Mechanistic study of proton transfer and hysteresis in catalytic antibody 16E7 by site-directed mutagenesis and homology modeling

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 4, 2005, Pages 1021-1029

  Zheng, Lei ^a   Manetsch, Roman ^b   Woggon, Wolf Dietrich ^b   Baumann, Ulrich ^a   Reymond, Jean Louis ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Catalytic antibody; Homology modeling; Proton transfer; Site directed mutagenesis

Indexed keywords

ACETAL DERIVATIVE; ALANINE; BENZISOXAZOLE; CARBON; CATALYTIC ANTIBODY; CATALYTIC ANTIBODY 16E7; CHIMERIC ANTIBODY; ENOL ETHER; ETHER DERIVATIVE; GLUTAMINE; HAPTEN; HEMIACETAL; IMMUNOGLOBULIN F(AB) FRAGMENT; ISOXAZOLE DERIVATIVE; PHENOL; SERINE; UNCLASSIFIED DRUG;

ANTIBODY STRUCTURE; ARTICLE; CATALYSIS; CATALYST; CHEMICAL REACTION; COMPLEX FORMATION; HYDROGEN BOND; HYSTERESIS; MICHAELIS MENTEN KINETICS; MOLECULAR MODEL; PROTON TRANSPORT; REACTION ANALYSIS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ANTIBODIES, CATALYTIC; BASE SEQUENCE; CLONING, MOLECULAR; DNA PRIMERS; IMMUNOGLOBULIN FAB FRAGMENTS; KINETICS; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; PROTONS;

EID: 12844268180     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.11.041     Document Type: Article

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