Thiazide-like diuretics attenuate agonist-induced vasoconstriction by calcium desensitization linked to Rho kinase

Hypertension

Volumn 45, Issue 2, 2005, Pages 233-239

  Zhu, Zhiming ^a   Zhu, Shanjun ^a   Liu, Daoyan ^a   Cao, Tingbing ^a   Wang, Lijuan ^a   Tepel, Martin ^b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Diuretics; Kinase; Vasoconstriction

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ANGIOTENSIN; CALCIUM; NORADRENALIN; PROTEIN TYROSINE PHOSPHATASE SHP 2; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; THIAZIDE DIURETIC AGENT;

AGONIST; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DESENSITIZATION; DNA SYNTHESIS; ENDOTHELIUM; HYPERTENSION; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; VASCULAR RING; VASOCONSTRICTION;

ACUTE-PHASE PROTEINS; ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA; BLOOD PRESSURE; CALCIUM; CHLORTHALIDONE; DIURETICS; DNA; DRUG RESISTANCE; HYDROCHLOROTHIAZIDE; INTRACELLULAR MEMBRANES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NOREPINEPHRINE; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; SODIUM CHLORIDE SYMPORTER INHIBITORS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 13144257671     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000152701.97426.5f     Document Type: Article

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