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Journal of Pharmaceutical and Biomedical Analysis

Volumn 37, Issue 2, 2005, Pages 351-358

In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes

(7) Agrawal, Arun K a,b Hop, Cornelis E C A a,c Pang, Jianmei a Silva Elipe, Maria V a Desai, Ranjit C a Leung, Kwan H a Franklin, Ronald B a

a MERCK RESEARCH LABORATORIES (United States)

b PFIZER INC (United States)

c PFIZER GLOBAL RESEARCH AND DEVELOPMENT (United States)

Author keywords

5 4 3 (4 Cyclohexyl 2 propylphenoxy)propoxy phenyl 1,3 oxazolidine 2,4 dione; Compound A; Cytochrome P450 (CYP); Liquid chromatography (LC); Mass spectrometry (MS); Nuclear magnetic resonance (NMR); Peroxisome proliferator activated receptor (PPAR)

Indexed keywords

ANTIDIABETIC AGENT; CYCLOHEXENE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; OXAZOLIDINEDIONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROXYLATION; IN VITRO STUDY; INSULIN RELEASE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; STEREOCHEMISTRY;

EID: 13544277459 PISSN: 07317085 EISSN: None Source Type: Journal
DOI: 10.1016/j.jpba.2004.10.036 Document Type: Article

Times cited : (10)

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