메뉴 건너뛰기




Volumn 24, Issue 4, 2004, Pages 1614-1627

Cdc6 Chromatin Affinity Is Unaffected by Serine-54 Phosphorylation, S-Phase Progression, and Overexpression of Cyclin A

Author keywords

[No Author keywords available]

Indexed keywords

CDC6 PROTEIN, VERTEBRATE; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 6; COMPLEMENTARY DNA; CYCLIN A; CYCLIN DEPENDENT KINASE 2; NONHISTONE PROTEIN; PHOSPHOSERINE; SERINE; UNCLASSIFIED DRUG;

EID: 0842325729     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.4.1614-1627.2004     Document Type: Article
Times cited : (66)

References (49)
  • 2
    • 0035997368 scopus 로고    scopus 로고
    • DNA replication in eukaryotic cells
    • Bell, S. P., and A. Dutta. 2002. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71:333-374.
    • (2002) Annu. Rev. Biochem. , vol.71 , pp. 333-374
    • Bell, S.P.1    Dutta, A.2
  • 3
    • 0026607331 scopus 로고
    • ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
    • Bell, S. P., and B. Stillman. 1992. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357:128-134.
    • (1992) Nature , vol.357 , pp. 128-134
    • Bell, S.P.1    Stillman, B.2
  • 4
    • 0034307720 scopus 로고    scopus 로고
    • Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response
    • Brush, G. S., and T. J. Kelly. 2000. Phosphorylation of the replication protein A large subunit in the Saccharomyces cerevisiae checkpoint response. Nucleic Acids Res. 28:3725-3732.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 3725-3732
    • Brush, G.S.1    Kelly, T.J.2
  • 5
    • 0026551134 scopus 로고
    • Dual functions of CDC6: A yeast protein required for DNA replication also inhibits nuclear division
    • Bueno, A., and P. Russell. 1992. Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division. EMBO J. 11:2167-2176.
    • (1992) EMBO J. , vol.11 , pp. 2167-2176
    • Bueno, A.1    Russell, P.2
  • 6
    • 0037415724 scopus 로고    scopus 로고
    • Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chkl
    • Clay-Farrace, L., C. Pelizon, D. Santamaria, J. Pines, and R. A. Laskey. 2003. Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chkl. EMBO J. 22:704-712.
    • (2003) EMBO J. , vol.22 , pp. 704-712
    • Clay-Farrace, L.1    Pelizon, C.2    Santamaria, D.3    Pines, J.4    Laskey, R.A.5
  • 7
    • 0030030623 scopus 로고    scopus 로고
    • An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast
    • Cocker, J. H., S. Piatti, C. Santocanale, K. Nasmyth, and J. F. X. Diffley. 1996. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379:180-182.
    • (1996) Nature , vol.379 , pp. 180-182
    • Cocker, J.H.1    Piatti, S.2    Santocanale, C.3    Nasmyth, K.4    Diffley, J.F.X.5
  • 8
    • 0030271388 scopus 로고    scopus 로고
    • The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts
    • Coleman, T. R., P. B. Carpenter, and W. G. Dunphy. 1996. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87:53-63.
    • (1996) Cell , vol.87 , pp. 53-63
    • Coleman, T.R.1    Carpenter, P.B.2    Dunphy, W.G.3
  • 9
    • 0036305474 scopus 로고    scopus 로고
    • Distinct roles for cyclins E and A during DNA replication complex assembly and activation
    • Coverley, D., H. Laman, and R. A. Laskey. 2002. Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat. Cell Biol. 4:523-528.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 523-528
    • Coverley, D.1    Laman, H.2    Laskey, R.A.3
  • 10
    • 0034045948 scopus 로고    scopus 로고
    • Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process
    • Coverley, D., C. Pelizon, S. Trewick, and R. A. Laskey. 2000. Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process. J. Cell Sci. 113:1929-1938.
    • (2000) J. Cell Sci. , vol.113 , pp. 1929-1938
    • Coverley, D.1    Pelizon, C.2    Trewick, S.3    Laskey, R.A.4
  • 11
