Brain Imaging Studies of the Anatomical and Functional Consequences of Preterm Birth for Human Brain Development

Annals of the New York Academy of Sciences

Volumn 1008, Issue , 2003, Pages 219-237

  Peterson, Bradley S ^a  

^a New York State Psychiatric Institute ^*  (United States)

Author keywords

Children; Cognition; Magnetic resonance imaging; Outcome; Prematurity

Indexed keywords

FREE RADICAL;

APOPTOSIS; BRAIN DEVELOPMENT; BRAIN FUNCTION; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN REGION; BRAIN SIZE; COGNITION; CONFERENCE PAPER; CORRELATION ANALYSIS; GENE EXPRESSION; GRAY MATTER; HUMAN; INTELLIGENCE; INTELLIGENCE QUOTIENT; LANGUAGE; NERVE CELL NETWORK; NEUROANATOMY; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARIETAL LOBE; PREMATURE LABOR; PREMOTOR CORTEX; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SENSORIMOTOR CORTEX; SYNAPSE; TEMPORAL LOBE; WHITE MATTER;

ANIMALIA;

EID: 1342326626     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1301.023     Document Type: Conference Paper

References (138)

1. HACK, M. et al. 1995. Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Network, November 1989 to October 1990. Am. J. Obstet. Gynecol. 172: 457-464.
2. JOSEPH, K.S. et al. 1998. Determinants of preterm birth rates in Canada from 1981 through 1983 and from 1992 through 1994. N. Engl. J. Med. 339: 1434-1439.
3. RICHARDSON, D.K. et al. 1998. Declining severity adjusted mortality: evidence of improving neonatal intensive care. Pediatrics 102: 893-899.
4. HACK, M., H. FRIEDMAN & A.A. FANAROFF. 1996. Outcomes of extremely low birth weight infants. Pediatrics 98: 931-937.
5. HALL, A. et al. 1995. School attainment, cognitive ability and motor function in a total Scottish very-low-birth weight population at eight years: a controlled study. Dev. Med. Child Neurol. 37: 1037-1050.
6. PIECUCH, R. et al. 1997. Outcome of extremely low birth weight infants (500-999 grams) over a 12-year period. Pediatrics 100: 633-639.
7. STEWART, A. & V. KIRKBRIDE. 1996. Very preterm infants at fourteen years: relationship with neonatal ultrasound brain scans and neurodevelopmental status at one year. Acta Paediatr. Suppl. 416: 44-47.
8. WHITAKER, A.M. et al. 1997. Psychiatric outcomes in low-birth-weight children at age 6 years: relation to neonatal cranial ultrasound abnormalities. Arch. Gen. Psychiatry 54: 847-856.
9. WOLKE, D. 1991. Annotation: supporting the development of low birthweight infants. J. Child Psychol. Psychiatry 32: 723-741.
10. SYKES, D.H. et al. 1997. Behavioral adjustment in school of very low birthweight children. J. Child Psychol. Psychiatry 38: 315-325.
11. BOTTING, N. et al. 1998. Cognitive and educational outcome of very-low-birthweight children in early adolescence. Dev. Med. Child Neurol. 40: 652-660.
12. KLEBANOV, P. et al. 1994. Classroom behavior of very low birth weight elementary school children. Pediatrics 94: 700-708.
13. MCCORMICK, M., K. WORKMAN-DANIELS & J. BROOKS-GUNN. 1996. The behavioral and emotional well-being of school-age children with different birth weights. Pediatrics 97: 18-25.
14. D'ANGIO, C.T. et al. 2002. Longitudinal, 15-year follow-up of children born at less than 29 weeks' gestation after introduction of surfactant therapy into a region: neurologic, cognitive, and educational outcomes. Pediatrics 110: 1094-1102.
15. MSALL, M.E. & M.R. TREMONT. 2002. Measuring functional outcomes after prematurity: developmental impact of very low birth weight and extremely low birth weight status on childhood disability. Ment. Retard. Dev. Disabil. Res. Rev. 8: 258-272.
