Oligoclonal expansions of CD8+ T cells in chronic HIV infection are antigen specific

Journal of Experimental Medicine

Volumn 188, Issue 4, 1998, Pages 785-790

  Wilson, Jamie D K ^a   Ogg, Graham S ^a   Allen, Rachel L ^a   Goulder, Philip J R ^a   Kelleher, Anthony ^a   Sewell, Andy K ^a   O'Callaghan, Christopher A ^a   Rowland Jones, Sarah L ^a   Callan, Margaret F C ^a   McMichael, Andrew J ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Cytotoxic T lymphocytes; Expansion; Human immunodeficiency virus; T cell receptor; Tetramer

Indexed keywords

CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; MESSENGER RNA; MONOCLONAL ANTIBODY; PEPTIDE; T LYMPHOCYTE RECEPTOR;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOFLUOROMETRY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; T LYMPHOCYTE;

CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CHRONIC DISEASE; CLONE CELLS; HIV INFECTIONS; HUMANS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 18144437802     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.4.785     Document Type: Article

References (28)

1. Koup, R.A., J.T. Safrit, Y. Cao, C.A. Andres, Y. Wu, G. McLeod, W. Borkowsky, C. Farthing, and D.D. Ho. 1994. Temporal association of cellular immune response with the initial control of viremia in primary HIV-1 syndrome. J. Virol. 67:1707-1711.
2. Moss, P.A.H., S.L. Rowland-Jones, P.M. Frodsham, S. McAdam, P. Giangrande, A.J. McMichael, and J.I. Bell. 1995. Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors. Proc. Natl. Acad. Sci. USA. 92:5773-5777.
3. Hoffenbach, A., P. Langlade-Demoyen, E. Vilmer, G. Dadaglio, F. Michel, C. Mayaud, B. Autran, and F. Plata. 1989. Very high frequencies of HIV specific cytotoxic T lymphocytes in humans. J. Immunol. 142:452-456.
4. Gotch, M., D.F. Nixon, N. Alp, A.J. McMichael, and L.K. Borysievicz. 1990. High frequency of memory and effector Gag-specific cytotoxic T lymphocytes in HIV seropositive individuals. Int. Immunol. 2:707-712.
5. Riviere, Y., M.B. McChesney, F. Porrot, F. Tanneau-Salvadori, P. Sansonetti, O. Lopez, G. Pialoux, V. Feuillie, M. Mollereau, S. Chamaret, et al. 1995. Gag-specific cytotoxic responses to HIV type-1 are associated with a decreased risk of progression to AIDS-related complex or AIDS. AIDS Res. Hum. Retroviruses. 118:903-907.
6. Ogg, G.S., X. Jin, S. Bonhoeffer, P.R. Dunbar, M.A. Nowak, S. Monard, J.P. Segal, Y. Cao, S.L. Rowland-Jones, V. Cerundolo, et al. 1998. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load viral RNA. Science. 279:2103-2106.
7. Price, D.A., P.J. Goulder, P. Klenerman, A.K. Sewell, P.J. Easterbrook, M. Troop, C.R. Bangham, and R.E Philips. 1997. Positive selection of HIV-1 cytotoxic T lymphocytes escape variants during primary infection. Proc. Natl. Acad. Sci. USA. 94:1890-1895.
8. Goulder, P.J., R.E. Philips, R.A. Colbert, S. McAdam, G. Ogg, M.A. Nowak, P. Giangrande, G. Luzzi, B. Morgan, A. Edwards, et al. 1997. Late escape from an immunodominant cytotoxic T lymphocyte response associated with progression to AIDS. Nat. Med. 3:212-217.
9. Pantaleo, G., J.F. Demarest, H. Soudeyns, C. Grazios, F. Denis, J.W. Adelsberger, P. Borrow, M.S. Saag, G.M. Shaw, R.P. Sekaly, and A.S. Fauci. 1994. Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV. Nature. 370:463-467.
