Comparison of antigen-specific T-cell responses of tuberculosis patients using complex or single antigens of Mycobacterium tuberculosis

Scandinavian Journal of Immunology

Volumn 48, Issue 5, 1998, Pages 535-543

  Mustafa, A S ^a   Amoudy, H A ^a   Wiker, H G ^b   Abal, A T ^a   Ravn, P ^c   Oftung, F ^d   Andersen, P ^c  

^a KUWAIT UNIVERSITY   (Kuwait)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c STATENS SERUM INSTITUT   (Denmark)

^d NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; GAMMA INTERFERON; HLA ANTIGEN; MYCOBACTERIUM ANTIGEN; RECOMBINANT EARLY SECRETORY ANTIGENIC TARGET ANTIGEN; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CYTOKINE RELEASE; DIAGNOSTIC VALUE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; RECOMBINANT DNA TECHNOLOGY; TUBERCULOSIS; VACCINE PRODUCTION;

ANTIGENS, BACTERIAL; CELL DIVISION; CELL LINE; HUMANS; LEUKOCYTES, MONONUCLEAR; MYCOBACTERIUM TUBERCULOSIS; T-LYMPHOCYTES; TH1 CELLS; TUBERCULOSIS;

EID: 0031763282     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1998.00419.x     Document Type: Article

References (65)