    • 0035920202 scopus 로고    scopus 로고
    • Multiple mechanisms regulate subcellular localization of human CDC6
    • Delmolino, L. M., P. Saha, and A. Dutta. 2001. Multiple mechanisms regulate subcellular localization of human CDC6. J. Biol. Chem. 276:26947-26954.
    • (2001) J. Biol. Chem. , vol.276 , pp. 26947-26954
    • Delmolino, L.M.1    Saha, P.2    Dutta, A.3
  • 15
    • 0037155926 scopus 로고    scopus 로고
    • Nuclear organization of DNA replication initiation proteins in mammalian cells
    • Fujita, M., Y. Ishimi, H. Nakamura, T. Kiyono, and T. Tsurumi. 2002. Nuclear organization of DNA replication initiation proteins in mammalian cells. J. Biol. Chem. 277:10354-10361.
    • (2002) J. Biol. Chem. , vol.277 , pp. 10354-10361
    • Fujita, M.1    Ishimi, Y.2    Nakamura, H.3    Kiyono, T.4    Tsurumi, T.5
  • 16
    • 0033520321 scopus 로고    scopus 로고
    • Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation
    • Fujita, M., C. Yamada, H. Goto, N. Yokoyama, K. Kuzushima, M. Inagaki, and T. Tsurumi. 1999. Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation. J. Biol. Chem. 274:25927-25932.
    • (1999) J. Biol. Chem. , vol.274 , pp. 25927-25932
    • Fujita, M.1    Yamada, C.2    Goto, H.3    Yokoyama, N.4    Kuzushima, K.5    Inagaki, M.6    Tsurumi, T.7
  • 17
    • 0032567761 scopus 로고    scopus 로고
    • Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and Cdc6, but dependent on Cdk2
    • Hua, X. H., and J. Newport. 1998. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and Cdc6, but dependent on Cdk2. J. Cell Biol. 140:271-281.
    • (1998) J. Cell Biol. , vol.140 , pp. 271-281
    • Hua, X.H.1    Newport, J.2
  • 18
    • 0032994432 scopus 로고    scopus 로고
    • Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
    • Jiang, W., N. J. Wells, and T. Hunter. 1999. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Proc. Natl. Acad. Sci. USA 96:6193-6198.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6193-6198
    • Jiang, W.1    Wells, N.J.2    Hunter, T.3
  • 19
    • 0030043371 scopus 로고    scopus 로고
    • Human replication proteins hCdc21, hCdc46, and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication
    • Krude, T., C. Musahl, R. A. Laskey, and R. Knippers. 1996. Human replication proteins hCdc21, hCdc46, and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication. J. Cell Sci. 109:309-318.
    • (1996) J. Cell Sci. , vol.109 , pp. 309-318
    • Krude, T.1    Musahl, C.2    Laskey, R.A.3    Knippers, R.4
  • 20
    • 0032498902 scopus 로고    scopus 로고
    • Interphase cell cycle dynamics of a late-replicating, heterochromatic homogeneously staining region: Precise choreography of condensation/decondensation and nuclear positioning
    • Li, G., G. Sudlow, and A. S. Belmont. 1998. Interphase cell cycle dynamics of a late-replicating, heterochromatic homogeneously staining region: precise choreography of condensation/decondensation and nuclear positioning. J. Cell Biol. 140:975-989.
    • (1998) J. Cell Biol. , vol.140 , pp. 975-989
    • Li, G.1    Sudlow, G.2    Belmont, A.S.3
  • 21
    • 0029048775 scopus 로고
    • ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
    • Liang, C., M. Weinreich, and B. Stillman. 1995. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 81:667-676.
    • (1995) Cell , vol.81 , pp. 667-676
    • Liang, C.1    Weinreich, M.2    Stillman, B.3
  • 22
    • 0029410628 scopus 로고
    • The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts
    • Madine, M. A., C.-Y. Khoo, A. D. Mills, C. Musahl, and R. A. Laskey. 1995. The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts. Curr. Biol. 5:1270-1279.
    • (1995) Curr. Biol. , vol.5 , pp. 1270-1279
    • Madine, M.A.1    Khoo, C.-Y.2    Mills, A.D.3    Musahl, C.4    Laskey, R.A.5
  • 23
    • 0033756308 scopus 로고    scopus 로고
