-
1
-
-
3342997926
-
New strategies for drug development
-
M. Veit New strategies for drug development Berl. Munch. Tierarztl. Wochenschr. 117 2004 276-287
-
(2004)
Berl. Munch. Tierarztl. Wochenschr.
, vol.117
, pp. 276-287
-
-
Veit, M.1
-
2
-
-
2442589578
-
New molecules and strategies in the field of anticancer agents
-
S. Marchini et al. New molecules and strategies in the field of anticancer agents Curr. Med. Chem. Anti-Canc. Agents 4 2004 247-262
-
(2004)
Curr. Med. Chem. Anti-Canc. Agents
, vol.4
, pp. 247-262
-
-
Marchini, S.1
-
3
-
-
0036527429
-
Protein kinases - The major drug targets of the twenty-first century?
-
P. Cohen Protein kinases - the major drug targets of the twenty-first century? Nat. Rev. Drug Discov. 1 2002 309-315
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 309-315
-
-
Cohen, P.1
-
4
-
-
1142291736
-
New anticancer agents and therapeutic strategies in development for solid cancers: A clinical perspective
-
A. Awada et al. New anticancer agents and therapeutic strategies in development for solid cancers: A clinical perspective Expert Rev. Anticancer Ther. 4 2004 53-60
-
(2004)
Expert Rev. Anticancer Ther.
, vol.4
, pp. 53-60
-
-
Awada, A.1
-
5
-
-
2942565827
-
Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: Mechanisms and clinical implications
-
S. Shankar R.K. Srivastava Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: Mechanisms and clinical implications Drug Resist. Updat. 7 2004 139-156
-
(2004)
Drug Resist. Updat.
, vol.7
, pp. 139-156
-
-
Shankar, S.1
Srivastava, R.K.2
-
6
-
-
0842330212
-
Combining EGFR inhibitors with radiation or chemotherapy: Will preclinical studies predict clinical results?
-
P.M. Harari S. Huang Combining EGFR inhibitors with radiation or chemotherapy: Will preclinical studies predict clinical results? Int. J. Radiat. Oncol. Biol. Phys. 58 2004 976-983
-
(2004)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.58
, pp. 976-983
-
-
Harari, P.M.1
Huang, S.2
-
7
-
-
0034104525
-
Tyrosine kinase inhibitor targeted to the epidermal growth factor receptor subfamily: Role as anticancer agents
-
S.B. Noonberg C.C. Benz Tyrosine kinase inhibitor targeted to the epidermal growth factor receptor subfamily: Role as anticancer agents Drugs 59 2000 753-767
-
(2000)
Drugs
, vol.59
, pp. 753-767
-
-
Noonberg, S.B.1
Benz, C.C.2
-
8
-
-
0036005846
-
ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small cell lung cancer
-
D. Raben et al. ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small cell lung cancer Semin. Oncol. 29 1 Suppl. 4 2002 37-46
-
(2002)
Semin. Oncol.
, vol.29
, Issue.1 SUPPL. 4
, pp. 37-46
-
-
Raben, D.1
-
9
-
-
0345734200
-
Synergistic interaction between the EGFR tyrosine kinase inhibitor Gefitinib ("Iressa") and the DNA Topoisomerase I inhibitor CPT-11 (Irinotecan) in human colorectal cancer cells
-
F. Koizumi et al. Synergistic interaction between the EGFR tyrosine kinase inhibitor Gefitinib ("Iressa") and the DNA Topoisomerase I inhibitor CPT-11 (Irinotecan) in human colorectal cancer cells Int. J. Cancer 108 2004 464-472
-
(2004)
Int. J. Cancer
, vol.108
, pp. 464-472
-
-
Koizumi, F.1
-
10
-
-
1242293090
-
Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: Focus on NSCLC
-
C.J. Langer Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: Focus on NSCLC Int. J. Radiat. Oncol. Biol. Phys. 58 2004 991-1002
-
(2004)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.58
, pp. 991-1002
-
-
Langer, C.J.1
-
11
-
-
0035674731
-
Oral administration of a novel taxane, an antisense oligonucleotide targeting protein kinase A, and the epidermal growth factor receptor inhibitor Iressa causes cooperative antitumor and antiangiogenic activity
-
G. Tortora et al. Oral administration of a novel taxane, an antisense oligonucleotide targeting protein kinase A, and the epidermal growth factor receptor inhibitor Iressa causes cooperative antitumor and antiangiogenic activity Clin. Cancer Res. 7 2001 4156-4163
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 4156-4163
-
-
Tortora, G.1
-
12
-
-
0036361439
-
ZD1839 (Iressa™): For more than just non-small cell lung cancer
-
M. Ranson ZD1839 (Iressa™): For more than just non-small cell lung cancer Oncologist 7 Suppl. 4 2002 16-24
-
(2002)
Oncologist
, vol.7
, Issue.SUPPL. 4
, pp. 16-24
-
-
Ranson, M.1
-
13
-
-
4143143098
-
In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines
-
G.P. Dasmahapatra et al. In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines Clin. Cancer Res. 10 2004 5242-5252
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 5242-5252
-
-
Dasmahapatra, G.P.1
-
14
-
-
85194561136
-
A mathematical model of combination therapy using the EGFR signaling network
-
(in press)
-
Araujo, R.P. et al. A mathematical model of combination therapy using the EGFR signaling network. Biosystems (in press)
-
Biosystems
-
-
Araujo, R.P.1