10. Callan, M.F.C., N. Steven, P. Krausa, J.D.K. Wilson, P.A.H. Moss, G.M. Gillespie, J.I. Bell, A.B. Rickinson, and A.J. McMichael. 1996. Large clonal expansions of CD8+ T cells in acute infectious mononucleosis. Nat. Med. 2:906-911.
11. Chen, Z.W., Z.C. Kou, C. Lekutis, L. Shen, D. Zhou, M. Halloran, J. Li, J. Sodroski, D. Lee-Parritz, and N.L. Letvin. 1995. T cell receptor Vβ repertoire in an acute infection of rhesus monkeys with simian immunodeficiency viruses and a chimeric simian-human immunodeficiency virus. J. Exp. Med. 182:21-31.
12. Pantaleo, G., H. Soudeyns, J.F. Demarest, M. Vaccarezza, C. Grazios, S. Paolucci, M. Daucher, O.J. Cohen, F. Denis, W.E. Biddison, et al. 1997. Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection. Proc. Natl. Acad. Sci. USA. 94: 9848-9853.
13. Wilson, J.D.K., M. Cranage, N. Cook, S. Leech, A.J. McMichael, and M.F.C. Callan. 1998. Evidence for the persistence of monoclonal expansions of CD8+ T cells following primary SIV infection. Eur. J. Immunol. 28:1172-1180.
14. Altman, J.D., P.A.H. Moss, P.J. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMichael, and M.M. Davis. 1996. Phenotypic analysis of antigen specific T lymphocytes. Science. 274:94-96.
15. + T cells during the primary immune response to Epstein-Barr virus in vivo. J. Exp. Med. 187:1395-1402.
16. Murali-Krishna, K., J. Altman, M. Suresh, D.J.D. Sourdive, A.J. Zajac, J.D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity. 8:177-187.
17. Posnett, D.M., R. Sinha, S. Kabak, and C. Russo. 1994. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammopathy". J. Exp. Med. 179:609-618.
18. Posnett, D.M., F. Romagne, A. Necker, B.L. Kotzin, and R.-P. Sekaly. 1996. First human TcR monoclonal antibody workshop. The Immunologist. 4:5-8.
19. Arden, B., S.P. Clark, D. Kabelitz, and T.W. Mak. 1995. Human T cell receptor variable gene segment families. Immunogenetics. 42:455-500.
20. Parker, K.C., M. DiBrino, L. Hull, and J.E. Coligan. 1992. The beta 2-microglobulin dissociation rate is in an accurate measure of the stability of MHC class I heterodimers and depends on which peptide is bound. J. Immunol. 149:1896-1904.
21. Tsomides, T.J., B.D. Walker, and H.N. Eisen. 1991. An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein. Proc. Natl. Acad. Sci. USA. 88:11276-11280.
22. Nixon, D.F., A.R.M. Townsend, J.G. Elvin, C.R. Rizza, J. Gallwey, and A.J. McMichael. 1988. HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides. Nature. 336:484-487.
23. Hingorani, R., I.H. Choi, P. Alkoklar, B. Gulwani-Akolkar, R. Pergolizzi, J. Silver, and P.K. Gregersen. 1993. Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects. J. Immunol. 151:5726-5769.
24. Tough, D.F., and J. Sprent. 1996. Induction of bystander T cell proliferation by viruses and type 1 interferon in vivo. Science. 272:1947-1950.
25. + T cells during the virus-induced polyclonal T cell response. J. Exp. Med. 185:1629-1639.
26. Beverley, P.C. 1990. Is T-cell memory maintained by cross-reactive stimulation? Immunol. Today. 11:203-205.
27. Roglic, M., R.D. Macphee, S.R. Duncan, F.R. Sattler, and A.N. Theofilopoulos. 1997. T cell receptor (TCR) BV gene repertoires and clonal expansions of CD4 cells in patients with HIV infections. Clin. Exp. Immunol. 107:21-30.
28. Gorochov, G., A.U. Neumann, A. Kereveur, C. Parizot, L. Taisheng, C. Katalama, M. Karmochkine, G. Raguin, B. Autran, and P. Debrè. 1998. Perturbations of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nat. Med. 4:215-221.