Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin

Molecular and Cellular Biology

Volumn 25, Issue 4, 2005, Pages 1560-1568

  Volkening, Melanie ^a   Hoffmann, Ingrid ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN 6; DNA; MINICHROMOSOME MAINTENANCE PROTEIN 2; MINICHROMOSOME MAINTENANCE PROTEIN 7; MINICHROMOSOME MAINTENANCE PROTEIN 8; PROTEIN HCDC6; PROTEIN HORC2; REPLICATION LICENSING FACTOR CDT1; REPLICATION PROTEIN A; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CHROMATIN STRUCTURE; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPLICATION; DNA REPLICATION ORIGIN; DOWN REGULATION; HUMAN; HUMAN CELL; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN INTERACTION; RNA INTERFERENCE;

CELL CYCLE PROTEINS; CELLS, CULTURED; CHROMATIN; DNA REPLICATION; DNA-BINDING PROTEINS; FLOW CYTOMETRY; HELA CELLS; HUMANS; NUCLEAR PROTEINS; ORIGIN RECOGNITION COMPLEX; PROTEIN BINDING; RNA, SMALL INTERFERING; S PHASE;

EID: 13444280146     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.4.1560-1568.2005     Document Type: Article

References (48)

1. Alexandrow, M. G., and J. L. Hamlin. 2004. Cdc6 chromatin affinity is unaffected by scrine-54 phosphorylation, S-phase progression, and overexpression of cyclin A. Mol. Cell. Biol. 24:1614-1627.
2. Aparicio, O. M., D. M. Weinstein, and S. P. Bell. 1997. Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91:59-69.
3. Aves, S. J., N. Tongue, A. J. Foster, and E. A. Hart. 1998. The essential Schizosaccharomyces pombe cdc23 DNA replication gene shares structural and functional homology with the Saccharomyces cerevisiae DNA43 (MCM10) gene. Curr. Genet. 34:164-171.
4. Bell, S. P., and A. Dutta. 2002. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71:333-374.
5. Bell, S. P., and B. Stillman. 1992. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357:128-134.
6. Brummelkamp, T. R., R. Bernards, and R. Agami. 2002. A system for stable expression of short interfering RNAs in mammalian cells. Science 296:550-553.
7. Chong, J. P., H. M. Mahbubani, C. Y. Khoo, and J. J. Blow. 1995. Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375:418-421.
8. Cocker, J. H., S. Piatti, C. Santocanale, K. Nasmyth, and J. F. Diffley. 1996. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379:180-182.
9. Cook, J. G., D. A. Chasse, and J. R. Nevins. 2004. The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. J. Biol. Chem. 279:9625-9633.
10. Coverley, D., C. Pelizon, S. Trewick, and R. A. Laskey. 2000. Chromatin-hound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process. J. Cell Sci. 113:1929-1938.
11. DePamphilis, M. L. 2003. The ORC cycle': a novel pathway for regulating eukaryotic DNA replication. Gene 310:1-15.
12. Diffley, J. F. 1994. Eukaryotic DNA replication. Curr. Opin. Cell Biol. 6:368-372.
13. Diffley, J. F., J. H. Cocker, S. J. Dowell, and A. Rowley. 1994. Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78:303-316.
14. Elbashir, S. M., J. Harboth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494-498.
15. Gozuacik, D., M. Chami, D. Lagorce, J. Faivre, Y. Murakami, O. Poch, E. Biermann, R. Knippers, C. Brechot, and P. Paterlini-Brechot. 2003. Identification and functional characterization of a new member of the human Mem protein family: hMcm8. Nucleic Acids Res. 31:570-579.
16. Gregan, J., K. Lindner, L. Brimage, R. Franklin, M. Namdar, E. A. Hart, S. J. Aves, and S. E. Kearsey. 2003. Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding. Mol. Biol. Cell 14:3876-3887.
17. Harlow, E., and D. Lane. 1999. Using antibodies, a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
18. Hoffmann, I., G. Draetta, and E. Karsenti. 1994. Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1-to-S transition. EMBO J. 13:4302-4310.
19. Homesley, L., M. Lei, Y. Kawasaki, S. Sawyer, T. Christensen, and B. K. Tye. 2000. Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. Genes Dev. 14:913-926.
20. Ishimi, Y. 1997. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. J. Biol. Chem. 272:24508-24513.
21. Izumi, M., K. Yanagi, T. Mizuno, M. Yokoi, Y. Kawasaki, K. Y. Moon, J. Hurwitz, F. Yatagai, and F. Hanaoka. 2000. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. Nucleic Acids Res. 28:4769-4777.
