Collagen/collagenase interaction: Does the enzyme mimic the conformation of its own substrate?

FASEB Journal

Volumn 10, Issue 8, 1996, Pages 927-930

  De Souza, Sandro J ^a,d   Pereira, Humberto M ^b   Jacchieri, Saul ^c   Brentani, Ricardo R ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c Divisao de Biologia Medica   (Brazil)

^d HARVARD UNIVERSITY   (United States)

Author keywords

collagen triple helix; metalloproteinase; neutrophil collegenase; proline hinge region; proline zipper; serine protease

Indexed keywords

COLLAGEN; COLLAGENASE;

COLLAGEN METABOLISM; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR MODEL; PRIORITY JOURNAL; REVIEW;

EID: 0029967113     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.8.8666171     Document Type: Review

References (18)

1. Woessner, J. F. (1991) Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 5, 2145-2154
2. Fields, G. B., Netzel-Arnett, S. J., Windsor, L. J., Engler, J. A., Birkedal-Hansen, H., and Van-Wart, H. E. S. (1990) Proteolytic activities of human fibroblast collagenase: hydrolysis of a broad range of substrates at a single active sites. Biochemistry 29, 6670-6677
3. de Souza, S. J., and Brentani, R. R. (1992) Collagen-binding site in collagenases can be determined using the concept of sense/anti-sense peptide interactions. J. Biol. Chem. 267, 13763-13767
4. Hirose, T., Patterson, C., Pourmotabbed, T., Mainardi, C. L., and Hasty, K. (1990) Structure/function relationship of human neutrophil collagenase: Identification of regions responsible for substrate specificity and general proteinase activity. Proc. Natl. Acad. Sci. USA 90, 2569-2573
5. Schnierer, S., Kleine, T., Gote, T., Hillemann, A., Knauper, V., and Tschesche, H. (1993) The recombinant catalytic domain of human neutrophil collagenase lacks type I collagen substrate specificity. Biochem. Biophys. Res. Commun. 191, 319-326
6. Knauper, V., Osthues, A., DeClerck, Y. A., Langley, K. E., Blaser, J., and Tschesche, H. (1993) Fragmentation of human polymorphonuclear-leukocyte collagenase. Biochem. J. 291, 847-854
7. Clarck, I. N., and Cawston, T. E. (1989) Fragments of human fibroblast collagenase. Purification and characterization. Biochem. J. 263, 201-206
8. de Souza, S. J., and Brentani, R. R. (1994) On the structure-function relationship of polymorphonuclear-leukocyte collagenase. Biochem. J. 300, 605
9. Ramachandran, G. N. (1967) In Treatise on Collagen, Vol. 1, Academic Press, New York
10. Blundell, T. L., Pitts J. E., Tickle, I. J., Wood, S. P., and Wu, C. W. (1981) X-ray analysis (1.4 Å resolution) of avian pancreatic polypeptide: Small globular protein hormone. Proc. Natl. Acad. Sci. USA 78, 4175-4179
11. Darbon, H., Bernassau, J. M., Deleuze, C., Chenu, J., Roussel, A., and Cambillau, C. (1992) Solution conformation of human neuropeptide Y by H-nuclear magnetic ressonance and restrained molecular dynamics. Eur. J. Biochem. 209, 765-771
12. Williamson, M. P. (1994) The structure and function of proline-rich regions in proteins. Biochem. J. 297, 249-260
13. Aimes, R. T., and Quigley, J. P. (1995) Matrix metalloproteinase-2 is an interstitial collagenase. J. Biol. Chem. 270, 5872-5876
14. Lovejoy, B., Cleasby, A., Hassell, A. M., Longley, K., Luther, M. A., Weigl, D., McGeehan, G., McElroy, A. B., Drewry, D., Lambert, M. H., et al. (1994) Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor. Science 263, 375-377
15. Bode, W., Reinemer, P., Huber, R., Kleine, T., Schnierer, S., and Tschesche, H. (1994) The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. EMBO J. 13, 1263-1269
16. Borkakoti, N. (1994) Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor. Nature Struct. Biol. 1, 106-110
17. Tsu, C. A., Perona, J. J., Schellenberger, V., Turck, C. W., and Craik, C. S. (1994) The substrate specificity of Uca pugilator collagenolytic serine protease 1 correlates with the bovine type I collagen cleavage sites. J. Biol. Chem 269, 19565-19572
18. Li, J., O'Hare, M. C., Skanynski, T., Lloyd, L. F., Curry, V. A., Clark, I. M., Bigg, H. F., Hazleman, B. L., Cawston, T. E., and Blow, D. M. (1995) Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed B-propeller. Structure 3, 541-549