Multiple epitopes from the Mycobacterium tuberculosis ESAT-6 antigen are recognized by antigen-specific human T cell lines

Clinical Infectious Diseases

Volumn 30, Issue , 2000, Pages S201-S205

  Mustafa, Abu Salim ^a   Oftung, F ^b   Amoudy, H A ^a   Madi, N M ^a   Abal, A T ^a   Shaban, F ^a   Rosen Krands, I ^c   Andersen, P ^c  

^a KUWAIT UNIVERSITY   (Kuwait)

^b NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^c STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; EARLY SECRETORY ANTIGENIC TARGET 6; EPITOPE; GAMMA INTERFERON; HLA DR ANTIGEN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; CONFERENCE PAPER; CONTROLLED STUDY; GENE MAPPING; HUMAN; HUMAN CELL; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; HISTOCOMPATIBILITY TESTING; HUMANS; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; PEPTIDES; TUBERCULOSIS, PULMONARY;

EID: 0034463531     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/313862     Document Type: Article

References (24)

1. Mycobacterial protein antigens: A compilation
2. Host responses and antigens involved in protective immunity to Mycobacterium tuberculosis
3. Evaluation of new vaccines in the mouse and guinea-pig model of tuberculosis
4. Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice
5. Comparison of antigen specific T cell responses of tuberculosis patients using complex and single antigens of Mycobacterium tuberculosis
6. Key epitopes on the ESAT-6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis
7. + cells mediate suppression of antigen-induced T cell proliferation
8. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor recipient matching in cadaveric transplantation
9. In vitro proliferation of lymphocytes from human volunteers vaccinated with armadillo-derived killed M. Leprae
10. + cytotoxic T cells from BCG vaccinated healthy subjects: Relation between cytotoxicity and suppression in vitro
11. Long lasting T cell reactivity to Mycobacterium leprae antigens in human volunteers vaccinated with killed M. Leprae
12. A novel mycobacterial antigen relevant to cellular immunity belongs to a family of secreted lipoproteins
13. Identification of T-cell-activating recombinant antigens shared among three candidate antileprosy vaccines, killed M. Leprae, M. Boris, BCG, and Mycobacterium w
14. Restoration of proliferative response to M. Leprae antigens in lepromatous T cells against candidate antileprosy vaccines
15. + T-cell clones from subjects vaccinated with killed M. Leprae
16. Heterogeneity among human T cell clones recognizing an HLA-DR4, Dw4 restricted epitope from the 18 Kd antigen of Mycobacterium leprae defined by synthetic peptides
17. Human T cells recognize mycobacterial heat shock proteins in the context of multiple HLA-DR molecules: Studies with healthy subjects vaccinated with Mycobacterium bovis BCG and Mycobacterium leprae
18. Mapping of multiple HLA class II restricted T-cell epitopes of the mycobacterial 70-kilodalton heat shock protein
19. Defining an HLA-DRw53-restricted T cell epitope from a novel M. Leprae protein antigen important to T cell repertoire against M. Leprae
20. Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis
21. Differential T cell responses to Mycobacterium tuberculosis ESAT6 in tuberculosis patients and healthy donors
22. ESAT-6 subunit vaccination against Mycobacterium tuberculosis
23. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis