Aryloxazolidinediones: Identification of potent orally active PPAR dual α/γ agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 20, 2003, Pages 3541-3544

  Desai, Ranjit C ^a   Gratale, Dominick F ^a   Han, Wei ^a   Koyama, Hiroo ^a   Metzger, Edward ^a   Lombardo, Victoria K ^a   MacNaul, Karen L ^a   Doebber, Thomas W ^a   Berger, Joel P ^a   Leung, Kwan ^a   Franklin, Ronald ^a   Moller, David E ^a   Heck, James V ^a   Sahoo, Soumya P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXAZOLIDINEDIONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 10744227404     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00785-6     Document Type: Article

References (13)

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11. Compounds 16 and 17 were identified as major metabolites following incubation of 12 with human liver microsomes. The details of metabolism studies of 12 will be published elsewhere.
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