The 1.8-Å Crystal Structure of a Matrix Metalloproteinase 8-Barbiturate Inhibitor Complex Reveals a Previously Unobserved Mechanism for Collagenase Substrate Recognition

Journal of Biological Chemistry

Volumn 276, Issue 20, 2001, Pages 17405-17412

  Brandstetter, Hans ^a   Grams, Frank ^c   Glitz, Dagmar ^b   Lang, Anja ^a   Huber, Robert ^a   Bode, Wolfram ^a   Krell, Hans Willi ^b   Engh, Richard A ^a,b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYST SELECTIVITY; CHEMICAL ACTIVATION; CHEMICAL BONDS; COLLAGEN; COMPLEXATION; CRYSTAL LATTICES; CRYSTAL SYMMETRY; DRUG PRODUCTS; ENZYME INHIBITION; METALLORGANIC POLYMERS; ONCOLOGY; REACTION KINETICS;

ANTICANCER DRUGS;

ENZYMES;

1 (2 PYRIMIDINYL)PIPERAZINE; 2 HYDROXY 5 PHENYL 5 N (4 NITROPHENYLPIPERAZINYL)] 4,6 PYRIMIDINEDIONE; 2 HYDROXY 5 PHENYL 5 N [4 (2 HYDROXYETHYL)PIPERAZINYL] 4,6 PYRIMIDINEDIONE; 2 HYDROXY 5 PHENYL 5 N [4 (2 HYDROXYETHYL)PIPERIDYL] 4,6 PYRIMIDINEDIONE; 2 HYDROXY N OCTYL 5 N (4 NITROPHENYLPIPERAZINYL) 4,6 PYRIMIDINEDIONE; 2 HYDROXY N OCTYL 5 N [4 (2 HYDROXYETHYL)PIPERAZINYL] 4,6 PYRIMIDINEDIONE; 2 HYDROXYPYRIMIDINE 4,6 DIONE; 4 PYRIMIDINONE DERIVATIVE; ASPARAGINE; BARBITURIC ACID DERIVATIVE; BATIMASTAT; COLLAGENASE; ENZYME INHIBITOR; HYDROGEN; HYDROXAMATE DERIVED INHIBITOR; HYDROXYPROLINE; I COL043; MATRIX METALLOPROTEINASE 8 BARBITURATE INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; NITROGEN; OXYGEN; PYRIMIDINE DERIVATIVE; RO 200 1770; RO 204 1924; RO 206 0027; RO 206 0032; SERINE; STROMELYSIN; TYROSINE; UNCLASSIFIED DRUG; COLLAGEN; GELATINASE A; INTERSTITIAL COLLAGENASE; PROTEINASE INHIBITOR; ZINC;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CRYSTAL STRUCTURE; CYTOARCHITECTURE; DRUG DESIGN; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; GENETIC VARIABILITY; HUMAN; METABOLISM; METHODOLOGY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BARBITURATES; BINDING SITES; COLLAGEN; CRYSTALLOGRAPHY, X-RAY; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 8; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEASE INHIBITORS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; VARIATION (GENETICS); ZINC;

EID: 0035907237     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007475200     Document Type: Article

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