Cytotoxic T lymphocytes against malaria and tuberculosis: From natural immunity to vaccine design

Clinical Science

Volumn 95, Issue 5, 1998, Pages 531-538

  Lalvani, Ajit ^a   Hill, Adrian V S ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cytotoxic T lymphocyte; ELISPOT; Falciparum; Interferon ; Malaria; MHC class I; Tuberculosis; Vaccine

Indexed keywords

ALPHA INTERFERON; BCG VACCINE; CD8 ANTIGEN; CHROMIUM 51; EPITOPE; HLA ANTIGEN CLASS 1; HLA B ANTIGEN; HLA B52 ANTIGEN; MALARIA VACCINE; UNCLASSIFIED DRUG;

AFRICA; ALLELE; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DRUG DESIGN; EFFECTOR CELL; ENZYME LINKED IMMUNOSPOT ASSAY; GAMBIA; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNITY; IMMUNOGENETICS; IMMUNOGENICITY; ISOTOPE LABELING; MEMORY CELL; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; VACCINE PRODUCTION; VIRUS INFECTION;

EID: 0031739023     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0950531     Document Type: Article

References (36)

1. The World Bank. (1993) World Development Report, Oxford University Press, New York
2. Rock, K. L. (1996) A new foreign policy: MHC class I molecules monitor the outside world. Immunol. Today 17, 131-137
3. Mazzacaro, R. J., Gedde, M., Jensen, E. R. et al. (1996) Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. U.S.A. 93, 11786-11791
4. Weiss, W. R., Sedegah, M., Beaudoin, R. L., Miller, L. H. and Good, M. F. (1988) CD8+ T cells are required for protection in mice immunized with irradiated sporozoites. Proc. Natl. Acad. Sci. U.S.A. 88, 573-576
5. Romero, P., Maryanski, J. L., Corradin, G., Nussenzweig, R. S., Nussenzweig, V. and Zavala, F. (1988) Cloned cytotoxic T cells recognise an epitope in the circumsporozoite protein and protect against malaria. Nature (London) 341, 323-326
6. Weiss, W. R., Mellouk, S., Houghten, R. A. et al. (1990) Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes. J. Exp. Med. 171, 763-773
7. Flynn, J. L., Goldstein, M. M., Triebold, K. J., Koller, B. and Bloom, B. R. (1992) Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. U.S.A. 89, 12013-12017
8. Silva, C. L., Silva, M. F., Pietro, R. C. L. R. and Lowrie, D. B. (1994) Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat-shock protein 65. Immunology 83, 341-346
9. Hill, A. V. S., Allsopp, C. E. M., Kwiatowski, D. et al. (1991) Common West African HLA antigens are associated with protection from severe malaria. Nature (London) 352, 595-600
10. Hill, A. V. S., Elvin, J., Willis, A. et al. (1992) Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature (London) 360, 434-139
11. Bloom, B. R. and Fine, P. E. M. (1994) In Tuberculosis: Pathogenesis, Protection and Control (Bloom, B. R., ed.), pp. 531-558, American Society for Microbiology, Washington DC
12. Dame, J. B., Williams, J. L., McCutchan, T. F. et al. (1984) Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science (Washington DC) 225, 593-599
13. Robson, K. J. H., Hall, J. R. S., Jennings, M. W. et al. (1988) A highly conserved amino acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite. Nature (London) 335, 79-82
14. Zhu, J. and Hollingdale, M. (1991) Structure of Plasmodium falciparum liver-stage antigen-1. Mol. Biochem. Parasitol. 48, 223-226
15. Fidock, D. A., Bottius, L., Brahimi, K. et al. (1994) Cloning and characterisation of a novel Plasmodium falciparum sporozoite surface antigen, STARP. Mol. Biochem. Parasitol. 45, 177-187
16. Horwitz, M. A., Lee, B.-W. E., Dillon, B. J. and Harth, G. (1995) Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 92, 1530-1534
17. Andersen, P., Andersen, A. B., Sorensen, A. L. and Nagai, S. (1995) Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice. J. Immunol. 154, 3359-3372
