Susceptibility of nontypeable Haemophilus influenzae to human β-defensins is influenced by lipooligosaccharide acylation

Infection and Immunity

Volumn 70, Issue 9, 2002, Pages 5287-5289

  Starner, Timothy D ^a   Swords, W Edward ^a   Apicella, Michael A ^a   McCray Jr , Paul B ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN; BETA DEFENSIN 2; BETA DEFENSIN 3; LIPID A; OLIGOSACCHARIDE; UNCLASSIFIED DRUG;

ACYLATION; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; GENE MUTATION; GENETIC COMPLEMENTATION; HAEMOPHILUS INFLUENZAE; HTRB GENE; HUMAN; LIPOGENESIS; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ACYLATION; ACYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-DEFENSINS; DRUG RESISTANCE, BACTERIAL; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; HAEMOPHILUS INFLUENZAE; HUMANS; LIPID A; LIPOPOLYSACCHARIDES; MUTATION;

EID: 0036717730     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.9.5287-5289.2002     Document Type: Article

References (26)

1. Evaluation of the virulence of nontypeable Haemophilus influenzae lipooligosaccharide htrB and rfaD mutants in the chinchilla model of otitis media
2. Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa
3. Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides
4. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic
5. A peptide antibiotic from human skin
6. Sialic acid in the lipopolysaccharide of Haemophilus influenzae: Strain distribution, influence on serum resistance and structural characterization
7. The structure of human beta-defensin-2 shows evidence of higher order oligomerization
8. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs
9. Discovery of new human beta-defensins using a genomics-based approach
10. Mutation of the htrB locus of Haemophilus influenzae non-typable strain 2019 is associated with modifications of lipid A and phosphorylation of the lipo-oligosaccharide
11. Ultrasensitive assays for endogenous antimicrobial polypeptides
12. Nasopharyngeal carriage of antibiotic-resistant Haemophilus influenzae in healthy children
13. Bacterial phosphorylcholine decreases susceptibility to the antimicrobial peptide LL-37/hCAP18 expressed in the upper respiratory tract
14. Identification of Proteus mirabilis mutants with increased sensitivity to antimicrobial peptides
15. Nontypable Haemophilus influenzae: A review of clinical aspects, surface antigens, and the human immune response to infection
16. A subtyping system for nontypable Haemophilus influenzae based on outer-membrane proteins
17. The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD-3 against Staphylococcus aureus
18. β-defensins in lung host defense
19. Production of beta-defensins by human airway epithelia
20. Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor
21. Acylation of the lipooligosaccharide of Haemophilus influenzae and colonization: An htrB mutation diminishes the colonization of human airway epithelial cells
22. Evaluation of phase variation of nontypeable Haemophilus influenzae lipooligosaccharide during nasopharyngeal colonization and development of otitis media in the chinchilla model
23. A PhoP/PhoQ-induced lipase (PagL) that catalyzes 3-O-deacylation of lipid A precursors in membranes of Salmonella typhimurium
24. Adaptation of Haemophilus influenzae to acquired and innate humoral immunity based on phase variation of lipopolysaccharide
25. Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein
26. Interactions between human defensins and lipid bilayers: Evidence for formation of multimeric pores