    • Chromatin association of human origin recognition complex, Cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis
    • Mendez, J., and B. Stillman. 2000. Chromatin association of human origin recognition complex, Cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol. Cell. Biol. 20:8602-8612.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8602-8612
    • Mendez, J.1    Stillman, B.2
  • 24
    • 0032190507 scopus 로고    scopus 로고
    • Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk
    • Mimura, S., and H. Takisawa. 1998. Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk. EMBO J. 17:5699-5707.
    • (1998) EMBO J. , vol.17 , pp. 5699-5707
    • Mimura, S.1    Takisawa, H.2
  • 25
    • 0026596327 scopus 로고
    • Dynamic organization of DNA replication in mammalian cell nuclei: Spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences
    • O'Keefe, R. T., S. C. Henderson, and D. L. Spector. 1992. Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences. J. Cell Biol. 116:1095-1110.
    • (1992) J. Cell Biol. , vol.116 , pp. 1095-1110
    • O'Keefe, R.T.1    Henderson, S.C.2    Spector, D.L.3
  • 26
    • 0035422288 scopus 로고    scopus 로고
    • Stability, chromatin association and functional activity of mammalian prereplication complex proteins during the cell cycle
    • Okuno, Y., A. J. McNairn, N. den Elzen, J. Pines, and D. M. Gilbert. 2001. Stability, chromatin association and functional activity of mammalian prereplication complex proteins during the cell cycle. EMBO J. 20:4263-4277.
    • (2001) EMBO J. , vol.20 , pp. 4263-4277
    • Okuno, Y.1    McNairn, A.J.2    Den Elzen, N.3    Pines, J.4    Gilbert, D.M.5
  • 27
    • 0034307181 scopus 로고    scopus 로고
    • Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle
    • Pelizon, C., M. A. Madine, P. Romanowski, and R. A. Laskey. 2000. Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle. Genes Dev. 14:2526-2533.
    • (2000) Genes Dev. , vol.14 , pp. 2526-2533
    • Pelizon, C.1    Madine, M.A.2    Romanowski, P.3    Laskey, R.A.4
  • 28
    • 0033556238 scopus 로고    scopus 로고
    • Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
    • Petersen, B. O., J. Lukas, C. S. Sorensen, J. Bartek, and K. Helin. 1999. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J. 18:396-410.
    • (1999) EMBO J. , vol.18 , pp. 396-410
    • Petersen, B.O.1    Lukas, J.2    Sorensen, C.S.3    Bartek, J.4    Helin, K.5
  • 30
    • 0029761435 scopus 로고    scopus 로고
    • 1 defines a 'point of no return' after which Cdc6 synthesis cannot promote DNA replication in yeast
    • 1 defines a 'point of no return' after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes Dev. 10:1516-1531.
    • (1996) Genes Dev. , vol.10 , pp. 1516-1531
    • Piatti, S.1    Bohm, T.2    Cocker, J.H.3    Diffley, J.F.X.4    Nasmyth, K.5
  • 31
    • 0029082391 scopus 로고
    • Cdc6 is an unstable protein whose de novo synthesis in G, is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae
    • Piatti, S., C. Lengauer, and K. Nasmyth. 1995. Cdc6 is an unstable protein whose de novo synthesis in G, is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J. 14:3788-3799.
    • (1995) EMBO J. , vol.14 , pp. 3788-3799
    • Piatti, S.1    Lengauer, C.2    Nasmyth, K.3
  • 32
    • 0029814785 scopus 로고    scopus 로고
    • XMcm7, a novel member of the Xenopus MCM family, interacts with XMcm3 and colocalizes with it throughout replication
    • Romanowski, P., M. A. Madine, and R. A. Laskey. 1996. XMcm7, a novel member of the Xenopus MCM family, interacts with XMcm3 and colocalizes with it throughout replication. Proc. Natl. Acad. Sci. USA 93:10189-10194.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10189-10194
    • Romanowski, P.1    Madine, M.A.2    Laskey, R.A.3
  • 33
    • 0031921561 scopus 로고    scopus 로고