18. Huygen, K., Content, J., Denis, O. et al. (1996) Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nature Med. 2, 893-898
19. Falk, K., Roetzschke, O., Stevanovic, S., Jung, G. and Ramensee, H. G. (1991) Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature (London) 351, 290-296
20. Elvin, J., Cerundolo, V., Elliot, T. and Townsend, A. R. M. (1991) A quantitative assay of peptide-dependent class I assembly. Eur. J. Immunol. 21, 2025-2031
21. Aidoo, M., Lalvani, A., Whittle, H. C., Hill, A. V. S. and Robson, K. J. H. (1997) Recombinant vaccinia viruses for the characterization of Plasmodium falciparum-specific cytotoxic T-lymphocytes: recognition of processed antigen despite limited restimulation efficacy. Int. Immunol. 9, 731-736
22. Lalvani, A., Dong, T., Ogg, G. et al. (1997) Optimization of a peptide-based protocol employing IL-7 for in vitro restimulation of human cytotoxic T lymphocyte precursors. J. Immunol. Methods 210, 65-77
23. Aidoo, M., Lalvani, A., Allsopp, C. E. M. et al. (1995) Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria. Lancet 345, 1003-1007
24. Smith, T., Charlwood, J. D., Kihonda, J. et al. (1993) Absence of seasonal variation in malaria parasitaemia in an area of intense seasonal transmission. Acta Tropica 54, 55-72
25. Lalvani, A., Hurt, N., Aidoo, M., Kibatala, P., Tanner, M. and Hill, A. V. S. (1996) Cytotoxic T lymphocytes to Plasmodium falciparum epitopes in an area of intense and perennial transmission in Tanzania. Eur. J. Immunol. 26, 773-779
26. Lalvani, A., Aidoo, M., Allsopp, C. E. M., Plebanski, M., Whittle, H. C. and Hill, A. V. S. (1994) An HLA-based approach to the design of a CTL-inducing vaccine against Plasmodium falciparum. Research in Immunology, 59th Forum in Immunology: T cell Immunity to Malaria 145, 461-468
27. Kaegi, D. and Hengartner, H. (1996) Different roles for cytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses. Curr. Opin. Immunol. 8, 472-477
28. Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Stewart, T. A. and Bloom, B. R. (1993) An essential role for interferon γ in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178, 2249-2254
29. Laochumroonvorapong, P., Wang, J., Liu, C. C. et al. (1997) Perform, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice. Infect. Immun. 65, 127-132
30. Klinman, D. M. (1994) ELISPOT assay to detect cytokine-secreting murine and human cells. Curr. Protoc. Immunol. 6.19, 1-8
31. Lalvani, A., Brookes, R., Hambleton, S., Britton, W. J., Hill, A. V. S. and McMichael, A. J. (1997) Rapid effector function in CD8+ memory T cells. J. Exp. Med. 186, 859-865
32. Lalvani, A., Brookes, R., Wilkinson, R. J. et al. (1998) Human cytolytic and interferon-γ-secreting CD8+ T cells specific for Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 95, 270-275
33. Roche, P. W., Peake, P. W., Billman-Jacobe, H., Doran, T. and Britton, W. J. (1994) T-cell determinants and antibody binding sites on the major mycobacterial secretory protein MPB59 of Mycobacterium bovis. Infect. Immun. 62, 5319-5326
34. Gibert, S. C., Plebanski, M., Gupta, S. et al. (1998) Association of malaria parasite population structure, HLA, and immunological antagonism. Science (Washington DC) 279, 1173-1177
35. Bachmann, M. F., Kuendig, T. M., Hengartner, H. and Zinkernagal, R. M. (1997) Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without 'memory T cells'? Proc. Natl. Acad. Sci. U.S.A. 94, 640-645
36. Stoute, J. A., Slaoui, M., Heppner, G. et al. (1997) A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparurn malaria. N. Engl. J. Med. 336, 86-91