Activation of PPARγ increases PTEN expression in pancreatic cancer cells

Biochemical and Biophysical Research Communications

Volumn 301, Issue 1, 2003, Pages 50-53

  Farrow, Buckminster ^a   Evers, B Mark ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Metastasis; Pancreatic cancer; Phosphatidylinositol 3 kinase; PPAR ; PTEN; Rosiglitazone

Indexed keywords

15 DEOXYPROSTAGLANDIN J2; 2 CHLORO 5 NITROBENZANILIDE; LUCIFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROSTAGLANDIN DERIVATIVE; PROTEIN KINASE B; RECEPTOR BLOCKING AGENT; ROSIGLITAZONE; TROGLITAZONE; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 2,4-THIAZOLIDINEDIONE; 9-DEOXY-DELTA-9-PROSTAGLANDIN D2; AKT1 PROTEIN, HUMAN; CELL RECEPTOR; DNA BINDING PROTEIN; DRUG DERIVATIVE; HYBRID PROTEIN; LIGAND; NUCLEAR PROTEIN; ONCOPROTEIN; PHOSPHATASE; PROSTAGLANDIN D2; PROSTAGLANDIN J2; PROTEIN SERINE THREONINE KINASE; PTEN PROTEIN, HUMAN; REPRESSOR PROTEIN; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUMINESCENCE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; CELL CULTURE; CHEMISTRY; GENETICS; METABOLISM; PANCREAS TUMOR; REPORTER GENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; DNA-BINDING PROTEINS; GENES, REPORTER; HUMANS; LIGANDS; NUCLEAR PROTEINS; PANCREATIC NEOPLASMS; PHOSPHORIC MONOESTER HYDROLASES; PROSTAGLANDIN D2; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0037473753     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02983-2     Document Type: Article

References (35)

1. Greenlee R.T., Hill-Harmon M.B., Murray T., Thun M. CA Cancer J. Clin. 51:2001;15-36.
2. Lillemoe K.D., Yeo C.J., Cameron J.L. CA Cancer J. Clin. 50:2000;241-268.
3. Shi X., Liu S., Kleeff J., Friess H., Buchler M.W. Oncology. 62:2002;354-362.
4. Franke T.F., Yang S.I., Chan T.O., Datta K., Kazlauskas A., Morrison D.K., Kaplan D.R., Tsichlis P.N. Cell. 81:1995;727-736.
5. Cheng J.Q., Ruggeri B., Klein W.M., Sonoda G., Altomare D.A., Watson D.K., Testa J.R. Proc. Natl. Acad. Sci. USA. 93:1996;3636-3641.
6. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M.E. Cell. 91:1997;231-241.
7. Cardone M.H., Roy N., Stennicke H.R., Salvesen G.S., Franke T.F., Stanbridge E., Frisch S., Reed J.C. Science. 282:1998;1318-1321.
8. Tanno S., Mitsuuchi Y., Altomare D.A., Xiao G.H., Testa J.R. Cancer Res. 61:2001;589-593.
9. Leslie N.R., Downes C.P. Cell. Signal. 14:2002;285-295.
10. Stambolic V., Suzuki A., de la Pompa J.L., Brothers G.M., Mirtsos C., Sasaki T., Ruland J., Penninger J.M., Siderovski D.P., Mak T.W. Cell. 95:1998;29-39.
11. Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., Simons J.W., Semenza G.L. Cancer Res. 60:2000;1541-1545.
12. Ali I.U., Schriml L.M., Dean M. J. Natl. Cancer Inst. 91:1999;1922-1932.
13. Zhou X.P., Loukola A., Salovaara R., Nystrom-Lahti M., Peltomaki P., de la Chapelle A., Aaltonen L.A., Eng C. Am. J. Pathol. 161:2002;439-447.
14. Kwabi-Addo B., Giri D., Schmidt K., Podsypanina K., Parsons R., Greenberg N., Ittmann M. Proc. Natl. Acad. Sci. USA. 98:2001;11563-11568.
15. Willson T.M., Brown P.J., Sternbach D.D., Henke B.R. J. Med. Chem. 43:2000;527-550.
16. Escher P., Wahli W. Mutat. Res. 448:2000;121-138.
17. Forman B.M., Tontonoz P., Chen J., Brun R.P., Spiegelman B.M., Evans R.M. Cell. 83:1995;803-812.
18. Kahn C.R., Chen L., Cohen S.E. J. Clin. Invest. 106:2000;1305-1307.
19. Elnemr A., Ohta T., Iwata K., Ninomia I., Fushida S., Nishimura G., Kitagawa H., Kayahara M., Yamamoto M., Terada T., Miwa K. Int. J. Oncol. 17:2000;1157-1164.
20. Motomura W., Okumura T., Takahashi N., Obara T., Kohgo Y. Cancer Res. 60:2000;5558-5564.
21. Wang Q., Wang X., Hernandez A., Hellmich M.R., Gatalica Z., Evers B.M. J. Biol. Chem. 277:2002;36602-36610.
22. K. Hashimoto, R.T. Ethridge, B.M. Evers, Int. J. Gastrointest. Cancer (in press).
23. Elstner E., Muller C., Koshizuka K., Williamson E.A., Park D., Asou H., Shintaku P., Said J.W., Heber D., Koeffler H.P. Proc. Natl. Acad. Sci. USA. 95:1998;8806-8811.
24. Kubota T., Koshizuka K., Williamson E.A., Asou H., Said J.W., Holden S., Miyoshi I., Koeffler H.P. Cancer Res. 58:1998;3344-3352.
25. Chang T.H., Szabo E. Cancer Res. 60:2000;1129-1138.
26. Su C.G., Wen X., Bailey S.T., Jiang W., Rangwala S.M., Keilbaugh S.A., Flanigan A., Murthy S., Lazar M.A., Wu G.D. J. Clin. Invest. 104:1999;383-389.
27. Kim E.J., Kwon K.J., Park J.Y., Lee S.H., Moon C.H., Baik E.J. Brain Res. 941:2002;1-10.
28. Gan X., Wong B., Wright S.D., Cai T.Q. J. Interferon Cytokine Res. 21:2001;93-98.
29. Di Cristofano A., De Acetis M., Koff A., Cordon-Cardo C., Pandolfi P.P. Nat. Genet. 27:2001;222-224.
30. Fu M., Zhang J., Lin Yg Y., Zhu X., Willson T.M., Chen Y.E. Biochem. Biophys. Res. Commun. 294:2002;597-601.
31. Simpson L., Li J., Liaw D., Hennessy I., Oliner J., Christians F., Parsons R. Mol. Cell. Biol. 21:2001;3947-3958.
32. Stambolic V., MacPherson D., Sas D., Lin Y., Snow B., Jang Y., Benchimol S., Mak T.W. Mol. Cell. 8:2001;317-325.
33. Sheng X., Koul D., Liu J.L., Liu T.J., Yung W.K. Biochem. Biophys. Res. Commun. 292:2002;422-426.
34. Lu Y., Lin Y.Z., LaPushin R., Cuevas B., Fang X., Yu S.X., Davies M.A., Khan H., Furui T., Mao M., Zinner R., Hung M.C., Steck P., Siminovitch K., Mills G.B. Oncogene. 18:1999;7034-7045.
35. Lebovitz H.E. Diabetes Metab. Res. Rev. 18(Suppl. 2):2002;S23-S29.