-
15
-
-
0034019315
-
Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades
-
B.N. Kholodenko Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades Eur. J. Biochem. 267 2000 1583-1588
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 1583-1588
-
-
Kholodenko, B.N.1
-
16
-
-
0142059836
-
Protein complexes and functional modules in molecular networks
-
V. Spirin L.A. Mirny Protein complexes and functional modules in molecular networks Proc. Natl. Acad. Sci. USA 100 2003 12123-12128
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 12123-12128
-
-
Spirin, V.1
Mirny, L.A.2
-
17
-
-
37649029119
-
Connectivity distribution of spatial networks
-
C. Herrmann et al. Connectivity distribution of spatial networks Phys. Rev. E 68 2 Pt. 2 2003 1-6
-
(2003)
Phys. Rev. E
, vol.68
, Issue.2 PART 2
, pp. 1-6
-
-
Herrmann, C.1
-
18
-
-
0037376655
-
Sniffers, buzzers, toggles and blinkers: Dynamics or regulatory and signaling pathways in the cell
-
J.J. Tyson et al. Sniffers, buzzers, toggles and blinkers: Dynamics or regulatory and signaling pathways in the cell Curr. Opin. Cell Biol. 15 2003 221-231
-
(2003)
Curr. Opin. Cell Biol.
, vol.15
, pp. 221-231
-
-
Tyson, J.J.1
-
19
-
-
0029790351
-
Ultrasenstivity in the mitogen-activated protein kinase cascade
-
C.Y. Huang and J.E. Ferrell Ultrasenstivity in the mitogen-activated protein kinase cascade Proc. Natl. Acad. Sci. USA 93 1996 10078-10083
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10078-10083
-
-
Huang, C.Y.1
Ferrell, J.E.2
-
20
-
-
17644446947
-
How robust are switches in intracellular signaling cascades?
-
N. Bluthgen and H. Herzel How robust are switches in intracellular signaling cascades? J. Theor. Biol. 225 2003 293-300
-
(2003)
J. Theor. Biol.
, vol.225
, pp. 293-300
-
-
Bluthgen, N.1
Herzel, H.2
-
21
-
-
0034633702
-
Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study
-
R.L. Bar-Or et al. Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study Proc. Natl. Acad. Sci. USA 97 2000 11250-11255
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 11250-11255
-
-
Bar-Or, R.L.1
-
22
-
-
0033570090
-
Quantification of short term signaling by the epidermal growth factor receptor
-
B.N. Kholodenko et al. Quantification of short term signaling by the epidermal growth factor receptor J. Biol. Chem. 274 1999 30169-30181
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30169-30181
-
-
Kholodenko, B.N.1
-
23
-
-
0036024583
-
Dosing strategies for anticancer drugs: The good, the bad and the body-surface area
-
A. Felici et al. Dosing strategies for anticancer drugs: The good, the bad and the body-surface area Eur. J. Cancer 38 2002 1677-1684
-
(2002)
Eur. J. Cancer
, vol.38
, pp. 1677-1684
-
-
Felici, A.1
-
24
-
-
3042766489
-
Molecular biological design of novel antineoplastic therapies
-
M. Vulfovich N. Saba Molecular biological design of novel antineoplastic therapies Expert Opin. Investig. Drugs 13 2004 577-607
-
(2004)
Expert Opin. Investig. Drugs
, vol.13
, pp. 577-607
-
-
Vulfovich, M.1
Saba, N.2
-
25
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
J.G. Paez et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy Science 304 2004 1497-1500
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
-
26
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
T.J. Lynch et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N. Engl. J. Med. 350 2004 2129-2139
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
-
27
-
-
0642368571
-
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
-
M.C. Heinrich et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor J. Clin. Oncol. 21 2003 4342-4349
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 4342-4349
-
-
Heinrich, M.C.1
-
28
-
-
2542520755
-
Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
-
A. Duensing et al. Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs) Oncogene 23 2004 3999-4006
-
(2004)
Oncogene
, vol.23
, pp. 3999-4006
-
-
Duensing, A.1
-
29
-
-
0242670019
-
PDGFRA activating mutations in gastrointestinal stromal tumors
-
M.C. Heinrich et al. PDGFRA activating mutations in gastrointestinal stromal tumors Science 299 2003 708-710
-
(2003)
Science
, vol.299
, pp. 708-710
-
-
Heinrich, M.C.1
-
30
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
H. Davies et al. Mutations of the BRAF gene in human cancer Nature 417 2002 949-954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
-
31
-
-
0038666476
-
Clinical trial design and end points for epidermal growth factor receptor-targeted therapies: Implications for drug development and practice
-
C.L. Artega J. Baselga Clinical trial design and end points for epidermal growth factor receptor-targeted therapies: Implications for drug development and practice Clin. Cancer Res. 9 2003 1579-1589
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1579-1589
-
-
Artega, C.L.1
Baselga, J.2
|