16. ICHIKI, M. et al. 2000. Intra-uterine physical growth in schizophrenia: evidence confirming excess of premature birth. Psychol. Med. 30: 597-604.
17. RAKIC, P. & K.P. RILEY. 1983. Overproduction and elimination of retinal axons in the fetal rhesus monkey. Science 209: 1441-1444.
18. RAKIC, P. 1988. Specification of cerebral cortical areas. Science. 241: 170-176.
19. DOBBING, J. & J. SANDS. 1973. Quantitative growth and development of human brain. Arch. Dis. Child. 48: 757-767.
20. NELIGAN, G.A. 1974. The human brain growth spurt. Dev. Med. Child Neurol. 16: 677-678.
21. BOURGEOIS, J.-P. & P. RAKIC. 1993. Changing of synaptic density in the primary visual cortex of the rhesus monkey from fetal to adult stage. J. Neurosci. 13: 2801-2820.
22. CHANGEUX, J.-P. 1993. A critical view of neuronal models of learning and memory. In Memory Concepts. P. Anderson, Ed.: 413-433. Elsevier. Amsterdam.
23. BECKER, L.E. et al. 1984. Dendritic development in human occipital cortical neurons. Brain Res. 315: 117-124.
24. MRZLJAK, L. et al. 1990. Neuronal development in human prefrontal cortex in prenatal and postnatal stages. Prog. Brain Res. 85: 185-222.
25. HUTTENLOCHER, P.R. & A.S. DABHOLKAR. 1997. Regional differences in synaptogenesis in human cerebral cortex. J. Comp. Neurol. 387: 167-178.
26. KATZ, L.C. & C.J. SHATZ. 1996. Synaptic activity and the constuction of cortical circuits. Science 274: 1133-1138.
27. SIMONATI, A., T. ROSSO & N. RIZZUTO. 1997. DNA fragmentation in normal development of the human central nervous system: a morphological study during corticogenesis. Neuropathol. Appl. Neurobiol. 23: 203-211.
28. BUONOMANO, D.V. & M.M. MERZENICH. 1998. Cortical plasticity: from synapses to maps. Annu. Rev. Neurosci. 21: 149-186.
29. FELDMAN, D.E. & E.I. KNUDSEN. 1998. Experience-dependent plasticity and the maturation of glutamatergic synapses. Neuron 20: 1067-1071.
30. PHAM, T.A. et al. 1999. CRE-mediated gene transcription in neocortical neuronal plasticity during the developmental critical period. Neuron 22: 63-72.
31. OLSÉN, P. et al. 1997. Magnetic resonance imaging of periventricular leukomalacia and its clinical correlation in children. Ann. Neurol. 41: 754-761.
32. OLSÉN, P. et al. 1998. Psychological findings in preterm children related to neurologic status and magnetic resonance imaging. Pediatrics 102: 329-336.
33. STEWART, A.L. et al. 1999. Brain structure and neurocognitive and behavioral function in adolescents who were born very preterm. Lancet 353: 1653-1657.
34. KEENEY, S.E., E.W. ADCOCK & C.B. MCARDLE. 1991. Prospective observations of 100 high-risk neonates by high-field (1.5 Tesla) magnetic resonance imaging of the central nervous system. II. Lesions associated with hypoxic-ischemic encephalopathy. Pediatrics 87: 431-438.
35. DE VRIES, L.S. et al. 1993. Correlation between the degree of periventricular leukomalacia diagnosed using cranial ultrasound and MRI later in infancy in children with cerebral palsy. Neuropediatric 24: 263-268.
36. GUIT, G.L. et al. 1990. Prediction of neurodevelopmental outcome in the preterm infant: MR-staged myelination compared with cranial US. Pediatric Radiology. 175: 107-109.
37. HÜPPI, P.S. et al. 1996. Structural and neurobehavioral delay in postnatal brain development of preterm infants. Pediatr. Res. 39: 895-901.
38. COOKE, R.W.I. & L.J. ABERNETHY. 1999. Cranial magnetic resonance imaging and school performance in very low birth weight infants in adolescence. Arch. Dis. Child Fetal Neonatal Ed. 81: F116-F121.
39. BARKOVICH, A.J. & S.K. SARGENT. 1995. Profound asphyxia in the premature infant: Imaging findings. AJNR 16: 1837-1846.
