Inhibition of the transcription factors AP-1 and NF-κB in CD4 T cells by peroxisome proliferator-activated receptor γ ligands

International Immunopharmacology

Volumn 1, Issue 4, 2001, Pages 803-812

  Wang, Ping ^a,b   Anderson, Per O ^a   Chen, Shangwu ^a   Paulsson, Kajsa M ^a   Sjögren, Hans Olov ^a   Li, Suling ^a,c  

^a LUND UNIVERSITY   (Sweden)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

Inflammatory cytokines; PPAR ; T cell activation; Transcription factors

Indexed keywords

CD4 ANTIGEN; CIGLITAZONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CELL DIFFERENTIATION; COMPLEMENT ACTIVATION; CYTOKINE RELEASE; DRUG EFFECT; EFFECTOR CELL; GENE EXPRESSION REGULATION; GLUCOSE HOMEOSTASIS; LIGAND BINDING; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; LIGANDS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; NF-KAPPA B; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EID: 0035105403     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(01)00015-7     Document Type: Article

References (33)

1. Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life?
2. The nuclear receptor superfamily: The second decade
3. 15-Deoxy-12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
4. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
5. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
6. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
7. The PPARα-leukotriene B4 pathway to inflammation control
8. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
9. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology
10. PPARγ is required for placental, cardiac, and adipose tissue development
11. PPARγ is required for the differentiation of adipose tissue in vivo and in vitro
12. Differential expression of peroxisome proliferator-activated receptors (PPARγ): Tissue distribution of PPARα, β and γ in the adult rat
13. Isolation of the human peroxisome proliferator-activated receptor gamma cDNA expression in hematopoietic cells and chromosomal mapping
14. A novel therapy for colitis utilizing PPARγ ligands to inhibit the epithelial inflammatory response
15. The peroxisome proliferator-activated receptor is a negative regulator of macrophage activation
16. PPAR-agonists inhibit production of monocyte inflammatory cytokines
17. PPAR promotes monocyte/macrophage differentiation and uptake of oxidized LDL
18. Expression of the peroxisome proliferator-activated receptor in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein
19. Activation of proliferator-activated receptors and induces apoptosis of human monocyte-derived macrophages
20. Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens
21. IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmmue disease
22. Th1 and Th2 CD4 T cells in the pathogenesis of organ specific therapy for inflammatory autoimmmune diseases
23. The T lymphocyte in experimental allergic encephalomyelitis
24. The nuclear receptor PPAR and immunoregulation: PPAR mediates inhibition of helper T cell responses
25. T-cell activation by superantigens
26. Thymus histopathology in relation to SIVsm infection of cynomolgus monkeys
27. Rapid detection of octamer binding proteins with "mini-extracts", prepared from a small number of cells
28. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
29. Mitogen-activated protein kinase cascades and regulation of gene expression
30. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IB kinase
31. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
32. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
33. Interleukin-4-dependent production of PPARγ ligands in macrophages by 12/15-lipoxygenase