Highly focused T cell responses in latent human pulmonary Mycobacterium tuberculosis infection

Journal of Immunology

Volumn 174, Issue 4, 2005, Pages 2174-2184

  Tully, Glenn ^a   Kortsik, Cornelius ^b   Höhn, Hanni ^a   Zehbe, Ingeborg ^a   Hitzler, W E ^a   Neukirch, Claudia ^a   Freitag, Kirsten ^a   Kayser, Klaus ^c   Maeurer, Markus J ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b St Hildegardis Krankenhaus   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; GAMMA INTERFERON; HLA A2 ANTIGEN; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSURVEILLANCE; LATENT PERIOD; LUNG BIOPSY; LUNG TUBERCULOSIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 13544271153     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.4.2174     Document Type: Article

References (63)

1. Caruso, A. M., N. Serbina, E. Klein, K. Triebold, B. R. Bloom, and J. L. Flynn. 1999. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-γ, yet succumb to tuberculosis. J. Immunol. 162:5407.
2. Flynn, J. L., M. M. Goldstein, K. J. Triebold, B. Koller, and B. R. Bloom. 1992. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. USA 89:12013.
3. Flynn, J. L., M. M. Goldstein, K. J. Triebold, and B. R. Bloom. 1993. Major histocompatibility complex class I-restricted T cells are necessary for protection against M. tuberculosis in mice. Infect. Agents Dis. 2:259.
4. Flynn, J. L., and J. Chan. 2001. Immunology of tuberculosis. Annu. Rev. Immunol. 19:93.
5. Collins, H. L., and S. H. Kaufmann. 2001. The many faces of host responses to tuberculosis. Immunology 103:I.
6. Flynn, J. L., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for interferon γ in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249.
7. MacMicking, J. D., R. J. North, R. LaCourse, J. S. Mudgett, S. K. Shah, and C. F. Nathan. 1997. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc. Natl. Acad. Sci. USA 94:5243.
8. Sieling, P. A., D. Chatterjee, S. A. Porcelli, T. I. Prigozy, R. J. Mazzaccaro, T. Soriano, B. R. Bloom, M. B. Brenner, M. Kronenberg, P. J. Brennan, et al. 1995. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 269:227.
9. + αβ T cell pool. J. Immunol. 162:366.
10. Moody, D. B., T. Ulrichs, W. Muhlecker, D. C. Young, S. S. Gurcha, E. Grant, J. P. Rosat, M. B. Brenner, C. E. Costello, G. S. Besra, and S. A. Porcelli. 2000. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 404:884.
11. Barnes, P. F., C. L. Grisso, J. S. Abrams, H. Band, T. H. Rea, and R. L. Modlin. 1992. γδ lymphocytes in human tuberculosis. J. Infect. Dis. 165:506.
12. Manabe, Y. C., and W. R. Bishai. 2000. Latent Mycobacterium tuberculosis: persistence, patience, and winning by waiting. Nat. Med. 6:1327.
13. Hernandez-Pando, R., M. Jeyanathan, G. Mengistu, D. Aguilar, H. Orozco, M. Harboe, G. A. Rook, and G. Bjune. 2000. Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection. Lancet 356:2133.
14. + lymphocytes recognize tumor cells of epithelial origin. J. Exp. Med. 183:1681.
15. + T-cell evolution in vivo: response to peptide vaccination with Melan-A/MART-1. Int. J. Cancer 98:376.
16. Mustafa, A. S., F. Oftung, H. A. Amoudy, N. M. Madi, A. T. Abal, F. Shaban, I. Rosen Krands, and P. Andersen. 2000. Multiple epitopes from the Mycobacterium tuberculosis ESAT-6 antigen are recognized by antigen-specific human T cell lines. Clin. Infect. Dis. 30(Suppl 3):S201.
17. Ulrichs, T., M. E. Munk, H. Mollenkopf, S. Behr-Perst, R. Colangeli, M. L. Gennaro, and S. H. Kaufmann. 1998. Differential T cell responses to Mycobactenum tuberculosis ESAT6 in tuberculosis patients and healthy donors. Eur. J. Immunol. 28:3949.
18. Maeurer, M. J., P. Trinder, G. Hommel, W. Walter, K. Freitag, D. Atkins, and S. Storkel. 2000. Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice. Infect. Immun. 68:2962.
19. + T cells in HLA-transgenic mice and humans. J. Immunol. 165:6463.
20. + CTL specific for the mycobacterial major secreted antigen 85A. J. Immunol. 165:7088.
21. Mohagheghpour, N., D. Gammon, L. M. Kawamura, A. van Vollenhoven, C. J. Benike, and E, G. Engleman. 1998. CTL response to Mycobacterium tuberculosis: identification of an immunogenic epitope in the 19-kDa lipoprotein. J. Immunol. 161:2400.
22. + T cells enables preservation of a naive repertoire. J. Immunol. 161:5909.