1. World Health Organization fact sheet no. 93, 1995.
2. Fine PE. Variation in protection by BCG. Implications of and for heterologous immunity. Lancet 1995;346:1339-45.
3. Young DB, Kaufmann SHE, Hermans PWM, Thole JER. Mycobacterial protein antigens: a compilation. Mol Microbiol 1992;6:133-45.
4. Mustafa AS. Recombinant mycobacterial antigens and epitopes recognized by human T cells. In: Mustafa AS, Al-Attiyah R, Nath I. Chugh TD, eds. T-cell Subsets and Cytokines Interplay in Infectious Diseases. Basel: Karger, 1996:201-11.
5. Andersen P. Host responses and antigens involved in protective immunity to Mycobacterium tuberculosis. Scand J Immunol 1997;45:115-31.
6. Andersen P. Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect Immun 1994;62:2536-44.
7. Roberts AD, Sonnenberg MG, Ordway DJ. Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis. Immunology 1995;85:502-8.
8. Howritz MA, Lee B, Dillon BJ, Harth G. Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis. Proc Natl Acad Sci USA 1995;92:1530-4.
9. Pal PG, Horwitz MA. Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune response and substantial protection in a guinea pig model of pulmonary tuberculosis. Infect Immun 1992;60:4781-92.
10. Brandt L, Oettinger T, Holm A, Andersen P. Key epitopes on the ESAT-6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis. J Immunol 1996;157: 3527-33.
11. Harboe M, Nagai S, Patrroyo ME, Torres ML, Ramirez C, Cruz N. Properties of proteins MPB64, MPB70 and MPB80 of Mycobacterium bovis BCG. Infect Immun 1986;52:293-302.
12. Nagai S, Wiker HG, Harboe M, Kinomoto M. Isolation and partial characterization of main protein antigens in culture fluid of Mycobacterium tuberculosis. Infect Immun 1991;59:372-82.
13. Andersen P, Andersen AB, Sorensen AL, Nagai S. Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice. J Immunol 1995;154:3359-72.
14. Huygen K, Content J, Denis O et al. Immunogenecity and protective efficacy of a tuberculosis DNA vaccine. Nature Med 1996;2:893-8.
15. Andersen P, Heron I. Simultaneous electroelution of whole SDS-polyacrylamide gels for the direct cellular analysis of complex protein mixtures. J Immunol Methods 1993;161:29-39.
16. Wiker HG, Harboe M, Nagai S. A localization index for distinction between extracellular and intracellular antigens of Mycobacterium tuberculosis. J Gen Microbiol 1991;137:875-84.
17. Mustafa AS, Oftung F, Gill HK, Natvig I. Characteristics of human T cell clones from BCG and killed M. leprae vaccinated subjects and tuberculosis patients. Lepr Rev 1986;57 (Suppl. 2): 123-30.
18. Sorensen AL, Nagai S, Houen G, Andersen P, Andersen AB. Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis. Infect Immun 1995;63:1710-7.
19. Nagai S, Matsumoto J, Nagasuga T. Specific skin reactive proteins from culture filtrate of Mycobacterium bovis BCG. Infect Immun 1981;31:1152-60.
20. Mustafa AS, Godal T. In vitro induction of human suppressor T cells by mycobacterial antigens. BCG activated OKT4+ cells mediate suppression of antigen-induced T cell proliferation. Clin Exp Immunol 1983;52:29-37.
21. Seaton A, Seaton D, Leiten AG. Crofton & Douglas's Respiratory Diseases, 4th edn. Oxford: Blackwell Scientific Publications, 1989.
22. Gill HK, Mustafa AS, Godal T. In vitro proliferation of lymphocytes from human volunteers vaccinated with armadillo derived killed M. leprae. Int J Lepr 1987;55:30-5.
23. + cytotoxic T cells from BCG vaccinated healthy subjects: relation between cytotoxicity and suppression in vitro. Clin Exp Immunol 1987;69:255-62.
24. Mustafa AS, Oftung F. Long lasting T cell reactivity Mycobacterium leprae antigens in human volunteers vaccinated with killed M. lepae. Vaccine 1993;11:1108-12.
25. Mustafa AS. Restoration of proliferative response to M. leprae antigens in lepromatous T cells against candidate antileprosy vaccines. Int J Lepr 1996;64:257-67.
26. Oflung F, Borka E, Kvalheim G, Mustafa AS. Mycobacterial cross-reactivity of M. tuberculosis reactive T cell clones from naturally converted PPD positive healthy subjects. FLMS Immunol Med Microbiol 1998;20:231-8.
27. Mustafa AS, Gill HK, Nerland A. Human T cell clones recognize a major M. leprae antigen expressed in E. coli. Nature (London) 1986;319:63-6.
28. Mustafa AS. Identification of T-cell activating recombinant antigens shared among three candidate antileprosy vaccines, killed M. leprae, M. bovis BCG and Mycobacterium w. Int J Lepr 1988;50:265-73.
29. Mustafa AS, Lundin KEA, Oftung F. Human T cells recognize mycobacterial heat shock proteins in the context of multiple HLA-DR molecules: studies with healthy subjects vaccinated with Mycobacterium bovis BCG and Mycobacterium leprae. Infect Immun 1993;61:5294-301.
30. Oftung F, Geluk A, Lundin KEA et al. Mapping of multiple HLA class II restricted T-cell epitopes of the mycobacterial 70-kilodalton heat shock protein. Infect Immun 1994;62:5411-8.
31. Mustafa AS, Kvalheim G, Degre M, Godal T. Mycobacterium bovis BCG induced human T cell clones from BCG vaccinated healthy subjects: Antigen specificity and lymphokine production. Infect Immun 1986;53:491-7.
32. Oftung F, Mustafa AS, Husson R, Young RA, Godal T. Human T cell clones recognize two abundant Mycobacterium tuberculosis protein antigens expressed in Escherichia coli. J Immunol 1987;138:927-31.
33. Oftung F, Mustafa AS, Shinnick TM et al. Epitopes of the Mycobacterium tuberculosis 65-kilodalton protein antigen as recognized by human T cells. J Immunol 1988;141:2749-54.
