) Comparison of alcohol-preferring (P) and non-preferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol. Alcohol 10:1-10.
41. Taylor JR, Birnbaum S, Ubriani R, Arnsten FT (1999) Activation of cAMP-dependent protein kinase A in prefrontal cortex impairs working memory performance. J Neurosci 19(RC23):1-5.
42. Thiele TE, Marsh DJ, Marie LS, Berstein IL, Palmiter RD (1998) Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature (Lond.) 396:366-369.
43. Thiele TE, Willis B, Stafler J, Reynolds JG, Bernstein IL, McKnight GS (2000) High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice. J Neurosci 20(RC75):1-6.
44. Uz T, Qu T, Sugaya K, Manev H (2002) Neuronal expression of arylalkylamine N-acetyltransferase (AANAT) mRNA in the rat brain. Neurosci Res 42:309-316.
45. Wand G, Levine M, Zweifel L, Schwindger W, Abel T (2001) The cAMP-protein kinase signal transduction pathway modulates ethanol consumption and sedative effects of ethanol. J Neurosci 21:5297-5303.
46. Wilson GT (1988) Alcohol and anxiety. Behav Res Ther 26:369-381.
47. Yang X, Horn K, Baraban JM, Wand GS (1998) Chronic ethanol administration decreases phosphorylation of cyclic AMP-response element binding protein in granule cells of rat cerebellum. J Neurochem 70:224-232.
48. Yao I, Arolfo MP, Dohrman DP, Jiang Z, Fuchs S, Janak PH, Gordon AS, Diamond I (2002) Beta gamma dimmers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell 109:733-743.