23. Pilch, H., H. Hohn, K. Freitag, C. Neukirch, A. Necker, P. Haddad, B. Tanner, P. G. Knapstein, and M. J. Maeurer. 2002. Improved assessment of T-cell receptor (TCR) VB repertoire in clinical specimens: combination of TCR-CDR3 spectratyping with flow cytometry-based TCR VB frequency analysis. Clin. Diagn. Lab. Immunol. 9:257.
24. Haanen, J. B., M. G. van Oijen, F. Tirion, L. C. Oomen, A. M. Kruisbeek, F. A. Vyth-Dreese, and T. N. Schumacher. 2000. In situ detection of virus- and tumor-specific T-cell immunity. Nat. Med. 6:1056.
25. Hirsch, C. S., Z. Toossi, C. Othieno, J. L. Johnson, S. K. Schwander, S. Robertson, R. S. Wallis, K. Edmonds, A. Okwera, R. Mugerwa, et al. 1999. Depressed T-cell interferon-γ responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy. J. Infect. Dis. 180:2069.
26. Boussiotis, V. A., E. Y. Tsai, E. J. Yunis, S. Thim, J. C. Delgado, C. C. Dascher, A. Berezovskaya, D. Rousset, J. M. Reynes, and A. E. Goldfeld. 2000. IL-10-producing T cells suppress immune responses in anergic tuberculosis patients. J. Clin. Invest. 105:1317.
27. Torres, M., T. Herrera, H. Villareal, E. A. Rich, and E. Sada. 1998. Cytokine profiles for peripheral blood lymphocytes from patients with active pulmonary tuberculosis and healthy household contacts in response to the 30-kilodalton antigen of Mycobacterium tuberculosis. Infect. Immun. 66:176.
28. Wilkinson, R. J., H. M. Vordermeier, K. A. Wilkinson, A. Sjolund, C. Moreno, G. Pasvol, and J. Ivanyi. 1998. Peptide-specific T cell response to Mycobacterium tuberculosis: clinical spectrum, compartmentalization, and effect of chemotherapy. J Infect. Dis. 178:760.
29. Barnes, P. F., S. Lu, J. S. Abrams, E. Wang, M. Yamamura, and R. L. Modlin. 1993. Cytokine production at the site of disease in human tuberculosis. Infect. Immun. 61:3482.
30. Garcia, M., J. A. Vargas, R. Castejon, E. Navas, and A. Durantez. 2002. Flow-cytometric assessment of lymphocyte cytokine production in tuberculosis. Tuberculosis 82:37.
31. Schwander, S. K., M. Torres, C. C. Carranza, D. Escobedo, M. Tary-Lehmann, P. Anderson, Z. Toossi, J. J. Ellner, E. A. Rich, and E. Sada. 2000. Pulmonary mononuclear cell responses to antigens of Mycobacterium tuberculosis in healthy household contacts of patients with active tuberculosis and healthy controls from the community. J. Immunol. 165:1479.
32. Peters, W., H. M. Scott, H. F. Chambers, J. L. Flynn, I. F. Charo, and J. D. Ernst. 2001. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 98:7958.
33. Danska, J. S., A. M. Livingstone, V. Paragas, T. Ishihara, and C. G. Fathman. 1990. The presumptive CDR3 regions of both T cell receptor α and β chains determine T cell specificity for myoglobin peptides. J. Exp. Med. 172:27.
34. - subset. J. Exp. Med. 177:1763.
35. Levraud, J. P., C. Pannetier, P. Langlade-Demoyen, V. Brichard, and P. Kourilsky. 1996. Recurrent T cell receptor rearrangements in the cytotoxic T lymphocyte response in vivo against the p815 murine tumor. J. Exp. Med. 183:439.
36. Sourdive, D. J., K. Murali-Krishna, J. D. Altman, A. J. Zajac, J. K. Whitmire, C. Pannetier, P. Kourilsky, B. Evavold, A. Sette, and R. Ahmed. 1998. Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection. J. Exp. Med. 188:71.
37. Busch, D. H., I. Pilip, and E. G. Pamer. 1998. Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection. J. Exp. Med. 188:61.
38. Gambon-Deza, F., M. Pacheco Carracedo, T. Cerda Mota, and J. Montes Santiago. 1995. Lymphocyte populations during tuberculosis infection: Vβ repertoires. Infect. Immun. 63:1235.
39. Flynn, J. L., and B. R. Bloom. 1996. Role of T1 and T2 cytokines in the response to Mycobacterium tuberculosis. Ann. NY Acad. Sci. 795:137.
40. + T-cell responses are oligoclonal and exhibit a T-cell cytotoxic type 2 response cytokine-secretion pattern. Immunology 104:278.
41. Hohn, H., C. Kortsik, G. Tully, K. Nilges, A. Necker, K. Freitag, C. Neukirch, P. Galle, H. Lohr, and M. J. Maeurer. 2003. Longitudinal analysis of Mycobacterium tuberculosis 19-kDa antigen-specific T cells in patients with pulmonary tuberculosis: association with disease activity and cross-reactivity to a peptide from HIVenv gp120. Eur. J. Immunol. 33:1613.