22. Izumi, M., F. Yatagai, and F. Hanaoka. 2001. Cell cycle-dependent proteolysis and phosphorylation of human Mcm10. J. Biol. Chcm. 276:48526-48531.
23. Johnson, E. M., Y. Kinoshita, and D. C. Daniel. 2003. A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13. Nucleic Acids Res. 31:2915-2925.
24. Kelly, T. J., and G. W. Brown. 2000. Regulation of chromosome replication. Annu. Rev. Biochem. 69:829-880.
25. Labib, K., J. A. Tercero, and J. F. Diffley. 2000. Uninterrupted MCM2-7 function required for DNA replication fork progression. Science 288:1643-1647.
26. Lee, J. K., and J. Hurwitz. 2001. Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures. Proc. Natl. Acad. Sci. USA 98:54-59.
27. Li, C.-J., and M. L. DePamphilis. 2002. Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle. Mol. Cell. Biol. 22:105-116.
28. Liang, C., M. Weinreich, and B. Stillman. 1995. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 81:667-676.
29. Madine, M. A., M. Swietlik, C. Pelizon, P. Romanowski, A. D. Mills, and R. A. Laskey. 2000. The roles of the MCM, ORC, and Cdc6 proteins in determining the replication competence of chromatin in quiescent cells. J. Struct. Biol. 129:198-210.
30. Méndez, J., and B. Stillman. 2000. Chromatin association of human origin recognition complex, Cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol. Cell. Biol. 20:8602-8612.
31. Mendez, J., and B. Stillman. 2003. Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins. Bioessays 25:1158-1167.
32. Mendez, J., X. H. Zou-Yang, S. Y. Kim, M. Hidaka, W. P. Tansey, and B. Stillman. 2002. Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Mol. Cell 9:481-491.
33. Merchant, A. M., Y. Kawasaki, Y. Chen, M. Lei, and B. K. Tye. 1997. A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae. Mol. Cell. Biol. 17:3261-3271.
34. Mizushima, T., N. Takahashi, and B. Stillman. 2000. Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro. Genes Dev. 14:1631-1641.
35. Ohta, S., Y. Tatsumi, M. Fujita, T. Tsurimoto, and C. Obuse. 2003. The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle. J. Biol. Chem. 278:41535-41540.
36. Petersen, B. O., C. Wagener, F. Marinoni, E. R. Kramer, M. Melixetian, E. L. Denchi, C. Gieffers, C. Matteucci, J. M. Peters, and K. Helin. 2000. Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. Genes Dev. 14:2330-2343.
37. Piatti, S., C. Lengauer, and K. Nasmyth. 1995. Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J. 14:3788-3799.
38. Prasanth, S. G., K. V. Prasanth, K. Siddiqui, D. L. Spector, and B. Stillman. 2004. Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. EMBO J. 23:2651-2663.
39. Ritzi, M., M. Baack, C. Musahl, P. Romanowski, R. A. Laskey, and R. Knippers. 1998. Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin. J. Biol. Chem. 273: 24543-24549.
40. Sawyer, S. L., I. H. Cheng, W. Chai, and B. K. Tye. 2004. Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae. J. Mol. Biol. 340:195-202.
41. Sclafani, R. A. 2000. Cdc7p-Dbf4p becomes famous in the cell cycle. J. Cell Sci. 113:2111-2117.
42. Sommer, A., K. Bousset, E. Kremmer, M. Austen, and B. Luscher. 1998. Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators. J. Biol. Chem. 273:6632-6642.
43. Tye, B. K. 1999. MCM proteins in DNA replication. Annu. Rev. Biochem. 68:649-686.
44. Weinreich, M., C. Liang, and B. Stillman. 1999. The Cdc6p nucleotide-binding motif is required for loading mem proteins onto chromatin. Proc. Natl. Acad. Sci. USA 96:441-446.
45. Wohlschlegel, J. A., S. K. Dhar, T. A. Prokhorova, A. Dutta, and J. C. Walter. 2002. Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. Mol. Cell 9:233-240.
46. Young, M. R., and B. K. Tye. 1997. Mcm2 and Mcm3 are constitutive nuclear proteins that exhibit distinct isoforms and bind chromatin during specific cell cycle stages of Saccharomyces cerevisiae. Mol. Biol. Cell 8:1587-1601.
47. Zhang, Y., Z. Yu, X. Fu, and C. Liang. 2002. Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell 109:849-860.
48. Zou, L., and B. Stillman. 1998. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin. Science 280:593-596.