Cellular immune responses to ESAT-6 discriminate between patients with pulmonary disease due to Mycobacterium avium complex and those with pulmonary disease due to Mycobacterium tuberculosis

Clinical and Diagnostic Laboratory Immunology

Volumn 6, Issue 4, 1999, Pages 606-609

  Lein, A David ^a   Von Reyn, C Fordham ^a   Ravn, Pernille ^b   Horsburgh Jr , C Robert ^c   Alexander, Lorraine N ^c   Andersen, Peter ^b  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b STATENS SERUM INSTITUT   (Denmark)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON;

ADULT; ANTIGEN RECOGNITION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIAGNOSTIC ACCURACY; FEMALE; GENE LOCUS; HUMAN; IMMUNE RESPONSE; IMMUNOSTIMULATION; LUNG DISEASE; MALE; MYCOBACTERIUM AVIUM; MYCOBACTERIUM TUBERCULOSIS; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0032808569     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/cdli.6.4.606-609.1999     Document Type: Article

References (18)

1. Andersen, P., A. B. Andersen, A. L. Sørensen, and S. Nagai. 1995. Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice. J. Immunol. 154:3359.
2. Boesen, H., B. N. Jensen, T. Wilcke, and P. Andersen. 1995. Human T-cell responses to secreted antigen fractions of Mycobacterium tuberculosis. Infect. Immun. 63:1491-1497.
3. Brandt, L., T. Oettinger, A. Holm, A. B. Andersen, and P. Andersen. 1996. Key epitopes on the ESAT-6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis. J. Immunol. 157:3527- 3533.
4. Converse, P. J., L. J. Jones, J. Astemborski, D. Vlahov, and N. M. H. Graham. 1997. Comparison of a tuberculin interferon-γ assay with the tuberculin skin test in high-risk adults: effect of human immunodeficiency virus infection. J. Infect. Dis. 176:144-150.
5. Edwards, L., F. Acquaviva, and V. Livesay. 1973. Identification of tuberculous infected: dual tests and density of reaction. Am. Rev. Respir. Dis. 108:1334-1339.
6. Fiavey, N. P., and S. Frankenburg. 1992. Appraisal of the total blood lymphocyte proliferation assay as a diagnostic tool in screening for tuberculosis. J. Med. Microbiol. 37:283-285.
7. Harboe, M., T. Oettinger, H. G. Wiker, I. Rosenbrands, and P. Andersen. 1996. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculous and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect. Immun. 64:16-22.
8. Hirsh, C. S., J. J. Ellner, R. Blinkhorn, and Z. Toossi. 1997. In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor beta. Proc. Natl. Acad. Sci. USA 94:3926-3931.
9. Hirsh, C. S., R. Hussain, Z. Toossi, G. Dawood, F. Shahid, and J. J. Ellner. 1996. Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen-driven blastogenesis and interferon-γ production. Proc. Natl. Acad. Sci. USA 93:3193-3198.
10. Lein, A. D., and C. F. von Reyn. 1997. In vitro cellular and cytokine responses to mycobacterial antigens: application to diagnosis of tuberculosis infection and assessment of response to mycobacterial vaccines. Am. J. Med. Sci. 313:364-371.
11. Mahairas, G., P. Sabo, M. Hickey, D. Singh, and C. Stover. 1996. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J Bacteriol. 178:1274-1282.
12. Mehra, V., J. H. Gong, D. Iyer, Y. G. Lin, C. T. Boylen, B. R. Bloom, and P. F. Barnes. 1996. Immune response to recombinant mycobacterial proteins in patients with tuberculosis infection and disease. J. Infect. Dis. 174:431-443.
13. Pollock, J. M., and P. Andersen. 1997. The potential of the ESAT-6 antigen secreted by virulent mycobacteria for specific diagnosis of tuberculosis. J. Infect. Dis. 175:1251-1254.
14. Ravn, P., H. Boesen, B. K. Pedersen, and P. Andersen. 1997. Human T cell responses induced by vaccination with M. bovis Bacillus Calmette-Guérin. J. Immunol. 158:1949-1955.
15. Ravn, P., A. Demissie, T. Eguale, H. Wondwosson, D. Lein, H. A. Amoudy, A. S. Mustafa, A. K. Jensen, A. Holm, I. Rosengrands, F. Oftung, J. Olobo, F. von Reyn, and P. Andersen. 1999. Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis. J. Infect. Dis. 179:637-645.
16. 15a. Ravn, P. Unpublished data.
17. Verbon, A., G. Weverling, S. Kuijper, P. Speelman, H. Jansen, and A. Kolk. 1993. Evaluation of different tests for the serodiagnosis of tuberculosis and the use of likelihood ratios in serology. Am. Rev. Respir. Dis. 148:378-384.
18. von Reyn, C. F., D. E. Williams, C. R. Horsburgh, Jr., A. S. Jaeger, B. J. Marsh, K. Haslov, and M. Magnusson. 1998. Dual skin testing with Mycobacterium avium sensitin and purified protein derivative to discriminate pulmonary disease due to M. avium complex from pulmonary disease due to Mycobacterium tuberculosis. J. Infect. Dis. 177:730-736.