42. Anichini, A., A. Molla, R. Mortarini, G. Tragni, I. Bersani, M. Di Nicola, A. M. Gianni, S. Pilotti, R. Dunbar, V. Cerundolo, and G. Parmiani. 1999. An expanded peripheral T cell population to a cytotoxic T lymphocyte (CTL)-defined, melanocyte-specific antigen in metastatic melanoma patients impacts on generation of peptide-specific CTLs but does not overcome tumor escape from immune surveillance in metastatic lesions. J. Exp. Med. 190:651.
43. Masopust, D., V. Vezys, A. L. Marzo, and L. Lefrancois. 2001. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291:2413.
44. Arend, S. M., P. Andersen, K. E. van Meijgaarden, R. L. Skjot, Y. W. Subronto, J. T. van Dissel, and T. H. Ottenhoff. 2000. Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10. J. Infect. Dis. 181:1850.
45. Lein, A. D., C. F. von Reyn, P. Ravn, C. R. Horsburgh, Jr., L. N. Alexander, and P. Andersen. 1999. Cellular immune responses to ESAT-6 discriminate between patients with pulmonary disease due to Mycobacterium avium complex and those with pulmonary disease due to Mycobacterium tuberculosis. Clin. Diagn. Lab. Immunol. 6:606.
46. Ravn, P., A. Demissie, T. Eguale, H. Wondwosson, D. Lein, H. A. Amoudy, A. S. Mustafa, A. K. Jensen, A. Holm, I. Rosenkrands, et al. 1999. Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis. J. Infect. Dis. 179:637.
47. Ulrichs, T., P. Anding, S. Porcelli, S. H. Kaufmann, and M. E. Munk. 2000. Increased numbers of ESAT-6- and purified protein derivative-specific γ interferon-producing cells in subclinical and active tuberculosis infection. Infect. Immun. 68:6073.
48. Arend, S. M., A. C. Engelhard, G. Groot, K. de Boer, P. Andersen, T. H. Ottenhoff, and J. T. van Dissel. 2001. Tuberculin skin testing compared with T-cell responses to Mycobacterium tuberculosis-specific and nonspecific antigens for detection of latent infection in persons with recent tuberculosis contact. Clin. Diagn. Lab. Immunol. 8:1089.
49. Doherty, T. M., A. Demissie, J. Olobo, D. Wolday, S. Britton, T. Eguale, P. Ravn, and P. Andersen. 2002. Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients. J. Clin. Microbiol. 40:704.
50. Harboe, M., T. Oettinger, H. G. Wiker, I. Rosenkrands, and P. Andersen. 1996. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect. Immun. 64:16.
51. Sorensen, A. L., S. Nagai, G. Houen, P. Andersen, and A. B. Andersen. 1995. Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis. Infect. Immun. 63:1710.
52. + T cells in chronic HIV infection are antigen specific. J. Exp. Med. 188:785.
53. Coulie, P. G., V. Karanikas, D. Colau, C. Lurquin, C. Landry, M. Marchand, T. Dorval, V. Brichard, and T. Boon. 2001. A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by gene MAGE-3. Proc. Natl. Acad. Sci. USA 98:10290.
54. + T lymphocytes. J. Infect. Dis. 186:991.
55. Shi, L., Y. J. Jung, S. Tyagi, M. L. Gennaro, and R. J. North. 2003. Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence. Proc. Natl. Acad. Sci. USA 100:241.
56. Voskuil, M. I., D. Schnappinger, K. C. Visconti, M. I. Harrell, G. M. Dolganov, D. R. Sherman, and G. K. Schoolnik. 2003. Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J. Exp. Med. 198:705.
57. Pope, C., S. K. Kim, A. Marzo, D. Masopust, K. Williams, J. Jiang, H. Shen, and L. Lefrancois. 2001. Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection. J. Immunol. 166:3402.
58. Lalvani, A., and A. V. Hill. 1998. Cytotoxic T-lymphocytes against malaria and tuberculosis: from natural immunity to vaccine design. Clin. Sci. 95:531.
59. Pym, A. S., P. Brodin, L. Majlessi, R. Brosch, C. Demangel, A. Williams, K. E. Griffiths, G. Marchal, C. Leclerc, and S. T. Cole. 2003. Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Mol. Med. 9:533.
60. Mustafa, A. S., H. A. Amoudy, H. G. Wiker, A. T. Abal, P. Ravn, F. Oftung, and P. Andersen. 1998. Comparison of antigen-specific T-cell responses of tuberculosis patients using complex or single antigens of Mycobacterium tuberculosis. Scand. J. Immunol. 48:535.
61. Brandt, L., T. Oettinger, A. Holm, A. B. Andersen, and P. Andersen. 1996. Key epitopes on the ESAT-6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis. J. Immunol. 157:3527.
62. Orme, I. M. 1987. The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis. J. Immunol. 138:293.
63. + T-cell clones from Mycobacterium tuberculosis-immune mice. Infect. Immun. 54:291.