40. HÜPPI, P.S. et al. 1998. Quantitative magnetic resonance imaging of brain development in premature and mature newborns. Ann. Neurol. 43: 224-235.
41. INDER, T.E. et al. 1999. Periventricular white matter injury in the premature infant is followed by reduced cerebral cortical gray matter volume at term. Ann. Neurol. 46: 755-760.
42. MURPHY, B.P. et al. 2001. Impaired cerebral cortical gray matter growth following treatment with dexamethasone for neonatal chronic lung disease. Pediatrics 107: 217-221.
43. HÜPPI, P.S. et al. 1998. Microstructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging. Pediatr. Res. 44: 584-590.
44. PETERSON, B.S. et al. 2003. Regional brain volumes and their later neurodevelopmental correlates in term and preterm infants. Pediatrics 111: 938-948.
45. 18FDG positron emission tomography. Science 231: 840-843.
46. CHUGANI, H.T., M.E. PHELPS & J.C. MAZIOTTA. 1987. Positron emission tomography study of human brain functional development. Ann. Neurol. 22: 487-497.
47. CHUGANI, H.T. & M.E. PHELPS. 1991. Imaging human brain development with positron emission tomography. J. Nucl. Med. 32: 23-26.
48. GREISEN, G. 1986. Cerebral blood flow in preterm infants during the first week of life. Acta Paediatr. Scand. 75: 43-51.
49. KEHRER, M. et al. 2002. Measurement of volume of cerebral blood flow in healthy preterm and term neonates with ultrasound. Lancet 360: 1749-1750.
50. BORCH, K. & G. GREISEN. 1998. Blood flow distribution in the normal human preterm brain. Pediatr. Res. 43: 28-33.
51. KURMANAVICHIUS, J. et al. 1991. Fetal and preterm newborn cerebral blood flow velocity. Early Hum. Dev. 26: 113-120.
52. ANDO, Y., S. TAKASHIMA & K. TAKESHITA. 1985. Cerebral blood flow velocity in preterm neonates. Brain Dev. 7: 385-391.
53. PEZZATI, M. et al. 2002. Early postnatal doppler assessment of cerebral blood flow velocity in healthy preterm and term infants. Dev. Med. Child Neurol. 44: 745-752.
54. HAMBLETON, G. & J. WIGGLESWORTH. 1976. Origin of intraventricular haemorrhage in the preterm infant. Arch. Dis. Child. 51: 651-659.
55. KUBAN, K.C.K. & F.H. GILLES. 1985. Human telencephalic angiogenesis. Ann. Neurol. 17: 539-548.
56. VAN DE BOR, M. & F.J. WALTHER. 1991. Cerebral blood flow velocity regulation in preterm infants. Biol. Neonate 59: 329-235.
57. COUGHTREY, H., J.M. RENNIE & D.H. EVANS. 1997. Variability in cerebral blood flow velocity: observations over one minute in preterm babies. Early Hum. Dev. 47: 63-70.
58. TYSZCZUK, L. et al. 1998. Cerebral blood flow is independent of mean arterial blood pressure in preterm infants undergoing intensive care. Pediatrics 102: 337-341.
59. PERLMAN, J.M., J.B. MCMENAMIN & J.J. VOLPE. 1983. Fluctuating cerebral blood flow velocity in respiratory distress syndrome. N. Engl. J. Med. 309: 204-209.
60. PERLMAN, J.M. et al. 1985. Reduction in intraventricular hemorrhage by elimination of fluctuating cerebral blood-flow velocity in preterm infants with respiratory distress syndrome. N. Engl. J. Med. 312: 1353-1357.
61. TUOR, U.I. & D. GREWAL. 1994. Autoregulation of cerebral blood flow: influence of local brain development and postnatal age. Am. J. Physiol. 267: H2220-H2228.
62. PRYDS, O. et al. 1990. Vasoparalysis associated with brain damage in asphyxiated term infants. J. Pediatr. 117: 119-125.
63. RAMAEKERS, V.T. et al. 1990. Upper limits of brain blood flow autoregulation in stable infants of various conceptional age. Early Hum. Dev. 24: 249-258.
64. JORCH, G. & N. JORCH. 1987. Failure of autoregulation of cerebral blood flow in neonates studied by pulsed Doppler ultrasound of the internal carotid artery. Eur. J. Pediatr. 146: 468-472.
65. PRYDS, O. 1991. Control of cerebral circulation in the high-risk neonate. Ann. Neurol. 30: 321-329.
66. LOU, H.C., N.A. LASSEN & B. FRIIS-HANSEN. 1979. Impaired autoregulation of cerebral blood flow in the distressed newborn infant. J. Pediatr. 94: 118-121.
67. LOW, J.A. et al. 1993. The association between newborn hypotension and hypoxemia and outcome during the first year. Acta Paediatr. 82: 433-437.
68. LOU, H.C., H. SKOV & H. PEDERSEN. 1979. Low cerebral blood flow: a risk factor in the neonate. J. Pediatr. 95: 606-609.
69. ROTH, S.C. et al. 1997. Relation of deranged neonatal cerebral oxidative metabolism with neurodevelopmental outcome and head circumference at 4 years. Dev. Med. Child Neurol. 39: 718-725.
70. HOPE, P.L. et al. 1984. Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants. Lancet 2: 366-370.
71. AZZOPARDI, D. et al. 1989. Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr. Res. 25: 445-451.
72. MARTIN, E. et al. 1996. Diagnostic and prognostic value of cerebral 31P magnetic resonance spectroscopy in neonates with perinatal asphyxia. Pediatr. Res. 40: 749-758.
73. BHUTTA, A.T. et al. 2002. Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA 288: 728-737.
74. MULLER, A.M. et al. 1997. Loss of CO2 reactivity of cerebral blood flow is associated with severe brain damage in mechanically ventilated very low birth weight infants. Eur. J. Paediatr. Neurol. 1: 157-163.
75. BAENZIGER, O. et al. 1999. Cerebral blood flow and neurological outcome in the preterm infant. Eur. J. Pediatr. 158: 138-143.
76. BAENZIGER, O. et al. 1995. Regional differences of cerebral blood flow in the preterm infant. Eur. J. Pediatr. 154: 919-924.
77. MEEK, J.H. et al. 1998. Cerebral blood flow increases over the first three days of life in extremely preterm neonates. Arch. Dis. Child Fetal. Neonatal Ed. 78: F33-F37.
78. KLUCKOW, M. & N. EVANS. 2001. Low systemic blood flow in the preterm infant. Semin. Neonatol. 6: 75-84.
79. WINBERG, P., S.E. SONESSON & B.P. LUNDELL. 1990. Postnatal changes in intracranial blood flow velocity in preterm infants. Acta Paediatr. Scand. 79: 1150-1155.
80. RANTONEN, T. et al. 2001. Maternal magnesium sulfate treatment is associated with reduced brain-blood flow perfusion in preterm infants. Crit. Care Med. 29: 1460-1465.
81. AUSTIN, N.C. et al. 1992. Regional cerebral blood flow velocity changes after indomethacin infusion in preterm infants. Arch. Dis. Child. 67: 851-854.
82. VAN DE BOR, M., E.J. MA & F.J. WALTHER. 1991. Cerebral blood flow velocity after surfactant instillation in preterm infants. J. Pediatr. 118: 285-287.
83. LUNDSTROM, K.E. et al. 1995. Cerebral blood flow and left ventricular output in spontaneously breathing, newborn preterm infants treated with caffeine or aminophylline. Acta Paediatr. 84: 6-9.
84. BOEHM, G. & N.C. RAIHA. 1993. Postmenstrual age correlates to indices of protein metabolism in very low birth weight infants. J. Pediatr. Gastroenterol. Nutr. 16: 306-310.
85. PHAM, K. et al. 2003. Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus. Eur. J. Neurosci. 17: 879-886.
86. MAGARINOS, A.M., J.M. VERDUGO & B.S. MCEWEN. 1997. Chronic stress alters synaptic terminal structure in hippocampus. Proc. Natl. Acad. Sci. USA 94: 14002-14008.
87. MCEWEN, B.S. 2001. Plasticity of the hippocampus: adaptation to chronic stress and allostatic load. Ann. N.Y. Acad. Sci. 933: 265-277.
88. CHOU, I.C. et al. 2001. Behavioral/environmental intervention improves learning after cerebral hypoxia-ischemia in rats. Stroke 32: 2192-2197.
89. WEAVER, I.C., R.J. GRANT & M.J. MEANEY. 2002. Maternal behavior regulates long-term hippocampal expression of BAX and apoptosis in the offspring. J. Neurochem. 82: 998-1002.
90. ANISMAN, H. et al. 1998. Do early-life events permanently alter behavioral and hormonal responses to stressors? Int. J. Dev. Neurosci. 16: 149-164.
91. EICHLER, F. et al. 2001. Position dependent changes of cerebral blood flow velocities in premature infants. Eur. J. Pediatr. 160: 633-639.
92. RAMAEKERS, V.T. & P. CASAER. 1987. Influence of behavioral states on cerebral blood flow velocity patterns in preterm infants. J. Pediatr. 111: 795.
93. MULLAART, R.A. et al. 1992. Cerebral blood flow fluctuation in low-risk preterm newborns. Early Hum. Dev. 30: 41-48.
94. BRACEWELL, M. & N. MARLOW. 2002. Patterns of motor disability in very preterm children. Ment. Retard. Dev. Disabil. Res. Rev. 8: 241-248.
95. ADINOLFI, M. 1993. Infectious diseases in pregnancy, cytokines and neurological impairment: an hypothesis. Dev. Med. Child Neurol. 35: 549-558.
96. PATRICK, L.A. & G.N. SMITH. 2002. Proinflammatory cytokines: a link between chorioamnionitis and fetal brain injury. J. Obstet. Gynaecol. Can. 24: 705-709.
97. ANDREWS, W.W., J.C. HAUTH & R.L. GOLDENBERG. 2000. Infection and preterm birth. Am. J. Perinatol. 17: 357-365.
98. GONCALVES, L.F., T. CHAIWORAPONGSA & R. ROMERO. 2002. Intrauterine infection and prematurity. Ment. Retard. Dev. Disabil. Res. Rev. 8: 3-13.
99. BAERTS, W., R.A. VALENTIN & P.J. SAUER. 1992. Ophthalmic and cerebral blood flow velocities in preterm infants: influence of ambient lighting conditions. J. Clin. Ultrasound 20: 43-48.
100. PERLMAN, J.M. & J.J. VOLPE. 1983. Suctioning in the preterm infant: effects on cerebral blood flow velocity, intracranial pressure, and arterial blood pressure. Pediatrics 72: 329-334.
101. VOLPE, J.J. 2001. Neurobiology of periventricular leukomalacia in the premature infant. Pediatr. Res. 50: 553-562.
102. RADEMAKERS, R.P. et al. 1995. Central cortico-subcortical involvement: a distinct pattern of brain damage caused by perinatal and postnatal asphyxia in term infants. J. Comput. Assisted Tomogr. 19: 256-263.
103. VOLPE, J.J. et al. 1985. Positron emission tomography in the asphyxiated term newborn: parasagittal impairment of cerebral blood flow. Ann. Neurol. 17: 287-296.
104. VOLPE, J.J. et al. 1983. Positron emission tomography in the newborn: extensive impairment of regional cerebral blood flow with intraventricular hemorrhage and hemorrhagic intracerebral involvement. Pediatrics 72: 589-601.
105. DAVISON, A.N. & J. DOBBING. 1966. Myelination as a vulnerable period in brain development. Br. Med. Bull. 22: 40-44.
106. AZZARELLI, B., P. MEADE & J. MULLER. 1980. Hypoxic lesions in areas of primary myelination. A distinct pattern in cerebral palsy. Child's Brain 7: 132-145.
107. BØRCH, K. & G. GREISEN. 1998. Blood flow distribution in the normal human preterm brain. Pediatr. Res. 43: 28-33.
108. NELSON, M.D.J., I. GONZALEZ-GOMEZ & F.H. GILLES. 1991. The search for human telencephalic ventriculofugal arteries. AJNR. 12: 215-222.
109. HARUDA, F.D. 2001. The structure of blood vessels in the germinal matrix and the autoregulation of cerebral blood flow in premature infants. Pediatrics 108: 1050-1051.
110. SALIBA, E. & A. HENROT. 2001. Inflammatory mediators and neonatal brain damage. Biol. Neonate 79: 224-227.
111. TAKSHIMA, S. & K. TANAKA. 1978. Development of cerebrovascular architecture and its relationship to periventricular leukomalacia. Arch. Neurol. 35: 11-16.
112. RORKE, L.B. 1992. Anatomical features of the developing brain implicated in pathogenesis of hypoxic-ischemic injury. Brain Pathol. 2: 211-221.