    • Human CDC6/Cdc18 associates with Orc1 and cyclin-Cdk and is selectively eliminated from the nucleus at the onset of S phase
    • Saha, P., J. Chen, K. C. Thome, S. J. Lawlis, Z.-H. Hou, M. Hendricks, J. D. Parvin, and A. Dutta. 1998. Human CDC6/Cdc18 associates with Orc1 and cyclin-Cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol. Cell. Biol. 18:2758-2767.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2758-2767
    • Saha, P.1    Chen, J.2    Thome, K.C.3    Lawlis, S.J.4    Hou, Z.-H.5    Hendricks, M.6    Parvin, J.D.7    Dutta, A.8
  • 34
    • 0029831706 scopus 로고    scopus 로고
    • ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae
    • Santocanale, C., and J. F. X. Diffley. 1996. ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae. EMBO J. 15:6671-6679.
    • (1996) EMBO J. , vol.15 , pp. 6671-6679
    • Santocanale, C.1    Diffley, J.F.X.2
  • 37
    • 0033602276 scopus 로고    scopus 로고
    • The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin
    • Tada, S., J. P. Chong, H. M. Mahbubani, and J. J. Blow. 1999. The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin. Curr. Biol. 9:211-214.
    • (1999) Curr. Biol. , vol.9 , pp. 211-214
    • Tada, S.1    Chong, J.P.2    Mahbubani, H.M.3    Blow, J.J.4
  • 38
    • 0035147434 scopus 로고    scopus 로고
    • Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
    • Tada, S., A. Li, D. Maiorano, M. Mechali, and J. J. Blow. 2001. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat. Cell Biol. 3:107-113.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 107-113
    • Tada, S.1    Li, A.2    Maiorano, D.3    Mechali, M.4    Blow, J.J.5
  • 40
    • 0030849742 scopus 로고    scopus 로고
    • Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs
    • Tanaka, T., D. Knapp, and K. Nasmyth. 1997. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 90:649-660.
    • (1997) Cell , vol.90 , pp. 649-660
    • Tanaka, T.1    Knapp, D.2    Nasmyth, K.3
  • 41
    • 0029074364 scopus 로고
    • BM28,a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication
    • Todorov, I. T., A. Attaran, and S. E. Kearsey. 1995. BM28,a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication. J. Cell Biol. 129:1433-1445.
    • (1995) J. Cell Biol. , vol.129 , pp. 1433-1445
    • Todorov, I.T.1    Attaran, A.2    Kearsey, S.E.3
  • 43
    • 0001607723 scopus 로고
    • Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
    • Walker, J. E., M. Saraste, M. J. Runswick, and N. J. Gay. 1982. Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1:945-951.
    • (1982) EMBO J. , vol.1 , pp. 945-951
    • Walker, J.E.1    Saraste, M.2    Runswick, M.J.3    Gay, N.J.4
  • 44
    • 0033637837 scopus 로고    scopus 로고
    • Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
    • Walter, J., and J. Newport. 2000. Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol. Cell 5:617-627.
    • (2000) Mol. Cell , vol.5 , pp. 617-627
    • Walter, J.1    Newport, J.2
  • 45
    • 0033582262 scopus 로고    scopus 로고
    • The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin
    • Weinreich, M., C. Liang, and B. Stillman. 1999. The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin. Proc. Natl. Acad. Sci. USA 96:441-446.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 441-446
    • Weinreich, M.1    Liang, C.2    Stillman, B.3
  • 49
    • 0035842893 scopus 로고    scopus 로고
    • BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations
    • Ye, Q., Y.-F. Hu, H. Zhong, A. C. Nye, A. S. Belmont, and R. Li. 2001. BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. J. Cell Biol. 155:911-921.
    • (2001) J. Cell Biol. , vol.155 , pp. 911-921
    • Ye, Q.1    Hu, Y.-F.2    Zhong, H.3    Nye, A.C.4    Belmont, A.S.5    Li, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.