Non-peptidic, non-prenylic bisubstrate farnesyltransferase inhibitors. Part 3: Structural requirements of the central moiety for farnesyltransferase inhibitory activity

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 10, 2000, Pages 2399-2406

  Schlitzer, Martin ^a   Böhm, Markus ^a   Sattler, Isabel ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN FARNESYLTRANSFERASE INHIBITOR;

ARTICLE; CHROMATOGRAPHY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; AMIDES; BINDING SITES; DRUG DESIGN; EICOSANOIC ACIDS; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; MOLECULAR MIMICRY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; ZINC;

EID: 13444279538     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00173-5     Document Type: Article

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