113. STEWART, W.B., L.R. MENT & M. SCHWARTZ. 1997. Chronic postnatal hypoxia increases the numbers of cortical neurons. Brain Res. 760: 17-21.
114. OGUNSHOLA, O.O. et al. 2000. Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain. Brain Res. Dev. Brain Res. 119: 139-153.
115. MENT, L.R. et al. 1998. Association of chronic sublethal hypoxia with ventriculomegaly in the developing rat. Dev. Brain Res. 111: 197-203.
116. TASHIMA, L. et al. 2001. Prenatal influence of ischemia-hypoxia-induced intrauterine growth retardation on brain development and behavioral activity in rats. Biol. Neonate. 80: 81-87.
117. CAI, Z. et al. 2001. Chronic ischemia preferentially causes white matter injury in the neonatal rat brain. Brain Res. 898: 126-135.
118. GIDDAY, J.M. et al. 1999. Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning. J. Cereb. Blood Flow Metab. 19: 331-340.
119. CAI, Z. et al. 1999. Prenatal hypoxia-ischemia alters expression and activity of nitric oxide synthase in the young rat brain and causes learning deficits. Brain Res. Bull. 49: 359-365.
120. MALLARD, E.C. et al. 1998. Effects of chronic placental insufficiency on brain development in fetal sheep. Ped. Res. 43: 262-270.
121. YUE, X. et al. 1997. Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischemia. Neuropath. Appl. Neurobiol. 23: 16-25.
122. BONFOCO, E. et al. 1995. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA 92: 7162-7166.
123. FOLLETT, P.L. et al. 2000. NBQX attenuates excitotoxic injury in developing white matter. J. Neurosci. 20: 9235-9241.
124. YOSHIOKA, A., B. BACSKAI & D. PLEASURE. 1996. Pathophysiology of oligodendroglial excitotoxicity. J. Neurosci. Res. 46: 427-438.
125. MCDONALD, J.W. et al. 1998. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nat. Med. 4: 291-297.
126. GILL, R. et al. 2002. Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain. J. Cereb. Blood Flow Metab. 22: 420-430.
127. VANNUCCI, R.C. et al. 2001. Effect of extreme hypercapnia on hypoxic-ischemic brain damage in the immature rat. Pediatr. Res. 49: 799-803.
128. CURRISTIN, S.M. et al. 2002. Disrupted synaptic development in the hypoxic newborn brain. Proc. Natl. Acad. Sci. USA 99: 15729-15734.
129. GANAT, Y. et al. 2002. Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone. Neuroscience 112: 977-991.
130. BACK, S.A. et al. 1998. Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion. J. Neurosci. 18: 6241-6253.
131. SANCHEZ-ALVAREZ, R., A. ALMEIDA & J.M. MEDINA. 2002. Oxidative stress in preterm rat brain is due to mitochondrial dysfunction. Pediatr. Res. 51: 34-39.
132. MCARDLE, C.B. et al. 1987. Developmental features of the neonatal brain: MR imaging. Part I. Gray-white matter differentiation and myelination. Pediatr. Radiol. 162: 223-229.
133. DIETRICH, R.B. et al. 1988. MRI evaluation of early myelination patterns in normal and developmentally delayed infants. AJNR 150: 889-896.
134. DIETRICH, R.B. 1999. Maturation, myelination, and dysmyelination. In Magnetic Resonance Imaging, Vol. III. E. Corra, Ed.: 1425-1447. Mosby. St. Louis.
135. VAN DER KNAAP, M.S. & J. VALK. 1990. MR imaging of the various stages of normal myelination during the first year of life. Neuroradiology 31: 459-470.
136. PETERSON, B.S. et al. 2001. Automated measurement of latent morphological features in the human corpus callosum. Hum. Brain Map. 12: 232-245.
137. CHENG, Y. et al. 1997. Marked age-dependent neuroprotection by BDNF against neonatal hypoxic-ischemic brain injury. Ann. Neurol. 41: 521-529.
138. ALMLI, C.R. et al. 2000. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Exp. Neurol. 166: 99-114.