34. Mustafa AS, Deggerdal A, Lundin KFA, Meloen RM, Shinnick TM, Oftung F. An HLA-DRw53-restricted T cell epitope from a novel Mycobacterium leprae protein antigen important to the memory T-cell repertoire against M. leprae. Infect Immun 1994;62:5595-602.
35. Mustafa AS, Godal T. BCG induced suppressor T cells optimal conditions for in vitro induction and mode of action. Clin Exp Immunol 1985;62:474-81.
36. Mustafa AS, Oflung F, Deggerdal A, Gill HK, Young RA, Godal T. Gene isolation with human T lymphocyte probes. Isolation of a gene that expresses an epitope recognized by T cell specific for Mycobacterium bovis BCG and pathogenic mycobacteria. J Immunol 1988;141:2729-33.
37. Oftung F, Wiker HG, Deggerdal A, Mustafa AS. A novel mycobacterial antigen relevant to cellular immunity belongs to a family of secreted lipoproteins. Scand J Immunol 1997;46:445-51.
38. Ellner JJ. Immunosuppression in tuberculosis. Infect Agents Dis 1996;5:62-72.
39. Boeson B, Jensen BN, Wilcke T, Andersen P. Human T-cell responses to secreted antigen fractions of Mycobacterium tuberculosis. Infect Immun 1995;63:1391-497.
40. Barnes PF, Mistry SD, Cooper CL, Pirmez C, Rea TH, Modlin RL. Compartmentalization of a CD4+ lymphocyte subpopulation in tuberculous pleuritis. J Immunol 1989;142:1114-9.
41. Tacson RE, Colston MJ, Ragno S, Stavropoulos E, Gregory D, Lowrie DB. Vaccination against tuberculosis by DNA injection. Nature Med 1996;2:888-92.
42. Bonato VLD, Lima VMF, Tascon RE, Lowrie DB, Silva CL. Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice. Infect Immun 1998;66:169-75.
43. Haslov K, Andersen A, Nagai S, Gottschau A, Sorensen T, Andersen P. Guinea pig cellular immune responses to proteins secreted by Mycobacterium tuberculosis. Infect Immun 1995;63:804-10.
44. Pollock JM, Andersen P. The potential of the ESAT-6 antigen secreted by virulent mycobacteria for specific diagnosis of tuberculosis. J Infect Dis 1997;175:1251-4.
45. Pollock JM, Andersen P. Predominant recognition of the ESAT-6 protein in the first phase of infection with Mycobacterium bovis in cattle. Infect Immun 1997;65:2587-92.
46. Billman-Jacobe H, Radford AJ, Rothel JS, Wood PR. Mapping of the T and B cell epitopes of the Mycobacterium bovis protein, MPB70. Immunol Cell Biol 1990;68:359-65.
47. Pollock JM, Douglas AJ, Mackie DP, Neill SD. Identification of bovine T-cell epitopes for three Mycobacterium bovis antigens: MPB70, 19000 MW and MPB57. Immunology 1994;82:9-15.
48. Haga S, Yamaguchi R, Nagai S, Matsuo K, Yamazaki A, Nakamura RM. Delayed-type hypersensitivity to a recombinant mycobacterial antigen, MPB64, in guinea pigs sensitized to Mycobacterium tuberculosis or Mycobacterium bovis RCG. J Leukoc Biol 1995;57:221-5.
49. Oettinger T, Holm A, Mtoni IM, Andersen AB, Kaslov K. Mapping of the delayed-type hypersensitivity-inducing epitope of secreted protein MPT64 from Mycobacterium tuberculosis. Infect Immun 1995;63:4613-8.
50. Roche PW, Triccas JA, Avery DT, Fifis T, Billman-Jacobe H, Britton WJ. Differential T cell responses to mycobacteria-secreted proteins distinguish vaccination with bacille Calmette-Guerin from infection with Mycobacterium tuberculosis. J Infect Dis 1994;170: 1326-30.
51. Roche PW, Feng CG, Britton WJ. Human T-cell epitopes on the Mycobacterium tuberculosis secreted protein MPT64. Scand J Immunol 1996;3:662-70.
52. Roche PW, Winter N, Triccas JA, Feng CG, Britton WJ. Expression of Mycobacterium tuberculosis MPT64 in recombinant Myco. smegmatis: purification, immunogenicity and application to skin tests for tuberculosis. Clin Exp Immunol 1996;103:226-32.
53. Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. An essential role tor interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 1993;178:2249-54.
54. Orme IM, Roberts AD, Griffin JP, Abrams JS. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J Immunol 1993;151:518-26.
55. + T cells requires the production of gamma interferon. Infect Immun 1998; 66:830-4.
56. Ravn P, Boesen H, Pedersen BK, Andersen P. Human T cell responses induced by vaccination with Mycobacterium bovis bacillus Calmette-Guérin. J Immunol 1997;158:1949-55.
57. Jouanguy E, Altare F, Lamhamedi S et al. Interferon-gamma receptor deficiency in an infant with fatal Bacille Calmette-Guérin infection. N Engl J Med 1996;335:1956-61.
58. Newport MJ, Huxley CM, Huston S et al. A mutation in the interferon-γ receptor gene and susceptibility to mycobacterial infection. N Engl J Med 1996;335:1941-9.
59. Orme IM, Miller ES, Roberts AD et al. T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens. J Immunol 1992;148: 189-96.
60. Flynn JL, Goldstein MM, Triebold KJ, Koller B, Bloom BR. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc Natl Acad Sci USA 1992;89:12013-7.
61. Lalvani A, Brookes R, Wilkinson RJ et al. Human cytolytic and interferon-gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis. Proc Natl Acad Sci USA 1998;95: 270-5.
62. Silva CL, Silva MF, Pietro RC, Lowrie DB. Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65. Infect Immun 1996;64:2400-7.
63. Vordermeier HM, Zhu X, Harris DP. Induction of CD8+ CTL recognizing mycobacterial peptides. Scand J Immunol 1997;45: 521-6.
64. Harboe M, Oettinger T, Wiker HG, Rosenkrands I, Andersen P. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect Immun 1996;64:16-22.
65. Mahairas GG, Sabo JJ, Hickey MJ, Singh DC, Stover CK. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J Bacteriol 1996;178:1274-82.